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Synthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H-2-azacyclopenta[b]anthracene-5,10-diones  

Kwak, Jae-Hwan (College of Pharmacy, Chungbuk National University)
Jeong, Eun-Kyeong (College of Pharmacy, Chungbuk National University)
Oh, Ju-Hoon (College of Pharmacy, Chungbuk National University)
Jung, Jae-Kyung (College of Pharmacy, Chungbuk National University)
Hong, Jin-Tae (College of Pharmacy, Chungbuk National University)
Lee, Hee-Soon (College of Pharmacy, Chungbuk National University)
Publication Information
YAKHAK HOEJI / v.53, no.1, 2009 , pp. 41-44 More about this Journal
Abstract
A series of 2-alkyl-2,3-dihydro-1H-2-azacyclopenta[b]anthracene-5,10-diones ($3a{\sim}h$) were synthesized and evaluated in vitro cytotoxicity against colon cancer cell lines (HCT116 and SW620) and nuroblastoma cell lines (SK-N-SH and SK-N-MC). Among them, compound 3f showed significant cytotoxic activity ($IC_{50}$ against SK-N-SH; $14.8{\mu}M$, $IC_{50}$ against SK-N-MC; $11.3{\mu}M$).
Keywords
cytotoxicity; 2-azacyclopenta[b]anthracene-5,10-diones;
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Times Cited By KSCI : 2  (Citation Analysis)
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