• The Korean Journal of Physiology and Pharmacology
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• 제23권4호
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• pp.263-270
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• 2019

Hydrogen sulfide is well-known to exhibit anti-inflammatory and cytoprotective activities, and also has protective effects in the liver. This study aimed to examine the protective effect of hydrogen sulfide in rats with hepatic encephalopathy, which was induced by mild bile duct ligation. In this rat model, bile ducts were mildly ligated for 26 days. Rats were treated for the final 5 days with sodium hydrosulfide (NaHS). NaHS ($25{\mu}mol/kg$), 0.5% sodium carboxymethyl cellulose, or silymarin (100 mg/kg) was administered intraperitoneally once per day for 5 consecutive days. Mild bile duct ligation caused hepatotoxicity and inflammation in rats. Intraperitoneal NaHS administration reduced levels of aspartate aminotransferase and alanine aminotransferase, which are indicators of liver disease, compared to levels in the control mild bile duct ligation group. Levels of ammonia, a major causative factor of hepatic encephalopathy, were also significantly decreased. Malondialdehyde, myeloperoxidase, catalase, and tumor necrosis factor-${\alpha}$ levels were measured to confirm antioxidative and anti-inflammatory effects. N-Methyl-D-aspartic acid (NMDA) receptors with neurotoxic activity were assessed for subunit NMDA receptor subtype 2B. Based on these data, NaHS is suggested to exhibit hepatoprotective effects and guard against neurotoxicity through antioxidant and anti-inflammatory actions.

• Journal of Advanced Marine Engineering and Technology
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• 제34권5호
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• pp.638-644
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• 2010

사각 덕트내 열전달과 유동 양상을 조사하기 위해 꼬임식 테이프 만 설치한 경우와 꼬임식 테이프와 리브(rib)를 설치한 경우에 대해 충분히 발달된 난류유동에 관한 수치 해석을 행하였다. 수치 해석에서는 레이놀즈 수가 8,900에서 29,000 범위의 난류 스월유동, 채널수력직경에 대한 리브의 높이(e/$D_h$)가 0.067, 그리고 채널 수력 직경에 대한 시험부 길이(L/$D_h$)가 30인 경우에 대해 고려하였다. 리브는 채널 바닥면에 만 길이 방향으로 설치하였다. 꼬임식 테이프는 0.1 mm 두께의 탄소강 판 재질이며, 폭은 28 mm, 길이는 900 mm이고 2.5 번 회전시켰다. 각 벽면은 서로 단열된 알루미늄 판으로 구성되었다. 2가지의 가열 조건에 대해 조사 하였다: (1) 사각 전체 벽 면적에 일정한 열유속으로 가열, 그리고 (2) 사각 채널에서 마주보는 상하 양면 만 가열. 연구 결과 상하 양면 만 가열하는 경우가 4면 모두 가열하는 경우보다 열전달 계수가 우수하였고 꼬임식 테이프와 리브를 설치한 경우 열전달 계수가 현저히 향상되었다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집D
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• pp.115-120
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• 2001

The present study examined the possibility of $NO_{x}$ reduction in the high temperature industrial furnaces. duct burner of gas turbine cogeneration and two-stage gas turbine combustor. The experimental study was carried out for the diffusion flame of second stage combustor with the variations of oxygen concentration and supplying rate of hot exhaust gas from first stage combustor. It also examined the flammability range and $NO_{x}$ formation of the second stage combustor in which the fuel is supplying into the mixture of oxygen hot exhaust gas from first stage combustor. The results show that the enrichment of oxygen and increase of exhaust gas lead to increase the $NO_{x}$ up to 50 ppm with 23% $O_{2}$ condition.

• 한국항공운항학회지
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• 제12권2호
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• pp.17-28
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• 2004

In unmanned aerial vehicle (UAV), the high temperature results from friction with the air, combustion of fuel and combustion gas of a nozzle etc. It causes serious problems in the UAV structure. The characteristic analysis of heat resistant metal and ceramic materials and creep analysis for the functionally graded material (FGM) is presented in this paper. FGM is composed of two constituent materials that are mixed up according to the specific volume fraction distribution in order to withstand high heat condition. In addition, the creep behavior of FGM applied in duct structure of an engine is analyzed.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회B
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• pp.2029-2032
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• 2008

In this study, we have investigated the effects of upstream rectangular winglet pair (RWP) on the heat/mass transfer coefficients in a dimple. Dimple print diameter was fixed at 20mm and the dimple depth was 4.0mm (0.4H). The dimple surface was coated with naphthalene for mass transfer experiment and the test plate was positioned at a rectangular straight duct whose aspect ratio (W/H) was 20. A rectangular winglet pair was positioned at y/d=-2.5. The RWP angle ($\beta$) was varied from $15^{\circ}$ to $60^{\circ}$. The Reynolds number, based on the duct height (H), was 5,000. with changing the RWP angle ($\beta$), the induced vortices had different flow characteristics; longitudinal or transversal vortices. These variation of induced vortices affected on the heat/mass transfer characteristics in the dimple.

• International Journal of Naval Architecture and Ocean Engineering
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• 제7권2호
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• pp.390-398
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• 2015

Energy-saving devices for 317K VLCC have been developed from a propulsion standpoint. Two ESD candidates were designed via computational tools. The first device WAFon composes of flow-control fins adapted for the ship wake to reduce the loss of rotational energy. The other is WAFon-D, which is a WAFon with a duct to obtain additional thrust and to distribute the inflow velocity on the propeller plane uniform. After selecting the candidates from the computed results, the speed performances were validated with model-tests. The hydrodynamic characteristics of the ESDs may be found in improved hull and propulsive efficiencies through increased wake fraction.

• 동력기계공학회지
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• 제16권4호
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• pp.44-50
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• 2012

The present numerical study was performed to determine how the two perforated baffles( Inclined angle=$5^{\circ}$; perforation diameter=2cm) placed at a rectangular duct affect heat transfer and associated friction factors. The parametric effects of perforated baffles(3, 6 and 12 holes) and flow Reynolds number ranging from 28,900 to 61,000 on the heated target surface are explored. As for the investigation of heat transfer behaviours on the local Nusselt number with two baffles placed at $x/D_h=0.8$ and $x/D_h=0.8$ of the edge baffles, it is evident that the average Nusselt number increases with increasing number of holes, but the friction factor decreases with an increase in the hole number placed at baffles. The numerical results by commercial code CFX 10.0 are confirmed with the experimental data.

• 대한기계학회논문집B
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• 제30권9호
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• pp.873-881
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• 2006

The present study investigates the pressure drop characteristics in rotating two-pass ducts. The duct has an aspect ratio (W/H) of 0.5 and a hydraulic diameter $(D_h)$ of 26.67mm. Rib turbulators are attached crossly in the four different arrangements on the leading and trailing surfaces of the test ducts. The ribs have a rectangular cross section of $2mm(e){\times}3mm(w)$ and an attack angle of $70^{\circ}C$. The pitch-to-rib height ratio (pie) is 7.5, and the rib height-to-hydraulic diameter ratio $(e/D_h)$ is 0.075. The results show that the highest pressure drop among each region appears in the turning region for the stationary case, but appears in the upstream region of the second pass for the rotating case. Effects of cross rib arrangements are almost the same in the first pass for the stationary and rotating cases. In the second pass, however, heat transfer and pressure drop are high for the cases with cross NN or PP type ribs in the stationary ducts. In the rotating ducts, they are high for the cases with cross NP or PP type ribs.

• 대한기계학회논문집B
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• 제30권9호
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• pp.882-890
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• 2006

The present study investigates the pressure drop characteristics in rotating two-pass ducts. The duct has an aspect ratio (W/H) of 0.5 and a hydraulic diameter $(D_h)$ of 26.67mm. Rib turbulators are attached parallel in the four different arrangements on the leading and trailing surfaces of the test ducts. The ribs have a rectangular cross section of $2m(e){\times}3mm(w)$ and an attack angle of $70^{\circ}C$. The pitch-to-rib height ratio (p/e) is 7.5, and the rib height-to-hydraulic diameter ratio $(e/D_h)$ is 0.075. The results show that the highest pressure drop among each region appears in the turning region for the stationary case, but appears in the upstream region of the second pass for the rotating case. Effects of parallel rib arrangements are almost the same in the first pass for the stationary and rotating cases. In the second pass, however, heat transfer and pressure drop are high for the cases with parallel NN or PP type ribs in the stationary ducts. In the rotating ducts, they are high for the cases with parallel NN or PN type ribs.

• Journal of Microbiology and Biotechnology
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• 제19권12호
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• pp.1569-1572
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• 2009

The pharmacokinetics of decursin and decursinol angelate (D/DA) were investigated in male SD rats following oral and intravenous administration. D/DA and metabolites obtained from in vitro samples were evaluated by LC/MS. The levels of D/DA and metabolized decursinol in the blood following oral and intravenous administrations declined according to first-order kinetics, with $T_{1/2}$ values of 56.67, 58.01, and 57.22 h, respectively, being observed after administration of a dose of 2 mg/kg body weight. The large intestine was the major site of disposition following oral administration. These data indicate that D/DA is rapidly absorbed from the gastrointestinal tract. In in vitro experiment utilizing liver microsomal protein, the major metabolic reaction of D/DA occurred to change decursinol. The cumulative biliary, urinary, and fecal excretions of D/DA in bile duct-cannulated rats was $36.10{\pm}2.9%$, $25.35{\pm}3.8%$, and $34.20{\pm}3.2%$, respectively, at 72 h after administration. These results indicate that the absorption of D/DA is almost complete, and that its metabolites are primarily excreted into feces through the bile. These results indicate that D/DA is subject to enterohepatic circulation.