• Journal of Korea Game Society
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• v.16 no.6
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• pp.121-130
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• 2016

The purpose of this study was to develop the customized diet education game (Roly-Poly 160) for type II diabetes and to test its effectiveness. The diet education game for type II diabetic is composed of three kinds of modules as Meal self-management, Card Game, and Quiz Game. Meal self-management was developed to manage the dietary information of each day and to observe changes in the 12-month period. Card game is to find a changed card based on the recommended meal menu during a limited time and Quiz game is to learn knowledge while solving the quizzes about diet. Data was collected from September 28th to October 28th, 2016 at C hospital and G hospital in G district, and 5 times for 1 hour for every 30 people with type II diabetes who applied for diabetic diet education. Knowledge of diabetes and 2 hour postprandial blood glucose were measured repeatedly before and after the experiment. After the Roly-Poly 160 experiment, the knowledge of type II diabetes was statistically significantly increased (p = 0.04), and the fasting blood glucose and the 2 hour postprandial blood glucose decreased statistically decreased (p <.05) and Roly-Poly 160 game clinical efficacy was verified.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.9
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• pp.498-508
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• 2020

This study was a descriptive research study performed to identify the degree and correlation of variables and also explain the factors that influence self-efficacy of diabetes management. The participants were 150 diabetes patients who visited a primary medical institution in K city in Korea from September 17, 2015, to October 15, 2015. The data were analyzed using descriptive statistics, t-tests, ANOVA, Pearson correlation coefficients, and multiple regression with SPSS 18.0. Significant differences in age and education were detected in self-efficacy of diabetes management according to general characteristics. The levels of self-management knowledge and diabetes management self-efficacy were shown to be positively correlated. The levels of diabetes management self-efficacy and distress as well as levels of self-management knowledge and distress were shown to be negatively correlated. The significant factors influencing diabetes management self-efficacy were distress and self-management knowledge. The results suggest that appropriate diabetes management self-efficacy programs should be provided in order to improve self-management knowledge and decrease distress in type 2 diabetes patients. This study provides basic data to promote the effective education and development of arbitration in order to enhance self-efficacy of diabetes management.

• The Monthly Diabetes
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• s.240
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• pp.23-25
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• 2009

제 2형 당뇨병을 15년째 앓고 있는 김 씨는(70) 일주일 전부터 기침이 나오고 열과 오한 등의 몸살 증상이 계속됐지만 별로 대수롭게 생각하지 않았다. 처음에는 가벼운 감기거니 생각하여 조금 지나면 나아지겠지 하는 마음이었지만 날이 갈수록 회복될 기미는 보이지 않고 증상이 악화되어 결국에는 병원에 입원하게 됐다. 병명은 폐렴. 감기를 가볍게 여겨 그대로 방치한 것이 화근이었다. 신종플루 대란에 힘입어 당뇨병환자의 건강에 대한 우려의 목소리가 커지고 있다. 겨울이면 반갑지 않은 감기나 독감 등 계절성 질환이 기승을 부리는데, 일반인에 비해 면역력이 약한 당뇨병환자는 질병에 걸리지 않도록 조심해야 한다. 감기나 독감을 가볍고 우습게 여기다가 생명까지 위협할 수 있는 무기가 될 수 있기 때문이다.

• Restorative Dentistry and Endodontics
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• v.34 no.3
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• pp.169-176
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• 2009

Diabetes Mellitus (DM) is a syndrome accompanied with the abnormal secretion or function of insulin, a hormone that plays a vital role in controlling the blood glucose level (BGL). Type land 2 DM are most common form and the prevalence of the latter is recently increasing, The aim of this article was to assess whet her Type 2 DM could act as a predisposing risk factor on the pulpo-periapical pathogenesis. Previous literature on the pathologic changes of blood vessels in DM was thoroughly reviewed. Furthermore, a histopathologic analysis of artificially-induced periapical specimens obtained from Type 2 diabetic and DM-resistant rats was compared. Histopathologic results demonstrate that the size of periapical bone destruction w as larger and the degree of pulpal inflammation was more severe in diabetic rats, indicating that Type 2 D M itself can be a predisposing risk factor that makes the host more susceptible to pulpal infection. The possible reasons may be that in diabetic state the lumen of pulpal blood vessels are thickened by atheromatous deposits, and microcirculation is hindered, The function of polymorphonuclear leukocyte is also impair ed and the migration of immune cells is blocked, leading to increased chance of pulpal infection. Also, lack of collateral circulation of pulpal blood vessels makes the pulp more susceptible to infection. These decrease the regeneration capacity of pulpal cells or tissues, delaying the healing process, Therefore, when restorative treatment is needed in Type 2 DM patients, dentists should minimize irritation to the pulpal tissue un der control of BGL.

• Korean Journal of Psychosomatic Medicine
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• v.7 no.2
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• pp.203-212
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• 1999

Objectives : "Alexithymia" mean literally "no word for mood(or emotion)". It is not only a marked constriction in emotional functioning but a deficit in their cognitive processing. We designed this study to investigate the level of alexithymia, psychopathology and personality factors of patients with somatoform disorder and with diabetes mellitus. Methods : The subjects were consisted of patients with somatoform disorder(N=20), patients with diabetes mellitus(N=20), and normal control(N=20). The level of alexithymia, psychopathology and personality factors were assessed by the Toronto Alexithymia Scale(TAS), the Symptom Checklist 90-Revision(SCL 90-R), and the Sixteen Personality Factor Questionnaire(16-PF). And we compared demographic characteristics, psychopathology and personality factors among three groups, and assessed the relationship between alexithymia and psychopathology, and between alexithymia and personality factors. Results : The results were as follows. 1) Patients with somatoform disorder showed significantly higher TAS scores compared to patients with diabetes mellitus and the normal control group. 2) Patients With somatoform disorder showed significantly higher scores of somatization, anxiety scales than patients with diabetes mellitus and the normal control group, and showed significantly higher scores of obsessive-compulsive, depression, phobic anxiety, psychoticism scales than the normal control group by the SCL-90-R. 3) The normal control group showed high intelligence scores only as compared to patients with somatoform disorder by the 16-PF. 4) A significant relationship was found between TAS scores and psychopathology in patients with somatoform disorder. 5) All three groups did not shown any correlation between TAS and 16-PF. Conclusion : Patients with somatoform disorder showed higher TAS scores and more multiple psychopathology than patients with diabetes mellitus and the normal controls. A significant relationship was found between TAS scores and psychopathology in patients with somatoform disorder. We suggest that the therapeutic approach to patients with somatoform disorder to express emotions and manage psychopathology, and that the treatment methods of patients with diabetes mellitus aims to improve firstly physical conditions are more helpful.

• The Monthly Diabetes
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• s.217
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• pp.21-23
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• 2007

당뇨병환자에서 혈당조절의 중요성은 '앙꼬 없는 찐빵' 또는 '김 없는 김밥'과의 관계와 같다. 당뇨병이 우리가 먹은 음식이 우리 몸에서 잘 활용되지 못하고, 소변으로 당이 넘쳐흘러서 나오는 현상을 보고 붙여진 이름인 것을 생각하면 둘 간의 관계는 땔래야 땔 수 없는 관계라 할 수 있습니다. 우리가 무서워하는 당뇨병의 합병증은 혈당조절을 잘 하게 되면 많은 부분 예방이 가능하다는 것을 알 수 있습니다. 제 1형 당뇨병의 대표적 연구인 DCCT 연구 결과를 보면 당화혈색소를 8.0%에서 7.2%로 낮추면 망막증의 진행을 40$\sim$50%를 줄일 수 있었습니다. 제 2형 당뇨병의 대표적 연구인 UKPDS연구는 당화혈색소 1%를 줄이면 미세혈관합병증은 37%, 심근경색은 14% 감소된다는 것을 확인해 주었습니다. 그 이외에도 많은 연구들에서 결과의 차이는 있지만 적극적이고 엄격한 혈당조절은 합병증의 발생을 예방하며, 발생된 합병증의 진행 속도를 늦출 수 있는 가장 효과적인 방법으로 증명하고 있습니다. 그런데 여러분들께서는 위에 언급한 '당화혈색소'를 알고 계십니까? 공복 혈당조절 목표를 알고 계십니까? 식후 혈당조절 목표를 알고 계십니까? 혹시 모르고 계시다면 100미터 출발 선상에서 출발 신호가 났지만 어디로 달려갈지 모르고 있는 것과 같습니다. 아무리 잘 달리고 훌륭한 선수라도 뛰어갈 방향을 모르고 있다면 좋은 성적을 낼 수 없는 것과 같습니다. 혈당조절의 중요성을 알고 관리 목표를 알고 현재 나의 수치를 그 목표를 행해 열심히 실행한다면 건강한 삶을 영위할 수 있습니다.

• Journal of Life Science
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• v.20 no.4
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• pp.602-606
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• 2010

Type 2 diabetes is a typical polygenic disease complex, for which several common risk alleles have been identified. Proteins in the matrix metalloproteinase-3 (MMP3) family are involved in the breakdown of the extracellular matrix in normal physiological processes such as embryonic development, reproduction and tissue remodeling, as well as in disease processes. Therefore, we investigated the genotype for the A(-267)G, A658G and T813C polymorphisms in the MMP3 gene in the Korean population and compared genotypes of patients with those of the control group. 200 patients (male 108, female 92), who had previously been diagnosed with type 2 diabetes (T2DM) and 100 control subjects (male 36, female 64) participated in this study. There was a strong association between A(-267)G and A658G polymorphism in the MMP3 gene and T2DM. The present study shows that MMP3 polymorphisms (A(-267)G and A658G) may be associated with the pathogenesis of T2DM. Further studies with a larger population may be needed for the development of diagnostic methods at a genetic level, such as DNA chip.

• Journal of Digital Convergence
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• v.17 no.8
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• pp.249-255
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• 2019

Type 2 diabetes mellitus(T2DM) is included in metabolic disorders characterized by hyperglycemia, which causes many complications, and requires long-term treatment resulting in massive medical expenses each year. There have been many studies to solve this problem, but the existing studies have not been accurate by learning and predicting the data at specific time point. Thus, this study proposed a model using RNN to increase the accuracy of prediction of T2DM. This work propose a T2DM prediction model based on Korean Genome and Epidemiology study(Ansan, Anseong Korea). We trained all of the data over time to create prediction model of diabetes. To verify the results of the prediction model, we compared the accuracy with the existing machine learning methods, LR, k-NN, and SVM. Proposed prediction model accuracy was 0.92 and the AUC was 0.92, which were higher than the other. Therefore predicting the onset of T2DM by using the proposed diabetes prediction model in this study, it could lead to healthier lifestyle and hyperglycemic control resulting in lower risk of diabetes by alerted diabetes occurrence.

• The Journal of the Convergence on Culture Technology
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• v.4 no.1
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• pp.315-323
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• 2018

Rapid increase of diabetic population is a major health concern in Korea. In a trial to develop food components which can prevent and/or cure diabetes, we investigated the anti-diabetic activity of curcumin in high fat diet (HFD)-induced type 2 diabetes mellitus (T2DM) animal model. C57BL/6 mice were divided into three groups: normal diet (ND), high fat diet (HFD), and curcumin (CUR, HFD+0.02% curcumin). Mice were fed each diet for 16 weeks. CUR significantly reduced body weight gain, the levels of plasma glucose, insulin, total-cholesterol (T-C), and LDL-C, whereas increased HDL-C compared to those of HFD group. Notably, insulin signaling pathway was activated by CUR. This suggests that CUR improves obesity-associated T2DM by overcoming insulin resistance in part.

• Clinical and Experimental Pediatrics
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• v.48 no.6
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• pp.624-633
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• 2005

Purpose : This study analyzed the expression of HLA-DR and DQ genotypes and anti-thyroid autoantibodies[anti-thyroid peroxidase(TPO) and anti-thyroglobulin(TG) antibodies] in Korean patients with type 1 diabetes(T1DM) to investigate the susceptible HLA alleles to T1DM in Korea and the prevalence of thyroid autoantibodies and their significance for the development of thyroid disorders. Methods : A total of 59 Korean patients with type 1 diabetes[26 males, median age 13.7 years(range 5.7-29.9 years), diabetes duration 7.6 years(-1.7-22.5 years)] were enrolled in this study, and 200 healthy Koreans without a family history of diabetes were selected as a normal control for the comparison of HLA genotypes. Seventeen patients with anti-TPO or anti-TG were followed [median duration 3.96 years(1 day-10.7 years)] with measurement of anti-TPO, anti-TG, $T_3$, $T_4$ or free $T_4$, TSH levels and physical examinations. HLA-DR and DQ genotyping were done by PCR-SSO, PCR-SSCP, PCR-RFLP and PCR-SSP methods. Results : HLA analysis showed higher frequencies of HLA-DRB1*0301, *090102 and DQB1*0201, *030302 alleles, DRB1*0301/*090102, *090102/*090102 and DQB1 *0201/*030302, *030302/*030302, *0201/ *0302 genotypes in T1DM patients compared to controls(Pc<0.05). Fifteen(25.4 percent) had anti-TPO antibody, 12(20.3 percent) had anti-TG, 17(28.8 percent) had either autoantibody and 10(16.9 percent) had both autoantibodies. No clinical or subclinical hypothyroidism developed during follow-up after the first detection of anti-thyroid autoantibody. There was no significant correlation between thyroid autoimmunity and gender, onset age of T1DM, and diabetes duration, respectively(P>0.05). Conclusion : We thought this unique HLA-DR, DQ allele distribution might be an important factor for the low incidence of T1DM in Korea. And a high prevalence of thyroid autoantibodies in these populations suggests examinations of thyroid antibodies should be performed regularly. Optimal age for the initial screening and the frequency of re-screening for associated thyroid autoimmune diseases in T1DM remains to be determined through prospective follow-up.