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COMPARISON OF SALIVARY ANTIBODY IgA TITRE TO STREPTOCOCCUS MUTANS BETWEEN THE CARIES-EXPERIENCED AND NON-EXPERIENCED GROUPS USING IMMUNO-SLOT BLOT METHOD (Immuno-slot blot method를 이용한 우식 경험 아동과 비경험 아동간의 Streptococcus mutans에 대한 타액내 IgA 역가의 비교)

  • Eum, Jong-Hyeok;Jeong, Tae-Sung;Kim, Shin
    • Journal of the korean academy of Pediatric Dentistry
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    • v.29 no.3
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    • pp.354-361
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    • 2002
  • The aim of this study is to develop and establish rapid, convenient, and accurate method of analyzing salivary IgA against S. mutans semi-quantitatively. Relative salivary IgA titer was calculated as maximum dilution fold of S. mutans protein that was not detected by salivary antibody after measuring relative intensity of the immune blot bands by densitometry. Analyses were performed in caries-experienced and non-experienced children. Mean IgA titer of non-experienced group shows higher level than that of caries-experienced without statistical significance due to high individual variety of antibody titer in non-experienced group: $2^{6.278{\pm}2.260}$ in non-experienced group and $2^{5.730{\pm}0.499}$ in caries-experienced group(p=0.464). Those results suggest that naturally induced salivary IgA antibodies against S. mutans were present in all subjects, but high titer of antibodies were not achieved in caries-experienced group. On the contrary, antibody titer in non-experienced group shows marked individual variations suggesting that antibody production is multifactorial. In conclusion, immune-slot blot method developed in this study would be useful and applicable in semi-quantitative analysis of antibodies.

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Detection of Wildfire Smoke Plumes Using GEMS Images and Machine Learning (GEMS 영상과 기계학습을 이용한 산불 연기 탐지)

  • Jeong, Yemin;Kim, Seoyeon;Kim, Seung-Yeon;Yu, Jeong-Ah;Lee, Dong-Won;Lee, Yangwon
    • Korean Journal of Remote Sensing
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    • v.38 no.5_3
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    • pp.967-977
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    • 2022
  • The occurrence and intensity of wildfires are increasing with climate change. Emissions from forest fire smoke are recognized as one of the major causes affecting air quality and the greenhouse effect. The use of satellite product and machine learning is essential for detection of forest fire smoke. Until now, research on forest fire smoke detection has had difficulties due to difficulties in cloud identification and vague standards of boundaries. The purpose of this study is to detect forest fire smoke using Level 1 and Level 2 data of Geostationary Environment Monitoring Spectrometer (GEMS), a Korean environmental satellite sensor, and machine learning. In March 2022, the forest fire in Gangwon-do was selected as a case. Smoke pixel classification modeling was performed by producing wildfire smoke label images and inputting GEMS Level 1 and Level 2 data to the random forest model. In the trained model, the importance of input variables is Aerosol Optical Depth (AOD), 380 nm and 340 nm radiance difference, Ultra-Violet Aerosol Index (UVAI), Visible Aerosol Index (VisAI), Single Scattering Albedo (SSA), formaldehyde (HCHO), nitrogen dioxide (NO2), 380 nm radiance, and 340 nm radiance were shown in that order. In addition, in the estimation of the forest fire smoke probability (0 ≤ p ≤ 1) for 2,704 pixels, Mean Bias Error (MBE) is -0.002, Mean Absolute Error (MAE) is 0.026, Root Mean Square Error (RMSE) is 0.087, and Correlation Coefficient (CC) showed an accuracy of 0.981.

Calculation of Surface Heat Flux in the Southeastern Yellow Sea Using Ocean Buoy Data (해양부이 자료를 이용한 황해 남동부 해역 표층 열속 산출)

  • Kim, Sun-Bok;Chang, Kyung-Il
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.19 no.3
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    • pp.169-179
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    • 2014
  • Monthly mean surface heat fluxes in the southeastern Yellow Sea are calculated using directly observed airsea variables from an ocean buoy station including short- and longwave radiations, and COARE 3.0 bulk flux algorithm. The calculated monthly mean heat fluxes are then compared with previous estimates of climatological monthly mean surface heat fluxes near the buoy location. Sea surface receives heat through net shortwave radiation ($Q_i$) and loses heat as net longwave radiation ($Q_b$), sensible heat flux ($Q_h$), and latent heat flux ($Q_e$). $Q_e$ is the largest contribution to the total heat loss of about 51 %, and $Q_b$ and $Q_h$ account for 34% and 15% of the total heat loss, respectively. Net heat flux ($Q_n$) shows maximum in May ($191.4W/m^2$) when $Q_i$ shows its annual maximum, and minimum in December ($-264.9W/m^2$) when the heat loss terms show their annual minimum values. Annual mean $Q_n$ is estimated to be $1.9W/m^2$, which is negligibly small considering instrument errors (maximum of ${\pm}19.7W/m^2$). In the previous estimates, summertime incoming radiations ($Q_i$) are underestimated by about $10{\sim}40W/m^2$, and wintertime heat losses due to $Q_e$ and $Q_h$ are overestimated by about $50W/m^2$ and $30{\sim}70W/m^2$, respectively. Consequently, as compared to $Q_n$ from the present study, the amount of net heat gain during the period of net oceanic heat gain between April and August is underestimated, while the ocean's net heat loss in winter is overestimated in other studies. The difference in $Q_n$ is as large as $70{\sim}130W/m^2$ in December and January. Analysis of long-term reanalysis product (MERRA) indicates that the difference in the monthly mean heat fluxes between the present and previous studies is not due to the temporal variability of fluxes but due to inaccurate data used for the calculation of the heat fluxes. This study suggests that caution should be exercised in using the climatological monthly mean surface heat fluxes documented previously for various research and numerical modeling purposes.

Anticarcinogenic Responses of MCF-7 Breast Cancer Cells to Conjugated Linoleic Acid (CLA) (식이성 Conjugated Linoleic Acid (CLA)가 유선암 세포(MCF-7)에서의 항암효과에 미치는 영향)

  • 문희정;이순재;박수정;장유진;이명숙
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.32 no.3
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    • pp.418-427
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    • 2003
  • Conjugated linoleic acid (CLA) is the mixture of positional and geometric isomers of linoleic acid (LA, C18:2 $\omega$6), which is found abundantly in dairy products and meats. This study was peformed to investigate the anticarcinogenic effect of CLA in MCF-7 breast cancer cells. MCF-7 cell were treated with LA and CLA at the various concentrations of 15, 30, 60, 120 UM each. After incubation for 48 and 72 hours, cell proliferation, fatty acids incorporation into cell, peroxidation and activities of antioxidant enzymes were measured. Postaglandin E$_2$ (PGE$_2$) and thromboxane $A_2$ (TXA$_2$) were measured for the eicosanoids metabolism. There was no cell growth differences in both of LA and CLA treated MCF-7 cells at 48 hr incubation. Compared to LA, cell growth was decreased by CLA treatment according to increasing concentration at longer incubation times, respectively (p<0.05). Both of LA and CLA was incorporated into the cellular lipids 22~54% higher than in control but LA incorporation was not so linear as CLA according to concentration. Arachidonic acid (C20:4, $\omega$6) was synthesized after treatment of LA but did not in CLA, respectively. The lipid peroxide concentration in LA 120 $\mu$M group increased as 1.7 times as that in CLA 120 $\mu$M treated. The activities of antioxidant enzymes such as glutathione peroxidase and glutathione reductase were increased by the supplementation with CLA 120 $\mu$M at 72 hr incubation (p<0.001) compared to LA, otherwise activity of superoxide dismutase was not different in both. PGE$_2$ and TXA$_2$ levels were lower in condition of CLA treatments according to lower levels of arachidonic acids than those in LA treated group, respectively. Overall, the dietary CLA might change the MCF-7 cell growth by the changes of cell composition, production of lipid peroxide, activities of antioxidant enzymes and eicosanoid synthesis compared to dietary LA.

Comparison of Wind Vectors Derived from GK2A with Aeolus/ALADIN (위성기반 GK2A의 대기운동벡터와 Aeolus/ALADIN 바람 비교)

  • Shin, Hyemin;Ahn, Myoung-Hwan;KIM, Jisoo;Lee, Sihye;Lee, Byung-Il
    • Korean Journal of Remote Sensing
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    • v.37 no.6_1
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    • pp.1631-1645
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    • 2021
  • This research aims to provide the characteristics of the world's first active lidar sensor Atmospheric Laser Doppler Instrument (ALADIN) wind data and Geostationary Korea Multi Purpose Satellite 2A (GK2A) Atmospheric Motion Vector (AMV) data by comparing two wind data. As a result of comparing the data from September 2019 to August 1, 2020, The total number of collocated data for the AMV (using IR channel) and Mie channel ALADIN data is 177,681 which gives the Root Mean Square Error (RMSE) of 3.73 m/s and the correlation coefficient is 0.98. For a more detailed analysis, Comparison result considering altitude and latitude, the Normalized Root Mean Squared Error (NRMSE) is 0.2-0.3 at most latitude bands. However, the upper and middle layers in the lower latitudes and the lower layer in the southern hemispheric are larger than 0.4 at specific latitudes. These results are the same for the water vapor channel and the visible channel regardless of the season, and the channel-specific and seasonal characteristics do not appear prominently. Furthermore, as a result of analyzing the distribution of clouds in the latitude band with a large difference between the two wind data, Cirrus or cumulus clouds, which can lower the accuracy of height assignment of AMV, are distributed more than at other latitude bands. Accordingly, it is suggested that ALADIN wind data in the southern hemisphere and low latitude band, where the error of the AMV is large, can have a positive effect on the numerical forecast model.

Effect of Summer Sea Level Rise on Storm Surge Analysis (하계 해수면 상승이 폭풍해일고 분석에 미치는 영향)

  • Kim, A Jeong;Lee, Myeong Hee;Suh, Seung Won
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.33 no.6
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    • pp.298-307
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    • 2021
  • Typhoons occur intensively between July and October, and the sea level is the highest during this time. In particular, the mean sea level in summer in Korea is higher than the annual mean sea level about 14.5cm in the west coast, 9.0 to 14.5cm in the south coast, and about 9.0 cm in the east coast. When the rising the sea level and a large typhoon overlap in summer, it can cause surges and flooding in low-lying coastal areas. Therefore, accurate calculation of the surge height is essential when designing coastal structures and assessing stability in order to reduce coastal hazards on the lowlands. In this study, the typhoon surge heights considering the summer mean sea level rise (SH_m) was calculated, and the validity of the analysis of abnormal phenomena was reviewed by comparing it with the existing surge height considering the annual mean sea level (SH_a). As a result of the re-analyzed study of typhoon surge heights for BOLAVEN (SANBA), which influenced in August and September during the summer sea level rise periods, yielded the differences of surge heights (cm) between SH_a and SH_m 7.8~24.5 (23.6~34.5) for the directly affected zone of south-west (south-east) coasts, while for the indirect southeast (south-west) coasts showed -1.0~0.0 (8.3~12.2), respectively. Whilst the differences between SH_a and SH_m of typhoons CHABA (KONG-REY) occurred in October showed remarkably lessened values as 5.2~ 14.2 (19.8~21.6) for the directly affected south-east coasts and 3.2~6.3 (-3.2~3.7) for the indirectly influenced west coast, respectively. The results show the SH_a does not take into account the increased summer mean sea level, so it is evaluated that it is overestimated compared to the surge height that occurs during an actual typhoon. Therefore, it is judged that it is necessary to re-discuss the feasibility of the surge height standard design based on the existing annual mean sea level, along with the accurate establishment of the concept of surge height.

Development of Intelligent Severity of Atopic Dermatitis Diagnosis Model using Convolutional Neural Network (합성곱 신경망(Convolutional Neural Network)을 활용한 지능형 아토피피부염 중증도 진단 모델 개발)

  • Yoon, Jae-Woong;Chun, Jae-Heon;Bang, Chul-Hwan;Park, Young-Min;Kim, Young-Joo;Oh, Sung-Min;Jung, Joon-Ho;Lee, Suk-Jun;Lee, Ji-Hyun
    • Management & Information Systems Review
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    • v.36 no.4
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    • pp.33-51
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    • 2017
  • With the advent of 'The Forth Industrial Revolution' and the growing demand for quality of life due to economic growth, needs for the quality of medical services are increasing. Artificial intelligence has been introduced in the medical field, but it is rarely used in chronic skin diseases that directly affect the quality of life. Also, atopic dermatitis, a representative disease among chronic skin diseases, has a disadvantage in that it is difficult to make an objective diagnosis of the severity of lesions. The aim of this study is to establish an intelligent severity recognition model of atopic dermatitis for improving the quality of patient's life. For this, the following steps were performed. First, image data of patients with atopic dermatitis were collected from the Catholic University of Korea Seoul Saint Mary's Hospital. Refinement and labeling were performed on the collected image data to obtain training and verification data that suitable for the objective intelligent atopic dermatitis severity recognition model. Second, learning and verification of various CNN algorithms are performed to select an image recognition algorithm that suitable for the objective intelligent atopic dermatitis severity recognition model. Experimental results showed that 'ResNet V1 101' and 'ResNet V2 50' were measured the highest performance with Erythema and Excoriation over 90% accuracy, and 'VGG-NET' was measured 89% accuracy lower than the two lesions due to lack of training data. The proposed methodology demonstrates that the image recognition algorithm has high performance not only in the field of object recognition but also in the medical field requiring expert knowledge. In addition, this study is expected to be highly applicable in the field of atopic dermatitis due to it uses image data of actual atopic dermatitis patients.

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Arm Span-Height Relationship for Prediction of Spirometric Values in Korean Adult Women (우리나라 성인여성에서 정상 폐활량 예측을 위한 양팔벌린 손끝길이와 신장과의 관계)

  • Koh, Won-Jung;Ju, Young-Su;Kim, Tae-Yub;Park, Jae-Sung;Yu, Seung-Do;Choi, Kwaung-Soo;Paek, Do-Myung;Han, Sung-Koo;Shim, Young-Soo
    • Tuberculosis and Respiratory Diseases
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    • v.46 no.6
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    • pp.786-794
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    • 1999
  • Back ground : Arm span measurements provide a practical substitute for standing height to predict normal spirometric values in subjects unable to stand or those with a skeletal deformity such as kyphoscoliosis. The relationship between arm span and height has previously been reported as either a fixed ratio unaffected by age or as a regression equation in which the ratio varies as a function of age. The fixed ratio or regression equation is known to be specific for sex and race. Methods : We studied the relationship between standing height, arm span, and age in 381 Korean adult female subjects (ages 20 to 69 yrs) sampled in a general population. Results : The mean ratio for arm span to height is 1.004. Multiple linear analysis found arm span and age to be predictive of standing height (p=0.0001, $r^2$=0.76). We performed the analysis of the difference between the predicted height using either fixed ratio or regression equation and actual height. At the extremes of arm span and age, the ratio method either underestimated(at smaller arm span or younger age) or overestimated(at larger arm span or older age) as compared with actual height (p=0.0001). Conclusion : This results indicate that the estimated height using the fixed ratio method provides a less acceptable method of estimating height for the prediction of lung volumes in the Korean adult women when compared with the regression equations, especially at the extremes of stature or age.

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Comparison of Morphological and Chromosomal Characteristics and Cross Breeding of the Two Types Korean Mandarin Fish, Siniperca scherzeri (쏘가리와 황쏘가리(Siniperca scherzeri)의 염색체와 외부형태 비교 및 교배 실험)

  • Lee, Wan-Ok;Jang, Seon-Il;Lee, Jong-Yun;Son, Song -Jung
    • Korean Journal of Ichthyology
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    • v.9 no.2
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    • pp.228-234
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    • 1997
  • This study was carried out to confirm the taxonomical status by comparison of morphological and chromosomal charateristics and cross breeding in the two types of black and yellow body color of Korean mandarin fish, Siniperca sherzeri from Han River, Korea. Black and yellow types of Korean mandarin fish were similar in having 90-98 lateral line scale pores, 13 dorsal fin rays and XII XIII spines, 9 anal fin rays and 15 pectoral fin rays, but yellow type was differ from blacks type by yellow body color pattern. Diploid chromosome and arm number (fundamental number, NF) of the two types were the same to 2n=48 and NF=52. Karyotypes in the two types are consisted of 2 pairs submetacentric chromosome and 22 pairs of acro and/or telocentric chromosome. The black type females of Siniperca scherzeri were artificially crossed with yellow type males and black type males, respectively. The progenies from each cross breeding produced the normal individuls that possessed with parent types in the body color pattern. These data suggest that two types of Korean mandarin fish were same species, and yellow type was mutant by albino.

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Regulation of the Working Hour of Flight Crew in Germany (독일에서의 항공기승무원의 근로시간 규제)

  • Choi, Doo-Hwan
    • The Korean Journal of Air & Space Law and Policy
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    • v.20 no.2
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    • pp.235-251
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    • 2005
  • German working hour law of 1994(Arbeitszeitgesetz) provides maximum working hour as 8 hours a day and 48 hours per week. The law provides that minimum 11 hours rest-time is required between the end of a day's work and the beginning of the next day's work. Namely, the hour that the workers are put under commanding of the user is restricted within 13 hours per day. In the meantime, article 5, 7, 14, and 15 of the law have some letting the exceptional provisions regarding the working hour and rest-time of flight crew, and 2nd administrative order for the aviation transportation business owner, which is established based on such exceptional provisions(2.DV LuftBO), provides the working hour and rest-time of flight crew quite in detail. The administrative order is detailed quite regarding block time, flight working hour, and rest-time. So, it does not need to interpret additionally. Airlines in Korea should observe the both Labor Standard Act applying to general workers and Aviation Act focused on flight crew, so it is difficult that airlines manages working hour and rest-time of the flight crew efficiently. Therefore, it is desirable that our country refers to and considers adopting this legislation method of Germany which regulates working hour and rest-time of flight crew in detail in the 2.DV LuftBO.

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