• Proceedings of the Korean Society for Bioinformatics Conference
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• 2006.02a
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• pp.38-44
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• 2006

프로테오믹스는 생물체 안에 포함되어 있는 단백질을 통합적으로 연구하는 학문이다. 단백질을 동정(Protein identification)하고, 단백질의 상태를 분석(Protein characterization)하며, 단백질의 양적 변화를 관찰(Protein quantitation)한다. 유전자로부터 mRNA 로 복제되고 codon 의 규칙에 따라 합성되는 단백질이 세포 내에 얼만큼 존재하는가라는 단백질의 양적인 변화는 세포 내의 환경에 따라 시시각각 변화할 수 있으며, 이러한 변화의 추적은 단백질의 기능을 밝히는 기초자료로서 중요성을 가진다. 특히 질병의 조기 진단을 위한 바이오마커를 발굴하기 위한 스크리닝 역할로서, 단백질의 발현 양상을 비교하는 프로테오믹스는 기대를 모으고 있다. 단백질에 대한 분석, 특히 질량분석기에 의해 초고속으로 대량의 단백질 데이터를 생산하는 프로테오믹스의 연구는 정량적인 단백질 발현양상 분석의 정확도를 높이기 위해 다양한 실험기법과 데이터 분석기법을 동원하고 있다. 이번 발표에서는 프로테오믹스에서 단백질의 양을 측정하기 위한 실험 방법들과 그에 따른 데이터 분석 방법들을 소개하고자 한다. 프로테오믹스 연구의 초창기부터 사용되어온 2차원 전기영동법에 의해 생성되는 2D-gel image 에서의 spot 분석법으로부터, 탄뎀 질량분석기를 사용하는 ICAT, iTRAQ 등의 labeling 방법에 의한 정량분석, 그리고 질량분석기의 정확도를 최대한으로 활용하는 label-free 방법에 대한 기본 개념을 살펴보고 데이터 분석 기술의 적용 방법을 알아본다.

• Water for future
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• v.27 no.2
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• pp.155-166
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• 1994

Various Eulerian-Lagrangian numerical models for the one-dimensional longitudinal dispersion equation are studied comparatively. In the model studied, the transport equation is decoupled into two component parts by the operator-splitting approach ; one part governing adveciton and the other dispersion. The advection equation has been solved using the method of characteristics following fluid particles along the characteristic line and the results are interpolated onto an Eulerian grid on which the dispersion equation is solved by Crank-Nicholson type finite difference method. In solving the advection equation, various interpolation schemes are tested. Among those, Hermite interpolation polynomials are superior to Lagrange interpolation polynomials in reducing dissipation and dispersion errors in the simulation.

• Geophysics and Geophysical Exploration
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• v.2 no.4
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• pp.167-173
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• 1999

Since the resolution of the 2-D hole-to-hole seismic traveltime tomography is affected by the limited ray transmission angle, various methods were used to improve the resolution. Linear traveltime interpolation(LTI) ray tracing method was chosen for forward-modeling method. Inversion results using the LTI method were compared with those using the other ray tracing methods. As an inversion algorithm, SIRT method was used. In the iterative non-linear inversion method, the cost of ray tracing is quite expensive. To reduce the cost, each raypath was stored and the inversion was performed from this information. Using the proposed method, fast convergence was achieved. Inversion results are likely to be affected by the initial velocity guess, especially when the ray transmission angle was limited. To provide a good initial guess for the inversion, generalized regression neural network(GRNN) method was used. When the transmitted raypath angle is not limited or the geological model is very complex, the inversion results are not affected by initial velocity model very much. Since the raypath angles, however, are limited in most geophysical tomographic problems, the enhancement of resolution in tomography can be achieved by providing a proper initial velocity model by another inversion algorithm such as GRNN.

• Journal of the Korean Institute of Navigation
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• v.25 no.4
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• pp.371-379
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• 2001

We have reported the new measurement system which was substituted digital filter for the analog filter in order to develop the optimal system that could find the time delay between each sensors with high accuracy. And also we have confirmed through the experiments that the accuracy of measurements were differentiated by the methods what kind of digital filter had been adopted. This paper suggests two algorithms which approximate the sound source's bearing and distance. One is that sound source's relative bearing can be approximately regarded as the gradient of hyperbolic asymptote, the other is that the source's range can be approximated under the condition of a long range source relative to the sensor's interval. And a series of experiments were carried out with the source's distance 22.42meters and the random bearing interval within the limits of $-90^{\circ}$~$+90^{\circ}$. As a result, we have recognized that the approximation methods could measure the bearing and distance with higher accuracy than the method using trigonometric relation could do.

• Computational Structural Engineering
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• v.7 no.2
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• pp.139-146
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• 1994

In this study, the finite element analysis using joint elements, bolt elements, and shell elements is presented to investigate the behavior of bolted connections. The contact of plates and the high-strength, pretensioned bolts are simply idealized by joint elements and bolt elements, respectively. The initial stiffness is determined through the presented method and the non-linear analysis is archived by a constant-arc-length method based on Newton-Raphson method. The analysis results of a semi-rigid connection(web & flange angles) and a moment connection (shear & moment plates) demonstrate the exactness and applicability of the presented method. And the results indicates that the consideration of slip and 3-dimensional deformation is needed for an accurate prediction of bolted connections.

• Proceedings of the Korea Water Resources Association Conference
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• 2006.05a
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• pp.623-626
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• 2006

일정한 시간간격으로 제공되는 연속된 두 장의 레이더 반사도(합성 CAPPI) 자료의 최대 상관계수를 찾아 냄으로써 강수의 움직임을 산출하는 TREC(Tracking Radar Echoes by Correlation) 기법은 동일 고도의 레이더 반사도 자료를 이용하기 때문에 수평방향의 2차원이며, 대류성 구름체계에서 발생되는 수직 활동을 표현할 수 없는 한계성을 지니고 있다. 본 연구에서는 여러 고도의 레이더 반사도 자료를 이용하여 기존의 TREC 기법을 이용한 단시간 예보모형을 개선하고자 하였다. 특정고도의 레이더 반사도를 이용하여 에코를 추적하는 TREC 기법의 단점을 보완하기 위하여 서로 다른 고도의 레이더 반사도를 이용함으로써 기존의 접근법보다 실제 강수의 움직임에 더욱 가깝도록 단시간 강우 예보 정확도를 개선하였다.

• Journal of the Korean Society of Hazard Mitigation
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• v.10 no.1
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• pp.111-117
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• 2010

A three-dimensional numerical model is employed to investigate wave deformation due to a submerged structure. The three-dimensional numerical model solves the spatially averaged Navier-Stokes equations for two-phase flows. The LES(large-eddy-simulation) approach is adopted to model the turbulence effect by using the Smagorinsky SGS(sub-grid scale) closure model. The two-step projection method is employed in the numerical solutions, aided by the Bi-CGSTAB technique to solve the pressure Poisson equation for the filtered pressure field. The second-order accurate VOF(volume-of-fluid) method is used to track the distorted and broken free surface. A simple linear wave is generated on a constant depth and compared with analytical solutions. The model is then applied to study wave deformation due to a submerged structure and the predicted results are compared with available laboratory measurements.

• The Korean Society of Law and Medicine
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• v.20 no.2
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• pp.261-285
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• 2019

The essential policy of suicide prevention is to continuously manage and treat suicide attempted people through data base related to suicide retry rate and follow-up study report. In Korea, only few people are allowed to follow-up by the Personal Information Protection Act. As a result, the research participation rate and the service participation rate are rather low, so that the research participants is limited to a part of the suicide attempted people. Therefore, the policy proposals to be improved in the Ministry of Health and Welfare Act were examined comparatively in order to increase the practical utilization of the suicide prevention about Article 14 and Article 20 of the Suicide Prevention Act. As a criterion for policy improvement, measures for non-discrimination of information to be considered in terms of technical and ethical dimensions and non-profit research and medical information for medical purposes were suggested. In addition to the severity of the suicide, the suicide risk was assessed and the criteria for the objective assessment of the follow-up observation were considered in consideration of the severity of the suicide.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.3
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• pp.213-218
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• 2017

In this study, a reverse design of the F-theta lens was proposed for a 2D scanner in remote welding applications. The curvature and distance of the lens were set as variables, and the focal length of the lens was set as the marginal ray height. The ZEMAX commercial software was used to perform a simulation with unlimited iterations for the optimization process. The target value was optimized using the internal Merit function with the weight factors of focal length and spot diameter. The number of lenses was four, and the focal length obtained from the results was 135mm that is slightly less than that of the commercial lens, which is set with a focal length of 185 mm. The calculated spot diameters are $1.3{\mu}m$, $6.2{\mu}m$, and $16.1{\mu}m$ for $0^{\circ}$, $12.5^{\circ}$ and $23^{\circ}$ of incident laser beam, respectively. It is expected that an optimized lens design is possible by performing the reverse design of a lens by the ray tracing method.

• Journal of the Institute of Electronics and Information Engineers
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• v.49 no.9
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• pp.347-352
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• 2012

In this paper, an 2D spatial-map construction for workers identification and avoidance of AGV using the detection scheme of the spatial coordinates based on stereo camera is proposed. In the proposed system, face area of a moving person is detected from a left image among the stereo image pairs by using the YCbCr color model and its center coordinates are computed by using the centroid method and then using these data, the stereo camera embedded on the mobile robot can be controlled for tracking the moving target in real-time. Moreover, using the disparity map obtained from the left and right images captured by the tracking-controlled stereo camera system and the perspective transformation between a 3-D scene and an image plane, depth map can be detected. From some experiments on AGV driving with 240 frames of the stereo images, it is analyzed that error ratio between the calculated and measured values of the worker's width is found to be very low value of 2.19% and 1.52% on average.