• Genomics & Informatics
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• 제4권1호
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• pp.1-10
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• 2006

Epigenetic alterations are common features of human solid tumors, though global DNA methylation has been difficult to assess. Restriction Landmark Genomic Scanning (RLGS) is one of technology to examine epigenetic alterations at several thousand Notl sites of promoter regions in tumor genome. To assess sequence information for Notl sequences in RLGS gel, we cloned 1,161 unique Notl-linked clones, compromising about 60% of the spots in the soluble region of RLGS profile, and performed BLAT searches on the UCSC genome server, May 2004 Freeze. 1,023 (88%) unique sequences were matched to the CpG islands of human genome showing a large bias of RLGS toward identifying potential genes or CpG islands. The cloned Notl-loci had a high frequency (71%) of occurrence within CpG islands near the 5' ends of known genes rather than within CpG islands near the 3' ends or intragenic regions, making RLGS a potent tool for the identification of gene-associated methylation events. By mixing RLGS gels with all Notl-linked clones, we addressed 151 Notl sequences onto a standard RLGS gel and compared them with previous reports from several types of tumors. We hope our sequence information will be useful to identify novel epigenetic targets in any types of tumor genome.

• 한국구조물진단유지관리공학회 논문집
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• 제17권3호
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• pp.56-64
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• 2013

200m 이하의 아치 교량에서 동적 내풍 안정성은 일반적으로 일본의 Wind Resistant Design Manual for Highway Bridges에 따라 검토된다. 또한 내풍 안정성 검토는 모드 형상에 관계없이 1차 연직 진동수를 적용한다. 일본의 매뉴얼에 따라 설계된 경간장 183m의 닐슨 아치 교량에서 예상치 못한 와류 진동이 발생하였으며 이는 태풍시 교량의 모니터링 시스템에 의해 계측되었다. 본 논문에서는 태풍 발생시에 계측된 풍속, 풍향, 진동 변위와 가속도를 기반으로 닐슨 아치교량의 와류진동 특성을 분석하였다. 분석 결과 1차 연직 진동 모드가 역대칭 형상이고 2차 연직 진동 모드가 대칭 형상인 닐슨 아치교의 경우 와류 진동이 2차 연직 모드에서 지배적이다. 따라서 본 논문에서는 2차 연직 진동 모드가 대칭 형상인 닐슨 아치교의 내풍 안정성 평가시에는 1차 보다 2차 연직 진동 모드가 중요한 설계 요소임을 제시하였다.

• Archives of Reconstructive Microsurgery
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• 제5권1호
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• pp.70-79
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• 1996

From January 1980 to May 1995, ninety-six patients had been treated by free-flap transfer for the soft tissue defects of the extremities. Ninety-eight cases of free-tissue transfer were reviewed to evaluate the clinical reliability in terms of survival and quality of long-time function after reconstructive surgery. Among these 98 cases(27 cases in latissimus dorsi myocutaneous flap, 25 in dorsalis pedis flap, 20 in forearm fasciocutaneous flap, 9 in groin flap, 7 in gracilis myocutaneous flap, 6 in 1st web space flap of foot and 4 cases in tensor fascia lata flap), 92 cases of then were survived. 7 cases were performed with vein grafts. We ananalyzed the reconstruction of the extremities on 98 cases with the soft tissue defects which had been reconstructed free-flap transfer and followed for minimum 1 year period at Korea University Hospital. 1. 92 cases(93.9%) of the total 98 cases were successful and can be obtained the excellent results in soft tissue free-flap transfer. 2. While there were no clinically significant differences in survival rate of flaps transferred from different potential flap donor sites,3 cases of 9 groin flaps were showed higher failure rate due to the complications such as arterial thrombosis, infection and anatomical variation of vessels. 3. Postoperative thrombectomy was performed in 30 cases to be occured in the arterial and venous thrombosis. The revision was failed in 2 cases due to persistent arterial thrombosis and infection, then treated with skin graft. 4. Vein graft was frequently required in severely compromised-soft tissue defects resulted from high-energy trauma. The vein graft was not stitistically significant on the frequency of flap failure rate(P<0.04). 5. Meticulous monitoring, careful planning, early revision and technical considerations will provide for a high clinical success of the free-flap transfer.

• 한국산학기술학회논문지
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• 제10권1호
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• pp.19-24
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• 2009

구조물 동특성 변경법이란 부가 구조물의 첨가나 삭제, 재료 물성치의 변경, 구조물의 형상변경 등을 이용해 구조물의 동특성을 향상시킬 수 있는 매우 효과적인 방법이다. 하지만 이러한 구조물 동특성 변경법 중 구조물의 형상 변경을 통해 그 구조물의 동특성을 향상시키는 방법은 지금까지는 주로 엔지니어의 경험이나 많은 시간을 요하는 시행착오법에 의존해 왔다. 따라서, 앞선 연구를 통해 이러한 구조물의 형상 변경을 통한 동특성변경법에 있어서 기존의 경험이나 시행착오법에 의존하는 방법이 아닌, 체계화된 방법론을 제안하게 되었으며 하드디스크 드라이브 (HDD)에 성공적으로 적용하였다. 제안된 그루브를 통한 표면형상변형 동특성변경법을 검증해 보기 위하여, 본 연구에서는 모든 요소가 엠보싱 되어 있는 극한의 경우로부터 최적화를 수행하고 앞선 연구에서 얻어진 최적화 결과와 비교함으로써 제안된 방법론의 효과를 검토해 볼 수 있었으며, 1차 고유진동수를 높이기 위한 최적화 결과 그루브의 형상은 앞선 연구결과와 같음을 알 수 있었다.

• Journal of Magnetics
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• 제17권2호
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• pp.86-95
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• 2012

This study investigated the effects of adding a third alloying element, Ni, to create $Fe_{70-x}Pd_{30}Ni_x$ (x = 2, 4, 6, 8 at.% Ni) ferromagnetic shape memory alloys (FSMAs). The Ni replaced a portion of the Fe. The $Fe_{70-x}Pd_{30}Ni_x$ alloys were homogenized through hot and cold forging to gain a ~38% reduction in thickness, next they were solution-treated (ST) with annealing recrystallization at $1100^{\circ}C$ for 8 h and quenched in ice brine, and then aged at $500^{\circ}C$ for 100 h. Investigation of the microstructures and magnetostriction indicated that the greater Ni amount in the $Fe_{70-x}Pd_{30}Ni_x$ alloys reduced saturation magnetostriction at room temperature (RT). It was also observed that it was more difficult to generate annealed recrystallization. However, with greater Ni addition into the $Fe_{70-x}Pd_{30}Ni_x$ (x = 6, 8 at.% Ni) alloys, the $L1_0+L1_m$ twin phase decomposition into stoichiometric $L1_0+L1_m+{\alpha}_{bct}$ structures was suppressed after the $500^{\circ}C$/100 h aging treatment. The result was that the $Fe_{70-x}Pd_{30}Ni_x$ (x = 6, 8 at.% Ni) alloys maintained a high magnetostriction and magnetostrictive susceptibility (${\Delta}{\lambda}{_\parallel}{^s}/{\Delta}H$) after the alloys were aged at $500^{\circ}C$ for 100 h. This magnetic property of the $Fe_{70-x}Pd_{30}Ni_x$ (x = 6, 8 at.% Ni) alloys make it suitable for application in a high temperature (T > $500^{\circ}C$) and high frequency environments.

• 여성건강간호학회지
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• 제1권1호
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• pp.44-67
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• 1995

The problem related to sex is closely connected with human life. It is important to acquire accurate sexual knowledge and desirable attitude specially during adolescence, in the physical, psychological and emotional changing period. This study was made to find out the high school girls' knowledge, attitude and experience related to sex, and to support the progress of sex education at school in the future. The design was nonequivalent control pretest-posttest in the quasi-experimental design. In current study, the subjects were 102 girls from the 1 st grade of girls' commercial high school. It was control group 54 and experimental group 48. To teach the experimental group, the sex education program was combined the sex education program made in Korea Education Development Institute, Information of sex education by the Ministry of Education, other concerning articles and previous studies. The research tool was a questionnaire based on the literature review. The pretest-posttest was given to the two groups. The sex education had been taken for the experimental group but not been taken for the control group. The data was collected from May 22, 1993 to July 20, 1993 and was analyzed through spss $^{pc}$. The frequency, $x^2$-test and t-test were calculated. Summarized findings from the study are as follows : groups before sex education. 1. Regarding the first hypothesis was supported as following : "The scores of sexual knowledge in the experimental group who was given sex education will be higher than those of the control group who was not given." (t=-14.11, p=.000) 2. Regarding the second hypothesis was supported as following : "The scores of the attitude toward sex in the experimental group who given sex education will be higher than those of the control group who was not given." (t=-6.15, p=.000) The result of this study suggests that it is so necessary that school nurses should teach about sex regularly at school.

• 재활간호학회지
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• 제6권1호
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• pp.90-103
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• 2003

Pain management is a major issue in caring of cancer patients. Because pain management cancer patient of does not control effectively, it is important to educate reporting pain and using analgesics for having cancer patient's concerns and anxiety. The purpose of this study was to identify the effect of cancer pain management education on the pain and concerns of pain management in cancer patients. This study was a quasi-experimental as nonequivalent control pretest-post test design. The subjects of this study consisted of 50 (experimental group 25, control group 25) patients hospitalized in K university hospital in Busan. The data were collected from December 1, 2001 to April 12, 2002. The measurement tool for the concerns of pain management had used questionnaires interpretated by Kim(1999) developed by based Ward(1993) and pain nominal scale. The collected data were analyzed frequency, percentage, mean, SD, $X^2$-test, t-test, ANCOVA. The results of this study were as follows: 1. The 1st hypothesis : "The experimental group which had received the cancer pain management education were lower than the control group in the score of pain" was not supported (p>0.05). 2. The 2nd hypothesis : "The experimental group which had received the cancer pain management education were lower than the control group in concerns of pain management" was supported (F=5.285, p<0.01). In conclusion, the cancer pain management education can know what was effective to decrease in the concerns of pain management in cancer patients. Therefore, Pain Management Education must be positively utilized in clinical situation.

• Genomics & Informatics
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• 제13권4호
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• pp.137-145
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• 2015

Selective sweep can cause genetic differentiation across populations, which allows for the identification of possible causative regions/genes underlying important traits. The pig has experienced a long history of allele frequency changes through artificial selection in the domestication process. We obtained an average of 329,482,871 sequence reads for 24 pigs from three pig breeds: Yorkshire (n = 5), Landrace (n = 13), and Duroc (n = 6). An average read depth of 11.7 was obtained using whole-genome resequencing on an Illumina HiSeq2000 platform. In this study, cross-population extended haplotype homozygosity and cross-population composite likelihood ratio tests were implemented to detect genes experiencing positive selection for the genome-wide resequencing data generated from three commercial pig breeds. In our results, 26, 7, and 14 genes from Yorkshire, Landrace, and Duroc, respectively were detected by two kinds of statistical tests. Significant evidence for positive selection was identified on genes ST6GALNAC2 and EPHX1 in Yorkshire, PARK2 in Landrace, and BMP6, SLA-DQA1, and PRKG1 in Duroc. These genes are reportedly relevant to lactation, reproduction, meat quality, and growth traits. To understand how these single nucleotide polymorphisms (SNPs) related positive selection affect protein function, we analyzed the effect of non-synonymous SNPs. Three SNPs (rs324509622, rs80931851, and rs80937718) in the SLA-DQA1 gene were significant in the enrichment tests, indicating strong evidence for positive selection in Duroc. Our analyses identified genes under positive selection for lactation, reproduction, and meat-quality and growth traits in Yorkshire, Landrace, and Duroc, respectively.

• 디지털융복합연구
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• 제16권1호
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• pp.207-215
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• 2018

본 연구의 목적은 간호사의 여가활동 유형을 분류하고 실증적 분석을 실시하여 여가활동 유형에 따른 직무스트레스 및 직무만족도의 관계를 규명하기 위한 서술적 조사연구이다. 대상자는 B광역시, K시의 종합병원에 근무 중인 간호사를 대상으로 2017년 8월 1일부터 8월 15일까지 이루어졌다. 자료 분석은 빈도, 백분율, 평균과 표준편차, t-test, ANOVA, 상관관계로 분석하였다. 연구결과 직무스트레스는 중간보다 조금 낮았고 직무만족도는 중간보다 약간 높은 정도로 나타났다. 직무스트레스는 여가활동 유형 중 주당 여가활동 횟수와 음의 상관관계가 있는 것으로 나타났으며 직무만족도는 여가활동 유형과 관계가 없는 것으로 나타났다. 결론적으로 간호사의 직무스트레스를 줄이기 위해서는 주당 여가활동 횟수를 증가시켜주는 방안이 필요하겠고, 광범위한 지역의 다양한 간호사를 대상으로 한 추후 연구가 필요하다.

• 가정과삶의질연구
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• 제1권2호
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• pp.75-88
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• 1983

This study intends to examine the relations between the demographical and the socioeconomic variables on the post-purchase behavior of durable goods in rural household . Several concrete hypothesis in the above study were set as follows: 1) The evaluation on the post-purchase of rural household might be differently made in accordance with sex, age, resident district, education level, income level, family type and user's own purchasing, etc. 2)There can be differences in the attitude on the post-purchase of rural household in accordance with sex, age, resident district, education level, income level, family type and user's own purchasing, etc. 3) It must be of necessity to habe correlation between the evaluation and the attitude of the post- purchase. To examine these hypothesis, the study used the 27 questionnaires which are composed of 7 subject for general characteristics and 10 subjects respectively for the post-purchase evaluation and attitude of 285 rural households in Chon Nam Province. They were interviewed for 11days from Apr. 1st, 1983 to Apr. 11 the, 1983. Statistical methods such as frequency, percentage, Chi-Square test, arithmetical mean, t-test, F-test and Pearson's correlation coefficients, etc. are used for the data analysis. The summary and the conclusion resulted form such analysis are as follows; First, high significances are shown on the age the resident district the education level and the family type as significant variables affecting on the post-purchase evaluation of the rural house hold. Second, high significances are shown on the education level, the income level, the family type and the users own purchasing, etc. as significant variables affecting on the post-purchase attitude of rural household. Third, correlations between the post-purchase evaluation and the post-purchase attitude are very close. Therefore the hypothesis 1)and 2) of this study were accepted partially and the hypothesis 3) was confirmed wholely.