• Journal of Sasang Constitutional Medicine
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• v.4 no.1
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• pp.221-230
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• 1992

In order to investigate the effects of shipjuntaepotang (少陰人 十全大補湯) on immune response, the author performed this experimental study. Delayed type hypersensitivity (DTH) and rosette forming cells (RFC) for cell-mediated immune response, hemagglutinin (HA) titers, hemolysin (HL) titers, and carbon clearance for phagocytic function of MPS (mononuclear phagocyte system) were measured in ICR mice. The results were summarized as follows. 1. DTH in the experimental group was increased, as compared with the control group, with statistical significance. 2. RFC in the experimental group was increased, as compared with the control group, with statistical significance. 3. HA-titers were increased in the experimental group, as compared with the control group, with statistical significance. 4. HL-titers were increased in the experimental group, as compared with the control group, with statistical significance. 5. Carbon clearance was increased in the experimental group, as compared with the control group, with statistical significance. Through invivo experimental study in ICR mice, these findings suggest that shipjuntaepo-tang enhance both cellmediated and humoral immune responce.

• Journal of Korean Physical Therapy Science
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• v.4 no.1
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• pp.255-263
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• 1997

The purpose of this study was to examed the pain relief effects of myofascial pain syndrome patient by post-isometric relaxation. From July, 1996 to January, 1997, PIR was applied to myofascial pain syndrome associated with musculoskelatal lesions and was examed on 17 muscles in 98 patients at Sun General Hospital, Taejon city. The results of this study were as follows ; 1. Immediate pain relief group was 58(59%). 2. Only tenderness relief group was 24(25%). 3. No effect group was 16(16%). These results could be confirmed that the increased tension of the affected muscles with the resulting pain relieved by restoring the full stretch length of the muscle by PIR.

• Journal of mucopolysaccharidosis and rare diseases
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• v.5 no.1
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• pp.39-41
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• 2021

Prader-Willi syndrome (PWS) is a rare genetic neurodevelopmental disorder of hyperphagia leading to severe obesity, intellectual deficits, compulsivity, and other behavioral problems. PWS is caused by the inactivation of contiguous genes on chromosome 15q11-q13, which complicates the development of targeted, effective therapeutics. Various preclinical studies have been conducted by developing mouse models that exhibit phenotypes similar to PWS. Oxytocin deficiency in PWS is associated with hyperphagia with impaired satiety and, food-seeking and behavior disorders. Here, we summarize the oxytocin study of ingestion behavior tested in the PWS mouse model and published data from clinical trials that have evaluated treatment effectiveness on ingestion behavior and social dysfunction in patients with PWS.

• Journal of mucopolysaccharidosis and rare diseases
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• v.5 no.1
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• pp.34-38
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• 2021

Prader-Willi syndrome is a complicated genetic disorder caused by a mutation on chromosome 15q11-13. The disease results in morbid obesity due to hyperphagia, growth disturbance, multiple endocrine problems from hypopituitarism, developmental delay, and cognitive or behavioral problems. Recombinant human growth hormone has been used to improve body composition and muscle mass, which plays a main role in treating patients with Prader-Willi syndrome. We describe previous studies showing the efficacy and safety of growth hormone treatment in children with Prader-Willi syndrome and provide treatment guidelines. Growth hormone therapy could be beneficial for children with Prader-Willi syndrome and improve their quality of life.

• Journal of Korean Port Research
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• v.9 no.2
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• pp.1-8
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• 1995

Generally, berth assignment problem has conflicting factors according to the interested parties. In the view of shipping company, it is desirable that berth assignment is made according to the order of arrival. But in the view of port operator, it is better to be assigned regardless the order of arrival to promote the efficiency of berth operation. Thus, it is necessary to establish berth assignment planning which reflects both of interests in a practical situation. This paper aims to develop a reasonable berth assignment algorithm in a container terminal by considering the prescribed factors, and suggests three types of models minimizing the objective functions such as total port staying time, total mooring time and total maximum mooring time by using MPS concept. These models are formulated by 0-1 integer programming and min-max type function, but as the number of variables increases, an optimal solution cannot be achieved easily within a desired computational time. Thus, to tackle this problem this paper proposes a heuristic algorithm, and also the heuristic algorithm proposed in this paper is verified through the several examples.

• Ecology and Resilient Infrastructure
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• v.8 no.4
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• pp.281-289
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• 2021

Commercially used disposable cups undergo fragmentation in the environment and become microplastics (MPs). These MPs can be ingested by aquatic organisms and cause a range of adverse effects. We assessed the acute and chronic toxicity of disposable cup-derived MP fragments in Daphnia magna. MP fragments were identified as a polyethylene terephthalate (PET) fragment with a size of 33.18 ± 7.76 ㎛. The presence of three additives including 1- Propanone. 1-phenyl-3-[2-(phenylmethoxy)phenyl]-, p-Xylene and ethylbenzene was analyzed from MP fragments. The 48 h acute toxicity revealed that 20 % of immobilization and mortality were found at the highest concentration of PET MP (200 mg L^-1). The 21 d chronic toxicity revealed that PET MP fragments significantly (p < 0.05) more reduced survival rate (31 %), total offspring (52 %) in D. magna compared with control group. The developmental abnormality of offspring (3.5%) by PET MP fragments was significantly (p < 0.05) higher than control groups (0.3%). These results are possibly induced by gut blocking by ingestion of MP fragments and their longer retention time. These findings indicate that the fragmentation of disposable cups (PET polymers) into small-sized MP fragments pose a significant ecological risk to aquatic organisms. Further studies are required to elucidate the underlying toxicity mechanisms.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.5
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• pp.3378-3384
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• 2015

The problem of fast search for raman spectrum has attracted much attention recently. By far the most simple and widely used method is to calculate and compare the Euclidean distance between the given spectrum and the spectra in a database. But it is non-trivial problem because of the inherent high dimensionality of the data. One of the most serious problems is the high computational complexity of searching for the closet codeword. To overcome this problem, The fast codeword search algorithm based on the mean pyramids of codewords is currently used in image coding applications. In this paper, we present three new methods for the fast algorithm to search for the closet codeword. the proposed algorithm uses two significant features of a vector, mean values and variance, to reject many unlikely codewords and save a great deal of computation time. The Experiment results show about 42.8-55.2% performance improvement for the 1DMPS+PDS. The results obtained confirm the effectiveness of the proposed algorithm.

• Journal of The Korean Ophthalmological Society
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• v.58 no.5
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• pp.509-515
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• 2017

Purpose: To compare the amoebicidal effects of nephrite containing contact lens (CL) storage cases with conventional CL storage cases. Methods: Acanthamoeba lugdunensis were inoculated onto 5% nephrite containing CL storage cases as well as conventional CL storage cases both with and without silicone hydrogel contact lenses (SHCLs). Then the amount of Acanthamoeba proliferation on CL storage cases and the number of adherent Acanthamoeba on SHCLs were determined and compared. The effects of multipurpose solution (MPS) with and without 1% or 5% nephrite solution on Acanthamoeba adhesion were analyzed. Results: Nephrite containing CL storage cases showed more inhibitory effects on Acanthamoeba proliferation (p = 0.02) and significantly reduced the number of adherent Acanthamoeba on SHCLs compared with conventional CL storage cases, regardless of SHCLs generation (p = 0.001, p = 0.001 and p < 0.001, respectively). The number of adherent Acanthamoeba on the first generation of SHCLs was significantly reduced by MPS with 1% and 5% nephrite solutions (p = 0.03 and p = 0.004, respectively), but the numbers for the second and third generation SHCLs were not. Conclusions: Nephrite could be used as a new additive component for CL storage cases and multipurpose solutions to improve the disinfection effects on Acanthamoeba.

• Nuclear Medicine and Molecular Imaging
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• v.40 no.3
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• pp.155-162
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• 2006

Purpose: Diabetes mellitus (DM) is a critical disease with higher rates of cardiovascular morbidity and mortality due to myocardial ischemia and infarction. There is glowing interest in how to determine high-risk patients who are candidates for screening testing. This study was performed to evaluate the incidence of coronary artery disease (CAD) in diabetic patients detected by Tc-99m MIBI myocardial perfusion SPECT (MPS) and to assess risk factors of CAD and cardiac hard events. Subjects and Methods: 203 diabetic patients (64 male, mean age $64.1{\pm}9.0$ years) who underwent MPS were included between Jan 2000 and July 2004. Cardiac death and nonfatal myocardial infarction (MI) were considered as hard events, and coronary angioplasty and bypass surgery >60 days after testing were considered as soft events. The mean follow-up period was $36{\pm}18$ months. Patients underwent exercise (n=6) or adenosine stress (n=197) myocardial perfusion SPECT. Results: Perfusion defects on MPS were detected in 28.6% (58/203) of the patients. There was no cardiac death but 11 hard events were observed. The annual cardiac hard event rate was 1.1%. In univariate analysis of clinical factors, typical anginal pain, peripheral vascular disease, peripheral polyneuropathy, and resting ECG abnormality were significantly associated with the ocurrence of hard events. Anginal pain, peripheral vascular disease, and resting ECG abnormality remained independent predictors of nonfatal MIs with multivariate analysis. Abnormal SPECT results were significantly associated with high prevalence of hard events but not independent predictors on uni- and multivariate analyses. Conclusion: Patients who were male, had longer diabetes duration (especially over 20 years), peripheral vascular disease, peripheral polyneuropathy, or resting ECG abnormality had higher incidence of CAD. Among clinical factors in diabetic patients, typical angina, peripheral vascular disease, peripheral polyneuropathy, and resting ECG abnormality were strong predictors of hard events.

• Journal of mucopolysaccharidosis and rare diseases
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• v.2 no.2
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• pp.50-51
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• 2016

Combining basal insulin therapy with a glucagon-like peptide-1 receptor agonist (GLP-1 RA) has clear clinical advantages, and is supported by the latest EASD/ADA position statement (1). IDegLira is a once-daily combination of the basal insulin, degludec, and the GLP-1RA, liraglutide, in one pen. The DUAL phase 3 clinical trial program provides important evidence about the efficacy and safety of IDegLira in three different populations of patients with type 2 diabetes (T2D): insulin naïve subjects uncontrolled on oral antidiabetic drugs (OADs), subjects uncontrolled on OAD(s) and a GLP-1 RA, and subjects uncontrolled on OAD(s) and basal insulin. Treatment with IDegLira reduced mean HbA1c to below the EASD/ADA treatment target of 7.0% in all five trials. The mean reduction of HbA1c from baseline ranged from 1.3% and 1.9%. IDegLira resulted in weight loss for subjects uncontrolled on basal insulin, was weight neutral for subjects on OADs and weight gain was minimal (2 kg) for subjects previously treated with a GLP-1 RA. Rates of hypoglycaemia were low across all the trials, particularly considering the level of glycaemic control achieved.