• 대한화장품학회지
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• 제38권2호
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• pp.189-195
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• 2012

Slim813은 2-사이클로펜텐-1-온 옥심 유도체로서 다양한 염증성 자극원에 대한 TNF 생성을 억제하는 항 자극 및 UV에 의한 MMP1 억제를 통한 항 노화 효능을 갖는 물질이다. 본 연구를 통하여 이와 같은 효능 외에도 완전히 분화된 지방 세포에서 cAMP (cyclic adenosine monophosphate) 생성 촉진을 통한 HSL (hormone sensitive lipase) 활성을 증대시킴으로써 지방분해를 증가시킴을 확인하였다. 또한 Slim813을 사람의 팔과 허벅지 부위에 2주간 도포하였을 때 지방의 두께 감소를 유발하는 것으로 나타나 체내 피하 지방을 분해하는 효능을 갖는 것으로 사료된다.

• 대한원격탐사학회지
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• 제34권6_1호
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• pp.847-855
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• 2018

GMTI는 항공기에 탑재되어 지상에 움직이는 표적을 탐지하는 레이다 기능으로 군사적으로 널리 활용되고 있다. 본 논문에서는 GMTI 신호처리 방법을 제시하고, 구축된 항공용 GMTI 시스템으로부터 획득한 GMTI용 2채널 합/차 원시데이터를 이용하여 GMTI 신호처리 결과를 검증하였다.

• Archives of Pharmacal Research
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• 제23권4호
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• pp.332-337
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• 2000

This study describes the synthesis, in vitro evaluation and molecular modeling study of novel compounds for the inhibition of TNF-$\alpha$production, Among these compounds, 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone (9) was selected as a lead compound and its pyridine derivative 10 was more potent in activity and safer than rolipram.

• STI Policy Review
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• 제3권1호
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• pp.80-95
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• 2012

Few studies have focused on the impact of R&D outsourcing on technological innovation and productivity despite the increased importance of R&D outsourcing. This study analyzes the productivity effects of investment in R&D outsourcing with a sample of Korean manufacturing industries from 2001 to 2009. The estimation results show a nonlinear U-shaped relationship between productivity and the share of R&D outsourcing capital for total R&D capital. This implies that the cost of R&D outsourcing outweighs its benefits in the early stages of R&D outsourcing. The U-shaped relationship is particularly pronounced in high-technology industries.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.118.1-118.1
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• 2003

SS cream and its revised formula, CJ-4001 is topical Chinese herbal drugs for premature ejaculation. To evaluate the genotoxic potentials of these drugs, micronucleus test using Acridine orange (AO) staining method was performed. Acridine orange (AO) staining is adopted in OECD guideline 474 and widely used in micronucleus test. In dose range finding study, no mouse was dead at 2000 mg/kg using single treatment subcutaneously. Therefore, 3 dose levels were chosen at 500, 1000, 2000 mg/kg. (omitted)

• 대한화장품학회지
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• 제12권1호
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• pp.1-16
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• 1986

• 한국섬유공학회:학술대회논문집
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• 한국섬유공학회 2000년도 봄 한국섬유공학회 학술발표회 논문집(Proceedings of the Korean Textile Conference)
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• pp.1.1-11
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• 2000

• Journal of Ginseng Research
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• 제43권2호
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• pp.300-304
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• 2019

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 춘계총회 및 학술대회
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• pp.102.1-102.1
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• 2000

• Bulletin of the Korean Chemical Society
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• 제6권5호
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• pp.255-259
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• 1985

The NMR chemical shift arising from 4d electron orbital angular momentum and 4d electron spin dipolar-nuclear Spin angular momentum interactions for a $4d^2$ system in a strong crystal field environment of octahedral symmetry has been investigated when the four fold axis is taken as the quantization axis. The NMR results are comparted with the multipolar shift at various R-values and we find that the exact results are in agreement with the multipolar shift when $R{\geqslant}0.20 nm.$ We also separate the NMR shift into the contribution of the $1/R^5$ and $1/R^7$ terms. It is found that the contribution of the $1/R^5$term to the NMR shift is dominant than the contribution of the $1/R^7$ term. Temperature dependence analysis shows that the $1/T^2$ term is the dominant contribution to the NMR shift for a $4d^2$ system but the contribution of the 1/T term may not negligible. The similar results are obtained for a $4d^1$ system from the temperature dependence analysis.