• 대한치과보철학회지
• /
• 제58권2호
• /
• pp.153-160
• /
• 2020

증령에 따라 진행되는 치아의 마모는 자연스러운 현상이지만 생리적인 범위를 초과하여 나타나는 병적 마모는 기능 및 심미 문제를 야기하게 된다. 특히, 구치부 지지가 상실되면 전치부의 병적 마모로 인해 수직 고경의 감소와 교합평면의 부조화가 일어날 수 있다. 이러한 문제를 해결하려면 중심위를 고려한 적절한 수직 고경 설정이 필요하다. 본 증례의 환자는 상악 구치부 상실에 의한 하악 전치부의 심한 마모를 보이는 71세 남환으로 보철 수복 공간을 위해 수직 고경을 거상하여 전악 수복을 시행하였다. 8개월간의 평가 결과 안정적인 교합을 확인하였고 기능적, 심미적으로 만족할만한 결과를 보였기에 이를 보고하고자 한다.

• Molecular & Cellular Toxicology
• /
• 제5권2호
• /
• pp.160-164
• /
• 2009

Notch signaling plays a crucial role in development of the nervous system. Neurodevelopmental hypothesis on etiology of schizophrenia has been implicated. The aim of this study is to determine whether single nucleotide polymorphisms (SNPs) of Notch homolog 4 (Drosophila) (NOTCH4) gene are associated with schizophrenia. This study included 283 schizophrenia patients diagnosed according to DSM-IV and 301 normal control subjects. Control subjects without history of psychiatric disorders were recruited. Four missense SNPs [rs915894 (exon 3, Lys117Gln), rs2071282 (exon 4, Pro204Leu), rs422951 (exon 6, Thr320Ala), and rs17604492 (exon 18, Gly942Arg)] of NOTCH4 gene were genotyped by the direct sequencing method. Multiple logistic regression models (codominant, dominant, and recessive models) were employed to evaluate odds ratio, 95% confidence interval, and p value. For analysis of genetic data, SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs were also used. Of 4 SNPs, rs2071282 was weekly associated with schizophrenia in two alternative models (codominant model, P=0.049; dominant, P=0.041). However, these associations were not significant after Bonferroni correction. At 4 SNPs, one linkage disequilibrium (LD) block was made. This block consisted of rs915894 and rs2071282. In haplotype analysis, AC haplotype was weakly associated with schizophrenia (dominant, P=0.04). This association was disappeared after Bonferroni correction. Our result shows possibility that some SNPs of NOTCH4 gene may be weekly associated with development of schizophrenia in Korean population. However, replication result by other population will be needed.

• 전기전자학회논문지
• /
• 제10권2호통권19호
• /
• pp.156-160
• /
• 2006

Al2O3 층의 유무에 따른 Ge 나노입자가 형성된 MOS 구조의 캐패시터의 전압에 대한 캐패시턴스 (C-V)의 특성을 측정하였다. Al20O층이 형성된 MOS 캐패시터의 C-V 곡선은 전압의 변화에 대해 나타나는 반시계 방항의 히스테리시스 특성은 Si 기판과 Ge 나노입자 사이를 전자가 터널링하여 Ge 나노입자에 저장되었기 때문이다. Al2O3 층이 없는 MOS 캐패시터의 경우, 시계 방향의 히스테리시스 특성과 좌측으로 이동한 플랫-밴드 전압 값을 볼 수 있다. 이것은 SiO2 층에 존재하는 산소 결원 (oxygen vacancy) 으로 인한 전하 트랩이 이러한 특성을 나타냈다 할 수 있다. 또, 백색광이 C-V 특성에 미치는 영향에 대하여 논하였다.

• 대한한방부인과학회지
• /
• 제23권2호
• /
• pp.154-160
• /
• 2010

Purpose: This study was done to report the progress of treatment with oriental medicine on a woman who complained of irregular menstruation in menopausal transition. Methods: The patient in this case was treated with Chokyungjongoktanggamibang, acupuncture and moxibustion. And to assess the effectiveness of this treatment, we evaluated the ovarian function by using hormone assay. Results: During treatment period the patient had three times of uterine bleeding, two of the three seemed like normal menstrual bleeding. And analyzing the hormone assay, estraiol level was increased and FSH, LH levels were decreased significantly. However a month after treatment end, estradiol level was decreased and FSH, LH levels were incresead as the levels in menopausal transition or menopause state. And the patient had no more uterine bleeding since last one according to follow up by phone-call. Conclusion: In this study, the progress of ovarian function was specified with hormonal changes after treatment of oriental medicine during menopausal transition. And further studies are needed to find the more appropriate clinical approach for women in menopausal transition.

• 한국임상약학회지
• /
• 제30권3호
• /
• pp.149-160
• /
• 2020

Background: Basiliximab is used as an alternative to tacrolimus in patients with decreased renal function. However, studies on basiliximab as a maintenance immunosuppressant, particularly in patients with lung transplantation, are limited. Therefore, here, we investigated the efficacy and safety of basiliximab in patients with lung transplantation. Methods: Adult patients with acute kidney injury (AKI) who received lung transplantation at a single general hospital between July 1, 2014 and June 30, 2018, were selected and classified in tacrolimus and basiliximab groups. Both groups received a triple-drug regimen (tacrolimus, mycophenolate mofetil, and steroids). However, tacrolimus was discontinued in the basiliximab group when AKI occurred, and two or more repeat basiliximab doses were administered within 3 months after transplantation. The electronic medical records were analyzed retrospectively. Results: Of the 85 patients who met the selection criteria, 61 and 24 were assigned to the tacrolimus and basiliximab groups, respectively. Significant improvement in renal function was observed in the basiliximab group (p <0.001). However, there were no differences in acute and chronic rejection rates in both the groups. No difference was observed in the incidence rate of complications between the groups, except for chronic kidney disease, which showed higher incidence in the basiliximab group (25.0% vs. 4.9%; p =0.013). Conclusions: We suggest the use of basiliximab as an immunosuppressant alternative to tacrolimus in patients with acute renal failure after lung transplantation. Basiliximab demonstrated effectiveness as an immunosuppressant and improved renal function. Therefore, basiliximab can be used in patients with decreased renal function.

• 한국보건간호학회지
• /
• 제16권2호
• /
• pp.436-444
• /
• 2002

This study surveyed 146 obese elementary school children(94 male and 52 female) in Seoul, and measured height, body weight, degree of obesity, blood pressure, fasting blood sugar, serum lipid profiles and liver function. The hypertension was above 95 percentile depending on age and sex. and the hyperglycemia was defined as above 110mg/dl. The hypercholesterolemia and hypertriglyceridemia were defined as above 200mg/dl, 160mg/dl, repectively. The abnormal liver function was considered as elevated alanine aminotransferase(ALT>35IU/L)or aspartate aminotransferase(AST>35IU/L). The results were as follows: 1. The mean degree of obesity was $29.56\pm12.56\%$, and the percentage of overweight was $18.5\%$, mild obesity $41.1\%$, moderate obesity $35.6\%$, severe obesity $4.8\%$ respectively in surveyed children. 2. The systolic blood pressure was $108.34\pm13.73mmHg$, diastolic blood pressure was $67.46\pm8.27mmHg$. 3. FBS was $93.79\pm6.51mg/dl$. 4. Total cholesterol, triglyceride, ALT and AST were $183.34\pm31.38mg/dl$. $115.55\pm56.43mg/dl,\;24.08\pm18.42IU/L,\; 28.73\pm10.45IU/L,$ respectively. 5. The prevalence of complications was $47.2\%$ : hypertension$(13\%)$, hyperglycemia$(0.7\%)$, hypercholesterolemia$(23.3\%)$, hypertriglyceridemia$(17.1\%)$, and liver dysfunction$(21.9\%)$. In conclusion. childhood obesity is associated with various risk factors. Therefore, the aggressive approaches to successful prevention, early detection, and effective treatment of obesity in children are urgently required.

• Journal of Pharmaceutical Investigation
• /
• 제40권2호
• /
• pp.73-78
• /
• 2010

Hydrogels are thought to be a promising delivery carrier for protein drugs because of their favorable aqueous environment compared with nano/micro-particles of hydrophobic polymer such as PLGA. In this study, nano-sized hydrogels (nanogels) were fabricated using inverse-miniemulsion polymerization method. The mean size of nanogels in range of 90-160nm and affected by the preparation parameters such as sonication time and concentration of monomer. While longer sonication time and lower concentration of acrylamide monomer showed a tendency to produce smaller nanogels and to have lower lysozyme activity, variation of bis-methylene acrylamide concentration made no difference. Although both longer soncaton time and lower acrylamide concentration increased in vitro release rate, acrylamide concentration was more effectively affected to the control of protein release rate, which indicated that the release rate of protein from nanogels affected by not only their size but also internal structure. In conclusion, nanogels prepared by inverse-miniemulsion can be a useful carrier for application of protein drug, because of simple process, minimum contact of organic solvent and high protein activity.

• 한국치위생학회지
• /
• 제14권4호
• /
• pp.463-470
• /
• 2014

Objectives : The purpose of this study was to investigate the association factors of infection control practice based on health belief model in the dental hygienists in dental clinics. Methods : A self-reported questionnaire was filled out by 278 dental hygienists in 160 dental clinics in Gwangju by a proportional stratified sampling method from September 13 to October 7, 2013. Data were analyzed by t-test, ANOVA, correlation analysis, and multiple regression analysis using SPSS version 12.0. Results : In multiple regression analysis, practice scores were significantly higher in aged dental hygienists and those who took infectious disease history from the patients before treatment. With regard to health belief model, perceived barrier was negatively associated with the practice(${\beta}$=-.16, p<.001), importance of infection control in hand hygiene(${\beta}$=.14, p=.026), and use of personal protective equipment(${\beta}$=.17, p=.043). The intention of action was positively associated with the practice(${\beta}$=.13, p=.002). Conclusions : This study will provide the basic evidence for the quality improvement of infection control and prevention. So the dental hygienists will be able to put into practice in infection control management.

• 대한한의학회지
• /
• 제38권3호
• /
• pp.160-169
• /
• 2017

Objectives: Health in adolescent is very important in the whole life. But, students in Korea are very busy and hard to care about their health. This study is aimed to effectiveness and safety of effectiveness of School Doctor program in Korean Medicine. Method: From august to december, 2015, Korean medicine association in Sungnam city conducted school doctor program for 12 middle and 8 high school. School doctor visitied 8 times and treat, lecture and consulting for students and teachers. The number of students participating in health lecture is 1,905. The number of students participating in the school project was 147 students in junior high school and 187 students in high school, totaling 334 students. Results: The overall satisfaction rate of students was very high (83.2%) for school doctor program in Korean medicine. 92.8% of respondents answered that they should continue to school doctor program in Korean medicine. Conclusions: We find that Korean medicine is suitable for the school doctor program. But this study have some limitations. Large-scale prospective study will be needed.

• 임상간호연구
• /
• 제23권2호
• /
• pp.151-160
• /
• 2017

Purpose: The purpose of this study was to evaluate the effects of oral stimulation interventions on the transition from tube to oral feeding in preterm infants through systematic review. Methods: The randomized clinical trials published between 1980 and 2015 were searched using domestic and international databases, and five randomized studies were selected for this study. The quality of study was assessed by assessment tool from the SIGN and meta-analysis was performed using the Cochrane Review Manager software Version 5.3 (RevMan). Results: Oral stimulation intervention in preterm infants decreased the transition time from tube to oral feeding (Post Menstrual Age, Day of life). Especially, a significant medium effect size was found in the number of days needed on the transition (ES=-4.95, p=.02). The oral stimulation intervention also had a significant large effect on the length of stay at hospital (ES=-8.33, p<.001). Conclusion: Based on the findings, oral stimulation interventions could be useful to facilitate the transition from tube to oral feeding in preterm infants in terms of reducing the length of stay at hospital and the number of days needed on transition.