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Experimental sutdy on the anti-allergic effects of Onpyetang and Onpyetang-Gechongbaek (溫肺湯과 溫肺湯去총白의 抗알레르기效果 및 鎭痛, 解熱作用에 대한 實驗的 硏究)

  • Park, Jae-Hyun;Chae, Byun-Yoo
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.14 no.2
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    • pp.154-172
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    • 2001
  • Major symptoms of al1ergic rhinitis are nasal obstruction, sneezing and watery rhinorrhea. Onpyetang has been used to treat for nasal obstruction, which is one of the symptoms of allergic rhinitis. This Experimental study was done to research effects of Onpyetang and transformed Onpyetang(Allii Radix is deducted from Onpyetang) on the anti-allergic effects. We have studied the vascular permeability response induced by serotonin and histamine, the contact dermatitis response induced by picryl chloride, the delayed type hypersensitivity response to SRC, the mice paw edema induced by carrageenin, the writhing syndrome induced by $0.7\%$ acetic acid, and the rectal temperature in febrile rats induced by yeast. The results were as follows : 1. In the vascular permeability response to intradermal serotonin and histamine. Onpyetang proved significant inhibitory effect(P<0.05, p<0.001) But transformed Onpyetang proved significant inhibitory effect only to histamine(P<0.05) 2. In the contact dermatitis response induced by picryl chloride, Onpyetang and transformed Onpyetang proved significant inhibitory effect.(P<0.05, P<0.05) 3. In the delayed type hypersensitivity response induced by SRC, Onpyetang and transformed Onpyetang proved significant inhibitory effect on mice paw edema.. (P<0.05, P<0.05) 4. In the delayed type hypersensitivity response induced by SRC, Onpyetang proved significant inhibitory effect to serum IgE.(P<0.01) But transformed Onpyetang proved insignificant inhibitory effect on serum Ig E. 5. In the mice paw edema induced by carrageenin, Onpyetang and transformed Onpyetang proved significant anti-inflammatory effect. (P<0.01, P<0.01) 6. In the writhing syndrome induced $0.7\%$ acetic acid, Onpyetang and transformed Onpyetang proved significant analgestic effect. (P<0.01, P<0.01) 7. In the rectal temperature in febrile rats induced by yeast, Onpyetang and transformed Onpyetang proved significant anti-pyretic effect.(P<0.001, P<0.01) according to this result Onpyetang was conclude to be effective on anti-allergic, anti-pyretic, anti-inflammatory and analgestic action. but transformed Onpyetang(Allii Radix is deducted from Onpyetang) was not effective on the vascular permeability response to intradermal serotonin and increasing Ig E of delayed type hypersensitivity response induced by SRC. In addition, transformed Onpyetang is not effective as Onpyetang. More study should be done about the role of Allii Radix.

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The Oriental and Occidental bibliographic Study of Psoriasis (乾癬에 對한 東.西醫 文獻的 硏究)

  • Kim, Nam-Kwen;Hwang, Chung-yeon;Lim, Gye-sang
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.12 no.1
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    • pp.154-178
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    • 1999
  • Psoriasis is the recurrent disease of skin and till now its mechanism, pathogenesis and treatment are not clearly discovered. So, like these papers, we must investigate more safety and effective treatment of psoriasis. And I obtained the following condusions from the Oriental and Occidental bibliographic investigation. 1. In Oriental medicine. Baikbi, Pungsun, Eunselbyong, Songpisun, Baikselpung were the other names of Psoriasis. 2. In Occidental medicine, genetic factors, aggravation and inducible factors, biochemical factors, immunologic factors, disorder of epidermal kinetics, vascular malformation of dermis were cosidered to the pathogenic factors of psoriasis. 3. In Oriental medicine, the pathogenic factors of psoriasis were divided two parts. One is exogenous pathogenic factors which including the blood-heat, blood dryness, blood stasis, deficiency of liver and kidney, inharmony of impulsive and appointed pulsation, deficiency of blood. The other is exogenous pathogenic factors which including the wind-evil, wind-wetness, wind-heat, wind-cold, wetness-heat, cold-wetness, heat-evil. 4. In Occidental medicine, external applicative medicine, internal medicine, ultraviolet therapy, ultraviolet - external applicative medicine compound therapy and etc. were used the therapy of psoriasis. 5. In Oriental medicine, clean away heat and cooling blood, aliment the blood and moisturize, activating blood and expelling blood stasis, harmonize and invigorate the liver and kidney, invigorate the kidney, aliment the blood and moisturize the skin, aliment the blood and expelling the wind, expelling the wind and wetness, clean away heat and expelling wind, expelling the wind and scatter the cold, clean away heat and expelling the wetness, heat up the meridian and scatter the cold, clean away heat and remove the toxin and etc. were used the method of internal therapy of psoriasis. 6. Until Qing dynasty, wind expelling effective prescriptions like Bangpungtongsungsan, Sopungsan. Supungsunkisan and etc. were used and recently Yanghyelgeupungtang, Hwalhyelgeupungtang, Samultanggagam and etc. were used the internal therapy of psoriasis. 7. In the external therapy of psoriasis, Yuhonggo, Pungyugo, Sekryupiyeongo were used the plaster therapy and Folium Rerillae, Camphora, Fructus, Xanthii, Herba Spirodelae compound prescription were used the cleansing therapy, Okgisan, Chiunsan, Galmyogo, Hobunsan, Muisan, Madugo, Jeyugohengin were used the rubbing skin therapy. Rangdok Radix Aconiti, Bijeonilchoalkwang were used the attaching therapy, the extract of Rhizoma Et Radix Veratri was used the spreading pouder therapy. 8. In the acupuncture therapy of psoriasis, the Jelgol, chok Samni(S36), Kansa(P5), Haegye(S41), Wijung(B40) and etc. were used the acupuncture point, and the angle of helix incision threapy that disinfect and cut the angle of helix and plaster the Semen Glycine and Squama Manitis were used.

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The Effect of Various Hot Environments on Physiological Responses and Information Processing Performance Following Firefighting Activities in a Smoke-Diving Room

  • Hemmatjo, Rasoul;Motamedzade, Majid;Aliabadi, Mohsen;Kalatpour, Omid;Farhadian, Maryam
    • Safety and Health at Work
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    • v.8 no.4
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    • pp.386-392
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    • 2017
  • Background: Fire service workers often implement multiple duties in the emergency conditions, with such duties being mostly conducted in various ambient temperatures. Methods: The aim of the current study was to assess the firefighters' physiological responses, information processing, and working memory prior to and following simulated firefighting activities in three different hot environments. Seventeen healthy male firefighters performed simulated firefighting tasks in three separate conditions, namely (1) low heat (LH; $29-31^{\circ}C$, 55-60% relative humidity), (2) moderate heat (MH; $32-34^{\circ}C$, 55-60% relative humidity), and (3) severe heat (SH; $35-37^{\circ}C$, 55-60% relative humidity). It took about 45-50 minutes for each firefighter to finish all defined firefighting activities and the paced auditory serial addition test (PASAT). Results: At the end of all the three experimental conditions, heart rate (HR) and tympanic temperature (TT) increased, while PASAT scores as a measure of information processing performance decreased relative to baseline. HR and TT were significantly higher at the end of the experiment in the SH ($159.41{\pm}4.25beats/min$; $38.22{\pm}0.10^{\circ}C$) compared with the MH ($156.59{\pm}3.77beats/min$; $38.20{\pm}0.10^{\circ}C$) and LH ($154.24{\pm}4.67beats/min$; $38.17{\pm}0.10^{\circ}C$) conditions (p < 0.05). There was no significant difference in PASAT scores between LH and MH (p > 0.05). Nonetheless, there was a measurable difference in PASAT scores between LH and SH (p < 0.05). Conclusion: These consequences demonstrate that ambient temperature is effective in raising the physiological responses following firefighting activities. It is therefore argued that further increase of ambient temperature can impact firefighters' information processing and working memory during firefighting activity.

Photoluminescence from $Si^+-implanted \; SiO_2$ films on Crystalline Silicon (실리콘이온주입된 실리콘산화막의 광루미니센스에 관한 연구)

  • 김광희;이재희;김광일;고재석;최석호;권영규;이원식;이용현
    • Journal of the Korean Vacuum Society
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    • v.7 no.2
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    • pp.150-154
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    • 1998
  • Photoluminescence(PL), XRD, TEM results $5\times1016/\textrm{cm}^2, 1\times10^{17}/\textrm{cm}^2, 3\times10^{17}/\textrm{cm}^2$ Si-implanted $SiO_2$ films on crystalline silicon are reported. At low dose implantation and low annealing temperature, visible PL are observed. The PL spectrum has 7400$\AA$ and 8360$\AA$ peaks. As annealing time increased, the PL intensity are increased and peak positions are changed. The PL spectrum are not observed at high dose implantation and high annealing temperature. For the samples of low dose and high annealing temperature, visible PL are observed at short annealing time (30 minutes) and disappear for more than 1 hour annealing. From XRD and TEM results, silicon cluster are related to nonradiative defects. It is concluded that the origin of visible PL in Si implanted SiO2 films are not nanocrystal but two kinds of radiative defects. The Si-O-O bonding related defects (O rich defects) and Si-Si-O bonding related defects (Si rich defects) are related to the PL spectrum and depend on concentraion of Si implantation, annealing temperature and time.

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The Risk Analysis of Flood in Nakdong-river Basin-Focused on the Effect of Hydraulic Structure (수공구조물 영향을 고려한 낙동강 유역에서의 홍수 위험 분석)

  • Kim, Hyun-Jung;Moon, Bo-Ram;Bae, Sung-Hwan;Han, Kun-Yeun
    • Proceedings of the Korea Water Resources Association Conference
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    • 2012.05a
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    • pp.608-608
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    • 2012
  • 현재 기후변화의 기상변동성이 커짐에 따라 태풍 및 집중호우 등의 이상기후 현상이 전 지구상에 걸쳐 광역적으로 나타나고 있다. IPCC에서는 이러한 기후변화가 기온 상승에 따른 증발산량의 증가, 강수량 및 유출량의 시공간적 분포의 변동 등을 초래하여 수자원의 효율적 관리 및 안정적인 공급에 어려움을 증대시킬 것으로 전망하였다. 뿐만 아니라 현재 국내 전반에 걸쳐 4대강 사업이 진행되고 있고, 낙동강에서도 낙동강 살리기 사업이 실시되어 주변 지형들의 변화가 진행되고 있다. 이러한 지형의 변화는 현재까지 구축되어 있는 기존자료의 대폭적인 변화를 의미하므로 홍수관련 연구결과에도 변화를 의미하고 있다. 이에 따라 4대강 사업 이후의 기후 변화에 따른 낙동강유역에서의 유출량의 증가를 분석하여 극한홍수의 발생가능성을 제시하고 이러한 극한홍수발생에 따른 위험지역도 과거에 의해 변경될 것으로 판단되어 국내외적으로 하천의 수리검토에 널리 사용되고 있는 1차원 수리해석 프로그램인 FLDWAV를 이용하여 취약지점을 분석하고 위험도를 분석하고자 한다. 낙동강 살리기 사업으로 낙동강에 건설된 8개의 보를 고려한 본류 및 지류에서의 제내지 및 제외지 지형데이터를 구축하고 구축된 자료을 이용해 낙동강 본류 및 지류에 대해서 극한홍수시 200년 빈도, 500년 빈도 홍수량 및 홍수위를 FLDWAV를 통해 정상류로 계산해서 예측하고 500년 빈도 홍수량과 홍수위를 부정류로 계산하여 제방고와 홍수위를 비교하여 범람위험지역을 선정하였다. 그리고 그 결과를 통해 GIS를 통하여 범람위험지역 제내지의 주요도심 구간 포함, 범람 범위를 분석함과 동시에 극한홍수에 따른 도심구간, 비도시구간 등의 범람범위를 분석하였다. 또한 선정한 범람위험지역의 범람 피해규모를 산정하고 피해범위의 현황을 파악하였다. 연구의 결과는 다음과 같이 나타났다. 500년 빈도 홍수시 범람위험지역은 낙동강 본류의 하류부에서 각각 154.7km, 123.2km, 12.9km에 위치한 지점이 선정되었으며 각 지점의 피해규모는 제내지에 범람된 유출량의 수위는 각각 21.7m, 24.3m, 2.11m로 계산되었고 이때의 피해면적은 각각 $2.68km^2$, $2.64km^2$, $1.25km^2$로 나타났다. 이 결과는 기후변화로 인한 극한홍수 발생 가능성과 취약지점의 분석을 통한 지역의 홍수피해 저감과 정책개발에 기본 자료로 활용될 것이며 낙동강 살리기 사업으로 인한 하천주변 지형의 변화를 제공함으로서 앞으로 진행될 연구의 기본 자료로서 이용가능 할 것으로 판단된다. 또한 이전의 홍수방어계획을 개선한 새로운 홍수방어계획의 수립을 통하여 향후 발생될 홍수의 예방 및 대응방안 수립의 참고자료로 이용될 것이며 제내지 및 제외지의 공간확보 연구를 통해 해당 지자체의 토지매수계획의 참고자료로 이용 가능할 것으로 기대된다.

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Characteristics of mulberry cultivar 'palchung' (Morus Lhou(Ser.) Koidz.) for mulberry breeding as pollen parent (오디 생산용 뽕 품종 육성을 위한 교배모본 '팔청'의 특성)

  • Sung, Gyoo Byung;Kim, Yong Soon;Kim, Kee Young;Kim, Hyun-Bok;Ji, Sang;Kang, Pil Don
    • Journal of Sericultural and Entomological Science
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    • v.52 no.2
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    • pp.147-154
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    • 2014
  • We bred a mulberry cultivar named Palcheong, through local adaptability test, which is under registration as a new cultivar for fruit production. Local adaptability test had been carried out at four places (Suwon, Kongju, Wanju, and Jinju) for seven years from 2007. This is belonging to (Morus Lhou(Ser.) Koidz.) selected among mulberry genetic resources preserved in Suwon. Its sex expression was hermaphrodite, which can be used for the production of seedling for fruit production by artificial crossing as pollen parent Palchung showed lower yielding in fruit productivity by 16% compared to control cultivar 'Chungil (Morus alba L.)' for five years. Although Palchung was higher in sugar content of mulberry fruits, it was bigger than that of 'Chungil'. It is adaptable to every where except the places where cold damage and sclerotic disease happen frequently.

A study on the adsorption characteristic and safety assessment of railway subsoil material (철도 노반 재료의 중금속 흡착특성과 안전성에 관한 연구)

  • Paek, Seoungbong;Gil, Kyungik
    • Journal of Wetlands Research
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    • v.17 no.2
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    • pp.146-154
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    • 2015
  • Domestic railway industry has grown in numbers, scale of railway ndustrial and operation because was focused on an environmentally sustainable transportation. However, it is not enough to treat and prevent heavy metals which occur as the railway operation increases. The heavy metals occurred when the operating railway and it will be flow into water system with rainfall effluent during rainfall. will flow out along with the rainfall effluent when rainfall comes. In case of a railway bridge, In particular, heavy metals were flow into the water system without any treatment from railway bridges where located nearby rivers and lakes. So, rainfall effluent from railway facilities was occurred pollution of water system. For the prevent of heavy metal runoff during rainfall, the adsorptivity of material in railway roadbed is important.In this study, adsorptivity of gravel which is main gravel and blast-furnace slag were conducted adsorption test and deducted Freundlich's and Langmuir's isothermal adsorption equations. Safety as railway subbase course material was evaluated using modeling. As a result, absorption amount of slag, Cd and Cu, was shown higher than gravel and Pb along with Zn showed higher absorption amount of gravel. However, absorption amount of slag was shown higher than gravel used as railway subbase course material as time passes by. Absorption features had more suitable determination coefficient of heavy metals in warm absorption type such as Langnmuir compared to warm absorption type like Freundlich. To add, they showed less transformation by about 10% compared to gravel in safety evaluation through modeling. This is a railway subbase course material that prevents water outflow of heavy metal thus we can know slag is needed to be used.

Prevalence of Canine Retinal Diseases in Korea: 65 cases (국내 개에서 발생한 망막질환 65례)

  • Jeong, Man-Bok;Park, Shin-Ae;Kim, Won-Tae;Kim, Se-Eun;Che, Je-Min;Yi, Na-Young;Seo, Kang-Moon
    • Journal of Veterinary Clinics
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    • v.24 no.2
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    • pp.154-159
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    • 2007
  • The objective of this retrospective study was to investigate the prevalence of retinal diseases in dogs presented to the Veterinary Medical Teaching Hospital, Seoul National University from April 2004 to December 2005. Sixty-five dogs (120 eyes) with retinal diseases involving blindness were included in this study. Age, breed, and gender data for all breeds were collected from medical records documenting vision loss. Generalized progressive retinal atrophy (gPRA) was the most common manifestation. Other prevalent findings included sudden acquired retinal degeneration (SARD) and retinal detachment (RD). Bilateral gPRA was found in 32 dogs with a female-to-male ratio of 1 : 1. The mean $age{\pm}SD$ of all dogs in this group was $4.66{\pm}2.30$ years with a range of 3 to 12 years. Breeds with highest prevalence of gPRA were Miniature Schnauzer (24/32, $mean{\pm}SD$ age: $3.79{\pm}0.78$ yr) and Poodle (2/32, $6.50{\pm}0.71$ yr). Twelve dogs (24 eyes) were diagnosed with SARD bilateraly, ranging from 3 to 13 years of age ($mean{\pm}SD:\;6.91{\pm}2.61$ yr). There were no abnormalities in fundus of 11 dogs at presentation. Electroretinography (ERG) without anesthesia was performed in 7 dogs, and all response was totally extinguished. Retinal detachment was identified in 21 dogs (32 eyes): 11 bilateral and 10 unilateral (7 right eye, 3 left eye). The most common breed was Shih Tzu (15/21, $mean{\pm}SD$ age: $4.39{\pm}3.24$ yr). Four other breeds comprised the remaining 6 cases (8 eyes). The everall mean age of the group was: $4.18{\pm}2.89$ years (range 0.8 to 14 years) with a female-to-male ratio of 1 : 1.1 (10 females, and 11 males).

Studies on Effect and its Mechanism of Herbicide Mixtures of Cyhalofop-butyl, Bispyribenzoxim and Pyrazosulfuron-ethyl - I. Interaction of Herbicide Mixture (Cyhalofop-butyl, Bispyribenzoxim 및 Pyrazosulfuron-ethyl의 상호작용효과(相互作用效果) 및 상호작용(相互作用) 기작(機作)에 관(關)하여 - 제(第) 1 보(報) 제초제간(除草劑間)의 상호작용효과(相互作用效果))

  • Wu, Ming-Gen;Kim, Kil-Ung;Shin, Dong-Hyun
    • Korean Journal of Weed Science
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    • v.18 no.2
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    • pp.154-160
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    • 1998
  • This study was conducted to develop a foliar applied herbicide mixture covering wide spectrum weeds in dry direct seeded rice. Uniform precision central composite design(UPCCD) was employed to evaluate the effect of herbicide mixture among cyhalofop-butyl(cyhalofop), bispyribenzoxim and pyrazosulfuron-ethyl(pyrazosulfuron) having different weed control spectrum and to determine the best application rates of the three herbicide mixtures. The partial additive effect was observed in the mixture of cyhalofop and bispyribenzoxim with pyrazosulfron against Echinochloa crus-galli Beauv var crus-galli L., attributed to the negative interaction between cyhalofop and bispyribenzoxim system. Additive effect was observed in the mixture of bispyribenzoxim and pyrazosulfuron against Cyperus serotinus R. and Aneilema keisak H. but cyhalofop had no effect on these weeds. The most appropriate rate of the mixture of cyhalofop with bispyribenzoxim and pyrazosulfuron was 100 : 12 : 10g ai/ha exhibiting $ED_{90}$ against three weeds such as E. crus-galli, C. serotinus and A. keisak.

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Purification and Cellular Localization of Extracellular Nuclease of Serratia marcescens Expressed in Escherichia coli (대장균에 발현된 Serratia marcescens의 Nuclease의 정제와 세포내 분포)

  • Kim, Woe-Yeon;Lee, Hoon-Sil;Suh, Sook-Jae;Cho, Moo-Je;Lee, Sang-Yeol;Kim, Jae-Won
    • Korean Journal of Microbiology
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    • v.32 no.2
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    • pp.147-154
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    • 1994
  • Nuclease was secreted to the environmental media from the Escherichia coli JM107 tranformant harboring the extracellular nuclease gene of Serratia marcescens in the plasmid of pNUC4. Under the growth conditions, the amount of secreted enzyme was increased in parallel with bacterial growth conditions, the amount of secreted enzyme was increased in parallel with bacterial growth. The enzyme was purified using chromatofraphic procedures of Matrex green gel and heparin agarose affinity gel, resulted in 50-fold purification with 15% recovery of the enzyme. The apparent molecular weight of the enzyme was estimated to be 29Kda by sodium dodecylsulfate denaturing gel electrophoresis. Using the purified enzyme, polyclonal antibody was obtained from the rabbit. The specificity of the antibody was confirmed by immunoblotting and immunoprecipitaion. For the investigation of cellular distribution of the enzyme, cells were fractionated into three fractions; cytoplasm, periplasm and extracellular fluid. While more than 80% of the enzymatic activity was detected in the extracellular fluid and periplasm, a little was found in the cytoplasm, indicating that the enzyme was likely to be immediately exported to the membrane for excretion after biosynthesis. These results were confirmed again by immunocytochemistry technique using the antibody.

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