• 약학회지
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• 제39권3호
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• pp.268-275
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• 1995

A novel polyacetylene was isolated from Cirsium spp., as well as five known ones, and its chemical structure was determined as heptadeca-1-en-11.13-diyne-8R, 9S, 10R-triol(1) on the basis of spectral data and chemical reactions. $^{1}$H-and $^{13}$C-NMR data of these polyacetylenes were completely assigned by the appfication of 2D-NMR techniques.

• 생약학회지
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• 제34권1호통권132호
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• pp.10-13
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• 2003

This study is to establish the quality control method of Adenophorae Radix. (6R,7R)-E,E-tetradeca-4,12-diene-8,10-diyne-1,6,7-triol (1) isolated from this plant was adequate as an analytical marker. Content of 1 in Adenophorae Radix was $0.006\;{\pm}\;0.003%$ (n = 43). In addition, total ash content was $6.5\;{\pm}\;4.0%$, and loss on drying was $12.1\;{\pm}\;2.1%$.

• 생약학회지
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• 제42권2호
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• pp.110-116
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• 2011

As part of our ongoing study focused on the discovery of antioxidants from natural products by measuring the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity, methanol extract of flowers of Carthamus tinctorius L. was found to show potent antioxidant activity. Activity-guided fractionation of the methanol extract lead to the isolation of twenty compounds including two flavonol glycosides, quercertin-3-O-${\beta}$-D-glucopyranoside (12) and kaempferol-3-O-${\alpha}$-L-rhamnopyranosyl-${\beta}$-D-glucopyranoside (18), two flavanone glycosides, (2S)-4',5,6,7-tetrahydroxyflavanone 6-O-${\beta}$-D-glucopyranoside (15) and (2R)-5,7,8',4-tetrahydroxyflavanone 8-O-${\beta}$-D-glucopyranoside (16), and two acetylenic glycosides, 8Z-decaene-4,6-diyne-1-O-${\beta}$-D-glucopyranoside (13) and 4,6-decadiyne-1-O-${\beta}$-D-glucopyranoside (14). Their chemical structures were identified by using spectroscopic analysis. Among them, compounds 12-18 were tested in DPPH assay. Compounds 13-16 were first reported to their antioxidant activity. Quercertin-3-O-${\beta}$-D-glucopyranoside (12) showed the most potent inhibitory effect on DPPH with $IC_{50}$ value of 56.7 ${\mu}M$.