• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.05a
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• pp.399-401
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• 2022

A definitive diagnosis to classify the breast malignancy status may be achieved by microscopic analysis using surgical open biopsy. However, this procedure requires experts in the specializing of histopathological image analysis directing to time-consuming and high cost. To overcome these issues, deep learning is considered practically efficient to categorize breast cancer into benign and malignant from histopathological images in order to assist pathologists. This study presents a pre-trained convolutional neural network model architecture with a 100% fine-tuning scheme and Adagrad optimizer to classify the breast cancer histopathological images into benign and malignant using a 40× magnification BreaKHis dataset. The pre-trained architecture was constructed using the InceptionResNetV2 model to generate a modified InceptionResNetV2 by substituting the last layer with dense and dropout layers. The results by demonstrating training loss of 0.25%, training accuracy of 99.96%, validation loss of 3.10%, validation accuracy of 99.41%, test loss of 8.46%, and test accuracy of 98.75% indicated that the modified InceptionResNetV2 model is reliable to predict the breast malignancy type from histopathological images. Future works are necessary to focus on k-fold cross-validation, optimizer, model, hyperparameter optimization, and classification on 100×, 200×, and 400× magnification.

• Journal of Microbiology and Biotechnology
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• v.26 no.1
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• pp.66-71
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• 2016

PikD is a widely known pathway-specific regulator for controlling pikromycin production in Streptomyces venezuelae ATCC 15439, which is a representative of the large ATP-binding regulator of the LuxR family (LAL) in Streptomyces sp. RapH and FkbN also belong to the LAL family of transcriptional regulators, which show greatest homology with the ATP-binding motif and helix-turn-helix DNA-binding motif of PikD. Overexpression of pikD and heterologous expression of rapH and fkbN led to enhanced production of pikromycin by approximately 1.8-, 1.6-, and 1.6-fold in S. venezuelae, respectively. Cross-complementation of rapH and fkbN in the pikD deletion mutant (ΔpikD) restored pikromycin and derived macrolactone production. Overall, these results show that heterologous expression of rapH and fkbN leads to the overproduction of pikromycin and its congeners from the pikromycin biosynthetic pathway in S. venezuelae, and they have the same functionality as the pathwayspecific transcriptional activator for the pikromycin biosynthetic pathway in the ΔpikD strain. These results also show extensive "cross-communication" between pathway-specific regulators of streptomycetes and suggest revision of the current paradigm for pathwayspecific versus global regulation of secondary metabolism in Streptomyces species.

• Bulletin of the Korean Chemical Society
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• v.34 no.9
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• pp.2680-2684
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• 2013

Protein kinases (PKs) are an important source of drug targets, especially in oncology. With 500 or more kinases in the human genome and only few kinase inhibitors approved, kinase inhibitor discovery is becoming more and more valuable. Because the discovery of kinase inhibitors with an increased selectivity is an important therapeutic concept, many researchers have been trying to address this issue with various methodologies. Although many attempts to predict the activity and selectivity of kinase inhibitors have been made, the issue of selectivity has not yet been resolved. Here, we studied kinase selectivity by generating predictive models and analyzing their descriptors by using kinase-profiling data. The 5-fold cross-validation accuracies for the 51 models were between 72.4% and 93.7% and the ROC values for all the 51 models were over 0.7. The phylogenetic tree based on the descriptor distance is quite different from that generated on the basis of sequence alignment.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.15 no.4
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• pp.251-259
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• 2015

In this paper, a ship detection method is proposed; this method uses edge-based segmentation and histogram of oriented gradient (HOG) with the ship size ratio. The proposed method can prevent a marine collision accident by detecting ships at close range. Furthermore, unlike radar, the method can detect ships that have small size and absorb radio waves because it involves the use of a vision-based system. This system performs three operations. First, the foreground is separated from the background and candidates are detected using Sobel edge detection and morphological operations in the edge-based segmentation part. Second, features are extracted by employing HOG descriptors with the ship size ratio from the detected candidate. Finally, a support vector machine (SVM) verifies whether the candidates are ships. The performance of these methods is demonstrated by comparing their results with the results of other segmentation methods using eight-fold cross validation for the experimental results.

• Journal of Electrical Engineering and Technology
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• v.12 no.2
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• pp.969-980
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• 2017

Galloping is one of the most serious vibration problems in transmission lines. Power lines can be extensively damaged owing to aerodynamic instabilities caused by ice accretion. In this study, the accident probability induced by galloping phenomenon was analyzed using logistic regression analysis. As former studies have generally concluded, main factors considered were local weather factors and physical factors of power delivery systems. Since the number of transmission towers outnumbers the number of weather observatories, interpolation of weather factors, Kriging to be more specific, has been conducted in prior to forming galloping accident estimation model. Physical factors have been provided by Korea Electric Power Corporation, however because of the large number of explanatory variables, variable selection has been conducted, leaving total 11 variables. Before forming estimation model, with 84 provided galloping cases, 840 non-galloped cases were chosen out of 13 billion cases. Prediction model for accidents by galloping has been formed with logistic regression model and validated with 4-fold validation method, corresponding AUC value of ROC curve has been used to assess the discrimination level of estimation models. As the result, logistic regression analysis effectively discriminated the power lines that experienced galloping accidents from those that did not.

• Computers and Concrete
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• v.16 no.6
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• pp.919-932
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• 2015

This paper presents a new method for assessing the three-point-bending (3PB) strength of mortar beams in a non-destructive manner, based on neural network (NN) models. The models are based on the radial basis function (RBF) architecture and the fuzzy means algorithm is employed for training, in order to boost the prediction accuracy. Data for training the models were collected based on a series of experiments, where the cement mortar beams were subjected to various bending mechanical loads and the resulting pressure stimulated currents (PSCs) were recorded. The input variables to the NN models were then calculated by describing the PSC relaxation process through a generalization of Boltzmannn-Gibbs statistical physics, known as non-extensive statistical physics (NESP). The NN predictions were evaluated using k-fold cross-validation and new data that were kept independent from training; it can be seen that the proposed method can successfully form the basis of a non-destructive tool for assessing the bending strength. A comparison with a different NN architecture confirms the superiority of the proposed approach.

• CELLMED
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• v.7 no.3
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• pp.14.1-14.4
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• 2017

Rumex crispus (RC) or Cordyceps militaris (CM) has been used traditionally to treat various diseases and has been also consumed as a functional food made by humanitas medicine concept. We prepared a new herbal mixture, AST2017-01 which is mainly composed of processed (Beopje)-RC (P-RC) and -CM (P-CM). This study aims to validate marker compounds (chrysophanol and cordycepin) in P-RC and P-CM and water extracted-RC and -CM using liquid chromatography-tandem mass spectrometry. In addition, we analyzed contents of chrysophanol and cordycepin in AST2017-01. The linarites of chrysophanol and cordycepin were obtained in calibration curve with a coefficient of correlation of 0.999. The results showed that the concentrations of chrysophanol and cordycepin in P-RC and P-CM were almost 1.70 and 1.23 fold higher than that in RC and CM, respectively. Furthermore, contents of chrysophanol and cordycepin in the AST2017-01 are approximately 0.13% and 0.028%, respectively. In conclusion, these results indicate that chrysophanol and cordycepin were validated as marker compounds in the AST2017-01.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.67 no.9
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• pp.1224-1231
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• 2018

Automatic age estimation has been used in many social network applications, practical commercial applications, and human-computer interaction visual-surveillance biometrics. However, it has rarely been explored. In this paper, we propose an automatic age estimation system, which includes face detection and convolutional deep learning based on an inception module. The latter is a 22-layer-deep network that serves as the particular category of the inception design. To evaluate the proposed approach, we use 4,000 images of eight different age groups from the Adience age dataset. k-fold cross-validation (k = 5) is applied. A comparison of the performance of the proposed work and recent related methods is presented. The results show that the proposed method significantly outperforms existing methods in terms of the exact accuracy and off-by-one accuracy. The off-by-one accuracy is when the result is off by one adjacent age label to the above or below. For the exact accuracy, the age label of "60+" is classified with the highest accuracy of 76%.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.4
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• pp.877-879
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• 2011

Bowel sounds (BS) are produced by the movement of the intestinal contents in the lumen of the gastro-intestinal tract during peristalsis and thus, it can be used clinically as useful indicators of bowel motility. We devised an estimation algorithm of bowel motility based on the regression modeling of the jitter and shimmer of BS signals measured by auscultation. Ten healthy males ($23.5\pm2.1$ years) were examined. Consequently, the correlation coefficient, coefficient of determination and standard error between the colon transit times (CTT) measured by a conventional radiograph and the values estimated by our algorithm were 0.98, 0.96 and 2.86, respectively. Also, through k-fold cross validation, the average value of the absolute differences between them was $5.0\pm2.5$ hours. This method could be used as a complementary tool for the non-invasive measurement of bowel motility.

• Proceedings of the Korean Information Science Society Conference
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• 2010.06c
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• pp.414-418
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• 2010

최근 라이프 로그의 수집과 관리에 관련된 연구가 많이 진행 중에 있다. 또 핸드폰 카메라, 디지털 카메라, 캠코더 등의 발전으로 자신의 일상생활을 비디오로 저장하고, 인터넷을 통해 공유하는 사람도 증가하고 있다. 비디오 데이터는 많은 정보를 포함하고 있는 라이프 로그의 한 예로. 동영상의 촬영 및 수집이 활발해짐에 따라 동영상의 메타정보를 생성하고, 이를 이용해 동영상 검색과 관리에 이용하려는 연구들이 진행 중이다. 본 논문에서는 라이프 로그를 수집하고 수집된 동영상과 라이프 로그를 이용하여 의미정보를 추출하는 시스템을 제안한다. 의미정보란 사용자의 행동을 나타내는 정보로써 컴퓨터 사용, 식사, 집안일, 이동, 외출, 독서, 휴식, 일, 기타로 9가지의 의미정보를 추출한다. 제안하는 방법은 사용자로부터 GPS, 가속도센서, 캠코더를 이용해 실제 데이터를 수집하고, 전처리 과정을 통하여 특징을 추출한다. 이때 추출될 특징은 위치정보와 사용자의 상태정보 그리고 영상처리릍 통한 RGB와 HSL 색공간의 요소와 MPEG-7의 EHD(Edge Histogram Descriptor). CLD(Color Layout Descriptor)이다. 추출된 특징으로부터 사람 행동과 같은 불안정한 상황에서 강점을 보이는 확률모델 네트워크인 베이지안 네트워크를 이용하여 의미정보를 추출한다. 제안하는 방법의 유용성을 보이기 위해 실제 데이터를 수집하고 추론하고 10-Fold Cross-validation을 이용하여 데이터를 검증한다.