• YAKHAK HOEJI
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• v.30 no.5
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• pp.208-213
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• 1986

Rifampicin suspension was administered orally at a does of 34mg/kg to six rabbits after 5, 10 and 20mg/kg pretreatment of isoniazid twice daily for 9 days. The blood level of rifampicin was decreased significantly by isoniazid 10mg/kg 20mg/kg pretraetment. The renal clearance(CLr) of rifampicin was increased by isoniazid 20mg/kg and the biliary clearance(CLb) was incresed by isoniazid 10mg/kg and 20mg/kg pretreatmetn. Elimination rate constant(K) and time to reach maximum concentration(tmax) were increased by isoniazicl pretreatment. But half-life and maximum concentration(C max) were decreased. Relative bioavailability was decreased significantly by isoniazid 10mg/kg and 20mg/kg pretreatment.

• Journal of Food Hygiene and Safety
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• v.37 no.5
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• pp.323-327
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• 2022

The mineral content of Tricholoma matsutake was evaluated for comparison of mineral contents according to the area of cultivation. Ten domestic and thirty Chinese (10 Yanji, 10 Yunnan and 10 Tibet) T. matsutake specimens were assessed using an atomic absorption spectrophotometer (AAS) and inductively coupled plasma mass spectrometer (ICP-MS). The Na, Mg, K, and Ca contents of domestic T. matsutake were 128.12±85.25 mg/kg, 218.52±105.35 mg/kg, 7,534.58±2,691.52 mg/kg, and 17.69±7.14 mg/kg, respectively, while those of Yanji T. matsutake were 124.89±57.24 mg/kg, 64.07±27.52 mg/kg, 1,439.18±311.04 mg/kg, and 10.88±4.52 mg/kg, respectively. The Na, Mg, K, and Ca contents of Yunnan T. matsutake were 90.78±23.23 mg/kg, 77.40±28.36 mg/kg, 1,446.29±126.33 mg/kg, and 28.42±5.18 mg/kg respectively, while those of Tibet T. matsutake were 143.50±41.54 mg/kg, 124.64±50.18 mg/kg, 3,530.95±2,714.99 mg/kg, and 21.05±8.71 mg/kg, respectively. The Cu contents of domestic, Yanji, Yunnan, and Tibet T. matsutake were 105.43±32.97 mg/kg, 19.92±8.95 mg/kg, 54.51±16.91 mg/kg, and 64.80±23.01 mg/kg, respectively. Both domestic and Chinese T. matsutake samples showed significantly different K, Mg, and Cu levels in this study. Therefore, a comparative evaluation of the K, Mg, and Cu contents of multiple domestic and Chinese T. matsutake varieties is needed to determine the appropriate area of cultivation in the future.

• Journal of the Mineralogical Society of Korea
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• v.28 no.2
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• pp.173-185
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• 2015

Janggun mine (longitude $129^{\circ}$ 03'38.91" Latitude $36^{\circ}$ 51'31.59") had been operated as an underground mine for last few decades. As the part of the remediation process, the surface of tailing dump was covered with uncontaminated soil about 20 cm in depth and acacia trees were planted. Heavy metal uptake of acacia from tailing soil has continued for the past 15 years. Heavy metal concentration ranges of tailing soil that contaminated with As (66.43-9325.34 mg/kg), Cd (0.96-1.09 mg/kg), Cu (16.90-57.60 mg/kg), Pb (57.33-945.67 mg/kg), and Zn (154.48-278.61 mg/kg) have higher than those of control soil As (38.98 mg/kg), Cd (0.42 mg/kg), Cu (10.26 mg/kg), Pb (8.21 mg/kg), Zn (46.74 mg/kg). The As, Cd, Cu, Pb and Zn concentrations of leaf of acacia in highly contaminated tailing dump were 165.95, 0.04, 10.68, 3.18, 48.11 mg/kg, respectively. The metal contents of leaf of acacia tree that obtained from uncontaminated control soil are 1.31 of As, 3.90 of Cu, 0.22 of Pb and 11.01 mg/kg of Zn. It was investigated that in the acacia tree, heavy metals such as As, Cu, Pb and Zn tend to be more highly concentrated in bark and leaf, compared with sapwood and heartwood.

• The Korean Journal of Pesticide Science
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• v.12 no.1
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• pp.34-42
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• 2008

In order to know the residual pattern of some pesticides and predict to the degradation period until below MRL, we experimented chlorothalonil, indoxacarb, lufenuron, metalaxyl and methomyl for Chinese cabbage. They were frequently detected pesticides in Chinese cabbage by NAQS (National Agricultural product Quality management Service) monitoring survey. In this experiment, we sprayed those pesticides 10days before harvest and analyzed 0, 1, 2, 3, 5, 7, 10 day samples to establish logical equation and to calculate $DT_{50}0$. During the cultivating period, the residue amount of chlorothalonil was changed from $55.58\;mg\;kg^{-1}$ (0 day) to $20.08\;mg\;kg^{-1}$ (10 day), $DT_{50}$ was 7.45 days, indoxacarb was $7.85\;mg\;kg^{-1}$ (0 day) to $1.46\;mg\;kg^{-1}$ (10 day), and 4.2 days, lufenuron was $1.57\;mg\;kg^{-1}$ (0 day) to $0.49\;mg\;kg^{-1}$ (10 day), and 5.85 days, metalaxyl was $8.12\;mg\;kg^{-1}$ (0 day) to $0.10\;mg\;kg^{-1}$ (10 day), and 175 days, and methomyl was $11.51\;mg\;kg^{-1}$ (0 day) to $0.80\;mg\;kg^{-1}$ (10 day), and 2.42 days at single dose application, respectively. The $DT_{50}$ of double amount in those pesticides were 9.05 days in chlorothatonil, 7.09 days in indoxacarb, 8.82 days in lufenuron, 3.32 days in metalaxyl, and 2.72 days in methomyl, respectively.

• Analytical Science and Technology
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• v.31 no.6
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• pp.247-258
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• 2018

The purpose of the present study was to investigate whether the degree of air pollution can be evaluated via examination of local plants. Selected sites included two parks in an industrial area, as well as two parks in an urban area. Selected plant samples comprised one-year-old pine shoot leaves. Leaves growing over 2 m from the ground were collected from over 10 pine trees. Leaf surface was analyzed for deposition of 14 trace elements and 16 polycyclic aromatic hydrocarbons (PAHs), including particle size and mass, surface imaging, precipitation-mediated particle removal rate, and concentration. Particle size ranged from 0.4 to $200{\mu}m$, and the volume percentage of particles ${\leq}10$ was 20 %. Deposited particle mass ranged from 0.450-0.825 mg, and precipitation-mediated removal rate ranged from 10.0-27.6 %. Trace element concentration, as measured by ICP/MS after microwave acid digestion, was 18.8-26.3 mg/kg As, 0.08-0.13 mg/kg Be, 0.06-0.08 mg/kg Cd, 4.91-17.8 mg/kg Cr, 5.26-405 mg/kg Cu, 1,930-2,670 mg/kg Fe, 3.03-28.1 mg/kg Pb, 26.9-42.8 mg/kg Mn, 2.66-10.4 mg/kg Ni, 4,560-8,730 mg/kg Al, 2,500-6,120 mg/kg Ba, 5.27-17.8 mg/kg Rb, 40.9-95.3 mg/kg Sr, and 4,030-8,260 mg/kg Zn. Concentration of PAHs, as analyzed by GC/MS/MS after liquid-liquid extraction and purification of deposited particles, ranged from 1.17 to 12.378 mg/kg for ${\Sigma}PAH_{16}$ and from 1.17 to 12.378 mg/kg for ${\Sigma}PAH_7$.

• Journal of Food Hygiene and Safety
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• v.16 no.4
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• pp.315-323
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• 2001

This study was concentrated that the contents of heavy metals were estimated from 782 samples of sold fisheries in Seoul(33 species in fishes, 15 in bivalves, 12 in crustaceans and 10 in others) by Atomic Absorption Spectrometer. The contents of As, Cd and Pb [minimum~maximum (mean)] were N.D.~0.162 mg/kg(0.021),0.001~0.120 mg/kg(0.014) and 0.015~0.499 mg/kg(0.111) in fishes, 0.003~0.311 mg/kg(0.052), N.D.~1.905 mg/kg(0.182) and 0.013~0.462 mg/kg(0.138) in bivalves, N.D.~0.328 mg/kg(0.042), 0.002~1.113mg/kg(0.079) and 0.006~-.510 mg/kg(0.109) in crustaceans, N.D. ~0.181 mg/kg(0.024), 0.001~0.214 mg/kg(0.033) and 0.010~0.877 mg/kg(0.118) in others respectively, bivalves were the highest than others. The average weekly intakes of three metals from sold fisheries took about 1.4~26.4% of PTWI (provisional tolerable weekly intakes) that FAO/WHO Joint Food Additive and Contaminants Committee had set to evaluate their safety.

• Journal of Pharmaceutical Investigation
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• v.10 no.1
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• pp.4-12
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• 1980

The studies of the compounding analgestic antipyretics were examined by the converted Koster's method (mice) and the converted Mac Donald's method (mice) induced on the three assumption crossover test. And the following results were found. 1. The same effect of the writhing inhibition in this compounding antipyretic dosage by it's oral administration is as follows. Aminopyrine 100mg/kg. (standard), aminopyrine 50mg/kg compounding with chlorpheniramine maleate 2mg/kg., compounding with diphenhydramine hydrochloride 8mg/kg., compounding with atropine sulfate 0.2mg/kg., or compounding with scopolamine hydrobromide 0.2mg/kg. And aspirin80mg/kg., Salicylamide 90mg/kg., sulpyrine 60mg/kg., or phenacetin 70mg/kg. compounding with the same dosage of the adjutants above. 2. The elevation-rate of the reaction threshold in this compounding antipyretic dosage by it's oral administration calculate as follows. When the elevation-rate (ER) of aminopyrine (100mg./kg.) is 1.00 (Standard), ER of aminopyrine (50mg./kg.) compounding with chlorpheniramine maleate (2mg./kg.) calculated 1.42, aspirin (80.mg./kg.) compounding with diphenhydramine hydrochloride (80mg./kg.) calculated 1.18, salicylamide (90mg./kg.) compounding with chlorpheniramine maleate (2mg./kg.) calculated 1.15, sulpyrine (60mg./kg.) compounding with chlorpheniramine maleate(2mg./kg.) calculated 1.28, and ER phenacetin (70mg./kg.) compounding with chlorpheniramine maleate (2mg./kg.) calculated 1.19.

• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.6
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• pp.779-784
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• 2003

Nitrate a common component of man's chemical environment, is present in foods either naturally or in an additive introduced during processing of foods. Nitrate level of foods have been found depending on nitrosation of soils and other various environmental factors. Therefore data on nitrate contents of foods reported in other countries can not be adapted to Korean foods. Also data on nitrate levels of Korean foods available were reported 10 years ago, which would be assumed to differ from those of foods currently consuming by Koreans. The present study was attempted to determine nitrate contEnts of common foods. Based on National Nutrition Survey Report 143 food items out of 14 food groups were selected for this study Nitrate levels of common foods used in the study were from N.D (not detected) to 6733.33 mg/kg foods. Mean nitrate levels of food groups 27.2 mg/kg of cereal and grain products, 78.1 mg/kg in potatoes and potato products, 8.3 mg/kg in legumes and their products N.D of seeds and nuts, 1012.1 mg/kg of vegetables and their products,76.3 mg/kg fungi and mushrooms 42.2 mg/kg fruits,34.5 mg/kg of meat, poultry and their products,0 mg/kg in eggs, 23.9 mg/kg in fish, shellfishes and their products,23.0 mg/kg in seaweeds, 7.7 mg/kg milk and dairy products, 26.3 mg/kg in seasonings, 68.0 mg/kg in others.

• Journal of fish pathology
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• v.6 no.2
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• pp.163-175
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• 1993

1. By feeding on high Peroxidation Value(POV : 90.4mEq/kg) diets for 180 days, the cultured flounder were induced ceroidosis antificially. 2. The supplementation of glutathione to the diets having POV of 15.5mEq/kg improved the growth of the flounder that had shown depressed by the previous high POV diets(90.4mEq/kg). However, we found very much the same degree of improvement on growth by the supplemented diets of glutathione from 10mg/kg/day to 40mg/kg/day. 3. After 7 days, the flounder fed on the diets supplemented with 10, 30mg/kg/day glufthione start the recover from the accumulated ceroid and damaged tissues. These treated flounders with glutathione showed completely normal histlogical signo after 21 days. The effect of glutathione treatment with high concentration(30mg/kg/day) was better than that of low concentration(10mg/kg/day).

• YAKHAK HOEJI
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• v.48 no.4
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• pp.226-230
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• 2004

The pharmacokinetics of orally administered paclitlxel (50 mg/kg) was studied in six rabbits after 1hr pretreatment (2.0 mg/kg and 10 mg/kg) of tetramethoxyflavone or coadministration of (2.0 mg/kg, 10 mg/kg and 20 mg/kg) tetramethoxyflavone. The area under the plasma concentration-tine curve (AUC) and plasma concentration of paclitaxe1 coadministered with tetramethoxyflavone (10 mglkg) were increased significantly (p<0.05) compared with control. However, coadministration of tetramethoxyflavone (2 and 20 mg/kg) showed no significant effect on the pharmacokinetic parameters of paclitaxel. Pretreatment with tetramethoxyflavone significantly (p<0.05) increased the plasma concentration of paclitaxel. The area under the plasma concentration-time curve (AUC) and the peak concentration (C$_{max}$) of paclitaxel pretreated with tetramethoxyflavone were increased significantly (p<0.01, p<0.05) compared with control. The terminal half. life of paclitaxel pretreated with tetramethoxyflavone (2 mg/kg and 10 mg/kg) was significantly (p<0.05) prolonged compared with control. Pretreatment with tetramethoxyflavone (2.0 mg/kg, 10 mg/kg) significantly (p<0.01, p<0.05) increased the absolute bioavailability of paclitaxel compared with the control (154∼179%). On the basis of the results, it might be considered that tetramethoxyflavone may inhibit cytochrome P450 or P-glycoprotein efflux pump which are engaged in paclitaxel metabolism, result in increased AUC and t$_{1}$2/ of paclitaxel. However, further study should be conducted to clarify the roles of cytochrome P450 and P-glycoprotein on paclitaxel bioavailability with/or without tetramethoxyflavone. P-glycoprotein on paclitaxel bioavailability with/or without tetramethoxyflavone.