• Biomolecules & Therapeutics
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• v.27 no.1
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• pp.48-53
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• 2019

Reactive oxygen species (ROS) are widely generated in biological processes such as normal metabolism and response to xenobiotic exposure. While ROS can be beneficial or harmful to cells and tissues, generation of ROS by diverse anti-cancer drugs or phytochemicals plays an important role in the induction of apoptosis. We recently identified a derivative of naphthalene, MS-5, that induces apoptosis of an ovarian cell, CAOV-3. Interestingly, MS-5 induced apoptosis by down-regulating the ROS. Cell viability was evaluated by water-soluble tetrazolium salt (WST-1) assay. Apoptosis was evaluated by flow cytometry analysis. Intracellular ROS ($H_2O_2$), mitochondrial superoxide, mitochondrial membrane potential (MMP) and effect on cycle were determined by flow cytometry. Protein expression was assessed by western blotting. The level of ATP was measured using ATP Colorimetric/Fluorometric Assay kit. MS-5 inhibited growth of ovarian cancer cell lines, CAOV-3, in a concentration- and time-dependent manner. MS-5 also induced G1 cell cycle arrest in CAOV-3 cells, while MS-5 decreased intracellular ROS generation. In addition, cells treated with MS-5 showed the decrease in MMP and ATP production. In this study, we found that treatment with MS-5 in CAOV-3 cells induced apoptosis but decreased ROS level. We suspect that MS-5 might interfere with the minimum requirements of ROS for survival. These perturbations appear to be concentration-dependent, suggesting that MS-5 may induce apoptosis by interfering with ROS generation. We propose that MS-5 may be a potent therapeutic agent for inducing apoptosis in ovarian cancer cell through regulation of ROS.

• Journal of Nutrition and Health
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• v.51 no.2
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• pp.153-167
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• 2018

Purpose: This study was conducted to identify differences in dietary behaviors, dietary life consumer education related situation competencies, and dietary lifestyles between baby-boom and echo generations by gender. Methods: Data were drawn from the 2016 Food Consumption Behavior Survey, and 2,474 subjects (baby-boom generation 1,304; echo generation 1,170) were selected. Results: The baby-boom generation more frequently ate meals at home with family than the echo generation, whereas the echo generation had meals more frequently at cafeterias, cafes, bakeries, convenience stores and with friends or colleagues than the baby-boom generation. However, no significant differences in dietary life related consumer education were observed between generations, and experience with food related consumer education and food related promotional/events was very low in general. Baby-boomers received their primary dietary information from surrounding people, whereas the echo generation received it from broadcasting. The information use competence was lower for the baby-boom generation (3.29) than echo generation (3.35), although this difference was not significant. Healthy dietary life competence did not differ significantly, whereas the baby-boom generation showed a higher level of practice competence than the echo generation. Additionally, the baby-boom generation was more likely to pursuit health and less likely to be concerned with convenience and taste quality than the echo generation. Conclusion: The frequencies of meal eating places, drinking, and eating-out differed significantly between the two generations, while the participation ratios of food related consumer education/events, attitudes toward education, and information use competence did not. Additionally, knowledge regarding healthy dietary life competencies did not differ, whereas practice level showed significant differences between generations. Among dietary lifestyles, the baby-boom generation showed higher pursuit of health and lower pursuit of convenience and taste quality than the echo generation.

• Journal of Home Health Care Nursing
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• v.23 no.1
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• pp.34-44
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• 2016

Purpose: This study investigated the factors associated with suicidal ideation in the Korean Echo Generation using 2012 Korea Health Panel Data. Methods: The 2012 Korea Health Panel Data were collected from February 2012 to July 2012 and included 2,303 people who responded to a question asking whether they had experienced suicidal ideation. The data were analyzed by chi-square and multiple logistic regression test using SPSS 22.0. Results: The rate of suicidal ideation was 4.2% in the Echo Generation. Factors associated with suicidal ideation in the Echo Generation revealed that the following variables increased the rate of suicidal ideation: sex(odd ratio: 2.39, CI: 1.39-4.09), education(odd ratio: 1.95, CI: 1.08-3.52), depression(odd ratio: 12.06, CI: 6.92-21.03), frustrating experience(odd ratio: 2.52, CI: 1.22-5.20), anxiety about the future(odd ratio: 14.58, CI: 3.20-66.41), self-rated health status(odd ratio: 2.39, CI: 1.39-4.09 and odd ratio: 6.41, CI 2.87-14.33). Conclusion: This study provides a preliminary examination of the factors associated with suicidal ideation in the Echo Generation. A more careful examination may be warranted.

• International Journal of Contents
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• v.18 no.1
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• pp.76-84
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• 2022

Tidal power generation plays a critical role in reducing greenhouse gas emissions. It uses a tidal force generated by gravitational force between the moon, the earth, and the sun. The change of seawater height generates the tide-generating force, and the magnitude of the change is the tide level. The tide level change has the same period as the tide-generating force twice a day, every 29.5 days, every year, and every 18.6 years. Sihwa Lake Tidal Power Station is Korea's first tidal power plant that began commercial power generation in August 2011 and has been accumulating a large volume of data on electricity production, power generation sales, sluice displacement, and tide levels. The purpose of this paper was to analyze the impact of the inefficiency factors affecting production and the tidal level change on tidal power generation and their characteristics using Sihwa Lake Tidal Power's operational performance data. Throughout this paper we show that tidal power generating operation is accurately predicting the trends of magnitude of tidal force to be periodical for each day. determining the drop to initiate the water turbine generator factoring the constraints on the operation of Sihwa Lake, and reflecting the water discharge through the floodgate and water turbine during the standby mode in the power generation plan to be in the optimal condition until the initiation of the next power generation can maximize power generation.

• Proceedings of the KIEE Conference
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• 2000.07e
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• pp.9-12
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• 2000

A new type electrolyzing cell with slits on parallel plate electrodes and wire-to-cylinder type electrode system has been proposed instead of the conventional parallel plate type. An investigation was carried out on the effect of the number and size of slits on ion precipitation and oxidant generation characteristics, evidenced by eliminated space charge limiting action and by elevated electric fields in active interelectrode spacing. And it is also studied on the effect of the diameter of wire electrode to ion precipitation and oxidant generation characteristics. With electrode with 48 slits, very oxidants generation water of 3.1 [ppmm] and 19.0 [ppmm] in positive electrode side were obtained with tap water and 0.1 [wt%] NaCl dissolved tap waterfed. In addition, with wire-to-cylinder type electrode system, it is found that oxidant contained water of 0.48 [ppmm] and 5.46 [ppmm] in positive electrode side were obtained with tap water and 0.1 [wt%] NaCl dissolved tap water fed for the case of discharge electrode diameter of 0.5 [$mm{\phi}$]. Consequently, very high ion precipitation and dense oxidant generation characteristics can be realized by having slits on the electrodes of conventional cell as these slits increase the electric fields and decrease the space charge limiting actions in interelectrode spacing.

• Journal of the Korean Society of Visualization
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• v.21 no.1
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• pp.94-102
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• 2023

Three design parameters were considered in this study: outlet nozzle angle (30°, 60°, 80°), neck length (1 mm, 3 mm), and flow rate (0.5, 0.6, 0.7, 0.8 lpm). A neck diameter of 0.5 mm induced cavitation flow at a venture nozzle. A secondary transparent chamber was connected after ejection to increase bubble duration and shape visibility. The bubble size was estimated using a Gaussian kernel function to identify bubbles in the acquired images. Data on bubble size were used to obtain Sauter's mean diameter and probability density function to obtain specific bubble state conditions. The degree of bubble generation according to the bubble size was compared for each design variable. The bubble diameter increased as the flow rate increased. The frequency of bubble generation was highest around 20 ㎛. With the same neck length, the smaller the CV number, the larger the average bubble diameter. It is possible to increase the generation frequency of smaller bubbles by the cavitation method by changing the magnification angle and length of the neck. However, if the flow rate is too large, the average bubble diameter tends to increase, so an appropriate flow rate should be selected.

• Nuclear Engineering and Technology
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• v.21 no.1
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• pp.18-31
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• 1989

To analyze the impact of air pollution control on electricity generation cost, a computer program was developed. POGEN calculates levelized discounted power generation cost including additional air pollution control cost for coal power plant. Pollution subprogram calculates total capital and variable costs using governing equations for flue gas control. The costs are used as additional input for levelized discounted power generation cost subprogram. Pollution output for Rue Gas Desulphurization direct cost was verified using published cost data of well experienced industrialized countries. The power generation costs for the year 2001 were estimated by POGEN for three different regulatory scenarios imposed on coal power plant, and by levelized discounted power generation cost subprogram for nuclear power. Because of uncertainty expected in input variables for future plants, sensitivity and uncertainty analysis were made to check the importance and uncertainty propagation of the input variables using Latin Hypercube Sampling and Multiple Least Square method. Most sensitive parameter for levelized discounted power generation cost is discount rate for both nuclear and coal. The control cost for flue gas alone reaches additional 9-11 mills/kWh with standard deviation less than 1.3 mills/kWh. This cost will be nearly 20% of power generation cost and 40% of one GW capacity coal power plant investment cost. With 90% confidence, the generation cost of nuclear power plant will be 32.6-51.9 mills/kWh, and for the coal power plant it will be 45.5-50.5 mills/kWh. Nuclear is favorable with 95% confidence under stringent future regulatory requirement in Korea.

• Journal of the Korean Home Economics Association
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• v.26 no.3
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• pp.225-241
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• 1988

The purpose of this study is to find the difference between the parents generation and that of the children in the disciplinary methods by means of parental social population variation. With these purpose in mind, the problems have been suggested like following: 1) what are the general differences of between the two generations of parents and children in disciplinary method? 2)What are the general differences of the views between those two generations according to sex? 3) What are the general differences between the parents generation and the child generation according to age? 4) What are the general differences between the parents generation and the child generation according to education level? 5) What are the general differences between the parents generation and the child generation according to income level? In order to solve these problems, questionnaries were distributed on this appendix 374parents (father: 177, mother: 197) who have the children. Questionnaires were compose on "Parents Inventory" of Radke were employs, classfied five measures. To test and verifying the above hypothes, the following five measures. were used. 1) Philosophy of authority (authoritarian vs. democratic) 2) Parental restrition (strict and stubbon vs. democratic) 3) Severity of punishment (severity vs. mildness) 4) Parent-child rapport 9desirable vs. undesirable) 5) Relative responsibility of father and mothehr towards child disciplinary (equal vs. differ) The result of this study is like follows: 1) In general comparison of two generations, tends to be more democratic in the philosophy of authority, more relaxed and easygoing in the parental restroction, more severe in the severity of punishment, and good rapport in the parent-child rapport than grandparents generation and the responsibility of father don't change but that of mother tends to augment in child disciplinary 2) In comparison of two generation according to sex, the mother showed more democratic in the philosophy of authority and closely perceive her parents in the parent-child rapport as compared with the father. 3) In comparison of two generation according to age, the younger parents showed more relaxed attitudes towards the child disciplinary, the perception better relations of their parents in the parent-child rapport. 4) In the comparison of two generations according to education level the more educated parents showed the more relaxed and easygoing attitude towards in the parental restriction. 5) In comparison of two generation according to income, as the parents of large income generally (not always) showed easygoing than their previous generation in the parental restriction, and they perceive that they have a good one in parent-child rapport. This study caused by the some difficult problem required futher investigation on the result of two generations the problems happened in the inner unitary of items. And, it proposed some problems which constitutes the problems of the proper interpretation of the results between two generations brought about discordance of items between tow generations

• Journal of the Korean Solar Energy Society
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• v.37 no.2
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• pp.35-45
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• 2017

The types of installation of the photovoltaic system applied to domestic residential buildings are classified as follows: Mounted modules with air circulation, semi-integrated modules with air duct behind, integrated modules with fully insulated back. In order to study generation characteristics of PV system, we verified the validity of interpretation program based on long-term measurement data of demonstration house installed in BAPV form and also analyzed the generation characteristics and performance of each installation type. The results are as follows. First, the RMSE of amount of generation and simulation according to annual daily insolation of demonstration system located in Daejeon was 0.98kWh and the range of relative error of monthly power generation was -5.8 to 3.1. Second, the average annual PR of mounted modules was 82%, semi-integrated modules 76.1% and integrated modules 71.9%. This differences were attributed to temperature loss. Third, the range of operating temperature of annual hourly photovoltaic modules was -6.5 to $61.0^{\circ}C$ for mounted modules, $-6.0{\sim}73.9^{\circ}C$ for semi-integrated modules and -5.5 to $88.9^{\circ}C$ for integrated modules. The temperature loss of each installation type was -14.0 to 16.1%, -13.8 to 21.9%, and -13.6 to 28.5%, respectively.

• Journal of Life Science
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• v.12 no.1
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• pp.67-76
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• 2002

The effect of transgene inactivation in T2, T3 and F2 generations was analyzed in progeny seedlings which had been generated by Agrobacterium (LBA4404/pBI121)-mediated transformation in Arabidopsis thaliana. In a system which investigated in the expression of $\beta$-glucuronidase(GUS)gene in kanamycin-resistant (ke $n^{R}$)seedlings, GUS inactivated seedlings were observed in 5 of 12 tested lines of T2 generation and the frequency of GUS inactivation was approximately 2.3%. Lines with multi-copies of T-DNA exhibited severe GUS gene inactivation with the frequency of 5.8% in T2 generation. In T3 generation lines exhibited GUS gene inactivation with the frequency of 1.3%. In contrast, inactivation increased dramatically up to 12.6% in multi-copy T-DNA line. A similar phenomenon was also found in F2 progeny from a transgenic line which had been crossed with wild-type Arabidopsis plant, WS-O (GUS gene inactivation frequency 9.9%). These results indicate that the foreign gene introduced into the plant was inactivated progressively in its transmission during subsequent generations and the transgenic line with multi-copies of T-DNA tended to show more increased inactivation.