• Archives of Pharmacal Research
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• 제10권1호
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• pp.67-68
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• 1987

1-eicosanoyl cafferate, mp 109-$110^{\circ}$ was isolated from the underground parts of Echinosophora koreenis together with hexacosanol, mp 75-$110^{\circ}$ 1-Eicosanoyl cafferate was isolated for the first time from plant source.

• 생약학회지
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• 제30권3호
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• pp.290-294
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• 1999

From the legumes of Albizzia julibrissin Durazzini (Leguminosae), a mixture of long-chain alcohols, ${\alpha}-spinasterol$, a mixture of acylated sterol glycosides and ${\alpha}-spinasteryl$ $3-O-{\beta}-D-glucoside$ were isolated. Two mixtures of long-chain alcohols and acylated sterol glycosides were characterized as 1-hexacosanol (major) and 1-tetracosanol, and $3-O-[6'-O-palmitoyl-{\beta}-D-glucosyl]-{\alpha}-spinasterol$ (major) and its 6'-O-stearoyl ester. All compounds were identified on the basis of spectral data and chemical reactions.

• Natural Product Sciences
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• 제13권4호
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• pp.394-397
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• 2007

Investigation of the chemical constituents of the dichloromethane extract from the moss Hylocomium splendens has led to the isolation of $5{\alpha},8{\alpha}$-epidioxy-24(S)-ethylcholesta-6,22-dien-$3{\beta}$-ol (1), diploptene (2), ${\beta}-sitosterol$ (3), and 1-hexacosanol (4). The chemical structures of 1 - 4 were established by spectroscopic methods including extensive 1D and 2D NMR analysis. This is the first isolation of compound 1 from the mosses, although it has been isolated from marine sponge.

• 생약학회지
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• 제38권3호통권150호
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• pp.254-257
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• 2007

The aerial parts of Brassica juncea (Cruciferae) called by brown or oriental mustard have been widely used as a spice in food and also traditional folk medicine as stimulant, diuretic and expectorant agent. And Gatkimchi made of the aerial parts of this plant are very popular in Korea. The aerial parts of this plant was refluxed with MeOH and then fractionationed with $CH_2Cl_2$, EtOAc, n-BuOH and $H_2O$, successively. One higher alcohol compound and three flavonoids were isolated from the EtOAc fraction through silica gel and Sephadex LH-20 column chromatographies. Their structures were elucidated as n-hexacosanol(1), kaempferol(2), isorhamnetin $3-O-{\beta}-D-glucopyranoside(3)$ and isorhamnetin $3-O-(6'-O-acetyl)-{\beta}-D-glucopyranoside(4)$ by comparison of spectral data with those in references. And compounds 1 and 4 were firstly isolated from this plant.

• 한국약용작물학회지
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• 제3권2호
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• pp.151-155
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• 1995

국화과 식물인 산씀바귀(Lactuca raddeana)를 식물화학적 방법에 의하여 연구한 바 primaylong chain alcohol인 1-hexacosanol과 1-tetracosa not을, triterpene acetate로 ${\beta}-amyrin\;acetate,\;{\alpha}-amyrin acetate$, lupeol acetate, pseudotaraxasterol acetate, taraxasterol acetate 및 germanicol acetate등을, fatty acyl triterpene은 이들의 구성 triter pone alcohol이 triterpone acetate의 경우와 같았으며 acyl moiety는 myristate, palmitate, stearate및 arachidate로 각각 나타났다.

• 생약학회지
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• 제33권2호통권129호
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• pp.105-109
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• 2002

Besides chrysophanol and friedelin, mixtures of n-hydrocarbons [pentacosane (72.6%), heptacosane (14.6%), tetracosane (5.8%), nonacosane (4.1 %) and hexacosane (2.9%)], n-hydrocarbon alcohols [octacosanol (70.5%) and hexacosanol (29.5%)], l-monoacyl glycerols [acyl part; behenic acid (43.5%), lignoceric acid (32.4%), cerotic acid (9.3%), tricosanoic acid (8.9%), pentacosanoic acid (2.6%), octacosanoic acid (2.3%), heneicosanoic acid (1.0%)], wax esters [behenic acid (56.3%), lignoceric acid (23.0%), cerotic acid (19.8%), tricosanoic acid (4.6%), octacosanoic acid (4.0%), pentacosanoic acid (1.7%), triacontanoic acid (0.6%)/ octacosanol (33.7%), hexacosanol (21.0%), tetracosanol (15.6%), triacontanol (10.5%), docosanol (6.0%), tricosanol (6.0%), heptacosanol (4.2%), nonacosanol (3.0%)] and sterols [${\beta}-sitosterol$ (73.2%), stigmasterol (14.6%), campesterol (12.2%)] were isolated from the roots of Hemerocallis fulva. The acid : alcohol combinations of the major wax esters were $C_{48}$: 22 : 26, 24 : 24, $C_{46}$: 22 : 24, and $C_{44}$: 22 : 22. This is the first report of l-monoacyl glycerols and friedelin from this plant. All isolates were identified on the basis of spectral data and chemical reactions.

• Natural Product Sciences
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• 제28권2호
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• pp.45-52
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• 2022

The identification of Plasmodium falciparum enoyl acyl-carrier protein reductase (pfENR) is considered as a potential biological target against malaria. Trema orientalis is considered a rich source of phytochemicals useful in malaria treatment. This study evaluated the in-vitro inhibitory activity of the extract and isolated compounds of T. orientalis leaf; the isolated compounds and the analogues of the most active compound were subjected to in-silico molecular docking studies on pfENR. The methanolic extract of T. orientalis was subjected to repeated chromatographic separation which led to the isolation of some compounds. The isolated compounds from the plant were examined for their antimalarial activity using β-hematin inhibition assay. Virtual screening via molecular docking and ADMET studies were conducted to gain insight into the mechanism of binding of ligand and to identify effective pfENR inhibitors. The isolated compounds and the analogues of the most active isolates were gotten from PubChem library for use in docking study. Hexacosanol and β-sitosterol showed inhibition of the β-hematin formation. The docking results showed that hexacosanol, β-sitosterol and the analogues of β-sitosterol displayed binding energy ranging between -6.1 kcal/mol and -11.6 kcal/mol. Sitosterol glucoside has the highest docking score. Some of the ligands showed more binding affinity than known bioactive compounds used as reference. Analogues of β-sitosterol has been shown to be potential inhibitors of pfENR, therefore, the findings from this study suggest that sitosterol glucoside and ergosterol peroxide could act as antimalarial agents after further lead optimisation investigations.

• 한국잠사곤충학회지
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• 제34권2호
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• pp.59-66
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• 1992

1-4령 저염인공사료 공동육＋5령 뽕잎육(농가개별육)$\longrightarrow$일주일 양잠에 적합한 광식성 누에품종육성에 필요한 기초지식을 얻기 위해 광식성유전자의 검색, 유전현상, 특성, 광식성계통 작출, 실용광식성 누에 품종육성방법 등에 대하여 소고하였다. 1. 광식성 유전자의 검색은 의잠을 사용하는 것이 가장 성력적이고 편리하며, 또한 섭식성을 정확히 파악할 수 있다. 2. 광식성 누에의 LP-1 사료에 대한 섭식성은 사육온도, 광조건, 발육단계 및 절식에 의하여 크게 영향 받지 않는다. 3. 광식성 유전자는 열성형질이며 1개의 주유전자와 수개의 수식유전자로 구성되어 있는 것으로 추찰된다. 4. LP-1 인공사료에 첨가한 morin 및 n-hexacosanol의 누에 섭식촉진효과는 미소하였으나, 상엽분말 첨가로 인한 누에 섭식촉진효과는 매우 양호하였다. 5. 광식성누에의 섭식성은 어분 및 효모에 의해 영향받지 않았다. 6. 섭식저해물질인 brucin 및 salicine은 정도의 차는 있으나 광식성누에의 섭식성을 저해하였다. 7. 광식성 및 비광광성누에의 LP-1 인공사료에 대한 섭식성의 차이는 누에의 두부에 있는 감각기관의 형태적 차이 때문이 아니라 기능적 차이에 기인하는 것으로 추찰된다. 8. 광식성 육성소재창출은 광식성유전자의 도입육종에 의해 가능하다. 9. 실용 광식성 누에품종육성을 위해 광식성검정에 적합한 인공사료를 사용하고, 실용형질이 우수하면서도 광식성유전자를 가진 계통을 선발, 교잡 또는 계통육성법에 의해 실용형질 및 섭식성을 개량하여 육종 목표를 달성하는 것이 최선책으로 생각된다.

• 생약학회지
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• 제40권4호
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• pp.326-333
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• 2009

Fourteen compounds were isolated from the 70% ethanol extract of Lonicera Caulis (Caprifoliaceae) and their structures were identified as seven aliphatic compounds [long-chain alcohols (1, 2), trilinolein (3), hexacosanol (4), fatty acids (6), 9,12,13-trihydroxyoctadeca-10(E),15(Z)-dienoic acid (10), and pinellic acid (11)] and seven phenolics [bis(2-ethylhexyl) phthalate (dioctylphthalate, DOP) (5), coniferaldehyde (7), caffeic acid docosanoyl ester (8), caffeic acid (9), coniferyl aldehyde 4-O-glucoside (12), linarin (13), and coniferin (14)]. The chemical structures of these compounds were identified on the basis of spectroscopic methods and comparison with literature values. All the compounds except for caffeic acid (9) were isolated from this plant parts for the first time.