• Current Optics and Photonics
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• v.8 no.2
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• pp.138-150
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• 2024

This study is essential for advancing our knowledge about the interaction between long-range high-power lasers and energetic materials, with a particular emphasis on understanding the response of a 155-mm shell under various surface irradiations, taking into account external factors such as atmospheric disturbances. The analysis addresses known limitations in understanding the use of non-realistic targets and the negligence of ambient conditions. The model employs the three-dimensional level-set method, computer-aided design (CAD)-based target design, and a message-passing interface (MPI) parallelization scheme that enables rapid calculations of the complex chemical reactions of the irradiated high explosives. Important outcomes from interaction modeling include the accurate prediction of the initiation time of ignition, transient pressure, and temperature responses with the location of the initial hot spot within the shell, and the relative magnitude of noise with and without the presence of physical ambient disturbances. The initiation time of combustion was increased by approximately a factor of two with atmospheric disturbance considered, while slower heating of the target resulted in an average temperature rise of approximately 650 K and average pressure increase of approximately 1 GPa compared to the no ambient disturbance condition. The results provide an understanding of the interaction between the high-power laser and energetic target at a long distance in an atmospheric condition.

• Parasites, Hosts and Diseases
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• v.62 no.3
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• pp.351-364
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• 2024

The gut microbiome plays an essential role in host immune responses, including allergic reactions. However, commensal gut microbiota is extremely sensitive to antibiotics and excessive usage can cause microbial dysbiosis. Herein, we investigated how changes in the gut microbiome induced by ampicillin affected the production of IgG1 and IgG2a antibodies in mice subsequently exposed to Anisakis pegreffii antigens. Ampicillin treatment caused a notable change in the gut microbiome as shown by changes in both alpha and beta diversity indexes. In a 1-dimensional immunoblot using Anisakis-specific anti-mouse IgG1, a 56-kDa band corresponding to an unnamed Anisakis protein was detected using mass spectrometry analysis only in ampicillin-treated mice. In the Anisakis-specific anti-mouse IgG2a-probed immunoblot, a 70-kDa band corresponding to heat shock protein 70 (HSP70) was only detected in ampicillin-treated and Anisakis-immunized mice. A 2-dimensional immunoblot against Anisakis extract with immunized mouse sera demonstrated altered spot patterns in both groups. Our results showed that ampicillin treatment altered the gut microbiome composition in mice, changing the immunization response to antigens from A. pegreffii. This research could serve as a basis for developing vaccines or allergy immunotherapies against parasitic infections.

• Journal of Welding and Joining
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• v.17 no.1
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• pp.88-96
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• 1999

The effects of root gap on welding residual stress and deformation are dealt with the multi-pass weldment with three kinds(0, 6, 30mm) of root gap by F.E.M common code, and then compared with experiment data. In this analysis, an 100% ramp heat input model was used to avoid numerical convergence problem due to an instantaneous increase in temperature near the fusion zone, and the effect of a moving arc in a two dimensional plane was also included. During the analysis, a small time increment was applied in a period with instantaneous temperature fluctuation while a large time increment was used in the rest period. The residual stress is distributed as symmetric types and maximum value is also equivalent when the weldment with 0mm and 6mm root gap is welded. In the case of 30mm root gap welding, the distribution of the residual stress extends over a wide range as asymmetric types due to the built-up weld, and most of the residual stress is biased in the side of a built-up weld part. In case of 0mm gap welding and 6mm gap welding, a little angular distortion occurs, but the level of deformation is small. When the weldment with 30mm root gap is welded, the angular deformation of the asymmetric types, however, occurs larger than the other specimens. The experimental and the analytic results show good coincidence and indicate that the welding residual stress and deformation distribution of 30 mm root gap specimen may be asymmetric and the amplitude is larger than those of root gap specimen under standard.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.23 no.10
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• pp.670-677
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• 2011

Direct numerical simulation are performed in order to investigate the effect of the circular cylinder shape on the forced convection around a circular cylinder at the Reynolds number of 300 and Prandtl number of 0.71. Three-dimensional characteristics of fluid flow and heat transfer around the smooth, wavy and torsional cylinders are investigated. A wavy cylinder has the sinusoidal variation in the cross sectional area along the spanwise direction with the wave length of ${\pi}/3$ and wavy amplitude of 0.1. A torsional cylinder has the twisted elliptic cross section with a torsional period of ${\pi}/2$ and an axis ratio of 1.35 corresponding to the major axis of 1.15 and the minor axis of 0.85. The value of time-and surface-averaged drag coefficient for the smooth cylinder is similar to that for the wavy cylinder, but larger than that for the torsional cylinder. The time and surface-averaged lift coefficient for the smooth cylinder is larger than that for the wavy and torsional cylinders. The time-averaged local heat transfer rate for the wavy and torsional cylinders shows different distribution along the circumferential direction, compared to that for the smooth cylinder because of the shape change in the spanwise direction for the cases of the wavy and torsional cylinders.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.23 no.8
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• pp.978-986
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• 1999

In this study, the general thermal and flow characteristics of flat tube with micro-channels has been studied and the correlation of Nusselt number and friction factor is proposed. The optimal flat tube geometry is determined by optimal design process. It is assumed to be a three dimensional laminar flow in the analysis of thermal and flow characteristics. The periodic boundary condition is applied since the geometry of flat tube with micro-channels shows uniform cross-section in primary flow direction. Local Nusselt number is examined for thermal characteristics of each membrane, and module average Nusselt number and friction factor are calculated to determine the characteristics of the heat transfer and pressure drop in overall flat tube with microchannels. The correlations between Nusselt number and friction factor are given by Reynolds number, aspect ratio of membranes, and the width of flat tube. ALM (Augmented Lagrangian Multiplier) method is applied to the correlations to determine an optimal shape of flat tube. It is shown that the optimal aspect ratio of flat tube is approximately 1.0, irrespective of the width of flat tube and Reynolds number.

• Journal of the Semiconductor & Display Technology
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• v.15 no.1
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• pp.41-46
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• 2016

In this study, gas flow and temperature distribution in the multi-wafer planetary CVD reactor for the Si epitaxial growth were analyzed. Although the structure of the reactor was simplified as the first step of the study, the three-dimensional analysis was performed taking all these considerations of the revolution of the susceptor and the rotation of satellites into account. From the analyses, a reasonable velocity field and temperature field were obtained. However, it was found that analyses including the upper structure of the reactor were required in order to obtain more realistic temperature results. DCS mole fraction above the satellite surface and the susceptor surface without satellite was compared in order to check the gas species mixing. We found that satellite rotation helped gases to mix in the reactor.

• Journal of the Korean earth science society
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• v.30 no.6
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• pp.709-720
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• 2009

Field observation and numerical experiments were conducted to understand the impact of water retention pavement on the surface heat budget and on the regional circulation. The numerical model applied in this study is the atmospheric dynamic model Local Circulation Model (LCM) with two dimensional grid system, and a field observation was carried out under the clear sky and calm conditions of the weather on 19 July 2007. In the field observation, the maximum value of surface temperature on pavement covered with water retention material reached the $41.2^{\circ}C$ at 1430 LST and the values was lower for $16.1^{\circ}C$ than that of asphalt without the material. The Case BET03 assumed to be 0.3 for the surface evaporation efficiency was in good agreement with the observation and its sensible and latent heat fluxes were numerically estimated to be 229 and 227 $W/m^2$, respectively. Results of the numerical experiments demonstrated that the water retention pavement tends to induce the increase of latent heat flux associated with the lower surface temperature and mixing height during the daytime. Discontinuity of latent heat caused by the water retention pavement also tends to promote the development of mesoscale circulation called as land-land breeze or country breeze.

• Journal of the Korean Institute of Gas
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• v.2 no.1
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• pp.28-39
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• 1998

This study investigated the natural convection and radiation in a rectangular enclosure with ceiling vent experimentally and numerically. A heat source is located on the center of the bottom surface. The analysis was peformed a pure convection and is combination of natural convection and radiation. The shape of the considered two dimensional model is a square whose center of ceiling($30\%$) is opened. The numerical simulations are carried out for the pure natural convection case and the combined heat transfer case by using the SIMPLE algorithm. For the turbulent flow, Reynolds stresses are closed by the standard $k-{\epsilon}$ model and the wall function is used to determine the wall boundary conditions. The experiment was performed on the same geometrical shape as the computations. The radiative heat transfer is analized by the S-N discrete ordinates method. The results of pure natural convection are compared with those of combined heat transfer by the velocity vectors, stream lines, isothermal lines. The results obtained are as follows 1. Comparing the results of pure convection with those of the combined convection-radiation through the shape of stream lines, isothermal lines are similar to each other. 2. The temperature fields obtained by numerical method are compared to those obtained by experimental one, and it is found that they are showed mean relative error $8.5\%$. 3. Visualization bt smoke is similar to computational results.

• Structural Engineering and Mechanics
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• v.60 no.1
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• pp.1-19
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• 2016

In this study, the supersonic panel flutter of doubly curved composite sandwich panels with variable thickness is considered under aerothermoelastic loading. Considering different radii of curvatures of the face sheets in this paper, the thickness of the core is a function of plane coordinates (x,y), which is unique. For the first time in the current model, the continuity conditions of the transverse shear stress, transverse normal stress and transverse normal stress gradient at the layer interfaces, as well as the conditions of zero transverse shear stresses on the upper and lower surfaces of the sandwich panel are satisfied. The formulation is based on an enhanced higher order sandwich panel theory and the vertical displacement component of the face sheets is assumed as a quadratic one, while a cubic pattern is used for the in-plane displacement components of the face sheets and the all displacement components of the core. The formulation is based on the von $K{\acute{a}}rm{\acute{a}}n$ nonlinear approximation, the one-dimensional Fourier equation of the heat conduction along the thickness direction, and the first-order piston theory. The equations of motion and boundary conditions are derived using the Hamilton principle and the results are validated by the latest results published in the literature.

• The Journal of Korean Physical Therapy
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• v.20 no.1
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• pp.57-65
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• 2008

Purpose: Heat shock proteins (HSPs) are a group of proteins that are activated when cells are exposed to a variety of environmental stresses, such as infection, inflammation, exposure to toxins, starvation, hypoxia, brain injury, or water deprivation. The activation of HSPs by environmental stress plays a key role in signal transduction, including cytoprotection, molecular chaperone, anti-apoptotic effect, and anti-aging effects. However, the precise mechanism for the action of small HSPs, such as HSP27 and mitogen-activated protein kinases (MAPKs: extracellular-regulated protein kinase 1/2 (ERK1/2), p38MAPK, stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), is not completely understood, particularly in application of cell stimulators including platelet-derived growth factor (PDGF), angiotensin II (AngII), tumor necrosis factor $\alpha$ (TNF$\alpha$), and $H_2O_2$. This study examined the relationship between stimulators-induced enzymatic activity of HSP27 and MAPKs from rat smooth and skeletal muscles. Methods: 2-dimensional electrophoresis (2DE) and matrix assisted laser desorption ionizationtime-of-flight/time-of-flight (MALDI-TOF/TOF) analysis were used to identify HSP27 from the intact vascular smooth and skeletal muscles. Three isoforms of HSP27 were detected on silver-stained gels of the whole protein extracts from the rat aortic smooth and skeletal muscle strips. Results: The expression of PDGF, AngII, TNF$\alpha$, and $H_2O_2$-induced activation of HSP27, p38MAPK, ERK1/2, and SAPK/JNK was higher in the smooth muscle cells than the control. SB203580 (30${\mu}$M), a p38MAPK inhibitor, increased the level of HSP27 phosphorylation induced by stimulators in smooth muscle cells. Furthermore, the age-related and starvation-induced activation of HSP27 was higher in skeletal muscle cells (L6 myoblast cell lines) and muscle strips than the control. Conclusion: These results suggest, in part, that the activity of HSP27 and MAPKs affect stressors, such as PDGF, AngII, TNF$\alpha$, $H_2O_2$, and starvation in rat smooth and skeletal muscles. However, more systemic research will be needed into physical therapy, including thermotherapy, electrotherapy, radiotherapy and others.