• Title/Summary/Keyword: 1,3,4-Oxadiazole

Search Result 67, Processing Time 0.024 seconds

Synthesis and Surface Activity of New Quaternary Ammonium Salts Prepared from 2-Chloromethyl-5-(2-Phenylthiazol-4-yl)-1,3,4-Oxadiazole (2-클로로메틸-5-(2-Phenylthiazol-4-yl)-1,3,4-옥사디아졸의 새로운 4급 암모늄염의 합성과 계면활성도)

  • Bae, Sun Kun;Yeon, Young Heum
    • Applied Chemistry for Engineering
    • /
    • v.17 no.3
    • /
    • pp.286-290
    • /
    • 2006
  • New quaternary ammonium chlorides, [alkyldimethyl-[5-(2-phenylthiazol-4-yl]-1,3,4-oxadizol-2-ylmethyl]quaternary ammonium chlorides (ADOQACs): 6] were obtained with high yields by the reaction of compound 5 with N,N-dimethylalkyl amines in isopropyl alcohol. The structures and physical properties of the synthesized compounds were investigated and those surface-active properties were measured. The surface tension ($\gamma_{cmc}$) and the minimal inhibitory concentration (MIC) of compound 6 were found to be influenced by the number of alkyl chain carbon. Especially, compounds 6c and 6d exhibited high anti-bacterial activities and good surface-active properties.

Synthesis and Some Reactions of New Thieno[2,3-c]pyridazine Derivatives

  • Bakhite, Etify A.;Mohamed, Omima S.;Radwan, Shaban M.
    • Bulletin of the Korean Chemical Society
    • /
    • v.23 no.12
    • /
    • pp.1715-1718
    • /
    • 2002
  • Treatment of ethyl 5-hydroxy-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylate (1a) with hydrazine hydrate in ethanol gave the carbohydrazide 2,. Some derivatives of the latter compound have been synthesized. Also, 6-acetyl-3,4-diphenyl-5-hydroxythieno[2.3-c]pyridazine (1b) was subjected to some reactions to produce other new thienopyridazine derivatives.

Synthesis and Evaluation of the Analgesic and Antiinflammatory Activities of O-Substituted Salicylamides

  • Fahmy, H.H.;El-Eraky, W.
    • Archives of Pharmacal Research
    • /
    • v.24 no.3
    • /
    • pp.171-179
    • /
    • 2001
  • The present investigation deals with the synthesis of some new salicylamidoacetyl sulfonamides 3a,b, salicylamido ethylacetate 4, salicylamido acetic acid hydrazide 5, which is considered as the key intermediate for the synthesis of several series of new compounds such as salicylamido pyrazol 6 and pyrazolone 1. N-imido-derivatives 9, 10, 11, thiadiazole 13, oxadiazole 14, 15, Schiffs bases 16a-f. Cyclocondensation of Schiffs bases with thioglycolic acid gave thiazolidinone 18a-c while with acetylchloride afforded azitidinones 19a-c and with acetic anhydride gave 1,4-benzoxazepine-3,5-dione. Some of the compounds were tested for their analgesic and antiinflammatory activities as well as ulcerogenic effects. Some derivatives were more effective than salicylamide and ulcerogenic activity was variably lowered .

  • PDF

Strategies to Design Efficient Donor-Acceptor (D-A) Type Emitting Molecules: Molecular Symmetry and Electron Accepting Ability of D-A Type Molecules

  • Hyun Gi Kim;Young-Seok Baek;Sung Soo Kim;Sang Hyun Paek;Young Chul Kim
    • Applied Chemistry for Engineering
    • /
    • v.34 no.6
    • /
    • pp.633-639
    • /
    • 2023
  • We synthesized 2-(10-methyl-10H-phenothiazin-3-yl)-5-phenyl-1,3,4-oxadiazole (MPPO) and 5,5-(10-methyl-10H-phenothiazin-3,7-diyl)-bis-(2-phenyl-1,3,4-oxadiazole) (DPPO). MPPO has both electron-donating and electron-accepting substituents with asymmetric molecular geometry. By incorporating one extra electron-accepting group into MPPO, we created a symmetric molecule, which is DPPO. The optical and electrochemical properties of these compounds were measured. The lowest unoccupied molecular orbital (LUMO) level of DPPO was lower than that of MPPO. The excited-state dipole moment of DPPO, with symmetric geometry, was calculated to be 4.1 Debye, whereas MPPO, with asymmetric geometry, had a value of 7.0 Debye. The charge-carrier mobility of both compounds was similar. We fabricated non-doped organic light-emitting diodes (OLEDs) using D-A type molecules as an emitting layer. The current efficiency of the DPPO-based device was 7.8 cd/A, and the external quantum efficiency was 2.4% at 100 cd/m2, demonstrating significantly improved performance compared to the MPPO-based device. The photophysical and electroluminescence (EL) characteristics of the two D-A type molecules showed that molecular symmetry, as well as the lowered LUMO level of DPPO, played critical roles in the enhancement of EL performance.

The Possibility of 1,3,4-Oxadiazole Containing Polymer as a New Polymer Electrode in Redox Supercapacitor

  • Ryu, Kwang-Sun;Chang, Soon-Ho;Kwon, Soon-Ki;Kim, Yun-Hi;Hwang, Do-Hoon
    • Macromolecular Research
    • /
    • v.10 no.1
    • /
    • pp.40-43
    • /
    • 2002
  • Poly(1', 4'-phenylene-1", 4"-(2"-(2""-ethyl-hexyloxy)) phenylene-1",4"-phenylene-2,5-oxadiazolyl) (PPEPPO) was synthesized and its electrochemical characteristics was investigated as electrode material in redox supercapacitor. The cyclic voltammetry (CV) shows there was scarcely a redox reaction and further suggests n-doping is difficult to occur in this system. However, the discharge curve between 3.0 to 0.01 V is continuously decreased like a straight line, similar to the discharge pattern of EDLC. The initial specific discharge capacitance is ~6.4 F/g, while the specific capacitance of 1000th cycle is ~0.1 F/g. The PPEPPO can be used as the electrode of supercapacitor, emissive material, as well as charge-transporting material in polymer LED.ansporting material in polymer LED.

Synthesis and Antimicrobial Activity of New Substituted Anili-nobenzimidazoles

  • Nofal, Z.M.;Fahmy, H.H.;Mohamed, H.S.
    • Archives of Pharmacal Research
    • /
    • v.25 no.3
    • /
    • pp.250-257
    • /
    • 2002
  • A series of benzimidazole derivatives carrying different heterocycles such as 1,2,3-thiadiazole, 1,3,4-thiadiazole, thiazolidine, 2,3-dihydro-thiazole, 1,3,4-oxadiazole, semicarbazone and substituted thiosemi-carbazones were synthesized. Also a series of 1-methylbenzimidazole carrying hydroxy ethyl-amide, substituted sulfonyl hydrazide and benzoyl hydrazide from aminobenzoyl group at position 2 of 1-methylbenzimidazole were synthesized. The antimicrobial evaluation of some of the new compounds was carried out.

Design and Synthesis of New Fluorene-Based Blue Light Emitting Polymer Containing Electron Donating Alkoxy Groups and Electron Withdrawing Oxadiazole

  • Kim, Yun-Hi;Park, Sung-Jin;Park, Jong-Won;Kim, Jin-Hak;Kwon, Soon-Ki
    • Macromolecular Research
    • /
    • v.15 no.3
    • /
    • pp.216-220
    • /
    • 2007
  • A new polyfluorene-based copolymer having 2-ethylhexyloxy-5-methoxy-l,4-phenylene as an electron donating group and 2,5-diphenyl-oxadiazole as an electron withdrawing group was synthesized by the Suzuki coupling reaction. The obtained copolymer was characterized by $^1H-NMR,\;^{13}C-NMR$, and IR-spectroscopy. The weight average molecular weight ($M_w$) of the obtained polymer was 18,600 with a polydispersity index of 1.5. The maximum photoluminescence of the solution and film of the polymer was observed at 453 nm and 456 nm, respectively. A double-layer device with the configuration, ITO/PEDOT/copolymer/Al, emitted blue light at 460 nm.

Electronic excitation energy quenching of PPD by $CCl_4$ in different solvents

  • Biradar, D.S.;Thipperudrappa, J.;Hanagodimath, S.M.
    • Journal of Photoscience
    • /
    • v.12 no.1
    • /
    • pp.51-54
    • /
    • 2005
  • The electronic excitationenergy quenching of 2, 5-diphenyl-1, 3, 4-oxadiazole (PPD) by Carbon tetrachloride ($CCl_4$) in different solvents viz, n-hexane, n-heptane, toluene, benzene, cyclohexane, 1, 4- dioxane has been carried out at room temperature to understand the role of quenching mechanism. The Stern-Volmer plots have been found to be linear. As probability of quenching per encounter 'p' is less than unity, and the activation energy for quenching '$E_a$' is greater than the activation energy of diffusion '$E_d$', it is inferred that the fluorescence quenching mechanism is not due to material diffusion alone.

  • PDF

A Novel Synthesis of Heterocyclic Compounds Containing Coumarin Moiety of Potential Antimicrobial Activity

  • El-Fattah, M. E. Abd
    • Archives of Pharmacal Research
    • /
    • v.21 no.6
    • /
    • pp.723-728
    • /
    • 1998
  • The chemical behaviours of 4-methyl-2-oxo-2H-benzopyran-7-yl oxoacetyl hydrazine (2) towards some different reagents such as anhydride compounds, aromatic aldehydes, carb on disulphide, and nitrous acid yielded the corresponding pathalazine derivatives (3, 4, 5), hydrazone derivative (6), 1,3,4-oxadiazole derivative (7, 8, 9) and acid azide (10) respectively. Treatmen of 10 with absolute alcohols, amines and ethyl amino acid ester gave the corresponding carbamate derivative (11), substituted urea derivative (12) and ethyl substituted alkyl acetate (13) respectively. The biological activity of some synthesized compounds was evaluated.

  • PDF

Synthesis of Metal-free Organic Dye for Dye-sensitized Solar Cell (염료감응 태양전지를 위한 무금속 유기염료의 합성)

  • Pattarith, K.;Pungwiwat, N.;Laosooksathit, S.
    • Journal of the Korean Chemical Society
    • /
    • v.55 no.2
    • /
    • pp.279-282
    • /
    • 2011
  • Dye-sensitized solar cell (DSSC); an alternate energy source harvester has gained some attractive features such as high-energy conversion efficiency low production cost. Dye-sensitizer is a basic component of DSSC, which affecting the performance of the energy conversion efficiency. Current research has been focusing on development of high efficiency, metal-free dye-sensitizers, which would be more environmental friendly. We had successfully explored synthetic route to 6,6'-(1,2,5-oxadiazole-3,4-diyl)dipyridine-2,4-dicarboxylic acid (3A) which has been used as organic sensitizer. Investigation of light conversion efficiency (${\eta}$) of the compound uses standard measurement condition (one sun simulated irradiation, AM 1.5, 100 mW/$cm^2$) showed that it could reach 1.00% ($J_{SC}=2.63\;mAcm^{-2}$, $V_{OC}$=0.64 V and FF=0.59). Under the same conditions, the ruthenium complex (N719) gave the conversion efficiency as high as 4.02%($J_{SC}=10.50\;mAcm^{-2}$, $V_{OC}$=0.67V and FF=0.57).