• 응용통계연구
• /
• 제24권2호
• /
• pp.393-400
• /
• 2011

조사비용과 시간과 같은 현실적인 제약하에서 관측단위 (observation unit)의 집합인 집락(cluster)율 추출하는 집락추출법은 대부분의 대형조사(large scale survey) 에서 흔히 사용된다. 특별히 집락내의 관측단위가 매우 유사한 경우, 집락 내의 모든 관측치를 조사하는 대신 일부를 추출하여 조사하는 이단계 집락 추출법이 선호된다. 이단계 집락추출법의 적용시 집락인 1차추출단위 (Primary Sampling Unit; PSU)와 관측단위인 2차추출단위(Secondary Sampling Unit; SSU)의 표본수 결정은 주어진 비용과 표본으로부터 계산되어지는 통계량의 정도에 의존한다. 본 연구에서는 기존의 1차추출단위의 크기가 동일하다는 가정하에서 유도된 최적 PSU와 SSU 표본크기 산출과정을 일반화하여 1차추출단위의 크기가 같지 않을 경우의 최적 표본크기를 유도하고 그 결과를 제 4차 퇴원환자조사를 위한 표본추출 방안에 적용하여 기존방법과 비교하였으며 이를 바탕으로 제 7차 퇴원환자조사를 위한 표본크기를 제안하였다.

• 한국컴퓨터정보학회논문지
• /
• 제4권2호
• /
• pp.27-38
• /
• 1999

본 논문에서는 캐리 전파가 없어 고속 연산이 가능한 잉여수체계(Residue Number System)를 이용하여 고속의 디지털 뉴런 프로세서를 제안하였다. 제안된 뉴런프로세서는 MAC (Multiply And Accumulator) 연산부, 몫연산부, 시그모이드(Sigmoid)함수 연산부로 구성되며, 0.8$\mu$m CMOS공정으로 설계되었다 실험결과, 본 논문에서 구현한 디지털 뉴런프로세서는 19.2nsec의 속도를 보였으며, 실수연산기로 구현한 뉴런프로세서에 비하여 약1/2정도 하드웨어 크기를 줄일 수 있었다.

• Journal of Microbiology and Biotechnology
• /
• 제29권10호
• /
• pp.1644-1655
• /
• 2019

Saccharomyces cerevisiae (S. cerevisiae) and glucagon-like peptide-2 (GLP-2) have been employed to improve the intestinal development of weaned animals. The goal of this study was to determine whether either exogenous S. cerevisiae or GLP-2 elicits major effects on fecal microbiotas and cytokine responses in weaned piglets. Ninety-six piglets weaned at 26 days were assigned to one of four groups: 1) Basal diet (Control), 2) empty vector-harboring S. cerevisiae (EV-SC), 3) GLP-2-expressing S. cerevisiae (GLP2-SC), and 4) recombinant human GLP-2 (rh-GLP2). At the start of the post-weaning period (day 0), and at day 28, fecal samples were collected to assess the bacterial communities via sequencing the V1-V2 region of the 16S-rRNA gene, and piglets' blood was also sampled to measure cytokine responses (i.e., IL-$1{\beta}$, TNF-${\alpha}$, and IFN-${\gamma}$). This study revealed that, on the one hand, although S. cerevisiae supplementation did not significantly alter the growth of weaned piglets, it induced increases in the relative abundances of two core genera (Ruminococcaceae_norank and Erysipelotrichaceae_norank) and decreases in the relative abundances of two other core genera (Lachnospiraceae_norank and Clostridiale_norank) and cytokine levels (IL-$1{\beta}$ and TNF-${\alpha}$) (p < 0.05, Control vs EV-SC; p < 0.05, rh-GLP2 vs GLP2-SC). On the other hand, GLP-2 supplementation had no significant influence on fecal bacterial communities and cytokine levels, but it produced better body weight and average daily gain (p < 0.05, Control vs EV-SC; p < 0.05, rh-GLP2 vs GLP2-SC). Therefore, altered fecal microbiotas and cytokine response effects in weaned piglets were due to S. cerevisiae rather than GLP-2.

• Archives of Pharmacal Research
• /
• 제27권2호
• /
• pp.143-150
• /
• 2004

A trisaccharide, the O-antigenic repeating unit of C. jejuni serotype O:23 and O:36, was synthesized as a 2 -azidoethyl glycoside by block addition of perbenzylated thiogalactoside donors to $\alpha$-altroHepp-(1$\rightarrow$3)-GlcNPhth disaccharide acceptor in presence of IDCP promoter. The $\alpha$-linked altroheptopyranoside moiety in the glycosyl acceptor was effectively prepared by Swern oxidation of $\alpha$-mannohepp-(1$\rightarrow$3)-GlcNPhth disaccharide followed by mild reduction with1 $NaCNBH_3$.

• 한국광학회지
• /
• 제17권5호
• /
• pp.469-474
• /
• 2006

본 논문에서는 실리카 기반의 다중모드 간섭기를 이용하여 적은 초과손실을 갖는 $1{\times}16$ 마하젠더 스위치에 대한 설계 및 측정결과에 대하여 논하였다. 제작된 $1{\times}16$ 마하젠더 스위치는 마하젠더 간섭계(Mach-Zehnder Interferometer, MZI) 구조를 갖는 $2{\times}2$ 열광학스위치를 단위소자로 하였으며, 15개의 단위소자를 이용하여 4단(stage)으로 구성하였다. 먼저 광분배기와 $2{\times}2$ MZI 열광학 스위치등의 개별적인 특성을 파악하였고, 그 결과를 전체 소자의 설계에 적용함으로써 보다 좋은 성능을 얻을 수 있었다. 제작된 다중모드 간섭기를 이용한 MZI 구조의 단위스위치 당 초과손실은 최소 -0.5dB로 측정되었다.

• BMB Reports
• /
• 제32권6호
• /
• pp.561-566
• /
• 1999

CA(1-8)-ME(1-12) [CA-ME], composed of cecropin A(1-8) and melittin(1-12), is a synthetic antimicrobial peptide having potent antibacterial and antitumor activities with minimal hemolytic activity. In order to investigate the effects of the flexible hinge sequence, Gly-Ile-Gly, of CA-ME on antibiotic activity, CA-ME and three analogues, CA-ME1, CA-ME2, and CA-ME3, were synthesized. The Gly-Ile-Gly sequence of Ca-ME was deleted in CA-ME1 and replaced with Pro and Gly-Pro-Gly in CA-ME2 and CA-ME3, respectively. CA-ME1 and CA-ME3 showed a significant decrease in antitumor activity and phospholipid vesicle-disrupting ability. However, CA-ME2 showed similar antitumor and vesicle-disrupting activities, as compared with CA-ME. These results suggest that the flexibility or ${\beta}$-turn induced by Gly-Ile-Gly or Pro in the central part of CA-ME may be important in the electrostatic interaction of the N-terminus cationic ${\alpha}$-helical region with the cell membrane surface and the hydrophobic interaction of the C-terminus amphipathic ${\alpha}$-helical region with the hydrophobic acyl chains in the cell membrane. CA-ME3 exhibited lower antitumor and vesicle-disrupting activities than CA-ME and CA-ME2. This result suggests that the excessive ${\beta}$-turn structure caused by the Gly-Pro-Gly sequence in CA-ME3 seems to interrupt ion channel/pore formation in the lipid bilayer. We concluded that the appropriate flexibility or bilayer. We concluded that the appropriate flexibility or ${\beta}$-turn structure provided by the central hinge is responsible for the effective antibiotic activity of the antimicrobial peptides with the helix-hinge-helix structure.

• 한국주거학회논문집
• /
• 제25권6호
• /
• pp.39-47
• /
• 2014

The background of this study is to examine the structure of housing price of which characteristics are not equal but hierarchical in the apartment complexes. So, the purpose of this study is to analyze the influences of apartment complex characteristics on the housing price within the same regional boundary by HLM. The data used as dependent variables were the market prices of 938 units from 29 apartment complexes by stratified sampling. The 2nd level independent variables is the Housing complex characteristics which are composed of the housing complex & locational variables and the 1st level independent variables are the unit characteristics. The results are as follows. First, the first model shows that the 2nd level variables explains 68% of the housing prices. Second, the influential variables of the 1st level unit variable are 'dwelling exclusive area', 'floor of dwelling' and 'direction of dwelling'. Third, the influential variables of the housing complex variables in the 2nd level are 'lot area', 'the building-to-land ratio', 'the number of unit', 'the number of parking lots per unit', 'Green space area' and 'open space area per unit'. The last, the influential variables of the housing locational variables in the 2nd level are 'distance to subway and park' and the number of school and park within a radius of 1km.

• 한국압력기기공학회 논문집
• /
• 제6권2호
• /
• pp.28-33
• /
• 2010

As a part of license renewal for the continued operation of Wolsong unit 1, the periodic safety review report was submitted near the end of design lifetime, 2012, and now is under reviewing. Major components of primary system such as pressure tubes, feeder pipes and so on are being replaced and many components of secondary system are also being repaired. So the license renewal of Wolsong unit 1 is expected to be acquired without significant issues. But on the other hand, steam generators of Wolsong unit 1 had the good performance and therefore the replacement and repair for the steam generator are not needed. Recently it is reported that some cracks were detected in a few of european steam generator with Alloy 800 tubes and the cause of cracks was the outer diameter stress corrosion cracking(ODSCC) due to the concentration of chemical impurities on the outer surface of tube. Accordingly the overall review on this issue was performed. The long-term operation is likely to results to form the concentration mechanism for the tube corrosion as the sludge build-up in the secondary side of steam generator and the crack in the crevice between tube and tube-sheet and expansion transitions is apt to be occurred. In this paper, the history of steam generator inspection and operation of Wolsong unit 1 are reviewed and the reliability of steam generator tube is evaluated and the steam generator aging management program for Wolsong unit 1 is introduced.

• 물과 미래
• /
• 제8권1호
• /
• pp.61-79
• /
• 1975

본연구는 1974년 건설부 수자원국의 연구사업중의 하나인 $\ulcorner$홍수량 추정을 위한 합성단위유량도유도의 연구$\Ircorner$의 일부로서 건설부에서 제공한 재정적 후원에 감사를 드린다.

• Clinical and Experimental Pediatrics
• /
• 제63권6호
• /
• pp.226-231
• /
• 2020

Background: Probiotics and prebiotics have strain-specific effects on the host. Synbiotics, a mixture of probiotics and prebiotics, are proposed to have more beneficial effects on the host than either agent has alone. Purpose: We performed a randomized controlled trial to investigate the effect of Lactobacillus and Bifidobacterium together with oligosaccharides and lactoferrin on the development of necrotizing enterocolitis (NEC) or sepsis in very low birth weight neonates. Methods: Neonates with a gestational age ≤32 weeks and birth weight ≤1,500 g were enrolled. The study group received a combination of synbiotics and lactoferrin, whereas the control group received 1 mL of distilled water as placebo starting with the first feed until discharge. The outcome measures were the incidence of NEC stage ≥2 or late-onset cultureproven sepsis and NEC stage ≥2 or death. Results: Mean birth weight and gestational age of the study (n=104) and the control (n=104) groups were 1,197±235 g vs. 1,151±269 g and 29±1.9 vs. 28±2.2 weeks, respectively (P>0.05). Neither the incidence of NEC stage ≥2 or death, nor the incidence of NEC stage ≥2 or late-onset culture-proven sepsis differed between the study and control groups (5.8% vs. 5.9%, P=1; 26% vs. 21.2%, P=0.51). The only significant difference was the incidence of all stages of NEC (1.9% vs. 10.6%, P=0.019). Conclusion: The combination of synbiotics and lactoferrin did not reduce NEC severity, sepsis, or mortality.