• Progress in Medical Physics
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• v.11 no.2
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• pp.131-139
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• 2000

We designed high dose rate Ir-192 source which was prepared for substitute the Co-60 source in Ralstron unit (Simatsu, Japan) which is supplied for cervical cancer treatment. The source dimension is 1.5 mm in a diameter and 1.5mm thickness of cylinder and encapsulated with 3 mm diameter of stainless steel(SUS316L) to substituted for the Co-60 source size. The Ir-192 source was prepared the dose model for tissue dose computation through the experimental determination of apparent activity and applied the empirical tissue correction factors extended to 20cm distance. The tissue dose model was applied the 4.69 R/cm-mCi-hr gamma constant and the ratio of energy absorption coefficient of water to that of air showed 1.112 include filteration of the self-absorptions. In this experiments, we prepared the dose computation software to clinical usefulness.

• Journal of the Korean Society of Radiology
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• v.16 no.7
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• pp.1007-1014
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• 2022

Targeted radionuclide therapy (TRT) is a method of treating tumor cells using radiopharmaceuticals. Cells and nuclei constituting tissues of the human body are composed of spherical and oval shapes, but cancer cells are composed of various cell types. Therefore, this study analyzed the absorbed dose for each organelle according to the change in the size of the cell nucleus for beta-emitting nuclides during targeted radionuclide therapy through the Monte Carlo method. Cells were set in two sphere shapes, 5 ㎛ and 10 ㎛, and the internal structure was divided into cell nucleus, cytoplasm, and cell surface. Next, the absorbed dose according to the increase in the size of the cell nucleus was evaluated. As a result, ¹⁷⁷Lu among the target radionuclides showed the highest dose in all cell compartments. As the ratio of the nucleus in the cell increased, the absorbed dose on the cell surface increased, but the absorbed dose in the cytoplasm and nucleus tended to decrease. Accordingly, it is judged that it is important to select a radionuclide considering the size of cancer cells and determine an appropriate amount of radioactivity during targeted radionuclide treatment.

• Journal of the Korean Society of Radiology
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• v.11 no.6
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• pp.459-466
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• 2017

The purpose of this study was to evaluate the difference of dose and image quality according to the material of the additional filter plate by selecting copper and nickel. First, the absorbed dose was measured using a Rando phantom setting the additional filter plates of copper and nickel None, 0.1 mm, 0.2 mm, and 0.3 mm under 120 kVp, and 6.3 mAs. Second, We acquired image according to filter thickness of copper and nickel. by changing the tube voltage of 90 kVp, 100 kVp, 110 kVp, 120 kVp and exposure indexes of 400, 800 and 1600. Third, we obtained the SNR and CNR values using the Image J program and evaluated quantitatively and then evaluated image quality. As a result, Absorbed dose measurements showed that nickel was higher than copper, and the absorbed dose decreased as the thickness increased(p<0.05). Furthermore, Quantitative analysis of images showed no significant difference between the two images according to change the voltage and the exposure index(p>0.05). In conclusion, this study confirms that the nickel addition plate can maintain the current image quality while reducing the exposure dose compared to copper.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2011.10a
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• pp.415-416
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• 2011

• Journal of the Korean Society of Radiology
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• v.12 no.4
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• pp.467-474
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• 2018

CBCT is useful for improving the accuracy of the treatment site, but Repeated use increases the exposure dose. In this study, we aimed to provide basic data for dose reduction in CBCT implementation by dataization the simulating and dose reduction effect using shielding substance. Material in this study, Analyzation the photon beam by simulate the CBCT Through MCNPX and then calculate the absorption dose of body organ at shooting moment of thoracic abdominal position as target UF-Revise simulated body. At this time. Dose reduction effects at this time were evaluated according to the texture of materials and presence of shielding materials( lead, antimony, barium, sulfate, tungsten, bismuth). When CBCT was taken without shielding, the dose was calculated to be high in the breast and spine, and the dose in the esophagus and lung was calculated to be low. The doses according to the shield material were calculated as barium sulfate, antimony, bismuth, lead, and tungsten. The shielding rate was the highest in the thymus (73.6%) and the breast (59.9%) compared with the dose reduction according to presence or absence of the shield. However, it showed the lowest shielding rate in lung (2.1%) and spine (12.6%).

• Radiation Oncology Journal
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• v.15 no.1
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• pp.57-64
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• 1997

Purpose : Before we report the results of curative radiotherapy in cervix cancer patients, we review the significance and safety of our dose specification methods in the brachytherapy system to have the insight of the potential Predictive value of doses at specified points. Matersials and Methods : We analyze the 리5 cases of cervix cancer patients treated with intracavitary brachytherapy in the lateral simulation film we draw the isodose curve and observe the absorbed dose rate of point A, the reference point of bladder(SBD) and rectum(SRD). In the sagittal view of Pelvic MRI film we demarcate the tumor volume(TV) and determine whether the prescription dose curve of point A covers the tumor volume adequately by drawing the isodose curve as correctly as possible. Also we estimate the maximum Point dose of bladder(MBD) and rectum(MRD) and calculate the inclusion area where the absorbed dose rate is higher than that of point A in the bladder(HBV) and rectum(HRV), respectively. Results : Of forty-five cases, the isodose curve of point A seems to cover tumor volume optimally in only 24(53%). The optimal tumor coverage seems to be associated not with the stage of the disease but with the tumor volume. There is no statistically significant association between SBD/SRD and MBD/MRD, respectively. SRD has statistically marginally significant association with HRV, while TV has statistically significant association with HBV and HRV. Conclusion : Our current treatment calculation methods seem to have the defect in the aspects of the nonoptimal coverage of the bulky tumor and the inappropriate estimation of bladder dose. We therefore need to modify the applicator geometry to optimize the dose distribution at the position of lower tandem source. Also it appears that the position of the bladder in relation to the applicators needs to be defined individually to define 'hot spots'.

• Progress in Medical Physics
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• v.20 no.4
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• pp.308-316
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• 2009

To achieve the accurate evaluation of given absorbed dose from output dose of linear accelerator photon beam through investigate the characteristics of LiF:Mg,Cu,P TLD powder. This experimental TL phosphor is performed with a commercial LiF:Mg,Cu,P powder (Supplied by PTW) and TL reader (LTM, France). The TLD was exposed to 6 MV X rays of linear accelerator photon beam with range 15 to 800 cGy in blind dose at two hospitals. The dose evaluation of TLD was through the experimental algorithms which were dose dependency, dose rate dependency, fading and powder weight dependency. The glow curve has shown the three peaks which are 110, 183 and 232 degrees of heating temperature and the main dosimetric peak showed highest TL response at 232 high temperature. In this experiments, the LiF:Mg,Cu,P phosphor has shown the 2.5 eV of electron trap energy with a second order. This experiments guided the dose evaluation accuracy is within 1% +2.58% of discrepancy. The TLD powder of LiF:Mg,Cu,P was analyzed to dosimetric characterists of electron captured energy and order by glow shape, and dose-TL response curve guided the accuracy within 1.0+2.58% of output dose discrepancy.

• Journal of radiological science and technology
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• v.33 no.4
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• pp.387-394
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• 2010

In the field of healthcare, the conventional sterilization treatments have been replaced by irradiation methods which are in accordance with internationally well established quality standards. The quality control in radiation sterilization assures that the absorbed dose of the irradiated material is in agreement with its requirements and standards. The electron beam irradiation requires technical assessments of more process parameters than gamma irradiation does. Korea has witnessed wide uses of electron accelerators since early 2000 but there hasn't been research experiences relating to quality system in accordance with international standards. The new large scale e-beam irradiation system with the specification of 10 MeV, 8 kW was installed and operated in 2008 by Seoul Radiology Services Co. It consists of the electron accelerator, product handling system, safety, documentation and control subsystems into an integrated system to meet the requirement of the Good Manufacturing Practice such as process quality assurance and management of product tracking records. To implement the international standard such as EN ISO11137, it is necessary to understand the purposes aimed in the standard and carry out the tests following the procedures required. This study presented the specification of the e-beam facility and showed what its design requirements and features are. The test results on a variety of process parameters were presented and validated it they are within the required limits.

• Progress in Medical Physics
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• v.11 no.2
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• pp.109-116
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• 2000

One consideration of radiation delivery in cervical cancer is the complication of critical organs, e.g., bladder and rectum. The absorbed dose of bladder and rectum in HDR intracavitary brachytherapy is measured indirectly with TLD dosimetry A method for the complication reduction of bladder and rectum is suggested. For two-hundred cervical cancer patients, follow-up MRI images were reviewed and distances from cervical central axis to bladder and rectum and vaginal wall thickness were measured. The sealed TLDs were placed upon the gauze packing of the ovoids and the distances to the TLDs from the ovoid center were measured in the simulation film and actual doses of bladder and rectum were calculated. From published data, maximal tolerance doses of bladder and rectum were derived and based on the permissible doses per fraction in HDR brachytherapy the packing thicknesses were determined in both directions. The required minimal packing thicknesses for bladder and rectum were 0.43 and 0.92 cm, respectively. The results were compared with computer calculation using the Meisberger polynomial approach. It is our hope this study can be used for a guideline for users in clinic in estimating critical organ dose in bladder and rectum in HDR brachytherapy in vivo dosimetry.

• Progress in Medical Physics
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• v.9 no.3
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• pp.185-192
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• 1998

It is necessarily to evaluate the energy of X-ray emitted from linear accelerator in order to determine the accurate absorbed dose. The method of direct measurement for x-ray energy is very difficult and impractical. Therefore the method of using beam quality index is generally used. Several dosimetry protocols recommend the use of quality indices such as depth of dose maximum at radiation central axis, dose gradient, and dose level. The linear accelerator manufactures follow the recommendation as dosimetry protocols. The study was performed for us to select the most suitable parameter among the Quality indices as described above. For photon beams of 4, 6, 10, 15, and 21 MV nominal energies produced by four kinds of accelerators(Mitsubishi, Scanditronix, Siemens, Varian) in eleven institutions, We evaluated the x-ray energies obtained by the Quality indices as recommended by several dosimetry protocols and manufactures. Results showed that there were energy spreads according to the same accelerators and Quality indices even though nominal energies were same. It appeared that the percent depth dose at 10 cm (D$_{10}$(%)) gave the smallest deviation and spread of energies. As energies increased, the energy deviation increased for all the quality indices. It is desirable for the use of unified quality index to compare the evaluation of beam quality at different institutions.