• Journal of Life Science
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• v.20 no.2
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• pp.275-280
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• 2010

Sulforaphane is a naturally occurring member of the iosothiocyanate family, which reveals chemopreventive capacities including anti-cancer, anti-inflammation and inhibition of MMP-9 activities. In this study, we investigated the effect of sulforaphane on the expression of matrix metalloproteinase-9 (MMP-9) in lipopolysaccharide (LPS)-induced Raw 264.7 cells. Sulforaphane strikingly suppressed the LPS-induced MMP-9 activity and mRNA expression in a dose-dependent manner. In addition, sulforaphane inhibited not only the LPS-induced MMP-9 promoter activity but also LPS-mediated activator protein-1 (AP-1) and nuclear factor-kB (NF-${\kappa}B$) promoter activity. Transient transfection by MMP-9 constructs, in which specific transcriptional factors were mutagenized, indicated that the effects of LPS and sulforaphane were mediated via AP-1 and NF-${\kappa}B$ response elements. We found that sulforaphane had the ability to suppress LPS-induced invasion in vitro. Taken together, these results demonstrated that sulforaphane effectively suppressed LPS-induced MMP-9 expression via modulation of promoter elements (AP-1 and NF-${\kappa}B$) in MMP-9 transcriptional activation.

• Journal of Life Science
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• v.27 no.6
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• pp.708-725
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• 2017

Ionizing radiation is enough energy to interact with matter to remove orbital electrons, neutrons, and protons in the atom. Ionizing radiation like this leads to oxidizing metabolism that alter molecular structure through direct and indirect interactions of radiation with the deoxyribonucleic acid in the nucleus and cytoplasmic organelles or via products of cytoplasm radiolysis. These ionization can result in tissue damage and disruption of cellular function at the molecular level. Consequently, ionizing radiation-induced modifications of ion channels and transporters have been reported. When the harmful effects exceed those of homeostatic biochemical processes, induced biological changes persist and may be propagated to progeny cells. Also, Reactive oxygen species formed on the effect of ionizing radiation can get across into neighboring cells through the cell junctions that are responsible for intercellular chemical communication, and may there bring about changes characteristic to radiation damage. Depending on radiation dose, dose-rate and quality, these protective mechanisms may or may not be sufficient to cope with the stress. This paper briefly reviewed reports on ionization radiation effects on cellular level that support the concept of radiation biology. A better understanding of the biological effects of ionizing radiation will lead to better use of and better protection from radiation.

• Research in Plant Disease
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• v.17 no.2
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• pp.136-141
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• 2011

In other previous in vitro tests, the hyphal growth of Raffaelea quercivorus was inhibited by the treatments of various concentration of nano-silver. In this field tests, treatment of different concentrations of nano-silver to oak trees in Cheolwon and Hongcheon sites showed the inhibition effects against wilt disease caused by Raffaelea quercivorus. However, nano-silver-treated oak tree in Chuncheon site showed mild wilt symptoms with no phytotoxicity. Scanning electron microscope (SEM) observation confirmed that the spore and hypha of Raffaelea sp. inside the vessels were damaged by nano-silver. This result indicates the application of nanosilver is effective for control of Raffaelea quercivorus in the field.

• Proceedings of the Korea Society of Information Technology Applications Conference
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• 2002.11a
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• pp.502-511
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• 2002

컴퓨터의 기술적 발전은 사회 여러 분야에 막대한 영향을 끼쳤다. 그중 악보 인식분야에도 커다란 영향을 주었다 그러나, On-line 상에서 그린 악보를 실시간으로 정형화된 악보형태로 변환하는 처리에 대한 연구가 미흡하여 이에 대한 연구가 필요하다. 본 논문에서는 실시간으로 악보를 인식하고, 사용자의 편의를 도모하기 위해 DP(Dynamic Programming) 매칭법을 이용한 On-Line 악보인식에 관한 방법을 제안하였다. 본 연구에서는 실시간으로 입력되는 악상기호를 인식하기 위해, 가장 유효한 정보인 악상 기호내의 방향, x, y 좌표를 이용하여 벡터형태로 추출한 후 음표와 비음표(쉼표, 기타기호)의 두개의 그룹으로 나누어진 표준패턴과의 DP매칭을 통해 인식한다. 먼저 tablet을 통해 실시간으로 악상 기호를 입력할 때 생기는 x, y좌표를 이용하여, 펜의 움직임에 대한 16방향 부호화를 수행한다. 음표와 비음표를 구분하기 위한 시간을 줄이고자 16방향 부호화를 적용하치 않고 사사분면부호화를 적용한다. 음표를 약식으로 그릴 경우 음표 머리에 해당하는 부분의 좌표는 삼사분면에 분포하고, 폐곡선의 음표일 경우에는 좌표가 사사분면에 고르게 나타난다. 폐곡선을 제외한 음표의 머리는 폐곡선과 같은 조건이면서 입력받은 y좌표값들 중에서 최소값과 최대값을 구한 다음 2로 나눈 값을 지나는 y좌표의 개수가 임의의 임계값 이상이면 음표로 판단한다. 위 조건을 만족하지 않을 경우 비음표로 취급한다. 음표와 비음표를 결정한 다음, 입력패턴과 표준패턴과의 DP매칭을 통하여 벌점을 구한다. 그리고 경로탐색을 통해 벌점에 대한 각각의 합계를 구해 최소값을 악상기호로 인식 하였다. 실험결과, 표준패턴을 음표와 비음표의 두개의 그룹으로 나누어 인식함으로써 DP 매칭의 처리 속도를 개선시켰고, 국소적인 변형이 있는 패턴과 특징의 수가 다른 패턴의 경우에도 좋은 인식률을 얻었다.r interferon alfa concentrated solution can be established according to the monograph of EP suggesting the revision of Minimum requirements for biological productss of e-procurement, e-placement, e-payment are also investigated.. monocytogenes, E. coli 및 S. enteritidis에 대한 키토산의 최소저해농도는 각각 0.1461 mg/mL, 0.2419 mg/mL, 0.0980 mg/mL 및 0.0490 mg/mL로 측정되었다. 또한 2%(v/v) 초산 자체의 최소저해농도를 측정한 결과, B. cereus, L. mosocytogenes, E. eoli에 대해서는 control과 비교시 유의적인 항균효과는 나타나지 않았다. 반면에 S. enteritidis의 경우는 배양시간 4시간까지는 항균활성을 나타내었지만, 8시간 이후부터는 S. enteritidis의 성장이 control 보다 높아져 배양시간 20시간에서는 control 보다 약 2배 이상 균주의 성장을 촉진시켰다.차에 따른 개별화 학습을 가능하게 할 뿐만 아니라 능동적인 참여를 유도하여 학습효율을 높일 수 있을 것으로 기대된다.향은 패션마케팅의 정의와 적용범위를 축소시킬 수 있는 위험을 내재한 것으로 보여진다. 그런가 하면, 많이 다루어진 주제라 할지라도 개념이나 용어가 통일되지 않고 사용되며 검증되어 통용되는 측정도구의 부재로 인하여 연구결과의 축적이 미비한 상태이다. 따라서, 이에 대한 재고와 새로운 방향 모색이 필요하다고 사료된다.로 사료되며, 임신관련 cytokine에 대한 다양한 연구가 요구되고 있다.₂/Hf(Variable)/Si 계에서 HfO₂ 박막이 Si 기판위에 직접 증착되면, 순수 HfO₂ 박막의

• Korean Journal of Food Science and Technology
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• v.38 no.5
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• pp.684-690
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• 2006

Eriobotrya japonica has been used as a folk medicine for treatment of skin diseases, inflammation, coughing, phlegm, and ulcers in Korea and other Asian countries. In a search for possible bioactive agents from natural sources, we found that the methanolic extracts from various parts of E. japonica showed moderate antioxidative and antimicrobial activities in several in vitro bioassay systems. Additionally, the respective parts of E. japonica were irradiated at 20 kGy to investigate the effects of irradiation. Gamma irradiation of E. japonica extracts removed the deep greenish color without affecting its natural biological activities such as its antioxidative and antimicrobial properties. Based on these findings, the methanolic extracts of this plant source may be not affected by gamma irradiation as its bioactive constituents may be insensitive to this irradiation. Moreover, the methanolic extract of E. japonica may serve as a good natural resource for beneficial functions in food and other related industries.

• Journal of the Korean Society of Marine Environment & Safety
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• v.22 no.5
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• pp.527-535
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• 2016

The Manseongri Coast meets the sea on the southeast and is composed of coarse sediment as a mesotidal beach. The waves that strike the beach are stronger than the tides or tidal currents as external forces of beach deformation. Storm waves frequently reach significant wave heights of 2-3m and hit in spring and summer, leaving the sea calm during fall and winter. Incident waves reach remarkable heights that correspond with observed shoreline changes. The shoreline erodes in spring and summer due to these strong waves but recovers in fall and winter as a result of the more moderate waves. On the basis of these observed results, a numerical calibration for experiments on shoreline change was established. Results revealed that according to hindcast data, calculated shoreline changes agreed with the observed shoreline, with a minimum RMS error of 1.26m with calibration parameters $C_1=0.2$ and $C_2=1C_1$. Using these calibration parameters, long-term shoreline change was predicted after the construction of submerged breakwaters and jetties, etc. The numerical model showed that the shoreline would move forward by 5-15m behind the submerged breakwaters and recede by 5-15m north of the structure.

• Journal of Korean Tunnelling and Underground Space Association
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• v.10 no.3
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• pp.233-243
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• 2008

A tunnel behavior predicted in the investigation and design stage is often different from its actual behavior due to mainly the complexity of ground conditions. In a tunnel construction, therefore, it is necessary to ensure the stability of the tunnel by predicting the behaviors of the ground and the supports through observations and measurements, and modifying immediately excavation and reinforcing methods when necessary. To do so, it is important to be able to predict the final tunnel behavior based on the initial tunnel behavior as early as possible. In this study, the correlations were obtained between the initial and the final convergence by analyzing statistically the convergence measurement data, collected from two domestic road tunnels under construction using NATM. In order to estimate the unknown displacements, occurred during the period between the excavation and the first measurement, two methods were used - one is the method by means of regression analysis using a modified exponential function and the other the method by a simple linear regression analysis using the data measured within the distance from tunnel face equal to the tunnel diameter (D). Finally, the relationships were obtained between the initial and final convergence, including the non-measured displacements estimated from the two different methods, by performing linear regression analyses. The regression analysis results showed that there are clear linear relationships between the initial and final convegence and the difference between the two linear regression equations was not that large for when using the exponential function and the simple linear function to estimate the non-measured displacements.

• Journal of the Microelectronics and Packaging Society
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• v.10 no.3
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• pp.29-35
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• 2003

The Sn-based lead-free solders with varying microstructure were prepared by changing the cooling rate from the melt. Bulky as-cast SnAg, SnAgCu, and SnCu, alloys were cold rolled and thermally stabilized before the creep tests so that there would be very small amount of microstructural change during creep (TS), and thin specimens were water quenched from the melt (WQ) to simulate microstructures of the as-reflowed solders in flip chips. Cooling rates of the WQ specimens were 140∼150 K/sec, and the resultant $\beta-Sn$ globule size was 5∼10 times smaller than that of the TS specimens. Subsequent creep tests showed that the minimum strain rate of TS specimens was about $10_2$ times higher than that of the WQ specimens. Fractographic analyses showed that creep rupture of the TS-SnAgCu specimens occurred by the nucleation of voids on the $Ag_3Sn$ Sn or $Cu_6Sn_5$ particles in the matrix, their subsequent growth by the power-law creep, and inter-linkage of microcracks to form macrocracks which led to the fast failure. On the other hand, no creep voids were found in the WQ specimens due to the mode III shear rupture coming from the thin specimens geometry.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.39 no.1
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• pp.97-107
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• 2002

In this paper, we propose the realization of on-line handwritten Chinese character recognition for mobile personal digital assistants (PDA). We focus on the development of an algorithm having a high recognition performance under the restriction that PDA requires small memory storage and less computational complexity in comparison with PC. Therefore, we use index matching method having computational advantage for fast recognition and we suggest a unit reconstruction method to minimize the memory size to store the character models and to accomodate the various changes in stroke order and stroke number of each person in handwriting Chinese characters. We set up standard model consisting of 1800 characters using a set of pre-defined units. Input data are measured by similarity among candidate characters selected on the basis of stroke numbers and region features after preprocessing and feature extracting. We consider 1800 Chinese characters adopted in the middle and high school in Korea. We take character sets of five person, written in printed style, irrespective of stroke ordering and stroke numbers. As experimental results, we obtained an average recognition time of 0.16 second per character and the successful recognition rate of 94.3% with MIPS R4000 CPU in PDA.

• Korean Journal of Agricultural Science
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• v.11 no.2
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• pp.264-269
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• 1984

The single edged blade was efficient to reduce tilling torque requirement than the double edged blade as previous reported study. This study was carried out to find reducing effects of tilling torque requirement of single edged blade comparing to double edged one in according to wearing by tilling operation. The single and double edged rotary blades were attached on same rotary shaft, and tilling operation was done in hard glass land. The wearing weights of the blade were checked out each 3 hrs tilling operation, at same time, the tilling toruqe requirements were measured with soil bin system in laboratory. The results of the study were summarized as follows: 1. The edged blade shape was not changed during the tilling operation of the rotary blade. The single edged blade was saved 5-10% in the maximum tilling torque and 3-15% in the mean tilling torque than the double edged blade for total durable period. 2. Generally, the tilling torques according to operation were decreased until original shape was maintained, but it was increased after 12 hrs tilling operation, and the tip shape of rotary blade was changed seriously. It is noted that the tip shape of the rotary blade is another factor affecting tilling torque, it should be desirable to study on the rotary blade tip shape to reduce tilling torque requirement after changing its original shape with wearing.