• Journal of Yeungnam Medical Science
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• v.22 no.2
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• pp.166-182
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• 2005

Background: Cyclin-dependent kinase (CDK) inhibitors are family of molecules that regulate the cell cycle. The CDKN2, a CDK4 inhibitor, also called p16, has been implicated in human tumorigenesis. The CDKN2 inhibits the cyclin/CDK complexes which regulate the transition from G1 to S phase of cell cycle. There is a previous report that homozygous deletion of CDKN2 region on chromosome 9p21 was detected frequently in astrocytoma, glioma and osteosarcoma, less frequently in lung cancer, leukemia and ovarian cancer, but not detected in colon cancer and neuroblastoma. However, little is known about the relationship between CDKN2 and laryngeal cancer. Therefore this study was initiated to investigate the role of CDKN2 in human laryngeal squamous cell carcinoma development.1) Materials and methods: We used 5 human laryngeal carcinoma cell lines whether they have deletions or losses of CDKN2 gene expression by DNA-PCR or RT-PCR, respectively. We examined 8 fresh frozen human laryngeal cancer tissues to detect the loss of heterozygosity (LOH) of CDKN2. PCR was performed by using microsatellite markers of short arm of human chromosome 9 (D9S126, D9S144, D9S156, D9S161, D9S162, D9S166, D9S171, D9S200 and D9SIFNA). For informative cases, allelic loss was scored if the signal of one allele was significantly decreased in tumor DNA when compared to the same allele in normal DNA. Results: The CDKN2 DNA deletion was observed in 3 cell lines. The CDKN2 mRNA expression was observed in only one cell line, which was very weak. LOH was detected in 7 cases (87.5%). Conclusion: These results suggest that CDKN2 plays a role in the carcinogenesis of human laryngeal squamous cell carcinoma.

• Korean Journal of Head & Neck Oncology
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• v.33 no.2
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• pp.95-99
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• 2017

Schwannoma, also known as a neurilemmomas or neurinomas, is benign peripheral nerve sheath tumors arising from the Schwann cells. About 25~45 % of all schwannomas are found in the head and neck region, and the majority are found in the parapharyngeal space. Schwannoma of the larynx is very rare with an incidence of 0.1~1.5% in all benign laryngeal tumors. Recently, we experienced a case of a pedunculated schwannoma arising from the left aryepiglottic fold in a 80-year-old patient. The tumor was completely excised under direct laryngoscopy with the use of a $CO_2$ laser and subsequently confirmed as schwannoma. So, we report this case with a review of the literatures.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.14 no.2
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• pp.83-87
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• 2003

Background and Objectives : Sphincteric function of the larynx, essential to lower airway protection, is most efficiently achieved through strong reflex adduction by both vocal cords. We hypothesize that central facilitation is an essential component of a bilateral adductor reflex and that its disturbance could result in weakened sphincteric closure. Materials and Method : Seven adult 20kg dogs underwent evoked response laryngeal electromyoraphy under 0.5 to 1.0 MAC isoflurane anesthesia. The internal branch of superior laryngeal nerve was stimulated through bipolar platinum-iridium electrodes and recording electrodes were positioned in the ipsilateral and contralateral thyroaryteonoid muscles. Results : Consistent threshold responses were obtained ipsilaterally under all anesthetic levels. However, contralateral reflex responses disappeared as anesthetic levels approached 1.0 MAC. Additionally, at 0.5 MAC, late responses (R2) were detected in one animal. Conclusion : Alteration of central facilitation by deepening anesthesia abolishes the crossed adductor reflex, predisposing to a weakened glottic closure response. Precise understanding of this effect may improve the prevention of aspiration in patients emerging from prolonged sedation or under heavy psychotropic control.

• Korean Journal of Bronchoesophagology
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• v.13 no.2
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• pp.65-67
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• 2007

Congenital epiglottic cyst is rare cause of stridor in neonate and if managed inadequately, disaster such as death can occur. Diagnosis of congenital epiglottic cyst includes imaging studies and endoscopy. Fiberoptic or rigid endoscopic examination excludes other causes of stridor in neonate. Complete excision of cyst is treatment of choice under suspension laryngoscopic guidance. Here, we report a case of congenital epiglottic cyst and concomitant laryngomalacia presenting with seizure and respiratory difficulty in neonate with a review of literature.

• Korean Journal of Bronchoesophagology
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• v.17 no.2
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• pp.108-111
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• 2011

Epiglottic cysts cause stridor mimicking asthma and hinder intubation in surgery. A huge cyst can obstruct the airway, making laryngeal examinations impossible. Before surgery, complete visualization of the larynx is necessary for the successful excision of a cyst. If laryngeal examination fails, computed tomography (CT) scanning can provide detailed information. Virtual endoscopy based on CT data reconstruction can yield a detailed three-dimensional image of the larynx. Here, we report two cases of epiglottic cysts along with virtual endoscopic findings and surgical photographs.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.8 no.2
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• pp.185-192
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• 1997

Behavior of the intrinsic laryngeal muscles : Thyroarytenoid(TA), cricothyroid(CT), lateral cricoarytenoid(LCA), interarytenoid(IA) and posterior cricoarytenoid(PCA) : were evaluated under the in vivo canine laryngeal model in three individual papers. This is the review of the relating three articles. In vivo preparation of the laryngeal model was summarized. Video-laryngoscopic findings of the individual intrinsic laryngeal muscles were documented by electrical stimulation of the individual muscular branches of the laryngeal nerve. Effects on fundamental frequency, subglottic pressure, intensity and open quotient by the stimulation of the individual intrinsic laryngeal muscles were tested.

• Journal of Yeungnam Medical Science
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• v.24 no.2
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• pp.154-161
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• 2007

Background : This study was undertaken to evaluate the effectiveness of the Bonfils intubation fibrescope for cases of difficult tracheal intubation. Materials and Methods : For patients with an ASA physical status 1 or 2 betwen the ages of 20-90, direct laryngoscopy was performed and the layngoscopic view graded according to the Cormack and Lehane classification. Forty patients with Cormack and Lehane grade 3 or 4 were intubated using the Bonfils intubation fibrescope. During intubation, the success rates for tracheal intubation, overall time to intubation, number of attempts and adverse effects were recorded. The Thyromental and sternomental distances were recorded after the orotracheal intubation. Results : The success rates were significantly higher in Cormack and Lehane grade 3 (96.9%) patients compared to grade 4 (50%) (P<0.01). The time to intubation was significantly faster in patients with grade 3 compared to grade 4 (20 (10-49[7-300]) sec vs. 180 (31-300[10-300]) sec, P=0.01). The number of cases with a $SpO_2$<90% was significantly lower in patients with grade 3 (3.1%) compared to grade 4 (50%) (P<0.01). Conclusion : In patients with Cormack and Lehane grade 3, tracheal intubation using the Bonfils intubation fibrescope appears to be an effective technique for the management of a difficult intubation. However, the Bonfils intubation fibrescope can not always be used for the management of a difficult intubation in grade 4 patients; for these patients other effective instruments should be considered for difficult intubations.

• Proceedings of the KSLP Conference
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• 1998.11a
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• pp.198-198
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• 1998

성악발성 시 전문적인 성악가와 비전문가에서 성대외근의 수축 경향을 파악함으로써, 성대외근이 성악발성에 갖는 중요성을 파악하고, 얻어진 자료를 토대로 성악발성 숙련도의 판정이나 성악인의 음성치료에 활용할 수 있는 가능성을 알아보고자 하였다. 서양음악을 전공한 지 10년 이상 된 20-30대의 소프라노 4인을 성악가 군으로, 비전공자 여성 4인을 대조군으로 하여, E3 부터 C6 내의 9개 음을 낮은 음부터 시작하여 차례로 /이/ 모음을 수초간 발성하게 하였다. Multi-Mode Program (UP) Plus (Nicolet, Viking IV)와 1개 채널의 음성신호 및 3개 채널의 surface electrode를 이용하여 발성 시설골상근, 설골하근, 견갑설골근의 활동전위를 측정한 뒤, 단위시간 당 근전위 진폭의 합을 구하여 두 군간에 그 양상을 비교하였다. (중략)

• Proceedings of the KSLP Conference
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• 1993.12a
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• pp.20-20
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• 1993

저자들은 1983년 4월부터 1993년 9월까지 10년 6개월간 연세대학교 의과대학 영동세브란스병원 이비인후과에 내원한 종양에 의한 성대마비환자 29례에 대한 임상적 분석을 통하여 다음과 같은 결론을 얻었다. 1) 종양의 종류별로는 폐암이 13예(44.8％)로 가장 많았으며 갑상선암이 8예(27.6％), 신경성종양이 3예(10.4％), 종격동종양이 2예(6.9％), 그 외 경부식도암, 기관지암, 경정맥소체종양이 각각 1예로 나타났다. (중략)

• Proceedings of the KSLP Conference
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• 1993.12a
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• pp.17-17
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• 1993

한국어 모음 발성시 책은 Videovelopharyngogram과 동시에 녹음된 음성을 분석하여, 각 모음별로 성도내 좁힘에 대한 성문으로부터의 거리를 측정하고, 음 대를 구하여 그 상관관계를 알아보았다. 측정 인원은 표준말을 사용하는 것으로 판정된 성인 남녀 각 5명으로 하고, 측정방법으로 Simens Pantoscop 를 이용하여 Videovelopharyngogram을 얻고, DT282-F-6 SE board로 digitized된 음성을 CSpeech version 3. 의 software로 분석하였다.(중략)