• Journal of the Korean Society of Radiology
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• v.11 no.4
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• pp.177-181
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• 2017

Dose response curves using absorbed dose to the biological effect are usually available in case of conventional X beam. However, absorbed dose is not consider in treatment planning for carbon beam such as heavy ions. Because the biological effects also depend on other quantities such as the local variation, which is often characterized by the linear energy transfer (LET). So LQ model cannot explain the entire response of fractionated carbon beam irradiation. The variation in LET with penetration depth leads to substantial differences in biological effect of carbon beam. And it is therefore essential in treatment planning to calculate not only the absorbed dose but also the LET to estimate the biological outcome of the radiation of interest. LET variation plays an important role in the fractionated irradiations. It is suggested that consideration of LET is necessary in biophysical model.

• Review of KIISC
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• v.13 no.1
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• pp.42-55
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• 2003

차세대 광 인터넷 백본망 기술은 WDM(Wavelength Division Multiplexing)기반의 고속 대용량 전광 전달망인 AOTN (All-Optical Transport Network)으로 발전하고 있고, 가입자의 원활한 멀티미디어 서비스의 제공을 위한 망 생존성 보장이 중요한 이슈로 부각되고 있다. 특히 광소자의 고유한 특성을 교묘히 이용하는 물리적 공격은 AOTN의 투명한 데이터 전달 특성으로 인해 기존의 오버헤드를 이용한 관리 시스템이 더 이상 유효하지 않아, 새로운 검출/회복 메커니즘이 요구된다. 본 고에서는 AOTN에서 발생 가능한 공격 유형을 광소자별로 분석하고, 광 레벨에서의 공격 검출과 회복 메커니즘을 소개한다. 이를 바탕으로 공격관리 시스템(Attack Management System: AMS)의 제어 모델을 기술한다.

• Journal of the Korean Society of Radiology
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• v.9 no.6
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• pp.417-420
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• 2015

We obtained Surviving Fraction (SF) after irradiation carbon beam to compare the applicability of the Linear-Quadratic model, Incomplete Repair model, Marchese model. Mathematica software(ver 9.0) used to calcurate parameters and compared result. LQ model could not explain the entire response of fractionated carbon beam irradiation. It becomes necessary to construct models that extend the LQ model of conventional radiotherapy for the carbon beam therapy. By combining both Potentially Lethal Damage Repair (PLDR) and Sublethal Damage Repair (SLDR) a new LQ model can develop that aptly modeled the cellular response to fractionated irradiation.

• Journal of the Korea Society for Simulation
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• v.30 no.1
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• pp.1-9
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• 2021

In actual battlefield environment, the naval ships which have specific missions have to respond to the attack of hostile forces. Especially, in modern warfare, the importance of the survivability of naval ships are increasing due to the high lethality of armaments. Naval ship survivability is generally considered to encompass three constituents, susceptibility, vulnerability and recoverability. Recently, among these three constituents, many researches on vulnerability have been conducted. However, for the vulnerability of naval ships, most of researches are aimed towards the detailed design stages where implementing changes is heavily constrained or even impractical. In this paper, vulnerability assessment model for naval ships on a theater engagement is developed by using M&S technique. By using this model, the characteristics of platform and armaments are reflected on the damage of naval ship. The basic logic of damage assessment is also considered in detail. The damage status of the naval ship is quantified by defining a representative state index of onboard equipment for each system.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.170-170
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• 1993

유전독성물절외 검출과 평가에 용이하게 사용할 수 있는 모델 시스템의 개발 및 DNA 회복기작을 규명할 목적으로 수종의 돌연변이, 발암원을 이용하여 배양 포유동물세포 및 어류세포에서 세포생존률, DNA 합성 및 복제억제의 양상 등을 비교 분석하였다. MMS및 MNNG 와 같은 알칼라제는 CHO 세포에서 유의한 DNA 합성저해, DNA 복재억제, DNA 단사절단 및 비주기성 DNA 합성률의 증가를 유발하였다. Benzo(a)pyrene과 3-methylcholanthrene좌 같은 DNA 상해 전구물질의 경우 유전독성 여부의 판정에는 반드시 S-9/15과 같은 대사활성계 또는 mouse embryonic fibroblast와 같은 대사 활성능이 있는 세포와의 co-culture system들이 필요함을 확인하였으며, 이들에 의한 DNA 상해와 복재억제 유도의 작용양상은 자외선의 작용양상과 유사하였다. 배양 어류세포에서 자외선에 의한 세포생존율의 측정, 광재활성능의 분석 및 자외선에 의해 유발된 피리미딘 이량체 절제능 검토 및 DNA 합성 저해능의 결과를 분석함으로써 유전독성 평가를 위한 모델 시스템 구축의 기초결과를 얻었다.

• Journal of Chest Surgery
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• v.31 no.12
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• pp.1147-1158
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• 1998

Background: Portable cardiopulmonary bypass(CPB) technique has been used increasingly as a potent and effective option for emergency cardiopulmonary resuscitation(CPR) because it can maintain more stable hemodynamics and provide better survival than conventional CPR techniques. This study was designed to develop a prototype of Korean portable CPB system and, by applying it to CPR, to discriminate whether it would be superior to standard open-chest CPR. Material and Method: By using adult mongrel dogs, open-chest CPR(OCPR group, n=4) and portable-CPB CPR(CPB group, n=4) were compared with respects to restoration of spontaneous circulation(ROSC), hemodynamics, effects on blood cells, blood gas patterns, biochemical markers, and survivals. Ventricular fibrillation-cardiac arrest(VF-CA) of arrest(VF-CA) of 4 minutes followed by basic life support(BLS) of 15 minutes was applied in either group, which was standardized by the protocol of American Heart Association. Then, advanced life support(ALS) was applied to either group under the support of internal cardiac massage or CPB. ALS was maintained until ROSC was achieved but not longer than 30 minutes regardless of the presence of ROSC. All of the measured values were expressed as means±SD percent change from baseline. Result: During the early ALS, higher mean arterial pressure was maintained in CPB group than in OCPR group(90±19 vs. 71±32 %; p<.05) and lower mean pulmonary arterial pressure was also maintained in CPB group than in OCPR group(105±24 vs. 146±6%; p<.05). ROSC was achieved in all dogs. Post-ROSC levels of hematocrit, RBC, and platelet were decreased and plasma free hemoglobin was increased significantly in CPB group compared to OCPR group(p<.05). Changes in blood gas patterns, lactate, and CK-MB levels were not different between groups. Early mortality was seen in 3 dogs in OCPR group(survival time 31±36 hours) and 2 in CPB group(228±153 hours, p=ns). The remainders in both groups showed prolonged survival. Conclusion: These findings indicate that portable CPB can be effective to maintain stable hemodynamics during cardiac arrest, to achieve ROSC and to prolong survival. Further study is needed to refine the portable CPB system and to meet clinical challenges.

• The Korean Journal of Emergency Medical Services
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• v.20 no.2
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• pp.7-19
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• 2016

Purpose: To investigate the effect of early hypothermia on post-resuscitation myocardial recovery and survival time after cardiac arrest and resuscitation in a rat model of myocardial infarction(MI). Methods: Thoracotomies were performed in 10 male Sprague Dawley rats weighing 450-455g. Myocardial infarction was induced by ligation of the left anterior descending coronary artery. Ninety minutes after arterial ligation, ventricular fibrillation was induced, cardiopulmonary resuscitation was subsequently performed before defibrillation was attempted. Animals were randomized to control group and experimental group(acute MI-normothermia)($32^{\circ}C$ for 4 hours). Duration of survival was recorded. Myocardial functions, including cardiac output, left ventricular ejection fraction, and myocardial performance index were measured using echocardiography. Results: Myocardial function was significantly better in hypothermia group than the control group during the first 4 hours post-resuscitation. The survival time of the experimental group was greater than that of the control group(p<.050). Conclusion: This study suggests that early hypothermia can attenuate post-resuscitation myocardial dysfunction after acute myocardial function, and may be a useful strategy in post-resuscitation care.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.31 no.2
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• pp.11-23
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• 2018

목적 : 본 연구에서는 $TNF-{\alpha}$와 $IFN-{\gamma}$로 자극한 인간피부각질형성세포 (HaCaT keratinocytes) 모델을 사용하여 지모가 피부장벽 기능에 미치는 영향을 알아보고자 하였다. 방법 : MTT assay를 통하여 지모 주정(70% 에탄올) 추출물 (EAA)이 HaCaT keratinocytes의 세포생존율에 미치는 영향을 확인하였으며 wound healing assay를 통해 EAA가 HaCaT 세포의 이주 능력에 영향을 주는지 관찰하였다. 또한 western blot analysis와 qRT-PCR을 통하여 EAA가 $TNF-{\alpha}/IFN-{\gamma}$로 자극한 HaCaT 세포에서 iNOS의 단백질 발현 및 IL-4, IL-13, IL-6의 mRNA 발현, filaggrin의 단백질과 mRNA 발현에 미치는 영향을 조사하였다. 결과 : EAA는 처리 농도 $500{\mu}g/ml$까지 HaCaT keratinocytes의 세포생존율에 영향을 미치지 않았다. EAA는 wound healing assay에서 HaCaT 세포의 이주 능력을 증가시켰으며, $TNF-{\alpha}/IFN-{\gamma}$로 자극한 HaCaT 세포에서 iNOS의 단백질 수준을 감소시켰다. 또한 EAA가 IL-4, IL-13, IL-6의 mRNA 발현을 억제하는 것 역시 확인할 수 있었다. 뿐만 아니라 EAA는 $TNF-{\alpha}/IFN-{\gamma}$ 자극에 의해 감소했던 filaggrin을 단백질과 mRNA 수준에서 회복시켰다. 결론 : EAA가 HaCaT 세포에서 Th2 type cytokines, pro-inflammatory cytokine의 억제와 filaggrin 회복을 통해 피부장벽 기능 손상에 대한 억제활성을 갖는 것을 확인하였으며, 이를 통해 EAA가 염증으로 인해 손상된 피부장벽 기능 개선에 효과적일 것으로 사료된다.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.40 no.10
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• pp.67-78
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• 2003

As optical network technology advances and high bandwidth Internet is demanded for the exponential growth of internet traffic volumes, the Dense-Wavelength Division Multiplexing (DWDM) networks have been widely accepted as a promising approach to the Next Generation Optical Internet (NGOI) backbone networks for nation wide or global coverage. Important issues in the NGOI based on DWDM networks are the Routing and Wavelength Assignment(RWA) problem and survivability. Especially, fault/attack detection, localization and recovery schemes in All Optical Transport Network(AOTN) is one of the most important issues because a short service disruption in DWDM networks carrying extremely high data rates causes loss of vast traffic volumes. In this paper, we suggest a fault/attack management model for NGOI through analyzing fault/attack vulnerability of various optical backbone network devices and propose fault/attack recovery procedure considering Extended-LMP(Link Management Protocol) and RSVP-TE+(Resource Reservation Protocol-Traffic Engineering) as control protocols in IP/GMPLS over DWDM.

• Korean Journal of Social Welfare
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• v.37
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• pp.1-31
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• 1999

In Korea, little is known about unemployment duration and exit rate from unemployment. This paper empirically examines the duration of unemployment using data for the years 1996 and 1997 on unemployed individuals who are eligible for unemployment insurance benefits in Korea. A parametric survival model (log-normal model) is adopted to identify factors predicting transitions to reemployment. Factors that affect unemployment duration are sex, age, employment duration (year), prior salary, region, prior employment industry, cause of unemployment, officially determined unemployment benefit duration, degree of benefit exhaustion, and amount of benefits for early reemployment. However, education is not statistically significant In degree of benefit exhaustion, the exit rate from unemployment decreases as benefit exhaustion is approached. In amount of benefits for early reemployment, the exit rate from unemployment increases as amount of benefits increases. Hazards for reemployment gradually increase until 80 days after unemployment and gradually decrease in the following period. Thus, we find that distribution of hazards for reemployment has log-normal shapes between inverted U and inverted L This paper takes advantage of a unique analysis about unemployment duration and exit rate from unemployment in the Korean Unemployment Insurance system which functions as the most valuable social safely-net mechanism in the recent national economic crisis. Indeed, this paper provides a basic knowledge about realities of unemployed individuals in the Unemployment Insurance system and identifies research areas that require further study.