• Progress in Medical Physics
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• v.20 no.3
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• pp.132-138
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• 2009

Studies on target motion in 4-dimensional radiotherapy are being world-widely conducted to enhance treatment record and protection of normal organs. Prediction of tumor motion might be very useful and/or essential for especially free-breathing system during radiation delivery such as respiratory gating system and tumor tracking system. Neural network is powerful to express a time series with nonlinearity because its prediction algorithm is not governed by statistic formula but finds a rule of data expression. This study intended to assess applicability of neural network method to predict tumor motion in 4-dimensional radiotherapy. Scaled Conjugate Gradient algorithm was employed as a learning algorithm. Considering reparation data for 10 patients, prediction by the neural network algorithms was compared with the measurement by the real-time position management (RPM) system. The results showed that the neural network algorithm has the excellent accuracy of maximum absolute error smaller than 3 mm, except for the cases in which the maximum amplitude of respiration is over the range of respiration used in the learning process of neural network. It indicates the insufficient learning of the neural network for extrapolation. The problem could be solved by acquiring a full range of respiration before learning procedure. Further works are programmed to verify a feasibility of practical application for 4-dimensional treatment system, including prediction performance according to various system latency and irregular patterns of respiration.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1983.05a
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• pp.5.2-5
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• 1983

It is well known that laryngeal papilloma is histopathological benign, but clinically one of the most troublesome disease in otolaryngologic department, usually seen in child age. Since Cleesmann reported papilloma of the vocal cord, 1817 first, the etiology had not been known exactly. The symptoms in children are dyspnea, dysphonia due to recurrence, and papilloma in adult can change into neoplasm. The papilloma is thought as real neoplastic lesion and there is not effective treatment, using now repeated removal and combined therapy. This report is based on the typical findings and progress of one case of laryngeal papilloma observed for the past 13 years with repeated removal and topical application of 5-FU at our department. Authors have experienced this subject is interesting that the change of the tumor region during the course than to any new therapeutic methods employed, and so report with some reviews of the literatures.

• 유학연구
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• v.43
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• pp.165-192
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• 2018

이 논문은 『주역참동계고이(周易參同契考異)』를 주희의 철학에서 고립된 영역으로 간주하는 대신, 주희의 삶의 후반기에 있어 그의 사유, 특히 그의 철학의 핵심 개념 인 리(理)에 관한 사유와 관련하여 고찰했다. 『참동계』는 우주론이나 선천역학(先天易學)과 관련이 있지만, 『참동계』의 저자인 위백양(魏伯陽)은 『주역』의 해석이 아니라, 연단술의 기초를 확립하기 위해 음양 개념과 선천역학의 괘상 형성 원리를 빌렸을 뿐이다. 그러므로 우주론과 선천역학과의 관계는 간접적인 것이다. 주희에 따르면, 연단술이 근거하고 있는 『참동계』는 과학과 자연학의 공통 기반으로서 리에 기초하고 있다. 이런 맥락에서, 그는 리의 기초 위에서 자연학으로서의 외단술과 내단술을 정립하려고 했다. 주희에 따르면, 외단술은 도가의 일원론에서 일자(一者)와 같은 종류의 물질로 만들어진 단약을 찾는 방법이다. 주희는 단약이 영원한 존재와 동류로 구성되어야 함을 인정하지만, 기본적으로 외단술과 일원론을 이기이원론의 관점에서 비판한다. 또한 주희는 이기이원론에 기초하여 내단술을 재해석한다. 당시 내단을 수행함으로써 불사의 존재로 인정되던 선인(仙人)은 사실 불사의 존재가 아니라고 한다. 주희는 수명의 한계 내에서 내단의 호흡술을 통해 기의 발산을 조금 지연시킬 가능성은 인정하지만, 내단은 외단과 마찬가지로 기의 양생(養生)에 지나지 않는다고 주장한다. 그러나 양심(養心)은 마음속 리에 기초한 불사관의 새로운 전망을 가능하게 한다. 말하자면, 기의 양생과 달리 리와 관련된 자기수양은 일종의 불사와 영생에 관련된다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.9
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• pp.4429-4436
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• 2013

Measurements of CNR(Contrast to Noise Ratio) and SNR(Signal to Noise Ratio) of T-spine breathing technique (TBT) using spontaneous breathing and T-spine exhalation technique (TET) with full exhalation were carried out, and with which the more appropriate method was suggested. Both TBT and TET were examined in a sample of fifty-three patients who visit to our hospital for spinal disease from June 2012 to November 2012. All images were evaluated with CNR measured from the differences between the mean pixels and contrast density as setting ROI of spinous process, pedicle, vertebral body, intervertebral foramen, and intervertebral disk using Image J. SNR was measured with the mean pixels and the standard deviation as setting ROI of vertebral body using Image J. In CNR comparison and SNR comparison of TET and TBT, TBT was indicated as excellent in ROI of pedicle, vertebral body, intervertebral foramen and intervertebral disk, and statistical analysis were significant(p<.01). As TBT indicated excellent images compared to the existing T-spine lateral radiography, T-spine lateral radiography would be reestablished and significant as applying to various medical institutions.

• Water for future
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• v.28 no.1
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• pp.107-120
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• 1995

This study is concerned with the hydraulic experiments of Modi Khola Hydroelectric in Nepal. The experimental domain consists of the intake structure and the settling basin. The intake structure was made by the undistorted model with the scale of 1:20, the settling basin by the distorted model with the scale of 1:10(vertical) and 1:15(horizontal). Based on the movable bed model theory, the 'Anthracite'($\rho_s$ =1.48) is chosen as a model material. According to the model tests, the installation of the guide wall with proper height and the proper control of the flushing gate are required for the effective flushing in the intake structure. In the settling basin a more proper design of the inlet in order to constrain the turbulence flow is required for an efficient sedimentation and the installation of another flushing pipe near the maximum sedimental area is required. Since the trap efficiency is measured about 95%, it is concluded that the design of the settling basin is proper.

• Tunnel and Underground Space
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• v.16 no.6 s.65
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• pp.526-535
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• 2006

An experimental study was carried out on a reduced scale tunnel model to grasp the behavioral feature of fire-induced smoke in the long tunnels. Based on Froude modeling, the 1/50 scaled tunnel model (20 m long) was constructed by acrylic tubes and paraffin gas was released inside the tunnel to simulate the 20 MW fire-induced smoke. me test results show, that after approximately 2 minutes of fire generation, was descended from the tunnel ceiling through the decrease of buoyancy, then it was symmetrically propagated about 90 meters for 4 minutes before jet fans were operated. The smoke was effectively controlled when the jet fans were operated and an air stream velocity was getting closed to reach a critical velocity (the minimum air velocity that requires to suppress the smoke spreading against the longitudinal ventilation flow during the tunnel fire situations). It was also found out that a range of smoke was spreaded about 3 meters from the origin of fire but the range was not propagated to the escape direction anymore. The early stage of the In operation, however, showed that the smoke was hardly controlled. It means that the operation of emergency ventilation system has many dangerous factors such as an intercepting breathing zone.

• Journal of the Korean Society of Physical Medicine
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• v.7 no.1
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• pp.119-124
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• 2012

목적 : 본 연구는 척수손상환자들 중 신체활동 정도가 급격하게 차이 나는 운동 선수군과 비선수군의 일상생활동작과 골밀도를 비교 분석하는데 그 목적이 있다. 방법 : 본 연구를 위해 20명(선수 10명, 비선수 10명)의 SCI 환자가 실험에 참가하였다. 골밀도 측정을 위해 이중에너지 방사선골밀도 측정기(Lunar Prodigy, GE Healthcare. England)를 이용하여 종골부위(calcaneus)의 골밀도를 측정하였다. 척수손상환자의 일상 생활 기능을 측정하기 위해 자조관리(self care), 호흡과 괄약근 조절 (respiration and sphincter management task), 이동(transfer)의 세 영역으로 나누어진 SCIM II(Spinal Cord Injury Measurement II)을 이용하였다. 척수손상환자들 중 운동 선수군과 비운동 선수군의 일상생활 동작과 골밀도를 비교 하기 위해 SPSS 14.0 통계 프로그램의 independent t-test를 이용하여 통계분석을 실시하였고 일상생활 동작과 골밀도의 상관관계는 Pearson correlation을 실시하였다. 유의수준은 ${\alpha}$=.05로 통계처리 하였다. 결과 : 검사 결과 선수군이 비선수군보다 통계적으로 유의하게 큰 SCIM 점수와 T-score를 보여주었다. 결론 : 일상생활동작을 측정하기 위하여 SCIM II(SpinalCordIndependenceMeasureII) 척도를 사용하였는데 선수군이 비선수군에 비해 유의하게 높은 SCIM II 총점을 나타내어 운동을 통한 훈련이 척수손상환자의 기능적 활동을 향상시킬 수 있다고 사료된다. 그리고 골밀도 측정 결과 선수군이 비선수군에 비해 통계적으로 유의하게 높은 골밀도를 나타내었다. 이 역시 강도 높은 훈련이 척수손상환자에게 나타날 수 있는 신체구성을 강화시켜줄 수 있을 것으로 사료된다. 운동을 통한 재활 중에서 그 강도가 높을수록 신체의 구성적, 기능적 측면 뿐 아니라 신경의 가소성 측면에서도 증가를 기대해 볼 수 있을 것으로 판단된다.

• Journal of Veterinary Clinics
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• v.26 no.3
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• pp.212-219
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• 2009

Anticholinergics, which are commonly given as a pre-anesthetic medication to prevent adverse effects in canine anesthesia, can cause cardiac adverse effects. To determine the effects of atropine and glycopyrrolate on the balance of sympathetic nervous tone and parasympathetic nervous tone of the heart during ketamine anesthesia in beagle dogs, heart rate variability(HRV), duration of anesthesia and behavioral changes were evaluated. There were no significant temporal domain differences between atropine and glycopyrrolate. Concerning the frequency domain component, atropine and glycopyrrolate effects were significantly lower(P<0.05) than the control saline-treated group. However, the root mean square of the interval differences between consecutive R peaks(RMSSD) and the standard deviation of Poincare plot perpendicular to the line-of-identity(SD1) in atropine were significantly decreased(P<0.05) from the baseline value, and the low frequency/high frequency ratio(LF:HF ratio) in glycopyrrolate was significantly increased from baseline value(P<0.05). The change of SD1 agreed with that of the high frequency(HF) in the frequency domain component and also with those of respiratory rate and $SpO_2-R$. Our results prove that glycopyrrolate is more suitable as a pre-anesthetic anticholinergic in ketamine anesthesia of dogs with respect to safety and duration of action.

• 재활복지
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• v.22 no.1
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• pp.169-194
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• 2018

The aim of this study is to examine changes in swallowing function and quality of life with therapeutic singing-based music therapy for patients with dysphagia. The music therapy program was based on the previous study (Kim, 2010), and designed to improve breathing, phonation, and swallowing functions focusing on laryngeal elevation. Three patients with dysphagia participated in this study and each participant received a total of 11 or 12 individual music therapy sessions and each session was conducted for 30 minutes. In this study, three kinds of measurements were used. First, the measures of maximum phonation time (MPT), fundamental frequency, average intensity, jitter, shimmer, noise to harmonics ratio (NHR) by Praat test, second, laryngeal-diadochokinesis (L-DDK) to investigate laryngeal elevation, and last, the Swallowing-Quality of Life (SWAL-QOL) was measured. These cases have shown improved breathing, phonation, swallowing function, and the scores of SWAL-QOL in all of the patients. It suggests that this music therapy intervention was effective on laryngeal elevation, and the music intervention with therapeutic singing can be effectively implemented in further research for patients with dysphagia.

• Journal of the Korean Society of Radiology
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• v.6 no.5
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• pp.365-371
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• 2012

The radiation therapy treatment technique is developed from 3D-CRT, IMRT to Tomotherapy. and these three technique was most widely using methods. We find out a comparison normal tissue doses and tumor dose of 3D-CRT, IMRT(Linac Based), and Tomotherapy on Head and Neck Cancer. We achieved radiological image used the Human model phantom (Anthropomorphic Phantom) and it was taken CT simulation (Slice Thickness : 3mm) and GTV was nasopharngeal region and PTV(including set-up margin) was GTV plus 2mm area. and transfer those images to the radiation planning system (3D-CRT - ADAC-Pinnacle3, Tomotherapy - Tomotherapy Hi-Art System). The prescription dose was 7020 cGy and measuring PTV's dose and nomal tissue (parotid gland, oral cavity, spinal cord). The PTV's doses was Tomotherapy, Linac Based - IMRT, 3D-CRT was 6923 cGy, 6901 cGy and 6718 cGy its dose value was meet TCP because its value was up to the 95% based on 7020 cGy, Nomal tissue (parotid gland, oral cavity, spinal cord) was 1966 cGy(Tomotherapy), 2405 cGy(IMRT), 2468 cGy(3D-CRT)[parotid gland], 2991 cGy(Tomotherapy), 3062 cGy(IMRT), 3684 cGy (3D-CRT)[oral cavity], 1768 cGy(Tomotherapy), 2151 cGy(IMRT), 4031 cGy(3D-CRT)[spinal cord] its value did not exceeded NTCP. All the treatment techniques are equated with tumor and nomal tissue doses. The 3D-CRT was worse than other techniques on dose distribution, but it is reasonable in terms of TCP and NTCP baseline Tomotherapy, IMRT -dose distribution was relatively superior- was hard to therapy to claustrophobic patients and patients with respiratory failure. Particularly, in case on Tomotherapy, it take MVCT before treatment so dose measurement will be unnecessary radiation exposure to patients. Conclusion, Tomotherapy was the best treatment technique and 2nd was IMRT, and 3rd 3D-CRT. But applicable differently depending on the the patient's condition even though dose not matter.