Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Autonomic Nervous Properties of Atropine and Glycopyrrolate on Heart Rate Variability during Anesthesia with Ketamine-Xylazine in Dogs

개에서 케타민-자일라진 마취동안 심박변이도에 대한 아트로핀과 글리코피롤레이트의 자율신경적 특성

  • Park, Woo-Young (Bayer health care) ;
  • Bae, Chun-Sik (College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Soo-Han (Department of Clinical Pharmacology and Therapeutics, Asan Medical Center) ;
  • Park, Woo-Dae (Department of Veterinary Nurse and Pet Science, Seojeong College)
  • Published : 2009.06.30
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Abstract

Anticholinergics, which are commonly given as a pre-anesthetic medication to prevent adverse effects in canine anesthesia, can cause cardiac adverse effects. To determine the effects of atropine and glycopyrrolate on the balance of sympathetic nervous tone and parasympathetic nervous tone of the heart during ketamine anesthesia in beagle dogs, heart rate variability(HRV), duration of anesthesia and behavioral changes were evaluated. There were no significant temporal domain differences between atropine and glycopyrrolate. Concerning the frequency domain component, atropine and glycopyrrolate effects were significantly lower(P<0.05) than the control saline-treated group. However, the root mean square of the interval differences between consecutive R peaks(RMSSD) and the standard deviation of Poincare plot perpendicular to the line-of-identity(SD1) in atropine were significantly decreased(P<0.05) from the baseline value, and the low frequency/high frequency ratio(LF:HF ratio) in glycopyrrolate was significantly increased from baseline value(P<0.05). The change of SD1 agreed with that of the high frequency(HF) in the frequency domain component and also with those of respiratory rate and $SpO_2-R$. Our results prove that glycopyrrolate is more suitable as a pre-anesthetic anticholinergic in ketamine anesthesia of dogs with respect to safety and duration of action.

개의 마취에서 부작용을 예방하기 위하여 전마취제로 가장 일반적으로 사용되어지는 항콜린제는 심장에 부작용을 일으킬 수 있다. 비글견에서 케타민 마취 동안 심장의 교감신경과 부교감 신경의 균형에 대한 아트로핀과 글리코피롤레이트의 효과를 검증하기 위하여, 심박변이도, 마취 기간 그리고 행동 변화가 평가 되어졌다. 아트로핀과 글리코피롤레이트에서는 어떠한 일시적인 domain 차이도 없었다. 주파수 영역과 연관되어서는, 아트로핀과 글리코피롤레이트 효과는 모두 대조군에 비해 유의하게 낮게 나타났다(P<0.05). 그러나, 아트로핀의 RMSSD와 SD1은 기준선보다 낮았으며(P<0.05), 글리코피롤레이트의 LF:HF ratio는 기준선보다 높은 유의한 변화를 보였다(P<0.05). SD1의 변화는 주파수 도메인의 HF와 일치하는 변화를 보였으며 호흡수와 $SpO_2-R$의 변화와도 일치하는 변화를 보였다. 우리의 결과는 심장의 자율신경적 특성을 이용하여 글리코피롤레이트가 안전성과 작용 시간을 고려하여 개에서 케타민 마취 시 항콜린제로 더욱 적당하다는 것을 증명한 것이다.

Keywords

References

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