• Journal of Chest Surgery
• /
• v.29 no.1
• /
• pp.73-78
• /
• 1996

From June 1989 to May 1994, 23 patients with myasthenia gravis underwent thymectomy in the Department of Thoracic Surgery, Asan Medical Center. For the evaluation of the effect of thymectomy, clinical analysis including age and sex distribution, preoperative disease severity, duration of the symptoms, thymic pathology, and postoperative clinical improvement was performed. The mean follow-up period was 15 mon hs(range : 5∼60mon1hs). The effectiveness of thymectomy according to the postoperative symptoms and drug dose was graded as follow : a) complete remission in 5 cases (21.7%), b) clinical improvement with dose reduction in II cases (47.9%), c) clinical improvement without dose reduction in 3 cases(13.0%), 4) unchanged in 2 cases (8.8%), e) early death in 1 case(4.3%) and f) recurrence in 1 case(4.3%). According to the preoperative disease stage by Modified Osserman classification, 6(66.7%) of the 9 patients in stage I and 13 (92.9%) of 14 patients in stage II were clinically improved after thymectomy. although there was no significant statistical differences between these two groups (p> 0.05). According to the thymic pathology, 4 (100%) of 4 cases with normal thymus were clinically improved. Ten (90.9%) of 11 cases with thymic hyperplasia and 5 (62.5%) of 8 cases with thymoma were clinically improved, but there was no significant statistical differences in these three groups (p> 0.05 . The thymectomy resulted in dramatic clinical improvement in 19 (82.5%) out of 23 patients. According to the preoperative disease stage by Modified Osserman classification or the thymic pathology, there was no significant statistical differeneces in the effect of thyinectomy (p> 0.05).

• Tuberculosis and Respiratory Diseases
• /
• v.44 no.2
• /
• pp.409-418
• /
• 1997

Objective : Appropriate antituberculosis chemotherapy may not prevent occurrence or progression of tracheobronchial stenosis and obstruction in the patients with endobronchial tuberculosis. The effect of corticosteroid treatment combined with antituberculosis chemotherapy was inconclusive. We evaluated prospectively the effect of corticosteroid treatment. Methods : We diagnosed endobronchial tuberculosis by bronchoscopic examination and bronchial biopsy in the patients of tuberculosis within one month of antituberculosis chemotherapy. After randomization, we prescribed isoniazid, rifampin, ethambutol, and pyrazinamide with or without prednisolone 40 mg for 4 weeks. We carried out bronchoscopy in second month and ninth month of treatment. Results : Edematous endobronchial tuberculosis showed significant improvement of bronchial stenosis after corticosteroid treatment(p < 0.05). Corticosteroid treatment did not have advantage of improvement of bronchial stenosis in the patients with infiltrative endobronchial tuberculosis. Conclusion : Corticosteroid is effective in the treatment of bronchial stenosis when endobronchial tuberculosis is edematous type, in the early period of antituberculosis chemotherapy.

• 프린팅코리아
• /
• s.10
• /
• pp.86-87
• /
• 2003

2/4분기에는 전반적인 경기가 다소 회복될 것으로 전망되고 있는 가운데 인쇄업종은 1/4분기보다 더 악화될 것으로 분석됐다. 대한상공회의소가 조사한 자료에 따르면 업종별 BSI가 97(전분기에는 88)을 기록해 상당히 호전될 것으로 나타난 반면 인쇄업종은 전분기 110에서 105로 하락했다.

• 대한핵의학회:학술대회논문집
• /
• 1998.11a
• /
• pp.27.2-27.2
• /
• 1998

• Tuberculosis and Respiratory Diseases
• /
• v.57 no.1
• /
• pp.72-77
• /
• 2004

Background : A tracheobronchial obstruction in lung cancer is associated with significant morbidity and mortality due to dyspnea, cough, hemoptysis, and recurrent respiratory infection. It is well known that one of standard treatments is photodynamic therapy (PDT) in tracheobronchial obstruction after radiotherapy, chemotherapy, and/or surgery. We reported here the role of PDT in airway obstruction in patients advanced lung cancer. Method : Pre-treatment protocol consisted of clinical, radiologic, and bronchoscopic examination, pulmonary function test, and assessment of Karnofsky performance status. A 2 mg/kg of porfimer sodium was injected intravenously, and then followed by cylindrical and/or interstitial irradiation with 630 nm of laser after 48 hours. The repeated bronchoscopy for debridement of necrotic tissue and re-illumination was performed after 48 hours. Result : Improved airway obstruction and selective tumor necrosis were achieved by photodynamic therapy in all cases. Dyspnea and performance status were improved in three cases. A purulent sputum, fever and hemoptysis were improved in one of five cases. After PDT, all patients showed temporarily aggravation of dyspnea, two of five showed febrile reaction for a few days and nobody presented photosensitivity reaction, hemoptysis and respiratory failure. Conclusion : Our experiences of PDT are effective in palliation of inoperable advanced lung cancer in terms of tracheobronchial obstruction.

• Journal of Korean Academy of Nursing
• /
• v.1 no.1
• /
• pp.44-48
• /
• 1970

무의식환자와 수술후환자의 구강청결방법으로 Milk of Magnesia를 사용하였을 때의 효과여부와 수술 환자에게 Milk of Magnesia와 함께 Chewing Gum을 사용했을 때의 효과여부를 측정하기 위하여 인디아나대학 Medical Center에 입원한 무의식환자 2명과 수술 후 마취에서 깨어난 환자 4명을 대상으로 하여 7-8시간 간격으로 2일간 구강청결을 실시했다. 본 연구는 1969년 가을학기에 시행했으며 분석방법으로는 표본 크기가 적은 경우에도 사용할 수 있는 방법의 T-test를 사용했으며 그 결과는 다음과 같다. 1. 무의식환자에서 Milk of Magnesia로 구강청결을 시행했을 때의 구강상태는 시행전보다 유의적으로 호전되지 못했다(p>0.1). 2. 수술 후 환자에서 Milk of Magnesia로 구강청결을 시행했을 때의 구강상태는 시행전보다 유의적으로 호전되었다(p>0.05). 3. 수술 후 환자에서 Milk of Magnesia와 Chewing Gum을 동반하여 사용했을 때의 구강상태는 유의적으로 호전되었다(p<0.05).

• Journal of Chest Surgery
• /
• v.30 no.1
• /
• pp.72-76
• /
• 1997

Myasthenia gravis is relatively rare disease which is related autoimmune response. There are various methods of management for myasthenia gravis, but nowaday radical thymectomy is the treatment of choice in the aspect of bringing out complete remission and clinical improvement. Sixteen patients of myasthenia gratis underwent radical thymectomy during last eight years, and its result was analysed. Complete rem ssion was achieved in five patients (31 %) and pharmacological or symptomatic improvement in seven patients (44%), thus giving a total remission in 12 patients (75%). Postoperative result was not correlated with age, sex, degree of preoperative symptom, surgical approach, pathologic diagnosis.

• Defense and Technology
• /
• no.7 s.233
• /
• pp.78-87
• /
• 1998

비무장지대에 매설되어 있는 100만여개의 지뢰와 북괴의 호전적인 태도를 감안한다면 전시에 전투력 발휘를 보장하기 위한 전력화 측면에서 그리고 인도주의적 측면에서 우리군도 정책적으로 추가적인 지뢰제거장비의 연구개발에 관심을 기울여야 하겠다. 지뢰제거장비는 1종류만 사용한다면 100% 지뢰제거에는 제한이 따르며 기계식, 전자기식, 폭파식, 비폭파식 장비를 종합적으로 운용하여 전시 기동부대에 기동성을 보장하고 또한 군사작전지역이 아닌 지역에서 지뢰로 인한 민간 사상자를 방지하고 통일에 대비할 수 있도록 지뢰탐지 및 제거장비개발 획득에 박차를 가해야 하겠다.

• Journal of The Korean Society of Inherited Metabolic disease
• /
• v.1 no.1
• /
• pp.5-12
• /
• 2001

아시아 및 한국에서 처음 발견된 3명의 소아 Ethylmalonic encephalopathy (EE) 환자들은 riboflavin을 이용한 치료법에 점진적인 호전을 보인 것으로 나타났다. Ethylmalonic aciduria가 3가지 효소-2-methyl-branched-chain acyl CoA dehydrogenase (2MBCAD), iso-valeryl CoA dehydrogenase (IVCAD), 그리고 short-chain acyl CoA dehydrogenase (SCAD) - 들의 부분적인 결함으로 생긴다는 가설하에 dehydrogenase (탈수효소)의 보조 효소인 riboflavin이 부분적으로 나마 치료 과정에서 어떤 역할을 수행하는지의 여부를 살펴보았다. 다음의 세 증례에서 riboflavin 혹은 coenzyme Q10을 병행하여 치료한 결과 인지 행동(cognitive behavior)과 만성 점액성 설사(chronic mucoid diarrhea)가 호전된 것으로 관찰되었다. 또한, 치료 후 운동 기능도 일부 호전되었다. EE의 질병 발생 기전이 현재까지 완전히 밝혀지지는 않았지만, 세 명의 EE 환자들의 치료경과를 관찰하여 위의 가설을 뒷받침 할 수 있었다.

• Journal of TMJ Balancing Medicine
• /
• v.5 no.sup
• /
• pp.6-10
• /
• 2015

A 8 year-old male patient with tic disorder was managed by appliance of Functional Cerebrospinal Therapy (FCST) for 7 months, combined with acupuncture. After being treated for 7 months, the patient's symptoms were improved. Assessment was made by Yale Global Tic Severity Scale (YGTSS) and clinical observation. A positive effect was observed and further clinical and biological research on FCST is expected.