• Title/Summary/Keyword: 혈액 질환

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Purification and Characterization of Anti-Coagulant Activity Fraction from Persimmon Stem (감꼭지로부터 혈액응고저해물질의 정제와 특성)

  • 사유선;김경아;최혜선
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.32 no.8
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    • pp.1323-1327
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    • 2003
  • Persimmon has been considered to have therapeutic values for various diseases in Korea. Dried persimmon has been applied to wounded parts for anti-inflammatory and analgesic activities. Anti-coagulant fraction from Persimmon stem was purified through gel filtration, phenyl Sepharose, DEAE-Sephadex and additional gel filtration column chromatographies. Its molecular weight was estimated to be 130,000 ∼ 180,000. By element analysis, its main components were C, H, and O. The anti -coagulant was heat- stable and completely inhibited after periodate oxidation, indicating that it was a complex carbohydrate.

Immunoglobulin G4-Related Disease Involving Various Head and Neck Regions: A Case Report (두경부에 국한된 표현형으로 발생한 면역글로불린 G4와 연관된 질환: 증례 보고)

  • Jun Yong Im;Miok Sunwoo
    • Journal of the Korean Society of Radiology
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    • v.83 no.4
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    • pp.910-917
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    • 2022
  • Immunoglobulin G4 (IgG4) related disease (IgG4-RD) is currently considered an immune-mediated condition and is recognized as a disorder group with common pathological, hematological, and clinical characteristics. This disease may involve diverse organs of the head and neck, and include mainly the lacrimal gland, orbit, thyroid gland, pituitary gland, and the meninges. Here, we report a case of IgG4-RD in a 65-year-old female showing head- and neck-limited but synchronously and mainly manifesting as otalgia and facial neuritis.

A Study on the Determinants of Liporotein(a) Level - Primary, Middle, and High School Teachers in Seoul - (혈액내 Lipoprotein(a) 농도의 결정요인에 관한 연구 - 서울시 일부 초, 중, 고교 교사들을 대상으로 -)

  • 최현오;이용욱;나승식;이후장
    • Journal of Food Hygiene and Safety
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    • v.13 no.2
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    • pp.155-163
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    • 1998
  • The purpose of this study was to determine the association between blood lipids, fibrinogen, fasting blood sugar, lifestyle-related factors and lipoprotein(a). This study was performed with 140 healthy adults (male:80, female:60) among the teachers in primary, middle, and high school in Seoul in November 1996. Lipoprotein(a) concentration was measured with an enzyme-linked-immunosorbents assay(ELISA), and the results showed that the distribution was highly skewed and the average concentrations of male and female were $16.94{\pm}12.70\;mg/dL\;and\;17.92{\pm}7.58\;mg/dL$, respectively. The percentage of subject with lipoprotein(a) concentrations higher than 30 mg/dL was 26.4%. Univariate analysis showed significant association between lipoprotein(a) and age, alcohol, meat, and NaCl consumption (p<0.05). In multivariate analysis, lipoprotein(a) correlated positively with age (p<0.05) and meat consumption (p<0.01). These data suggest that lifestyle-related factors may affect the lipoprotein(a) concentration regarded as a risk factor of atherosclerosis disease.

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Etiology of Bacteremia in Children With Hemato-Oncologic Diseases From 2013 to 2023: A Single Center Study

  • Sun Woo Park;Ji Young Park;Hyoung Soo Choi;Hyunju Lee
    • Pediatric Infection and Vaccine
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    • v.31 no.1
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    • pp.46-54
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    • 2024
  • Purpose: This study aimed to identify the pathogens of bloodstream infection in children with underlying hemato-oncologic diseases, analyze susceptibility patterns, compare temporal trends with those of previous studies, and assess empirical antimicrobial therapy. Methods: Retrospective review study of children bacteremia in hemato-oncologic diseases was conducted at Seoul National University Bundang Hospital from January 2013 to July 2023. Results: Overall, 98 episodes of bacteremia were observed in 74 patients. Among pathogens isolated, 57.1% (n=56) were Gram-positive bacteria, 38.8% (n=38) were Gram-negative bacteria, and 4.1% (n=4) were Candida spp. The most common Gram-positive bacteria were coagulase-negative staphylococci (n=21, 21.4%) and Staphylococcus aureus, (n=14, 14.3%) whereas the most common Gram-negative bacteria were Klebsiella pneumoniae (n=16, 16.3%) and Escherichia coli (n=10, 10.2%). The susceptibility of Gram-positive bacteria to penicillin, oxacillin, and vancomycin was 11.5%, 32.7%, and 94.2%, respectively and the susceptibility of Gram-negative bacteria to cefotaxime, piperacillin/tazobactam, imipenem, gentamicin, and amikacin was 68.6%, 80%, 97.1%, 82.9%, and 91.4%, respectively. Methicillin-resistant S. aureus was detected in 1 strain and among Gram-negative strains, extended spectrum β-lactamase accounted for 28.9% (12/38). When analyzing the antibiotic susceptibility and empirical antibiotics, the mismatch rate was 25.5% (n=25). The mortality rate of children within 30 days of bacteremia was 7.1% (n=7). Conclusions: Empirical antibiotic therapy for bacteremia in children with hemato-oncologic diseases should be based on the local antibiogram in each institution and continuous monitoring is necessary.

Fatigue Associated with Kidney Disease Symptoms in Female Patients Undergoing Hemodialysis (혈액투석을 받는 여성의 피로와 신 질환증상의 관련성)

  • Song, Hyo-Jeong;Kim, Hyeon-Ju
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.14 no.4
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    • pp.474-482
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    • 2007
  • Purpose: This study was done to provide fundamental data for nursing interventions to prevent and reduce fatigue and to identify fatigue and kidney disease symptoms in female patients on hemodialysis and evaluate factors associated with this fatigue. Method: A cross-sectional study design was used with self-administered questionnaires which included general characteristics and the fatigue scale developed by Brown, Dittner, Findly, & Wessely(2005)(Cronbach's $\alpha=0.98$ and for present study $\alpha=0.96$) and a review of laboratory data. From eight dialysis units, 84 women were enrolled. Data were analyzed using the SAS program. Results: Mean score for fatigue was 49.4(range $16{\sim}78$) and fatigue by research variables was significantly different by age(0.046), employment status(0.041), menopause(0.009), hypoalbuminemia(0.022), length of time on dialysis(0.48) and kidney disease symptoms(0.000). Correlations between fatigue and lack of strength, dizziness, and cramps after dialysis were significantly higher. Factors affecting fatigue were kidney disease symptoms and length of time on dialysis, explaining 49.2% of fatigue. Conclusion: A comprehensive approach considering kidney disease symptoms, length of time on hemodialysis, age, menopause, and hypoalbuminemia are required for interventions to reduce fatigue in female patients on hemodialysis.

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Study of the BIA component analysis for medical device companies (의료기기 기업을 위한 BIA 성분분석에 대한 연구)

  • Park, Eun Ju;Park, Roh Gook
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.9 no.6
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    • pp.145-152
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    • 2014
  • This Study was done to estimate the availability of biological resistance analysis method in medical equipment companies in Korea, and if it is usefull in predicting risk of obesity and cardiovascular disease and managing of it, by means of comparing it with blood tests. Especially, we analyzed the correlation between circumference length and fat thickness of each site of body area, which are ones of among measurement values of the BIA. This study has the purpose to propose the use of BIA as basement of diagnosis for efficient management and assessment in the medical device industry in our country.

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Traumatic Extrapleural Hematoma Mimicking a Hemothorax (혈흉으로 오인된 흉막외혈종)

  • Park, Young-Woo;Lee, Jae-Wook;Lee, Dong-Gi
    • Journal of Chest Surgery
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    • v.43 no.3
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    • pp.328-331
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    • 2010
  • Extrapleural hematoma results from blood accumulating between the parietal pleura and the endothoracic fascia, whereas hemothorax shows pooling in the pleural space. Extrapleural hematoma results from an intact parietal pleura that blocks blood from escaping the pleural cavity. Extrapleural fat, a fat layer outside the pleura in the chest wall between the parietal pleura and the endothoracic fascia, is pathognomonic on computed tomography. We diagnosed traumatic extrapleural hematoma and treated it with video-assisted thoracic surgery. We report here on this case along with a review of the literature.

VATS Resection for a Posterior Mediastinal Extramedullary Hematopoietic Mass: Resection of Extramedullary Hematopoiesis (후종격동 종괴로 발견된 골수외 조혈 종괴의 비디오 흉강경 수술을 이용한 절제 1예)

  • Chang, Jee-Won;Maeng, Young-Hee
    • Journal of Chest Surgery
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    • v.43 no.5
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    • pp.542-545
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    • 2010
  • Extramedullary hematopoiesis is a common compensatory mechanism of chronic anemia, but an asymptomatic posterior mediastinal mass is rarely diagnosed as an extramedullary hematopoiesis after surgical resection. The differential from neurogenic tumors is important, but fine needle aspiration biopsy is not recommended because of the difficulty of approach and risk of bleeding. Although diagnosis and treatment can involve resection via thoracotomy, video-assisted thoracic surgery may also be a useful strategy. We performed video-assisted thoracic surgery on a 59-year-old man for posterior mediastinal extramedullary hematopoiesis, with no evidence of recurrence or related hematologic diseases.

Correlation analysis between cerebral activation status and blood type (대뇌 활성화 상태 변화와 혈액형간의 상관성 분석)

  • Park, Yeon-Tae;Shin, Jeong-Hoon
    • Annual Conference of KIPS
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    • 2017.11a
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    • pp.1097-1099
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    • 2017
  • 본 논문은 대뇌 활성화 상태 변화와 혈액형간의 상관성 분석을 목적으로 한다. 혈액은 인체의 혈관을 통하여 몸 전체로 순환하는 액체 성 물질이다. 이 혈액을 구성하는 물질의 이질적 차이를 나타내는 차별적 유형을 혈액형이라 하며, 혈액형은 멘델의 법칙에 따라 부모에서 자식으로 유전된다. [1] 최근 들어 혈액형이 가지는 유전적 특징을 통한 질병 진단 및 치료, 예방을 위한 연구가 진행되고 있으나, 대부분의 연구는 육체적인 질병과 관련되어 있는 실정이다. 그러나, 혈액형의 경우 유전적 특성을 가지고 있으며, 신경 전달 망에 영향을 끼칠 것으로 추정 되는바 육체적 질병뿐만 아닌 정신적인 질환에도 혈액형에 따른 치료 및 예방방법을 차별화 하여, 보다 효율적인 치료 및 예방을 수행 할 수 있을 것으로 판단된다. 본 논문에서는 이를 위하여, 외부자극에 따른 대뇌 활성화 상태 변화를 분석하며, 특히 혈액형에 따른 상태변화의 상관성을 분석하고자 한다. 본 논문에서 활용하는 외부 자극은 청각 자극을 활용하며, 먼저 혈액형에 따른 피험자 군의 분류를 수행하여 동일 군 내 공통반응 및 상이한 군 간의 특이반응을 분석하여, 혈액형이 대뇌 활성화 상태 변화 및 정신질환에 따른 증상발현 등과 유관함을 검증하고자 한다.

Clinical Hemodialysis Cases with Estimation of the Adequacy in Four Dogs (혈액투석 4마리 개의 증례에서 투석적절성 평가)

  • Lee, Chang-Min;Lim, Chae-Young;Kim, Seung-Gon;Kang, Min-Hee;Park, Hee-Myung
    • Journal of Veterinary Clinics
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    • v.32 no.5
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    • pp.436-439
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    • 2015
  • Four cases of acute or acute-on-chronic kidney injury were referred for hemodialysis therapy. All cases had a history of uremic syndrome including refractory vomiting, anorexia, diarrhea and depression. They already had been treated with conventional therapies but the intractable clinical signs were remained without response of medications. Intermittent hemodialysis (IHD) sessions were executed in four cases. This study describes the clinical signs and biochemical features of four hemodialysis patients with dialysis adequacy indexed by Kt/V. This report introduced the estimation of hemodialysis adequacy method with clinical cases for establishment of standardization of hemodialysis therapy assess in dogs.