• 건강소식
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• v.30 no.5 s.330
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• pp.16-17
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• 2006

모든 암 사망률의 30%가 흡연으로 밝혀졌다. 담배 연기가 직접 접촉하는 부위에 생기는 암인 구강암, 혀암, 식도암, 기관지암, 폐암은 흡연이 원인의 90%를 차지한다. 담배 연기가 직접 접촉하지 않는 부위에 생기는 암인 자궁경부암, 췌장암, 방광암, 신장암, 위암, 혈액암의 위험은 흡연으로 인하여 1.5~3.0배 정도 증가하게 된다.

• The Science & Technology
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• v.15 no.10 s.161
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• pp.52-54
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• 1982

• Journal of Chest Surgery
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• v.40 no.9
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• pp.617-623
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• 2007

Background: Invasive pulmonary aspergillosis, a frequent fungal infection in immunocompromised patients, is known to have a poor prognosis despite the use of antifungal therapy in leukemic patients. We studied the outcome of surgical resection of invasive pulmonary aspergillosis where bleeding tendency, localized recurrence of infection, and incidence could be reduced. Material and Method: We retrospectively reviewed 14 patients with a hematological malignancy where invasive pulmonary aspergillosis was diagnosed during the 10 years between 1998 and 2007. From the medical records, we reviewed the type and treatment of the hematological malignancy, including the diagnostic methods of invasive pulmonary aspergillosis, the preoperative hematological conditions and their management, and the surgical methods and records. We also analyzed the development of postoperative complications and patient mortality, the recurrence of postoperative invasive pulmonary aspergillosis, and if the patients had a bone marrow transplant. Result: Fourteen patients with invasive pulmonary aspergillosis and a hematological malignancy underwent a pulmonary lobectomy. One patient had a complication of bronchopleural fistula, but there were no other serious complications such as bleeding or wound infection, and none of the patients died postoperatively. Conclusion: We have shown that pulmonary lobectomy is a safe and effective therapy for invasive pulmonary aspergillosis in patients with hematological malignancies that allow further treatment of the hematological malignancy.

• The Korean Chronic Disease News
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• no.105
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• pp.8-9
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• 1989

• Proceedings of the Korean Society of Applied Pharmacology
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• 1992.05a
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• pp.16-16
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• 1992

1940년대에 처음으로 암의 화학요법이 시도된 이래 많은 항암제들이 도입되어 사용되고 있다. 현재 항암제를 사용하여 비교적 치료율이 높은 암은 leukemia나 lymphoma와 같은 혈액암에 국한되어 있다. 고형암에 대하여는 고환암과 같은 극히 일부가 항암제에 의해 비교적 잘 치료되나 대부분은 여전히 치료가 되지 않고 있는 상태에 있다. 고형암의 발생빈도는 전체 암의 90％를 차지하고 있는 상태로 사망율이 매우 높아, 현대의 40대 이상 사망원인의 1위를 나타내고 있어 그 치료제의 개발이 매우 시급히 요구되고 있다. 이에 따라 고형암의 치료를 목적으로 많은 화합물들이 검토되어 왔다. 이중 최근 매우 큰 가능성을 보여주고 있는 diarysulfonylurea 유도체가 발견되어 임상시험에 도입됨으로서 이 화합물들에 대한 관심이 고조되고 있다. 이와 관련하여 고형암의 치료제를 개발할 목적으로 diarysulfonylurea의 특성과 강력한 항암효과를 발현하는 alkylating agent의 특성을 갖을 것으로 예상되는 새로운 2-alkoxy-1-arylsufonylimidazoline 유도체를 설계하고, 이들 유도체의 합성법을 개발하였다. 이들 유도체들은 일차적으로 생체내에서 DNA 또는 효소등에 alkylation을 일으킨후 diarysulfonylurea로 변하여 작용함으로서 보다 큰 항암효과를 발현할 것으로 기대된다.

• Journal of radiological science and technology
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• v.29 no.4
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• pp.285-291
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• 2006

During cancer therapy, gamma-ray irradiation and treatment of anti-cancer chemicals destroy the normal cells as well as cancer cells. In this study, we investigated the effect of epigallocathechin-gallate(EGCG) extracted from green tea, which is known to have anti-cancer and anti-oxident activities, in order to find out the feasible method to protect the normal cells and to kill the cancer cells efficiently. We investigated the effect of EGCG on the leukemia cell growth and cell necrosis, especially when treated along with gamma radiation. The EGCG inhibited the leukemia cell, HL-60, growth at the appropriate concentration while it exhibited no influence on the normal cell growth. More significantly, it enhanced leukemia cell necrosis when its treatment was combined with gamma irradiation. Simultaneous treatment of EGCG and gamma radiation increased leukemia cell necrosis up to 35% compared with separate treatments. These results suggest that drinking of green tea or co-treatment of EGCG during gamma irradiation therapy may result in better prognosis through enhancement of the tumor cell necrosis and protection of the normal cells.

• 건강소식
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• v.35 no.2
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• pp.18-19
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• 2011

건강검진이나 질병을 진단받기 위해 가장 먼저 거쳐야 할 관문은 노란 고무줄을 팔에 묶고 팔꿈치가 따끔한 주삿바늘을 참아 내는 것이다. 이 검사가 바로 피검사라 하는 혈액검사다. 혈액 검사로 모든 혈액 속 물질들의 결과를 알 수 있다고 하는데, 대체 어디까지 알 수 있는 것일까?

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2003.09b
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• pp.166-169
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• 2003

유전자에 대한 정보를 획득하는 기술적인 문제가 해결되면서, 질병 진단을 위한 새로운 접근 방법으로 혈액 속에 있는 모든 단백질(proteome)의 구성을 분석하는 프로테오믹스(proteomics)에 대한 연구가 최근 들어 활발하게 진행되고 있다. 본 논문은 암 진단을 위하여 혈액 중의 단백질의 구성을 측정한 2차원 전기영동 (2D electrophoresis) 젤 데이터를 해석하는 새로운 방법을 제시하였다. 우선 측정된 많은 단백질 스팟(spot) 중에서 T-statistics 방법으로 단백질 스팟들을 선택하였다. 선택된 단백질 스팟들로 이루어진 암 환자와 정상인 두 샘플들의 확률 분포를 각 집단에 따로 적용된 PCA 영역에서 계산하였다. 최종적으로 조건부 확률의 차이에 근거한 베이즈 분류(Bayes classification) 이론을 적용하여 암 진단을 하였다.

• Biomedical Science Letters
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• v.4 no.2
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• pp.121-128
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• 1998

We studied on the expression of apoptosis in colorectal cancer, lymph node, their corresponding normal mucosa and colorectal cancer patient's blood by genomic DNA electrophoresis and TUNEL labeling method. From 7 cases among 37, 20 cases among 47 and 5 cases among 15, DNA ladders were expressed in normal tissues, colorectal tissues and Iymph node tissues, respectively. A DNA ladder was not observed in 7 cases of colorectal cancer patients blood. In case of TUNEL labeling, we could observe TUNEL color espression in colorectal cancer and lymph node tissues. As these result suggest that apoptotic index may be associated with the colorectal cancer development, and mat be used as a prognostic indicator but further evaluations will be needed.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.10
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• pp.1317-1323
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• 2009

In the present study, we investigated the anti-proliferation activity of Citrus grandis Osbeck peel (CGP) in HL60 (human promyelocytic leukemia) cells. It was found that 80% ethanol extract of CGP could inhibit the cell growth in a dose-dependent manner ($250{\sim}1,000{\mu}g/mL$), which was associated with morphological changes and apoptotic cell death such as depolarized mitochondrial membrane, formation of apoptotic bodies and increased populations of apoptotic sub-G1 phase. The results indicate that CGP extract inhibits the growth of HL60 cancer cells by the induction of apoptosis, which may be mediated by its ability to change the Bcl family proteins and increase the activation of caspase-3 and PARP. Therefore, it is suggested that CGP has the potential to provide a remarkable natural defense against the proliferation of HL60 cells.