• Tuberculosis and Respiratory Diseases
• /
• v.57 no.1
• /
• pp.37-46
• /
• 2004

Background : Lung pericytes are important constituent cells of blood-air barrier in pulmonary microvasculature. These cells take part in the control of vascular contractility and permeability. In this study, it was hypothesized that change of lung pericytes might be attributable to pathologic change in microvasculature in acute lung injury. The purpose of this study was how hypoxia change proliferation and genetic expression in lung pericytes. Methods : From the lungs of several Sprague-Dawley rats, performed the primary culture of lung pericytes and subculture. Characteristics of lung pericytes were confirmed with stellate shape in light microscopy and immunocytochemistry. 2% concentration of oxygen and $200{\mu}M$ $CoCl_2$ were treated to cells. Tryphan blue method and reverse transcription-polymerase chain reaction were done. Results : 1. We established methodology for primary culture of lung pericytes. 2. Hypoxia inhibited cellular proliferation in pericytes. 3. Hypoxia could markedly induce vascular endothelial growth factor(VEGF) and smad-2. 4. Hypoxia-inducible factor-$1{\alpha}$(HIF-$1{\alpha}$) was also induced by 2% oxygen. Conclusion : Viability of lung pericytes are inhibited by hypoxia. Hypoxia can stimulate expression of hypoxia-responsive genes. Pericytic change may be contributed to dysfunction of alveolar-capillary barrier in various pulmonary disorders.

• Archives of Reconstructive Microsurgery
• /
• v.4 no.1
• /
• pp.1-8
• /
• 1995

장시간 허혈상태의 토끼 이개를 실험대상으로 하여 유로키나제와 헤파린을 병용 또는 단독으로 사용시와 또한 약물을 사용하지 않았을 때, 이들이 모세혈관의 개존성과 아울러 미세수술후의 조직 생존율에 미칠 수 있는 효과를 보기 위하여 허혈상태의 토끼 이개를 미세수술로 접합한 후 모세혈관으로의 혈류를 측정하기 위하여 레이저 초음파 혈류측정기(Laser doppler flowmetry)를 이용하였으며 방사선 구슬들(Cobalt-57 with plastic material with average diameter 15 micron)을 주입한 결과 유로키나제 조합에서 통계적으로 유효한 성적을 얻었다. 광학현미경 소견은 유로키나제와 헤파린을 병용한 조합에서 모세혈관내 내피세포의 배열이 유지되어 있었으며 헤파린을 사용한 조합에서도 유사한 소견을 보였으나 약물을 사용하지 않은 조합에서는 국소적인 내피세포의 배열이 결핍되어 있었다. 전자현미경 소견에서 유로키나제와 헤파린을 병용한 조합에서 내피세포가 혈관내벽에 배열되어 있었고 또 불규칙한 세포질이 돌출되어 있었다.

• Journal of Chest Surgery
• /
• v.37 no.10
• /
• pp.880-883
• /
• 2004

The graft infection within the abdomen is a notorious condition, which usually develops serious complications of anastomotic rupture or distal embolism that ended in death. There has been many controversies in the treatment of an aortobiiliac graft infection and varying results have been reported. The authors treated a case of aortobiiliac graft infection after abdominal aortic aneurysm surgery. The operation was performed with re-aortobiiliac bypass using bilateral superficial femoral veins. The result was successful.

• Journal of Chest Surgery
• /
• v.35 no.4
• /
• pp.283-289
• /
• 2002

Backgrouds: It is almost universally accepted that occlusive vascular diseases are best managed by anatomical reconstruction. However, the mortality and the morbidity have limited this operation for patients with high operation risks. In these patients, palliative operations such as extra-anatomic bypass and lumbar sympathectomy, are accepted as useful treatment. Material and Method: A retrospective study was conducted in 38 patients who underwent palliative operations for occlusive vascular disease at Korea University Guro Hospital between 1996 and 2000. Mean age of the patients was 60.37 $\pm$ 17.65 years, and preoperative diagnoses were atherosclerosis in 32 patients, Buerger's disease in 4 patients, Raynaud's syndrome in 1 patient and SVC syndrome in 1 patient. Result: Extra-anatomic bypass(40procedures), lumbar sympathectomy(17), thromboembolectomy(7) and femoral artery graft interposition(1) were performed. Six patients were required reoperation due to graft flow failure or fistula. Three year primary patency rate of entire operations was 78.29 $\pm$ 8.81%, and the correlation between type of operation and patency rate was not statistically significant. Conclusion: Palliative operations for occlusive vascular disease are useful treatment in limited patients with high operation risks or limited life expectancy.

• 건강소식
• /
• v.36 no.10
• /
• pp.26-27
• /
• 2012

가을은 단풍 산행을 위해 산을 찾는 사람들이 많아지는 계절이다. 등산은 심폐와 온몸의 근육과 인대를 강화시키는데 효과적인 운동이지만, 등산 전 몸 상태에 대한 점검 없이 무리한 등산을 할 경우 평소 약해진 다리 혈관이 늘어난 혈액량을 감당하지 못해서 건강을 해칠 수가 있다. 더욱이 등산을 즐기는 중장년층이라면 종아리 근육의 탄력이 약화되어 정맥혈관이 확장되는 정맥류가 발생할 가능성이 높고, 이미 정맥류가 있는 경우라면 악화될 수 있다.

• Proceedings of the KSMRM Conference
• /
• 1999.11a
• /
• pp.17-18
• /
• 1999

최근까지 복부 자기공명영상은 간의 국소병변의 특성을 규명하는 데 가장 많이 사용되어 왔다고 할 수 있다. 그러나, 자기공명영상의 기법과 장비의 발달로 인해 그 적응증이 더욱 확대되어 가는 추세에 있고 , 특히 자기공명담췌관촬영술의 도입과 발전은 복부 자기공명영상의 적응증을 한층 넓히는 데 크게 기여하고 있다. 이와 함께, 2차원 또는 3차원 경사에코기법과 조영제를 병용하여 호흡정지 상태에서 자기공명혈관촬영상을 얻을 수 있게 되어 자기공명담췌관촬영술과 혈관촬영술을 복합하여 다양한 담췌관질환을 평가하는 데 이용하는 빈도가 증가하고 있다. 이 강의 에서는 최근에 널리 사용되는 자기공명담췌혈관촬영술 또는 역동적 역상과의 복합적 사용의 유용성을 돌아보고자 한다.

• Tuberculosis and Respiratory Diseases
• /
• v.42 no.6
• /
• pp.913-922
• /
• 1995

Background: When we define the pressure of pulmonary vasculature in which a recruitment of blood flow occurs as $P_I$ and the proportion of change in pulmonary artery to that in cardiac output as IR and then we compare PI and IR with pulmonary vascular resistance, we would find some problems in pulmonary vascular resistance. In other words, it is the theory that, IR should be increased mainly in pulmonary embolism in which decreases the cross sectional area of pulmonary vasculature. But there are many contradictory reports resulted from various researches and the fact is known widely that any difference exists between PVR and PI, IR. For this reason, the purpose of this study is to observe how PI and IR change at the time of the outbreak and during treatment of the pulmonary embolism, and to find out the meaning of these new indicators and the difference from the pulmonary vascular resistance used generally when we subdivide the pulmonary vascular resistance into PI and IR. Method: After making AV fistula in experimental dog, we controlled cardiac output at the intervals of 15 minute in case of three kinds(all AV fistula are obstructed, only one of fistula is open and all of fistula is open), and after evoking massive pulmonary embolism with radioactive autologous blood clots, we measured the mean pulmonary artery pressure, and calculated PI and IR. We observed the pattern of change in PI and IR, without giving the control group any specific treatment and with injecting intravenously rtPA in the Group 1 and Group 2 at the dose of 1mg per kg, for 15 minutes fot the former and 3 hours for the latter. Result: 1) Pulmonary vascular resistance showed a change similar to that of pulmonary artery pressure and in all three group, PVR increased significantly, but group 1 and group 2 showed tendency that PVR keeps on decreasing after treatment, and the rate of decrease in group 1 is more rapid than group 2 significantly. 2) Both intersection(PI) and degree(IR) are proved statistically significant, in view of the straight line relationship between cardiac output and pulmonary artery pressure, calculated by minimal regression method. 3) PI changed similarly to pulmonary vascular resistance, while in the IR which is theoretically more similar to PVR, there was no significant difference or change after rtPA infusion. Conclusion: In the pulmonary embolism, Both change in IR which means real resistance of pulmonary vasculature and PI which was developed due to secondary vasoconstriction by pulmonary embolism are reflected same time.

• Journal of radiological science and technology
• /
• v.6 no.1
• /
• pp.21-26
• /
• 1983

DSA는 해상능(解像能)에 있어서는 일반적(一船的)인 혈관(血管) 조영술(造影術)에 비해서 다소 못미치지만 소량(小量)의 조영제(造影劑)로도 혈관구조(血管構造)를 잘 관찰(觀察)할 수 있으며 큰 차이의 조직(組織)두께차를 적절히 수용(受容)할 수 있으며 필름의 소모도 적게 되었다. DSA는 경동맥검사(頸動脈檢査)에 가장 중요한 위치를 차지하며 많이 시행(施行)되고 있다. 혈관(血管)의 모양을 변화(變化) 시키는 여러 질환에서 혈관(血管)상태나 혈류(血流)의 변화(變化), 내경(內經)도 알수 있다. 최근에는 흉부(胸部)나 후두(喉頭) 등(等)에도 적용하여 일반검사(一般檢査)와 비교(比較)하여 좋은 결과(結果)를 얻고있다. 또 확대촬영(擴大撮影)이나 입체촬영(立體撮影)까지 응용(應用)하여 좋은 성적을 얻고 있다. DSA는 보고자 하는 혈관상(血管像)만을 단시간에 볼 수 있고 유연성(柔軟性)이 있고 비침습성(非侵襲性)(noninvasive)이며 간단한 검사방법(檢査方法)이라는 점 등(等)에서 매우 유용(有用)한 검사(檢査)라 하겠다.

• Journal of Chest Surgery
• /
• v.30 no.6
• /
• pp.621-624
• /
• 1997

Conventional surgery for lower lumbar disc herniation is a common practice and its vascular complications have been reported rarely. If the hypotension is severe or prolonged postoperatively, one should suspect vascular injury and perform urgent laparotomy. We experienced two cases of major vascular injuries following semi-laminectomy and discectomy.

• Journal of Chest Surgery
• /
• v.38 no.3 s.248
• /
• pp.245-248
• /
• 2005

Drugs containing ergotamine are widely used in the treatment of migraine. Spastic vasoconstriction is one of the most serious side effects even with recommended dosage. We report a case of 63-year-old male with severe arterial occlusion of the upper limbs which might be related with vasospasm caused by ergotamine-containing medication because of migraine for f5 years. He was treated with bypass graft, sympathicotomy and heparin and prostaglandin E1 infusion. But dramatic clinical reversal of the vasospasm was obtained after withdrawal of ergotamine.