• Title/Summary/Keyword: 핵자기공명 현미영상

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3-Dimensional ${\mu}m$-Scale Pore Structures of Porous Earth Materials: NMR Micro-imaging Study (지구물질의 마이크로미터 단위의 삼차원 공극 구조 규명: 핵자기공명 현미영상 연구)

  • Lee, Bum-Han;Lee, Sung-Keun
    • Journal of the Mineralogical Society of Korea
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    • v.22 no.4
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    • pp.313-324
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    • 2009
  • We explore the effect of particle shape and size on 3-dimensional (3D) network and pore structure of porous earth materials composed of glass beads and silica gel using NMR micro-imaging in order to gain better insights into relationship between structure and the corresponding hydrologic and seismological properties. The 3D micro-imaging data for the model porous networks show that the specific surface area, porosity, and permeability range from 2.5 to $9.6\;mm^2/mm^3$, from 0.21 to 0.38, and from 11.6 to 892.3 D (Darcy), respectively, which are typical values for unconsolidated sands. The relationships among specific surface area, porosity, and permeability of the porous media are relatively well explained with the Kozeny equation. Cube counting fractal dimension analysis shows that fractal dimension increases from ~2.5-2.6 to 3.0 with increasing specific surface area from 2.5 to $9.6\;mm^2/mm^3$, with the data also suggesting the effect of porosity. Specific surface area, porosity, permeability, and cube counting fractal dimension for the natural mongolian sandstone are $0.33\;mm^2/mm^3$, 0.017, 30.9 mD, and 1.59, respectively. The current results highlight that NMR micro-imaging, together with detailed statistical analyses can be useful to characterize 3D pore structures of various porous earth materials and be potentially effective in accounting for transport properties and seismic wave velocity and attenuation of diverse porous media in earth crust and interiors.

Noninvasive study of Drug Delivery Systems using Nuclear Magnetic Resonance Microimaging (핵자기공명 현미영상법을 이용한 약물전달체계의 비파괴연구)

  • 이동훈;고락길
    • Journal of Biomedical Engineering Research
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    • v.18 no.2
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    • pp.173-178
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    • 1997
  • pH sensitive polymers have long been utilized as one important type among many interesting drug delivery systems. This is due to the reason of different pH environments in human organs, which requires different pH control mechanism depending upon the organs. In the present study the pH sensitivity was investigated for both pH sensitive and pH insensitive biopolymers using the diffusion effect along with the swelling effect. NMR microscopy was performed along with optical microscopy. For the analysis of diffusion effect, UMR Microscopy was perFormed to measure diffusion coefficients for various liquids such as distilled water, acetone and DMSO(dimethyl sulfoxide). Also, this technique is expected to contribute to the studies for many pH drug delivery systems.

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Application of NMR Microscopy for the Study of the Swelling Effect in Biopolymers (생체고분자의 팽윤현상연구를 위한 핵자기공명 현미영상법의 응용)

  • 이동훈;김승수
    • Journal of Biomedical Engineering Research
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    • v.18 no.2
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    • pp.167-172
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    • 1997
  • Novel measurement method has been performed for the noninvasive study of the swelling effect detected in hydrophilic polymers using Magnetic Resonance Microscopy. iN NMR images were acquired to measure geometric changes due to the swelling effect occurred in the polymer specimens. In addition to the geometric changes, the water ingress process was visualized noninvgsively. The measurement method performed .in the present study utilized some of NMR's valuable properties, both noninvasiveness and parameter selectivity. It is believed that the method used in the present study may be applicable to the study of biopolymers in which noninvasiveness is particularly important.

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Noninvasive study of the swelling effect for biopolymers using NMR Microimaging (핵자기공명 현미영상법을 이용한 생체고분자의 팽윤현상에 대한 비파괴연구)

  • Lee, D.H.;Ko, R.K.;Cho, Z.H.;Kim, S.S.
    • Proceedings of the KOSOMBE Conference
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    • v.1995 no.05
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    • pp.223-226
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    • 1995
  • Polymers have been developed and applied in many biomedical areas as well as engineering and industrial fields. The first essential to achieve successful development and applications is that properties of such polymer materials would be investigated. In many cases, such investigations are accomplished by observing polymeric behavior arising from the environmental changes such as pH, temperature, and ionic concentration. It has long been known that NMR is extremely sensitive to many biochemical and physical changes occurring in the polymer samples. In the present study we focus our study on NMR Microimaging, which is one of the important NMR applications, to characterize the swelling effect by observing the time dependent spatial variations of polymer specimens. For the samples three kinds of polyvinyl alcohol (PVA) specimens are prepared with different degrees of cross linking density. $^1H$ NMR microimages are acquired as a function of time to visualize the swelling behavior as well as volumetric changes occurring in the specimens. From the acquired time dependent images, the swelling process is exploited.

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