Noninvasive study of Drug Delivery Systems using Nuclear Magnetic Resonance Microimaging

핵자기공명 현미영상법을 이용한 약물전달체계의 비파괴연구

  • 이동훈 (배재대학교 물리학과) ;
  • 고락길 (배재대학교 물리학과, 한국화학연구소 생체고분자실, 배재대학교 고분자재료공학과)
  • Published : 1997.06.01

Abstract

pH sensitive polymers have long been utilized as one important type among many interesting drug delivery systems. This is due to the reason of different pH environments in human organs, which requires different pH control mechanism depending upon the organs. In the present study the pH sensitivity was investigated for both pH sensitive and pH insensitive biopolymers using the diffusion effect along with the swelling effect. NMR microscopy was performed along with optical microscopy. For the analysis of diffusion effect, UMR Microscopy was perFormed to measure diffusion coefficients for various liquids such as distilled water, acetone and DMSO(dimethyl sulfoxide). Also, this technique is expected to contribute to the studies for many pH drug delivery systems.

Keywords

References

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