• 한국해양학회지
• /
• v.20 no.2
• /
• pp.1-9
• /
• 1985

A simple analytic model of the sea surface temperature(SST) is developed in order to understand the effects of the Asian monsoon and the Kuroshio on the annual variations of SST by the Asian monsoon is almost in phase with the incoming radiation whereas that by the Kuroshio is out of phase with the incoming radiation. In the Yellow Sea, due to the heat advection by the Asian monsoon, the yearly mean SST is low and the annual range of SST exceeds 20$^{\circ}C$. The annual range of SST in the northwestern Japan Sea is large because of the combined effects of the Asian monsoon and the cold water advection. In the Kuroshio and in the Tsushima Current regions, the annual range of SST is small and the mean SST is high due to the heat advection by warm currents.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.31 no.1
• /
• pp.52-58
• /
• 2017

This study was aimed to examine relaxing effects of Acanthopanacis cortex(AC) through nitric oxide(NO) production and phosphodiesterase type 5(PDE-5) inhibition in corpus cavernosum. In order to define the relaxation effects of AC extract, rabbit corpus cavernous tissues were prepared in $2{\times}2{\times}8mm$ sized strip. AC extract ($0.01-3.0mg/m{\ell}$) were treated in contracted strips induced by phenylephrine(PE) and $N{\omega}$-nitro-L-arginine (L-NNA) was treated before AC extract-treated. And calcium chloride($Ca^{2+}$) 1 mM was infused into precontracted strips after pretreatment of AC extract in $Ca^{2+}-free$ krebs-ringer solution. When AC extract was applied to human umbilical vein endothelial cell(HUVEC), cell viability was measured by MTT assay, and NO concentration was measured by Griess reagent system. Ratio of smooth muscles to collagen fibers and eNOS, PDE-5 positive reaction were measured by histochemical and immunohistochemical process on mice corpus cavernosum. AC extract significantly affected relaxion of the cavernous strips, and the pretreatment of L-NNA inhibited AC extract-induced relaxation. Contraction induced by the addition of $Ca^{2+}$ was inhibited by treatment with the AC extract in $Ca^{2+}-free$ solution. In AC group, NO concentration, ratio of smooth muscle to collagen fibers, and eNOS positive reaction were increased, PDE-5 positive reaction was decreased compared to PE group. As a result of the above experiment, it was thought that AC extract inhibits the inflow of extracellular $Ca^{2+}$ by activating cGMP through the increase of eNOS / NO and the decrease of PDE-5 which inhibits cGMP activity, in the corpus cavernosum.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2009.05a
• /
• pp.179-183
• /
• 2009

본 연구에서는 GCM 기후변화 전망 시나리오를 이용하여 유역단위의 기후변화를 추정하였다. 원시 GCM 시나리오를 지역화 시키기 위해서 인공신경망 모형을 사용하였다. GCM에서 모의되는 강수플럭스, 해면기압, 지표면 근처에서의 일 평균온도, 지표면으로부터 발생하는 잠열플럭스 등과 같은 22개의 변수는 인공신경망의 잠재적 예측인자로 사용되었으며, AWS에서 관측된 강수량과 온도는 예측변수로 사용되었다. 원시 GCM 데이터는 CCCma(Canadian Centre for Climate Modeling and Analysis)에서 제공되는 CGCM3.1/T63 20C3M 시나리오를 사용하였으며, 인공신경망 학습과정에서 사용된 기준시나리오(reference scenario)자료의 기간은 1997년부터 2000년까지의 데이터를 사용하였다. 인공신경망을 학습을 통하여 결정된 각 층사이의 가중치를 이용하여 이산화탄소 배출농도를 가정하여 생성된 CGCM3.1/T63 SRES B1 기후변화시나리오(project scenario)를 인공신경망의 입력값으로 하여 미래의 기온과 강수변화를 전망하였다. 신경망의 학습효과를 높이기 위하여 기온과 강수에 대한 평균 및 누적기간을 각각 일단위와 월단위로 설정하였다. 본 연구에서 사용된 인공신경망은 3층 퍼셉트론(다층 퍼셉트론)을 사용하였으며, 학습방법으로는 역전파알고리즘(back-propagation algorithm)을 이용하였다. 민감도분석을 통하여 선택된 예측인자는 소양강댐유역(1011, 1012소유역)에서의 인공신경망 예측인자로 활용되었으며, 2001년부터 2100년까지의 일 평균온도와 일 강수량의 변화경향을 추정하였다. 1011유역, 1012유역에서는 여름철의 온도변화경향이 겨울철에 비하여 높게 나타났다. 일 평균온도의 통계분석 결과 평균예측오차가 가장 적게 나타나는 지역은 1001유역으로 -0.08로 평균예측오차가 가장 적게 나타났으며, 인공신경망기법을 이용하여 스케일 상세화된 일 평균온도와 관측된 일 평균온도가 얼마나 잘 일치하는지를 확인할 수 있는 1012유역에서 CORR이 0.74로 가장 높게 나타났다.

• The Korea Journal of Herbology
• /
• v.30 no.4
• /
• pp.71-79
• /
• 2015

Objectives : These present study was designed to investigate the relaxation effects of Alpiniae Oxyphyllae Fructus(AOF) on isolated corpus cavernosum smooth muscle.Methods : Rabbit corpus cavernous tissues were prepared in strip. Then relaxation responses of AOF at 0.01-3 ㎎/㎖ in contracted strips induced by phenylephrine(PE) were measured. To evaluate mechanisms, indomethacin(IM) tetraethylammonium chloride(TEA), Nω-nitro-L-arginine(_L-NNA), methylene blue(MB) were treated before AOF extract(0.1-3 ㎎/㎖) infused into precontracted strips induced by PE. And 1 mM Ca²⁺was infused into precontracted strips after pretreatment of AOF extract(3 ㎎/㎖) in Ca²⁺-free krebs-ringer solution. NO concentration was measured by Griess reagent system. Ratio of smooth muscles to collagen fibers and eNOS positive reaction were measured by histocheminal and immunohistochemical process.Results : The cavernous strips were significantly relaxed by AOF extract 0.1, 0.3, 1, 3 ㎎/㎖ and the pretreatment with IM 10 μM,_L-NNA 100 μM, MB 10 μM inhibited relaxation of AOF compared to non-pretreatment, but the pretreatment with TEA 100 μM didn't affect relaxation of AOF. In a Ca²⁺-free solution, pretreatment with AOF reduced increase on contraction of strips by Ca²⁺supply than non-pretreatment. On HUVEC, NO concentration was increased. On corpus cavernosum of penis in Spontaneous Hypertensive Rat, ratio of smooth muscles to collagen fibers and eNOS positive reaction in AOF group were increased compared to PE groupConclusions : Taken this results, we can suggest that AOF extract exerts a relaxation effects on rabbit corpus cavernosum smooth muscle in part by suppressing influx of extracellular Ca²⁺throughout prostacyclin, the NO-cGMP system.

• Journal of the Korean earth science society
• /
• v.21 no.6
• /
• pp.655-662
• /
• 2000

According to the development of internet with Web, WBI has greatly influence on the present educational society. However, it is difficutly to design the web of the dynamic motions of graphics or animation using general programming technique based on high or low level language. Recently, Mecromedia Company supported a tool that is called Authoware which is the leading visual rich-media authoring solution for creating Web and online learning applications, to solve the problem easily. In the paper, using the the Authoware we tried to develop a web page about tidal variations due to sea level change and intertidal zone variations using the Authorware 5.1. To do this, we used the ocean survey data of Iho beach and the tidal level data based on Tidal Tables of Cheju harbor. The results showed that the Authorware was very useful to construct the simulation of tidal phenomena on web. Therefore, the Authorware can be applied to the simulation related with animation and dynamic motions for the other WBI objective.

• Journal of Aquaculture
• /
• v.11 no.3
• /
• pp.401-419
• /
• 1998

The structure of benthic algal flora and feeding behavior of sea urchins (Anthocidaris crassispina and Hemicentrotus pulcherrimus), were investigated from the eight different locations along the coast of Cheju Island, Korea. Biomass distribution and dominance of the algal communities were studied in relation to the gut contents and population parameters of the sea urchins. As a result, although the largest algal biomass and biological characteristics of sea urchins, such as test diameter, test hight, body weight, gonad weight, etc. This inhdicated that sea urchins would not be dependednt sorely on the abundance of algal foods, and they might feed on other food items. In order to know such a trend with regard to food selectivity, the diets consumed by sea urchins were analyzed, and it was found that they were composed of benthic and drifted algae, various animal components (sponges, bryozoans, crustaceans, and various unidentified capsulated eggs, etc.) and biets turned out to be smaller than might be expected, and it is postulated that sea urchins were not likely to be the major grazing animals for the formation of algal bed and also canopy deterioration, so-called "white incrustation."

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.28 no.2
• /
• pp.169-177
• /
• 2014

This study aimed to investigate the relaxation effects and its underlying mechanisms of Epimedium koreanum Nakai(EK) in phenylephrine(PE) treated isolated rabbit corpus cavernosum smooth muscle. The dose-dependent relaxation responses of phenylephrine(PE, $1{\times}10^{-6}M$)-precontracted strips to EK at $0.01-3.0mg/m{\ell}$ were measured and also observed after endothelial denudation using organ bath. To analyze the underlying mechanisms of EK-induced relaxation, $N{\omega}$-nitro-L-arginine(L-NNA), methylene blue(MB), tetraethylammonium chloride(TEA), indomethacin(IM) were pretreated before EK extract infused into precontracted strips induced by PE. To investigate cytotoxic activity and nitric oxide(NO) concentration of EK extract on EA.hy926 cells, mitochondrial dehydrogenase activity(MTT) assay and nitric oxide detection kit were used. The cavernous strips were significantly relaxed by EK extract at $0.3mg/m{\ell}$, $1.0mg/m{\ell}$, $3.0mg/m{\ell}$ and the relaxation responses of PE-precontracted strips denuded endothelium also inhibited in comparison with intact endothelium. The pretreatment of L-NNA, MB, TEA reduced EK extract-induced endothelium-dependent relaxation, but the pretreatment of IM didn't affect EK extract-induced endothelium-dependent relaxation. When EK extract was applicated on EA.hy926 cells, the NO concentration was increased. Our findings have shown that EK extract exerts a relaxing effect on corpus cavernosum in part by suppressing influx of extracellular $Ca^{2+}$ through activating the NO-cGMP system.

• Archives of Plastic Surgery
• /
• v.33 no.4
• /
• pp.413-422
• /
• 2006

Purpose: This study was designed to compare the wound healing effect of silk fibroin, alginate and fibroin/ alginate blend sponge with clinically used Nu gauze in a rat skin defect model. Methods: Two full thickness excisions were made on the back of Sprague-Dawley rat. The excised wound was covered with either of the silk fibroin(SF), alginate (SA), or fibroin/alginate blend sponge(SF/SA). On the postoperative days of 3, 7, 10 and 14, the wound area was calculated by image analysis software. At the same time, a skin wound tissue was biopsied. Results: Healing time 50% ($HT_{50}$) of SF/SA sponge treated group was dramatically reduced as compared with that of control treatment. We also found that the $HT_{50}$ of SF/SA sponge was significantly decreased as compared with either those of SF or SA treatment. Furthermore, SF/SA treatment significantly increased the size of epithelialization and collagen deposition as well as the number of PCNA positive cells on epidermal basement membrane as comapred with those of control treatment. Conclusion: Our results suggest that the wound healing effect of SF/SA blend sponge is the best among other treatments including SF and SA during the whole wound healing period.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.31 no.6
• /
• pp.341-347
• /
• 2017

To investigate the effect of Corni Fructus(CF) water extracts on the relaxation of the corpus cavernosum, organ bath studies, histochemical and immunohistochemical methods were used and obtained the following results. In the organ bath study, the maximal contraction of the corpus cavernosum tissue by PE showed a significant relaxation effect at $3.0mg/m{\ell}$ of CF water extract. When ${\text\tiny{L}}$-NNA was pretreated corpuscular relaxation effect of CF water extract was significantly inhibited compared without ${\text\tiny{L}}$-NNA pretreatment. In $Ca^{2+}$-free solution, the increase of contraction due to $Ca^{2+}$ influx significantly inhibited in the pretreatment compared with no pretreatment of CF water extract. Histochemical and immunohistochemical studies showed that the ratio of smooth muscle to collagen fiber was increased in the CF group compared to the PE group in the corpus cavernosum, and the eNOS positive reaction increased and the PDE5 positive reaction decreased. These results suggest that CF extract has increased NO production through activation of eNOS and inhibited the action of PDE5 to block the extracellular $Ca^{2+}$ influx, thereby relaxing the smooth muscle of the corpus cavernosum.

• The Korea Journal of Herbology
• /
• v.30 no.3
• /
• pp.55-61
• /
• 2015

Objectives : This study aimed to investigate the effects of Shingi-whan(SG) on the male reproductive and sexual function, so we measured the spermatogenesis and the testicular toxicity in mice and the vasorelaxation in isolated rabbit corpus cavernosum smooth muscle. Methods : To evaluate effect on the spermatogenesis in mice, we prepared two groups, control group and SG group that was orally administered SG(1,000mg/kg) for 20 days, and compared. To analyze testicular toxicity in mice, we also prepared two groups, doxo group that was injected with doxorubicin (3mg/kg) on three times and doxo + SG group that was injected with doxorubicin and SG for 20 days, and compared. To investigate sexual function of SG in mice, we prepared three groups, normal group and aging elicited group consisting of 18-month-old mice, SG treated aging group that was orally administered SG for 60 days, and compared using histochemical staining on mice corpus cavernous tissues. In order to define the relaxation effects of SG, rabbit corpus cavernous tissues were prepared in $2{\times}2{\times}6mm$ sized strip. Then the dose-dependent relaxation responses of SG at 0.01-3.0 mg/ml in contracted strips induced by phenylephrine were measured. Results : The sperm density in dutus epididymis and the diameter of seminiferous tubules of SG group was significantly increased when compared to control group. The testicular weight and the diameter and height of epithelial layer of seminiferous tubules of doxo + SG group was significantly increased when compared to doxo group. The cavernous strips were significantly relaxed by SG extract In SG treated aging group, ratio of smooth muscles to collagen fibers and red blood cell count in venous sinus was increased as compared to aging elicited group. Conclusions : Our findings have shown that SG extract have effect on spermatogenesis and mitigating effect on doxo-induced testicular toxicity. Further, it also have the vasorelaxant effect on rabbit corpus cavernosum.