• KIPS Transactions on Software and Data Engineering
• /
• v.3 no.8
• /
• pp.329-334
• /
• 2014

In this study, a new method that automatically segments trabecular bone for its morphological analysis using micro-computed tomography imaging was proposed. In the proposed method, the bone region was extracted using a threshold value, and the outer boundary of the bone was detected. The sphere of maximum size with the corresponding voxel as the center was obtained by applying the sphere-fitting method to each voxel of the bone region. If this sphere includes the outer boundary of the bone, the voxels included in the sphere are classified as cortical bone; otherwise, they are classified as trabecular bone. The proposed method was applied to images of the distal femurs of 15 mice, and comparative experiments, with results manually divided by a person, were performed. Four morphological parameters-BV/TV, Tb.Th, Tb.Sp, and Tb.N-for the segmented trabecular bone were measured. The results were compared by regression analysis and the Bland-Altman method; BV/TV, Tb.Th, Tb.Sp, and Tb.N were all in the credible range. In addition, not only can the sphere-fitting method be simply implemented, but trabecular bone can also be divided precisely by using the three-dimensional information.

• Journal of Korea Multimedia Society
• /
• v.17 no.3
• /
• pp.342-352
• /
• 2014

This paper proposes an automatic segmentation method of cortical bone and trabecular bone and describes an implementation of structural analysis method of trabecular bone in micro-CT images. The proposed segmentation method extract bone region with binarization using a threshold value. Next, it finds adjacent contour lines from outer boundary line into inward direction and sets candidate regions of cortical bone. Next it remove cortical bone region by finding the candidate cortical region of which the average pixel value is maximum. We implemented the method which computes four structural indicators BV/TV, Tb.Th, Tb.Sp, Tb.N by using VTK(Visualization ToolKit) and sphere fitting algorithm. We applied the implemented method to twenty proximal femur of mouses and compared with the manual segmentation method. Experimental result shows that the average error rates between the proposed segmentation method and the manual segmentation method are less than 3% for the four structural indicatiors. This result means that the proposed method can be used instead of the combersome and time consuming manual segmentation method.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2011.06a
• /
• pp.1467-1468
• /
• 2011

• Journal of Radiation Protection and Research
• /
• v.40 no.1
• /
• pp.10-16
• /
• 2015

Bone changes are common sequela of irradiation in growing animal. The purpose of this study was to establish an experimental model of radiation-induced bone loss in growing mice using micro-computed tomography (${\mu}CT$). The extent of changes following 2 Gy gamma irradiation ($2Gy{\cdot}min^{-1}$) was studied at 4, 8 or 12 weeks after exposure. Mice that received 0.5, 1.0, 2.0 or 4.0 Gy of gamma-rays were examined 8 weeks after irradiation. Tibiae were analyzed using ${\mu}CT$. Serum alkaline phosphatase (ALP) and biomechanical properties were measured and the osteoclast surface was examined. A significant loss of trabecular bone in tibiae was evident 8 weeks after exposure. Measurements performed after irradiation showed a dose-related decrease in trabecular bone volume fraction (BV/TV) and bone mineral density (BMD), respectively. The best-fitting dose-response curves were linear-quadratic. Taking the controls into accounts, the lines of best fit were as follows: BV/TV (%) = $0.9584D^2-6.0168D+20.377$ ($r^2$ = 0.946, D = dose in Gy) and BMD ($mg{\cdot}cm^{-3}$) = $8.8115D^2-56.197D+194.41$ ($r^2$ = 0.999, D = dose in Gy). Body weight did not differ among the groups. No dose-dependent differences were apparent among the groups with regard to mechanical and anatomical properties of tibia, serum ALP and osteoclast activity. The findings provide the basis required for better understanding of the results that will be obtained in any further studies of radiation-induced bone responses.

• Journal of Veterinary Clinics
• /
• v.29 no.3
• /
• pp.259-262
• /
• 2012

A seven-year-old Yorkshire terrier 2.1 kg was admitted with a 2 months history of sever bilateral forelimb lameness and joint instability. Examination and radiographs revealed caudal luxation of bilateral antebrachiocarpal joint. Luxation of bilateral antebrachiocarpal (ABC) joint in a toy breed dog was treated with pancarpal arthrodesis. Modified external skeletal fixator (ESF) (type IIb) with polymethylmethacrylate (PMMA) was utilized in this case. Porcine cancellous bone graft (PCBG) was inserted to fill the joint space in carpus. The clinical and radiographic assessments of joint after the surgical procedure proved that PCBG can be used a promising alternative to Autogenous cancellous bone graft (ACBG).

• Proceedings of the Korean Operations and Management Science Society Conference
• /
• 2005.05a
• /
• pp.862-865
• /
• 2005

해면골에 대한 평가는 일반적으로 골밀도를 기준으로 평가하지만, 골밀도는 뼈의 특성을 70-80% 정도만 설명하는 것으로 알려져 있다. 이에 따라 골밀도로 설명이 되지 않는 나머지 특성을 뼈 미세구조의 형태학적 특성을 이용하여 설명하려는 노력이 생체역학 분야에서 오랫동안 있어 왔다. 본 연구는 CAD/CAM 분야의 feature extraction 기술을 이러한 생체역학 분야에 접목함으로써 뼈의 미세구조 평가를 위한 새로운 형태학적 지수 개발의 가능성을 탐색하고자 한다.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2013.05a
• /
• pp.1425-1426
• /
• 2013

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2009.06a
• /
• pp.967-968
• /
• 2009

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2007.06a
• /
• pp.703-704
• /
• 2007

• Journal of the Korean Society for Precision Engineering
• /
• v.26 no.6
• /
• pp.131-135
• /
• 2009

In this study, we performed the compressive strength test of trabecular bone in knee joint for measuring the elastic modulus and ultimate strength. The main knee joint is femorotibial articulation between the lateral and medial femorotibial condyle. In the case of osteoarthritis, some patients have only medial condylar osteoarthritis. We performed the mechanical test for comparison the difference of the each condylar strength. We used diamond core-drill and linear precision saw for making the specimens. Specimens were cored from both condyle in distal femur and proximal tibia in fresh cadaver (male 10, female 12), and tested by universal test machine with temperature control saline circulation system. Results of the test in distal femoral parts, averaged elastic modulus was $360.61{\pm}159.40MPa$ for male, $150.89{\pm}70.65MPa$ for female. Averaged ultimate strength was $6.79{\pm}2.91MPa$ for male, $2.89{\pm}1.31MPa$ for female. Male was 2.4 times stronger than female. In the proximal tibial parts, averaged elastic modulus was $108.80{\pm}52.88MPa$ for male, $73.45{\pm}55.06MPa$ for female. Averaged ultimate strength was $2.59{\pm}1.39MPa$ for male, $1.75{\pm}1.16MPa$ for female. Male was 1.5 times stronger than female. In the distal femoral condyle, medial condyle had more strength than lateral condyle at middle region. But lateral condyle had more strength than medial condyle at anterior & posterior regions (p<0.02). In the proximal tibial condyle, medial condyle had more strength than lateral condyle. (p<0.01).