• The Journal of Internal Korean Medicine
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• v.42 no.2
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• pp.104-113
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• 2021

Introduction: The aim of this study is to report on the effectiveness of Korean medicine to improve symptoms of chemotherapy-induced peripheral neuropathy (CIPN). Some patients are treated with medication, but medications may have no effect in some patients. Korean medicine treatments have been used in such patients, but few reports exist. Case Presentation: A 58-year-old female patient with CIPN reported symptoms of bilateral limb pain and tingling sensations as well as cold sensations in bilateral lower legs and hands, fatigue, and bilateral limb weakness. To reduce the patient's symptoms, we provided Korean medical treatment, including herbal medicine (Uchashinki-hwan), acupuncture, and moxibation. To evaluate the results of this treatment, we used a numeric rating scale (NRS), the manual muscle test (MMT), the National Cancer Institute Common Toxicity Criteria for Adverse Events (CTCAE), and the European Organization for Research and Treatment of Cancer quality-of-life questionnaire about CIPN (EORTC-QLQ-CIPN20). After 49 days of treatment, the NRS scores decreased for bilateral limb pain and tingling, for bilateral lower leg and hand cold sensation, and for fatigue. The MMT results for the upper and lower extremities were improved. CTCAE Grade and EORTC QLQ-CIPN20 score were also decreased. Conclusion: According to these results, Korean medicine treatment may be considered an effective treatment for CIPN. Prospective studies are needed in the future to confirm and expand these findings.

• Journal of East-West Nursing Research
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• v.27 no.1
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• pp.43-50
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• 2021

Purpose: The purpose of this study was to identify the influence of depression, optimism and posttraumatic growth on health-related quality of life in female breast cancer survivors received adjuvant chemotherapy. Methods: In total, 115 female breast cancer survivors participated in this descriptive correlational study. The participants answered self-report questionnaires. Data were collected from 1 June 2020 to 10 June 2020, and were analyzed using descriptive statistics, the t-test, one-way ANOVA, Pearson correlation coefficients, and stepwise multiple regression with SPSS for Windows ver. 24.0. Results: The mean age of the breast cancer survivors was 45.83 years. The mean score for the degree of health-related quality of life was 81.85 out of 148 points. Participants' scores for health-related quality of life differed significantly based on economic status (F=5.36 p=.006) and hobbies (t=-3.37, p=.001). Health-related quality of life was negatively correlated with depression (r=-.73, p<.001), and positively correlated with optimism (r=.65, p<.001) and posttraumatic growth (r=.28, p=.002). Depression (𝛽=-.55, p<.001) was the most significant factor that affects health-related quality of life, followed by optimism (𝛽=.29, p<.001), and post-traumatic growth (𝛽=.12, p=.048), which together accounted for 62.2% (F=63.61, p<.001) of the variance. Conclusion: It is necessary to develop educational programs for breast cancer survivors to reduce depression, increase optimism and post-traumatic growth, and improve the health-related quality of life. By adapting these programs, positiveness may increase and this may lead to improvement of health-related quality of life for breast cancer survivors.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.05a
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• pp.279-282
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• 2022

Acute lymphoblastic leukemia is an acute leukemia caused by suppression of bone marrow function due to overgrowth of immature lymphocytes in the bone marrow. It accounts for 30% of acute leukemia in adults, and children show a cure rate of over 80% with chemotherapy, while adults show a low survival rate of 20% to 50%. However, research on a machine learning algorithm based on medical image data for the diagnosis of acute lymphoblastic leukemia is in the initial stage. In this paper, we compare and analyze CNN algorithm models for quick and accurate diagnosis. Using four models, an experimental environment for comparative analysis of acute lymphoblastic leukemia diagnostic models was established, and the algorithm with the best accuracy was selected for the given medical image data. According to the experimental results, among the four CNN models, the InceptionV3 model showed the best performance with an accuracy of 98.9%.

• The Journal of Internal Korean Medicine
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• v.44 no.3
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• pp.594-601
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• 2023

Objective: To demonstrate an improvement in metastatic cancer pain and a decrease in tumor size in a patient with non-small cell lung cancer. Method: A 53-year-old female patient diagnosed with metastatic non-small cell lung cancer in August 2022 underwent integrative cancer treatment (ICT) for two months to decrease the tumor size and improve back pain from bone metastasis. The patient underwent chemotherapy with ICT. Radiologic outcomes were assessed by chest, abdomen, and pelvis computed tomography based on the Response Evaluation Criteria in Solid Tumors (RECIST) protocol. Clinical outcomes were assessed using National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), Eastern Cooperative Oncology Group (ECOG), and a numeric rating scale (NRS). Result: During the two months of treatment, the NRS scores for back pain were improved, and the ECOG score improved from grade 2 to 1. The size and metabolic activity of the primary lung tumor decreased and underwent partial remission based on RECIST. No serious side effects of grade 3 or higher were noted on the NCI-CTCAE test. Conclusion: This case suggests that ICT may have a therapeutic effect for cancer pain and a synergetic effect with chemotherapy for metastatic non-small cell lung cancer.

• Journal of Korean Traditional Oncology
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• v.28 no.1
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• pp.11-24
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• 2023

Objectives: To report the improvement of chemotherapy-induced peripheral neuropathy and pantalgia with integrative cancer treatment on adverse effects of chemotherapy in a breast cancer patient. Methods: A 63-year-old female patient who has been diagnosed with breast cancer got treated for 103 days with integrative cancer treatment including acupuncture, moxibustion, herbal medicine, physiotherapies, hand and foot bath to decrease side effects of chemotherapy. The patient was also treated Western immunotherapies like Thymosin, Viscum album. Paclitaxel, Carboplatin, Doxorubicin, Cyclophosphamide was applied and chemotherapy-induced peripheral neuropathy(CIPN), pantalgia and nausea occured. The efficacy of treatment was measured by a numeric rating scale(NRS) of symptoms, National Cancer Institute Common Terminology Criteria for Adverse Event(NCI-CTCAE) and Eastern Cooperative Oncology Group(ECOG) Performance Status Scale. Results: The NRS scroes for CIPN, pantalgia, nausea were improved. There was no adverse effects of 3 or higher assessed by the NCI-CTCAE. The ECOG grade improved from grade 2 to 1. Conclusions: This study suggests that integrative cancer treatment could improve CIPN, pantalgia after chemotherapy in breast cancer.

• The Journal of Internal Korean Medicine
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• v.44 no.5
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• pp.1092-1100
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• 2023

Introduction: We present a case of multiple myeloma with amyloidosis, which has features of peripheral neuropathy after induction chemotherapy before autologous peripheral blood stem cell transplantation, in a 56-year-old woman with Korean medicine. Case Presentation: For 17 days of hospitalization, the patient with complaints of numbness and a tingling sensation in the hands and feet was treated with acupuncture, herbal medicine. To reduce the symptoms, we provided Korean medicine treatments, including herbal medicine, acupuncture, and moxibustion. The Visual Analog Scale (VAS) was used to evaluate the results of the treatment. Until discharge, the VAS scores decreased for both hands and the foot tingling sensation. Conclusion: According to these results, Korean medicine treatment may be considered an effective treatment for tingling sensations in a patient with multiple myeloma with amyloidosis. Prospective studies are needed in the future to confirm and expand these findings.

• Journal of the Korean Society of Radiology
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• v.82 no.2
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• pp.429-434
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• 2021

Amyloidosis is a multisystemic disease characterized by the accumulation of abnormal proteins in extracellular spaces in various organs, with frequent involvement of the myocardium. We report a case of a patient who had cardiac amyloidosis with a trend of reduction in native T1 and T2 values and extracellular volume fraction on serial cardiac magnetic resonance imaging after chemotherapy and stem cell transplantation. The native T1 value and the extracellular volume fraction are closely associated with tissue amyloid burden in amyloidosis patients. This case demonstrated that cardiac magnetic resonance imaging may be used as a non-invasive and quantitative biomarker in the treatment monitoring of amyloidosis.

• The Journal of Internal Korean Medicine
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• v.45 no.3
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• pp.358-380
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• 2024

Objectives: This study was performed to research Korean medical treatment methods for chemotherapy-induced peripheral neuropathy by summarizing domestic studies. Methods: All domestic research papers on the Korean medical treatment of chemotherapy-induced peripheral neuropathy were selected from the literature published until April 2024 in four domestic databases. In total, 26 domestic papers were selected. Results: Eighteen clinical studies and eight experimental studies were published by April 2024. Most of the studied patients were in their fifties, and 93.4% of the subjects were women. Uchashinki-hwan (牛車腎氣丸) was the most frequently prescribed herbal formula, and Rehmanniae Radix Preparata was the most commonly used herb. All studies showed significant effects of Korean medical treatment, and any adverse events were not reported. Conclusion: This study included all domestic research papers on chemotherapy-induced peripheral neuropathy to identify research trends in the Korean medicine community. Based on this, it is meaningful to confirm areas that need to be supplemented in future research plans. However, large-scale studies are needed.

• Journal of Korean Clinical Nursing Research
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• v.30 no.2
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• pp.147-156
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• 2024

Purpose: The purpose of this study is to confirm the effect of resilience, family support, and spiritual well-being on posttraumatic growth(PTG) in lung cancer patients undergoing chemotherapy. Methods: The study collected data from January 20 to July 6, 2023 on 124 lung cancer patients who were admitted to hospital of C university in Seoul and received chemotherapy treatment. Patients were asked to complete a questionnaire consisting of general characteristics, disease characteristics, resilience, family support, spiritual well-being and PTG. Data were analyzed using t-tests, One-way ANOVA, Pearson's correlation and multiple regression analysis. Results: The mean score for PTG in lung cancer patients was 55.17, resilience was 72.46, family support was 49.00, and spiritual well-being was 53.50. Significant positive correlations were found for PTG with resilience (r=.62, p<.001), family support (r=.40, p<.001) and spiritual well-being (r=.47, p<.001). Factors contributing to PTG of lung cancer patients were resilience (β=.50, p<.001), spiritual well-being (β=.20, p=.008), and gender (β =.14, p=.043). Conclusion: This study aims to provide basic data for the PTG intervention program by identifying factors affecting the PTG of lung cancer patients. It is necessary to develop new nursing intervention programs to improve PTG for patients with lung cancer based on strategies to enhance resilience and spiritual well-being.

• Journal of the Health Care and Life Science
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• v.11 no.2
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• pp.441-448
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• 2023

The aim of this study was to examine the factors that affect the oral health knowledge, oral health performance and oral health quality of life of caner patients. A self-reported questionnaire was surveyed by 102 cancer patients in G area. The data were analyzed for frequency analysis, average, standard deviation, independent t-test, one-way ANOVA, pearson's correlation coefficient by using SPSS 21.0 program. The oral health knowledge were higher significantly having religion and in case of college graduation or higher monthly income(p<0.01). The oral health performance were higher significantly when married, higher monthly income. Multiple regression analysis showed significant differences in oral health knowledge and religion(p<0.05).