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http://dx.doi.org/10.22246/jikm.2021.42.2.104

Case Report of Chemotherapy-Induced Peripheral Neuropathy Treated with Korean Medicine  

Shin, Hyeryung (Dept. of Korean Internal Medicine, Wonkwang University Gwangju Medical Center)
Seo, Wookcheol (Dept. of Acupuncture & Moxibustion Medicine, Wonkwang University Gwangju Medical Center)
An, Sung-Hu (Dept. of Korean Rehabilitation Medicine, Wonkwang University Gwangju Medical Center)
Won, Jin-hee (Dept. of Korean Internal Medicine, Wonkwang University Gwangju Medical Center)
Song, Bong-keun (Dept. of Korean Internal Medicine, Wonkwang University Gwangju Medical Center)
Publication Information
The Journal of Internal Korean Medicine / v.42, no.2, 2021 , pp. 104-113 More about this Journal
Abstract
Introduction: The aim of this study is to report on the effectiveness of Korean medicine to improve symptoms of chemotherapy-induced peripheral neuropathy (CIPN). Some patients are treated with medication, but medications may have no effect in some patients. Korean medicine treatments have been used in such patients, but few reports exist. Case Presentation: A 58-year-old female patient with CIPN reported symptoms of bilateral limb pain and tingling sensations as well as cold sensations in bilateral lower legs and hands, fatigue, and bilateral limb weakness. To reduce the patient's symptoms, we provided Korean medical treatment, including herbal medicine (Uchashinki-hwan), acupuncture, and moxibation. To evaluate the results of this treatment, we used a numeric rating scale (NRS), the manual muscle test (MMT), the National Cancer Institute Common Toxicity Criteria for Adverse Events (CTCAE), and the European Organization for Research and Treatment of Cancer quality-of-life questionnaire about CIPN (EORTC-QLQ-CIPN20). After 49 days of treatment, the NRS scores decreased for bilateral limb pain and tingling, for bilateral lower leg and hand cold sensation, and for fatigue. The MMT results for the upper and lower extremities were improved. CTCAE Grade and EORTC QLQ-CIPN20 score were also decreased. Conclusion: According to these results, Korean medicine treatment may be considered an effective treatment for CIPN. Prospective studies are needed in the future to confirm and expand these findings.
Keywords
case report; chemotherapy induced peripheral neuropathy; Uchashinki-hwan; Korean traditional; herbal medicine;
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1 Zajaczkowska R, Kocot-Kepska M, Leppert W, Wrzosek A, Mika J, Wordliczek J. Mechanisms of chemotherapy-induced peripheral neuropathy. International journal of molecular sciences 2019;20(6):1451.   DOI
2 Hu LY, Mi WL, Wu GC, Wang YQ, Mao-Ying QL. Prevention and Treatment for Chemotherapy -Induced Peripheral Neuropathy: Therapies Based on CIPN Mechanisms. Curr Neuropharmacol 2019;17(2):184-96.   DOI
3 Nationwide College of Korean Medicine Faculty Council of Cardiology Internal Medicine. Cardiovascular and Neurological Medicine in Korean Medicine I. Seoul: Woori pub; 2016, p. 273-82.
4 National Cancer Institute. Common terminology criteria for adverse events (CTCAE). https://evs.nci.nih.gov/ftp1/CTCAE/About.html
5 Postma TJ, Aaronson NK, Heimans JJ, Muller MJ, Hildebrand JG, Delattre JY, et al. The development of an EORTC quality of life questionnaire to assess chemotherapy-induced peripheral neuropathy: the QLQ-CIPN20. European journal of cancer 2005;41(8):1135-9.   DOI
6 Back SY, Park BB, Park DW, Kim JH, Jung KH, Kim HY, et al. A case of vincristine-induced polyneuropathy in an patient with acute leukemia. The Korean Journal of Medicine 2009;76(5):611-6.
7 Park JH, Jung IC, Lee SH, Lee JS, Bae KR, Cho CK, et al. Preliminary Study to Develop an Instrument for Pattern Identification and Evaluation for Chemotherapy-induced Peripheral Neuropathy (CIPN). The Journal of Internal Korean Medicine 2016;37(1):77-89.
8 Kono T, Mamiya N, Chisato N, Ebisawa Y, Yamazaki H, Watari J, et al. Efficacy of goshajinkigan for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancer. Evidence-based complementary and alternative medicine 2011;2011:418481.   DOI
9 Kaku H, Kumagai S, Onoue H, Takada A, Shoji T, Miura F, et al. Objective evaluation of the alleviating effects of Goshajinkigan on peripheral neuropathy induced by paclitaxel/carboplatin therapy:A multicenter collaborative study. Experimental and therapeutic medicine 2012;3(1):60-5.   DOI
10 Park JH, Lee JS, Cho CK, Yoo HS. Electroacupuncture for the Treatment of the Chemotherapy-induced Peripheral Neuropathy in Breast Cancer Patient: A Case Report. Journal of Korean Traditional Oncology 2015;20(1):1-9.   DOI
11 Yun YG. The Oriental medicine herbal formula and prescription explanation. Seoul: Euiseongdang; 2007, p. 515-6, 559.
12 Ju YS. Ungok herbology Jeonju: Woosuk Press: 2013, p. 482, 708, 714, 727, 767, 779, 979, 1309, 1406.
13 Ozturk G, Anlar O, Erdogan E, Kosem M, Ozbek H, Turker A. The effect of Ginkgo extract EGb761 in cisplatin-induced peripheral neuropathy in mice. Toxicology and applied pharmacology 2004;196(1):169-75.   DOI
14 Lee JH, Park HL, Lee HY, Cho MK, Hong MN, Han CW, et al. Case Report of Chemotherapy Induced Peripheral Neuropathy Treated with Korean Medicine. Korean J Oriental Physiology & Pathology 2014;28(5):565-70.
15 Abad ANA, Nouri MK, Gharjanie A, Tavakoli F. Effect of Matricaria chamomilla hydroalcoholic extract on Cisplatin-induced neuropathy in mice. Chinese Journal of Natural Medicine 2011;9(2):126-31.   DOI
16 Muthuraman A, Singh N. Attenuating effect of hydroalcoholic extract of Acorus calamus in vincristine-induced painful neuropathy in rats. Journal of natural medicines 2011;65(3):480-7.   DOI
17 Lee SA, Kim MH, Jang MW, Jo WK, Kwon YJ, Choi DJ, et al. A case of Chemotherapy-induced Peripheral Neuropathy Treated with Bogijetongtanggami-bang. The Journal of Internal Korean Medicine 2012;33(6):118-25.
18 Bao T, Zhang R, Badros A, Lao L. Acupuncture treatment for bortezomib-induced peripheral neuropathy: a case report. Pain research and treatment 2011;2011:920807.   DOI