• Journal of the korean veterinary medical association
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• v.44 no.5
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• pp.466-477
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• 2008

• The Korea Swine Journal
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• v.29 no.11 s.339
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• pp.209-211
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• 2007

• Proceedings of the Korean Society for Food Science of Animal Resources Conference
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• 2002.05a
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• pp.154-154
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• 2002

• KOREAN POULTRY JOURNAL
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• v.28 no.9 s.323
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• pp.144-151
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• 1996

밀과 같은 곡류를 기본으로 하는 사료내에 질란아제(Xylanase)효소의 첨가는 사료효율을 향상시킨다. 어떤 종류의 성장촉진제와 질란아제 효소와의 결합된 첨가는 실행에 있어서 누가적(累加的)인 효과를 보여주는 실험이 증명됐다.

• Monthly Korean Chicken
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• v.15 no.3
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• pp.77-79
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• 2009

• The Microorganisms and Industry
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• v.18 no.3
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• pp.75-80
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• 1992

본 논문에서는 항생제의 생합성 및 내성 유전자에 대한 연구가 산업적으로 이용될 수 있는 길을 제시하기 위하여 첫째로는 이들 유전자를 이용하여 기존 항생제의 생산성을 높일 수 있는 방법과 둘째로는 항생제 생합성 유전자들을 이용한 새로운 물질의 창출에 대한 연구를 중심으로 살펴보고자 한다.

• The Korean Journal of Food And Nutrition
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• v.11 no.3
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• pp.347-353
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• 1998

An antibiotic for methicillin resistant Staphylococcus aureus(MRSA) produced by Streptomyces lydicus YSK-681 was extracted by chloroform, and then purified by the C18 reversed-phase HPLC and silica gel column HPLC. The molecular weight of the purified antibiotic was determined from the FAB analysis MS an m/z 1022.4 and 1036.4(M+H)+, indicating that the isolated antibiotic consisted of two similar compounds with the molecular weight difference of 14 m/z value. With the aid of the various nuclear magnetic resonance(NMR) spectroscopic techniques such as 1H NMR, 13C NMR, DEPT and HMQC spectroscopy, the characteristics of function al groups were deduced as the hydroxyl group and leucine. The MIC values of the purified antibiotic were observed at 1∼32 $\mu\textrm{g}$/$m\ell$ against Gram-positive bacteria compared to > 125 $\mu\textrm{g}$/$m\ell$ against Gram-negative bacteria or fungi. The antibiotic was active at 8 $\mu\textrm{g}$/$m\ell$ of MIC90 and S180 at the concentration of 500 $\mu\textrm{g}$/$m\ell$.

• The Korean Journal of Mycology
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• v.12 no.3
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• pp.85-92
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• 1984

To isolate antibiotic-producing microorganisms from Korean soils, microbes were isolated from the soil samples and screened for antibacterial activity. A strain which was isolated from the soil sample collected in Choong Chung Book Do had a high antibacterial activity against gram-positive bacteria. The examination of morphological and physiological characteristics of that strain according to the International Streptomyces Project methods showed that it was one of Streptomyces species. After the antibacterial constituent of the strain was produced in submerged culture method, it was isolated and purified by XAD-2 and CM-Sephadex column chromatography. And it was found to be one of quinone type antibiotics.

• Microbiology and Biotechnology Letters
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• v.21 no.1
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• pp.41-46
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• 1993

A strain showing antibiotic activities against various bacteria and fungi was selected from approximately 2,000 microorganisms obtained from soil samples. This strain, designated as KH-431, was identified as a Clostridium sp. by its morphological, physiological and biochemical characteristics. The highest production of the antibiotics was achieved in a fermentation medium containing sorbitol, yeast extract, d-biotin and $CaCl_2$ The antibiotics were isolated from the culture broth by solvent extraction using ethyl acetate, silica gel column chromatography and recrystallization. Two kinds of antibiotics, KG-431A and KG-431B were obtained after the purification procedure, and only KG-431B was successful to recrystallize.

• Applied Biological Chemistry
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• v.40 no.1
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• pp.23-29
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• 1997

To develop novel cephem antibiotics, We have synthesized a new compound, named YH-487, by attaching the thiol and aminothiazole residue to $C_3$ and $C_7$ position of 7-ACA, respectively. Several characteristics such as structure, antibiotic spectrum, action mechanism, stability against ${\beta}-lactamase$ and synergistic effect were investigated. Anti-bactericidal activity of YH-487 against gram-positive and gram-negative bacteria were superior to that of the other cephem antibiotics. We have examined the action mechanisms of YH-487 using penicillin binding protein (PBP) assay, and found that the bactericidal activity was obtained by inhibiting PBP-1A, PBP-1B and PBP-3. YH-487 showed synergistic effect with gentamicin, tobramycin, and amikacin against Pseudomonas aeruginosa. In addition, YH-487 was effective against Enterobacter cloacae in combination with amikacin. Based on the above observations, YH-487 was classified as a novel third-generation ${\beta}-lactam$ antibiotics.