• 한국작물학회지
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• 제23권2호
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• pp.133-140
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• 1978

현재 농민들에 의해 전국적으로 재배되고 있는 재래종 옥수수를 가지고 양질 다수성인 옥수수 품종육성을 위한 육종재료로 이용하기에 앞서 전국의 109영군에서 수집된 907재 옥수수 이삭의 입에 대한 형태를 조사하고 또 이들 형태가 재배규모(재배면적과 103당 생산량)와는 어떤 연관성이 있는가를 알기 위해 조사분석하였던 바 그 결과를 요약하면 다음과 같다. 1. 옥수수의 재배규모에 따라 우리나라의 옥수수 재배는 강원도와 기타지역으로 이대 구분되며 강원도의 옥수수 재배면적은 전면적의 평균 27％인데 반하여 기타 지역은 5％ 미만에 지나지 않았다. 2. 재배면적률이 높은 지역과 낮은 지역에서의 10a당 생산량, 이삭의 무게, 이삭당 입중, 이삭의 크기 입의 연질성과 비중에 있어서 뚜렷한 차이가 있었다. 즉 옥수수가 많이 재배되는 곳에서의 이들 특성은 옥수수 재배면적률이 낮은 곳에서의 그것들 보다 훨씬 높은 수치를 가졌다. 3. 옥수수가 많이 재배되는 곳에서 조사한 특성들의 수치가 높았다는 것은 농민들의 재배기술이 보다 발달하였다기 보다는 옥수수를 보다 많이 재배함으로서 옥수수의 자식을 막고 가능한 한의 방임수분의 기회를 많이 주었기 때문이라 생각된다. 4. 조사한 특성들의 균일도에 있어서도 최소치와 최대치간에 차이가 컸고 특히 현재 장여되고 있는 황색 마치종에 비하여 균일도 뿐만 아니라 절대치에 있어서도 과반에 미치지 않았다. 5. 다만 입의 연질성에 있어서는 재래종들이 일반적으로 경질성이었는데 반하여 외래종은 연질성이라 할 수 있었다. 6. 입의 비중이 있어서는 재래종과 도입마치종이 비슷하였다. 7. 옥수수입의 크기에 있어서는 강원도지역의 옥수수는 다른 지역에서의 그것보다 평균 이배 가량 켰다. 8. 조사한 특성상호간의 관계를 지역적으로 나누어 본 결과 옥수수 재배면적과 10a당 수량은 옥수수가 많이 재배되는 곳에서는 r=0.85로 높았으나 옥수수의 재배가 그리 많지 않았던 지역에서는 이 두 변이간에 상관계수가 0.5이하였다. 이와 같은 경향은 특성들의 옥수수 재배면적에 대한 상대적 기여도에서도 확인되었다. 9. 10a당 수량과 이삭의 무게에 있어서 옥수수 재배가 많은 곳(강원도)에서는 낮은 상관을 보였으나 재배가 낮은 곳(E지역)에서는 r=0.7로 높았다. 상대적 기여도에 의해서도 동일한 결과를 얻었다. 10. 기타 입의 크기는 다른 모든 특성과 높은 정의 상관을 보였다. 11. 입의 크기가 재배면적이나 10a당 생산량에 미치는 상대적 기여도도 다른 특성에 비해서 훨씬 컸고 지역에 따라 정도에 차이가 있었다.

• 대한한방종양학회지
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• 제8권1호
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• pp.23-35
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• 2002

This study was carried out to investigate the oral toxicity of HAD in mice. The results were summarized as follows: 1. HAD did not induced any toxicological effect in the body weight changes of mice. 2. HAD(2.5g/kg, 0.25g/kg) treated group were increased as compared with control group in the hematological values of mice. 3. ALT, AST, BUN, creatinine, CPK were not increased in HAD(2.5g/kg, 0.25g/kg) treated group as compared with control group in the serological values of mice. 4. Brain, Heart, Liver, Spleen, Kidney's weight were not increased in HAD(2.5g/kg, 0.25g/kg) treated group as compared with control group in the organ's weight of mice. 5. HAD(2.5g/kg, 0.25g/kg) treated group did not induced any toxicological effect in the gross findings in mice's any organs. 6. HAD(10g/kg , 5g/kg, 2.5g/kg, 1.25g/kg) treated group did not induced any toxicological effect in the histopathological findings in mice's any organs. 7. HAD(2.5g/ kg, 0.25g/ kg) treated group did not induced any toxicological effect in the histopathological findings in mice's any organs. From above results, HAD has not toxicological effects to mice.

• 대한한방종양학회지
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• 제8권1호
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• pp.103-125
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• 2002

This experimental study was carried out to evaluate the anti-tumor and the immunomodulatory effects of Jiaweicitaowan(加未慈桃丸) against cancer. The in vitro anti-tumor effects were evaluated by MTT assay. The cytotoxicity, extension of survival days, the effect of inhibition solid tumor which was induced sarcoma 180, and the changes of body weight were evaluated for in vivo effects of anti-tumor. To evaluate the immunomodulatory effects of Jiawei- citaowan(加未慈桃丸), delayed type hypersensitivity, hemagglutinin, hemolysin titers for humoral immune response, rosette forming cells for cell-mediated immune response, natural killer cell activity, proliferation of lymphocyte, productivty of Interleukin-2, and carbon clearance were measured with methotrexate treated mice. The results were as follows; 1. In the case of existence ability of tumor cell, IC50 had an anti-tumor ativity resulted 2.52mg/ml to SNU-C4. 0.41mg/ml to SNU-396, resulted to 0.09mg/mlSNU-1. 2. The groups of Jiaweicitaowan(加未慈桃丸) 10mg/ml, 20mg/kg had no body weight loss. reduction in intake of water and feed, so these had no toxicity. 3. In the case of the effect of extention of existence. the group of 20mg/kg Jiaweicitaowan(加未慈桃丸) extract treated group was showed 250% in ILS. 4. The effect of inhibition solid tumor was significantly decreased in both 10mg/kg, 20mg/kg of Jiaweicitaowan(加未慈桃丸) extract treated groups as compared with control group S. The groups of 10mg/kg, 20mg/kg Jiaweicitaowan(加未慈桃丸) had significant effect of body weight change compared to control group. 6. Delayed type hypersensitivity was not significant in both Jiaweicitaowan(加未慈桃丸) extract treated groups as compared with control group. 7. Hemagglutinin and Hemolysin titers were significantly increased by dose-dependent. so these results showed that the humoral immume respose was activated. 8. For the effect of rosette formimg cells was not significant in hoth Jiaweicitaowan(加未慈桃丸) extract treated groups as compared with control group. 9. Natural killer cell activity was significantly increased in both Jiaweicitaowan(加未慈桃丸) extract treated groups as compared with control group in the ratio of 100: 1, 50: 1 of effector and target cells, but in the ratio of 10:1, the Jiaweicitaowan(加未慈桃丸) extract treated groups were not significant. 10. The proliferation of lymphocyte and productivty of Interleukin-2 were significantly increased by dose-dependent in both 10mg/ kg, 20mg/ kg of Jiaweicitaowan(加未慈桃丸) extract treated groups as compared with control group. 11. In the phagocytic effect, the 20mg/kg of Jiaweicitaowan(加未慈桃丸) extract treated group showed the increasing effect with significance as compared with control group. According to the results, we can suggest that Jiaweicitaowan(加未慈桃丸) has the antitumor and the immunomodulatory effects.

• 한방안이비인후피부과학회지
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• 제33권1호
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• pp.12-24
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• 2020

Objectives : The purpose of this study is to find an effective clerkship process for the implementation of participatory clinical practice that is practically applicable to most Colleges of Korean Medicine. Methods : Taking the 4th-grade students of the College of Korean Medicine, Kyung Hee University in 2019 as a subject, we conducted Role-playing and simulated CPX in the department of Ophthalmology, Otolaryngology and Dermatology and conducted a satisfaction survey through a questionnaire. Results : 1. The preliminary expectations for overall practice and Ophthalmology, Otolaryngology and Dermatology practice did not differ significantly. 2. The satisfaction, data adequacy, feedback adequacy, and usefulness of Ophthalmology, Otolaryngology and Dermatology course were 79.4%, 80.8%, 87.6%, and 86.5%, respectively. 3. When comparing the Role-playing of Ophthalmology, Otolaryngology with mock CPX of Dermatology, data relevance level was similar, feedback adequacy level was higher in mock CPX, satisfaction and usefulness level were higher in Role-playing. Conclusion : Comparing Role-playing with the simulated CPX method, Role-playing is a relatively realistic form than the CPX method, and moreover students showed higher satisfaction and usefulness in Role-playing.

• 사상체질의학회지
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• 제8권1호
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• pp.337-347
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• 1996

동의대학교 한의과대학 부속한방병원에 내원한 76명을 대상으로 체질진단분류와 질병 및 증상유형과의 관계를 문진표 (19개 항목 123문항)를 중심으로 비교 분석하여 다음과 같은 결론을 얻었다. 1. 체중감소증상은 체질에 따라 유의한 차이가 있었고 태음인이 소양인이나 소음인에 비하여 더욱 빈발하였다. 2. 구토증상은 체질에 따라 유의한 차이가 있었고 태음인이 소양인이나 소음인에 비하여 더욱 빈발하였다. 3. 목이 쉬는 증상은 체질에 따라 유의한 차이가 있었고 소음인이 소양인이나 태음인에 비하여 더욱 빈발하였다. 4. 호흡곤란 증상은 체질에 따라 유의한 차이가 있었고 태음인이 소양인이나 소음인에 비하여 더욱 빈발하였다. 5. 관절통 증상은 체질에 따라 유의한 차이가 있었고 소양인이 소음인이나 태음인에 비하여 더욱 빈발하였다. 6. 생리통증상은 체질에 따라 유의한 차이가 있었고 소음인이 소양인이나 태음인에 비하여 더욱 빈발하였다. 7. 과거력은 체질에 따라 유의한 차이가 없었으며 다만 과거력은 나이에 따라 일부 유의한 차이가 있었을 뿐이다. 이상의 결과로 볼 때 체질과 각종 질병이나 증상유형에 대한 임상적인 연구가 더욱 필요할 것으로 사려된다.

• 동의생리학회지
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• 제14권2호통권20호
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• pp.229-237
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• 1999

Hwanhonsan has been used for curing tumor as a Oriental medicine without any experimental evidence to support the rational basis for their clinical use. This experiment was carried out to evaluate the possible therapeutic or antitumoral effects of Hwanhonsan extract against cancer, and to study some mechanisms responsible for its effect. Some kind of tumors were induced by the typical application of 3-methylcholanthrene(MCA) or by the implantation of malignant tumor cells such as leukemia cells(3LL cells) or sarcoma cells(S180 cells) and FasII cells. Treatment of the Hwanhonsan extract(daily 1 mg/mouse, i.p.) was continued for 7 days prior to tumor induction and after that the treatment was lasted for 20 hrs. Against squamous cell carcinoma induced by MCA, Hwanhonsan decreased. not only the frequency of tumor production but also the number and weight of tumors per tumor bearing mice(TBM). Hwanhonsan also significantly suppressed the development of 3LL cells and S180 cells implanted tumors by frequency and their size, and some developed tumors were regressed by the continuous treatment of Hwanhonsan extract into TBM. However, when tumor was induced by FsaII cells implantation, the growth of implanted cells in mice was delayed by the water extract of Hwanhonsan until 7 days and then rapid growth ensued. In vitro treatment of Hwanhonsan extract had no inhibitory effect on the tumor induced by some kind of cell lines such as A431 cells strain but it significantly inhibited the proliferation of 3LL cells, S180 cells. These results suggested that Hwanhonsan extract exhibited a significant prophylactic benefits against tumors and its antitumor activity was manifested depending on the type of tumor cells.

• 동의생리학회지
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• 제14권2호통권20호
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• pp.189-198
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• 1999

Aminoglycosides, including gentamicin, have been used as antibiotics for the various infections by gram-negative bacteria. However, there are some restrictions for using these drugs. Gentamicin, a typical aminoglycoside, has the side effect of nephrotoxicity, including polyuria, glycosuria, proteinuria, glomerulonephritis, and uremia. The aims of this study were to examine the prevention or reduction effects of Jinmootang on the gentamicin-induced nephrotoxicity and to investigate the possible mechanisms on the effect of Jinmootang. The subcutaneous injections of 60mg of gentamicin per kg of boby weight to Sprague-Dawley rats for 8 days induced typical symptoms of nephrotoxicity by aminoglycosides. 0.6ml of water extract Jinmootang (100ml/chup) was orally treated in the experimental animal. 24-hour urine was collected with the metabolic cage and plasma was sampled from the abdominal aorta. The plasma concentration of sodium was significantly decreased by the treatment of gentamicin but it was not-significantly changed by the treatment of Jinmootang to the animal. The concentration of potassium was greatly decreased in the gentamicin-treated animals. However. it was returned to the normal level in the Jinmootang-treated animals. The concentrations of creatinine and urea were increased by gentamicin treatment. But, Jinmootang reduced these concentrations. Nevertheless, the osmolalities of plasma in both group were not different from each other. Even though the plasma concentration of aldosterone was not significantly changed, the mean value was increased by the gentamicin intoxication. The concentration of aldosterone was decreased by the treatment of Jinmootang. The reduction of aldosterone level in plasma could be a factor to improve the hypokalemia. The fractional excretion of potassium was much higher than normal by the treatment of gentamicin and it was decreased by 50% in the Jinmootang-treated rats. Therefore, the reabsorption of potassium was significantly increased by the treatment of Jinmootang, even though the filtered load of potassium in the experimental group was much highter than control. Even though the concentration of plasma aldosterone was decreased by the treatment of Jinmootang, the fractional excretion of sodium was not increased, slightly lower. These data suggested that Na reabsorption was increased in the proximal tubule by Jinmootang. The filtered load of glucose in the Jinmootang-treated group was greater than in control. Nevertheless, the fractional excretion of glucose in the experimental group was not different from that in control. These results indicate that glucose reabsorption was increase in the proximal tubule by Jinmootang treatment. The results of this study suggest that Jinmootang could improve the some nephrotoxic symptoms induced by gentramicin treatment. Hypokalemia, the reduced glomerular filtration rate, and dysfunctions of renal proximal tubule and distal nephron were significantly recovered to normal level. The increase of glomerular filtration rate by Jinmootang might contribute to eliminate the waste product, including creatinine and urea, and/or gentamicin through the kidney.

• 동의생리학회지
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• 제14권2호통권20호
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• pp.199-208
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• 1999

As the average life span have been lengthened and the rate of senile population have been raised, chronic degenerative diseases incident to aging has been increased rapidly and become a social problem. With this social background, recently, the facts that oxygen radicals(OR) have toxic effects on Central Nervous System and Peripheral Nervous System and cause neuropathy such as Parkinson's Disease, Alzheimer Disease have been turned out, and accordingly lots of studies on the mechanism of the toxic effects of OR on nerves, the diseases caused by OR and the approaches to curing the diseases have been made. The purpose of this study is to examine the toxic effects caused by Glucose Oxidase(GO) and the effects of herbal extracts such as Chilbokyeum(CBY) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. GO, a oxygen radical, decreased the survival rate of the cultured cells on NR assay and MTT assay 2. GO, a oxygen radical, increased lipid peroxidation and the amount of LDH. 3. CBY have efficacy of decreasing lipid peroxidation. 4. CBY have efficacy of decreasing the amount of LOH. From the above results, It is concluded that Chilbokyeum has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process. And Chilbokyeum is thought to have certain pharmacological effects on controlling over aging and treating Dementia. Further clinical study of this pharmacological effects of Chilbokyeum should be complemented.

• 동의생리학회지
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• 제14권2호통권20호
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• pp.157-178
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• 1999

In terms of the bolt-leaf-hanges in Three-yum and Three yang I referd to successive medical books and many recent literatures on the basis of Huangjenegeong Somun Treatise on the Darting and meeting of Yin and yang, thus considerd concept of successive commentators about the bolt-leaf-hanges in Three-yum and Three yang and reconstructed and systeamtically arranged the bolt-leaf-hanges's interrelationship, yum-yang's relation and movement of six chnnel, and then studied there trinciple in all the universe apply the body and the process is operated by the bolt-leaf-hanges in the trinciples followed in human make his life adaption environment. The process is operated by the bolt-leaf-hanges in Three-yum and Three yang. The trinciples followed in. Firstly, Three-yum and Three yang is not dirrerentiate by many, middle, little of yum-yanggi's different function & role. Secondly, Three-yum and Three yang is negatively related white showing that there is the bolt-leaf-hanges relationship through space of Three-yum and Three yang. Through internal relationship of Three yum channel & Three yang channel, it can be proven that Three-yum and Three yang is in negative relation and through achieving the bolt-leaf-hanges relation in dimensional concept, it can be proven that it can actually be applied to human. Thirdly, by showing Three-yum and Three yang's the bolt-leaf-hanges relation is relation between Three yum & Three yang as well as negative relation, it can be shown that Three-yum and Three yang's the bolt-leaf-hanges activity is circular, and that it maintains itself through appropriate transformation. Fourth, understanding of Three-yum and Three yang's the bolt-leaf-hanges relationship and yum-yang Concern & six channer's activity has been varied. It means that the understanding is affected by socity, philosophical & research culture of the various times. The purpose has been to systematically arrange and diagnosing Three-yum and Three yang's the bolt-leaf-hanges and thus make up a fundamental for recognition. But, further study should be carried out on medical explanation on the bolt-leaf-hanges and interpretation and operation of the bolt-leaf-hanges in O-UnYukKiron.

• 동의생리학회지
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• 제14권2호통권20호
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• pp.117-126
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• 1999

The purpose of this study is to examine the toxic effects caused by Glucose Oxidase(GO) and the effects of herbal extracts such as Acori Rhizoma(AR) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. GO, a oxygen radical, decreased the survival rate of the cultured cells on NR assay and MTT assay. 2. GO, a oxygen radical, decreased the amount of neurofilaments and total protein. 3. AR have efficacy of increasing the amount of neurofilament. 4. AR have efficacy of increasing the amount of total protein. From the above results, It is concluded that AR has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process. And AR is thought to have certain pharmacological effects on controlling over aging. Further clinical study of this pharmacological effects of AR should be complemented.