동의생리학회지 (Journal of Oriental Physiology)
- 제14권2호통권20호
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- Pages.229-237
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- 1999
환혼산(還魂散)이 실험적(實驗的)으로 유발(誘發)한 종양(腫瘍)에 미치는 영향(影響)
Influence of Hwanhonsan Extract against Chemically Induced and Xenografted Mice Tumor
- 송효원 (원광대학교 한의과대학 방제학교실) ;
- 류도곤 (원광대학교 한의과대학 생리학교실) ;
- 조동기 (원광대학교 한의과대학 생리학교실) ;
- 엄상섭 (원광대학교 한의과대학 생리학교실) ;
- 강성도 (원광대학교 한의과대학 생리학교실) ;
- 고정수 (원광대학교 한의과대학 생리학교실) ;
- 성은경 (원광대학교 한의과대학 생리학교실) ;
-
윤용갑
(원광대학교 한의과대학 방제학교실) ;
- 조남수 (원광대학교 한의과대학 생리학교실) ;
- 이춘우 (원광대학교 한의과대학 생리학교실) ;
- 강순수 (원광대학교 한의과대학 방제학교실)
- Song, Hyo-Won (Dept. of Oriental Prescription, college of oriental medicine, Won-Kwang Univ.) ;
- Ryu, Do-Gon (Dept. of Physiology, college of oriental medicine, Won-Kwang Univ.) ;
- Cho, Dong-Ki (Dept. of Physiology, college of oriental medicine, Won-Kwang Univ.) ;
- Um, Sang-Sub (Dept. of Physiology, college of oriental medicine, Won-Kwang Univ.) ;
- Kang, Sung-Do (Dept. of Physiology, college of oriental medicine, Won-Kwang Univ.) ;
- Go, Jeoin-Soo (Dept. of Physiology, college of oriental medicine, Won-Kwang Univ.) ;
- Sung, Yeun-Kyung (Dept. of Physiology, college of oriental medicine, Won-Kwang Univ.) ;
-
Yun, Young-Gap
(Dept. of Oriental Prescription, college of oriental medicine, Won-Kwang Univ.) ;
- Cho, Nam-Su (Dept. of Physiology, college of oriental medicine, Won-Kwang Univ.) ;
- Lee, Chun-Woo (Dept. of Physiology, college of oriental medicine, Won-Kwang Univ.) ;
- Kang, Soon-Soo (Dept. of Oriental Prescription, college of oriental medicine, Won-Kwang Univ.)
- 발행 : 1999.09.01
초록
Hwanhonsan has been used for curing tumor as a Oriental medicine without any experimental evidence to support the rational basis for their clinical use. This experiment was carried out to evaluate the possible therapeutic or antitumoral effects of Hwanhonsan extract against cancer, and to study some mechanisms responsible for its effect. Some kind of tumors were induced by the typical application of 3-methylcholanthrene(MCA) or by the implantation of malignant tumor cells such as leukemia cells(3LL cells) or sarcoma cells(S180 cells) and FasII cells. Treatment of the Hwanhonsan extract(daily 1 mg/mouse, i.p.) was continued for 7 days prior to tumor induction and after that the treatment was lasted for 20 hrs. Against squamous cell carcinoma induced by MCA, Hwanhonsan decreased. not only the frequency of tumor production but also the number and weight of tumors per tumor bearing mice(TBM). Hwanhonsan also significantly suppressed the development of 3LL cells and S180 cells implanted tumors by frequency and their size, and some developed tumors were regressed by the continuous treatment of Hwanhonsan extract into TBM. However, when tumor was induced by FsaII cells implantation, the growth of implanted cells in mice was delayed by the water extract of Hwanhonsan until 7 days and then rapid growth ensued. In vitro treatment of Hwanhonsan extract had no inhibitory effect on the tumor induced by some kind of cell lines such as A431 cells strain but it significantly inhibited the proliferation of 3LL cells, S180 cells. These results suggested that Hwanhonsan extract exhibited a significant prophylactic benefits against tumors and its antitumor activity was manifested depending on the type of tumor cells.
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