• 한방안이비인후피부과학회지
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• 제29권1호
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• pp.157-167
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• 2016

Objective : The purpose of this study is to know the effect of Korean medical treatments on sudden sensorineural hearing loss(SSNHL) without systemic or intratympanic steroid treatments.Method : We conducted retrospective review who was diagnosed as SSNHL and treated with Korean medicine in Dept. of Otolaryngology Kyung Hee University Hospital at Gangdong. There were two patients with SSNHL who refused to be treated with western medicine and were treated with Korean medicine including acupuncture, moxibustion, and herbal medicine.Result : One patient recovered completely after eight days of admission, and another patient partial recovered during 30 days through Korean medical treatments.Conclusion : Through these studies, SSNHL is expected to treated more effectively by conventional Korean medical treatments than corticosteroid treatments alone. But the additional study is needed to reveal the exact effects of Korean medical treatments.

• 대한한의학회지
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• 제40권1호
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• pp.124-152
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• 2019

Objectives: This study aimed to ascertain what should be considered in the "Guideline for Clinical Trials with Herbal Medicinal Products for Colorectal Cancer" by analyzing the existing guidelines and clinical trials. Methods: The development committee searched guidelines for herbal medicinal products for colorectal cancer that have already been developed. Then, clinical trials for colorectal cancer using herbal medicine were searched. The searched trials were analyzed in terms of inclusion and exclusion of participants, intervention, comparator, outcomes and trial design. Then, we compared the results of our analysis with the regulations and guidelines of the Ministry of Food and Drug Safety in order to identify the issues we will have to consider when making the "Guideline for Clinical Trials with Herbal Medicinal Products for Colorectal Cancer". Several guidelines for anti-tumor agents and clinical trials with herbal medicinal products were searched on the national institution homepage. In addition, 12 articles were searched using a combination of the following search terms: 'colorectal neoplasms', 'herbal medicine', 'Medicine, Korean traditional', 'Medicine, Chinese Traditional', 'medicine, East Asian medicine', 'medicine, Kampo', etc. Results: The characteristics of participants were various, such as people with medical histories of surgeries or recurrent cancers or who complained of chemotherapy-induced side effects. The types of interventions were also various and included decoctions, powders, intravenous fluids, intraperitoneal injections and gargles. Comparators used included placebos and conventional treatments. The outcome measurements used in the studies were quality of life, symptom score, tumor response, and survival duration, etc. Safety was evaluated by recording adverse events. Conclusions: Findings were made by reviewing existing guidelines and comparing them with clinical trials for colorectal cancer and herbal medicinal products. These results will be utilized in the development of the "Guideline for Clinical Trials with Herbal Medicinal Products for Colorectal Cancer".

• 한방안이비인후피부과학회지
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• 제35권4호
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• pp.200-208
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• 2022

만성 두드러기 환자에게 조위승기탕(調胃承氣湯) 가감방(加減方) 투여가 증상 호전에 효과를 나타냄을 확인할 수 있었다. 본 환자는 변비 및 상열감과 함께 구진성 두드러기와 중증도 이상의 소양감을 호소하였고, 항히스타민제와 외용 양약 제제에 반응하지 않았지만 한약 복용 후 피부 소양감 및 병변의 개선을 보였다. 조위승기탕(調胃承氣湯)의 완하(緩下)작용이 적열(積熱)을 풀어 피부 질환에 유효한 효과를 갖는 것으로 보이고, 이로써 만성 두드러기에서 치료 효과를 발휘한 것으로 사료된다.

• 한국가금학회지
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• 제34권4호
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• pp.245-251
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• 2007

한방생약제제(Herb $Mix^{(R)}$) 첨가가 중대추의 증체와 산란 개시 및 peak 도달일령, 산란 생산성, 계란 품질, 분내 미생물 균총 및 혈액성상에 대해 미치는 영향을 검정하기 위해 사양시험을 실시하였다. 14주령된 산란계(Hy-Line Brown) 중추 1,120수를 무첨가 대조구(T1), Herb $Mix^{(R)}$(HM)(T2), 지황 강화 HM구(T3), 당귀 강화 HM구(T4), 천궁 강화 HM구(T5), 작약 강화 HM구(T6) 그리고 플라보마이신 구(T7) 등 총 7개의 처리구에 처리당 8반복, 반복당 10케이지, 케이지당 2수씩 수용하여 난괴법으로 배치하였다. 산란율 10% 도달 시 체중은 처리간에 유의한 차이가 있었는데, 당귀 강화 HM구(T4)가 가장 무거웠고 다음으로 천궁 강화 HM구(T5), HM-original구(T2)와 작약 강화 HM구(T6), Flavomycin 구(T7) 그리고 지황 강화 HM구 (T3)이었으며, 대조구(T1)가 가장 가벼웠다. 산란율 50% 도달 일령 및 산란 피크 도달 일령 역시 당귀 강화 HM구(T4)가 가장 빨랐으며, 대조구(T1)가 가장 늦었다. 일계산란율, 난중, 사료 섭취량 및 사료 전환율은 처리간에 유의한 차이가 있었다. 일계산란율에 있어서 당귀 강화 HM구(T4)가 가장 높았고, 전체적으로 HM 첨가구들이 항생제 첨가구(T7)나 대조구(T1)보다 높았다. 난중은 천궁 강화 HM구(T5)가 가장 무거웠으며, 대조구(T1)가 가장 가벼웠다. 사료 전환율에 있어서는 항생제 첨가구(T7)이 2.14로 가장 낮았으며, 당귀 강화 HM구(T4)와 작약 강화 HM구(T6)가 2.30으로 가장 높았다. 모든 장내 미생물들의 수는 처리간에 유의한 차이가 없었지만, Cl. perfringens와 E. coli 수는 모든 첨가구들이 대조구에 비해 낮은 경향을 나타내었다. 백혈구 (WBC) 수와 heterophils(HE)의 수는 처리간에 유의한 차이가 있었는데, WBC는 모든 첨가구 특히 HM 첨가구들이 항생제 첨가구나 대조구에 비해 낮은 수치를 나타내었다. 림프구 (LY)의 경우 유의적 차이는 없었지만, 모든 첨가구가 증가한 경향을 보였다. 반면, stress indicator로 알려진 HE/LY는 HM첨가구들이 항생제 첨가구나 대조구에 비해 낮은 수치를 나타내었다. 결론적으로 중대추의 증체와 산란개시일령 및 peak 도달일령 단축, 산란 생산성에 미치는 Herb $Mix^{(R)}$ 의 첨가 효과는 기존 Herb $Mix^{(R)}$ 처방에 당귀, 작약 및 천궁을 강화시킴으로 개선 효과를 증대시킬 수 있으며, 이러한 결과는 이들 한방제제가 사료섭취량, 혈액 성상 및 장내 미생물에 미치는 영향에 기인하는 것으로 사료된다.

• 치위생과학회지
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• 제15권3호
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• pp.308-317
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• 2015

본 연구는 천연한방 식물 추출물의 치아우식 예방제제로서 가능성을 평가하고자 구강 양치용액과 함께 S. mutans에 대한 항균활성을 측정하고, 정상인 치은섬유모세포에 대한 독성 유무를 평가하여 다음과 같은 결과를 얻었다. 용매별 천연한방 추출물의 S. mutans에 대한 최소성장억제농도는 증류수보다 에탄올 추출물에서 우수한 성장억제 효과를 보였다. S. mutans에 대한 최소성장억제농도를 비교한 결과, 천연한방 에탄올 추출물은 보골지가, 구강양치액은 헥사메딘이 가장 낮은 농도에서 성장억제 효과를 보였다. S. mutans에 대한 최소살균농도를 비교한 결과, 천연한방 에탄올 추출물은 보골지가, 구강양치액은 헥사메딘과 가그린이 낮은 농도에서 사멸효과를 나타냈다. 정상인의 치은섬유모세포에 천연한방 에탄올 추출물을 최소성장억제농인 10, 39, $78{\mu}g/ml$로 처리하여 독성 유무를 측정한 결과 세포독성이 없었다. 그러나 최소살균농도 값을 토대로 각 추출물별 농도를 달리하여 처리한 결과, 보골지를 제외하고는 다른 추출물은 농도가 높아짐에 따라 세포독성이 있는 것으로 나타났다. 이상의 결과를 종합하면, 4종의 천연한방 추출물은 합성 화학물질인 구강양치액과 비교 시 유사한 항균효과가 있었다. 따라서 천연한방 추출물은 적정 농도를 첨가함으로써 치아우식 대체 예방제제로 실용화할 수 있을 것으로 생각된다.

• 한방안이비인후피부과학회지
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• 제21권2호
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• pp.94-101
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• 2008

Objectives : To discuss the types of control groups in randomized controlled trials (RCTs) of herbal medicine, and to provide suggestions for improving the design of control group in future clinical trials. Methods : We reviewed the 8 articles about clinical trial design of Chinese herbal preparation which were published from 2005 through 2008. We selected those articles from CNKI(中國知識基礎施設工程(http://www.cnki.net)). Results : It is necessary to have control group in randomized controlled trials(RCTs) of Korean herbal preparation. But there are problems in the selection of appropriate control group drug. This paper lists several problems about the choice of control drug and puts forward some proposals and countermeasures. There are problems such as ethics and manufacturing matching placebo and positive control herbal drug. Conclusion : To improve the quality of control group design, we introduce standard drug plus placebo drug method and add-on research for placebo control group design, double dummy technique, using negative control drug or composite control drug for active control group design.

• 대한한방소아과학회지
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• 제12권1호
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• pp.277-287
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• 1998

The present study is designed that the herb medicines which are returned to kidney, pancreas and are known by efficacy in growth are supplied to pigs, thereafter the effects to growth and secretion of growth hormone in serum is investigated. For this purpose the 24 days old pigs, which are crossbreeding, castrated are used. The conclusions are that after 4 weeks' supply of herb medicinal compounds, pigs' weight gain has increased in low nutritional group with statistical meaning(p〈0.05). And one day's weight gain has increased with statistical meaning(p〈0.05) in all groups. Regarding food take, the second nutritional group has more significant increase than control group. Utilization rate of nutrition doesn't have any statistical meaning in all groups, but it has the tendency that as herb medicinal compounds are added, utilization rate of nutrition is increased. Increase of vertebra lengths and level of growth hormone in serum according to supply of herb medicinal compound don't have any statistical meaning because of small sample size, but 10 - 20 % increase of vertebra lengths and 10 - 30 % increase of level of growth hormone are observed.

• 한방안이비인후피부과학회지
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• 제24권1호
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• pp.181-191
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• 2011

Backgrounds : Pompholyx is a distinctive reaction pattern presenting as symmetric vesicular hand and foot dermatitis. Other than acute symptoms like itching and vesicles, chronic changes with scaling, fissure and pain may follow. As patients are treated by steroid for a long period, it tends to present side effects after quitting steroid treatment. Objectives : This study was carried out to investigate the effect of carbon arc lamp therapy and oriental medical therapy that venesection therapy, ointments and herbal medicine on chronic plantar pompholyx including steroids side effects. Methods : We treated one case of chronic plantar pompholyx which had continued about 10 years, including steroids side effects with venesection therapy, carbon arc lamp therapy, ointments and herbal medicine. To evaluate the results of this treatment, we categorized symptoms into six items which are vesicles, itching, fissures, pain, erosions and scales. Results : Except mild itching, vesicles and scales in a small area, all the symptoms were subsided. Conclusions : It is considered that various kinds of oriental medical therapy including carbon arc lamp therapy could replace steroid therapy which has many side effects.

• 대한한방내과학회지
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• 제34권3호
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• pp.267-277
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• 2013

Objectives : The aim of this study was to investigate the correlation between Cold-Heat pattern tendency and demographic traits, physical character, and vital signs in hypertensive patients taking anti-hypertensive agents. Methods : 28 hypertensive patients 30 to 69 years old were recruited. We assessed their general characteristics, physical characteristics (height, weight, waist circumference, etc.), vital signs without respiratory rate (blood pressure, pulse rate, temperature) and administered a Cold-Heat pattern questionnaire. After that, we analyzed statistical data on separate groups according to Cold-Heat characteristics or other criteria. Results : 1. Heat group patients had statistically higher scores in waist, body mass index (BMI), waist circumference and pulse rate. 2. Over weighted group patients had statistically lower scores in cold Pattern Identification. 3. Higher BMI group (above 23/25) patients had statistically significantly higher Heat scores and lower Cold scores, higher waist circumference group patients had lower Cold scores. Conclusions : From the above result in hypertensive patients taking hypertensive agents, Heat group had a obesity tendency and the inverse is also valid. Later, progressed study based on more samples and varied data will contribute to diagnosis the Cold-heat Pattern identification in hypertensive patients.

• 대한한방부인과학회지
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• 제18권1호
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• pp.156-168
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• 2005

Objective : The purpose of this study is to identify the clinical effects of Chiljehyangbuhwan in the treatment of dysmenorrhea patients. Methods : We studied fifty patients who visited Kyung Hee University Oriental Medical Center from July, 2004 to August, 2004. Women with organic disease such as ut. myoma, ov. cyst and pelvic inflammatory disease were excluded from this study. We treated them with Chiljehyangbuhwan for one menstrual cycle. The severity of dysmenorrhea were measured by MVRS (Multidimensional Verbal Rating scale), VRS (Verbal Rating scale) and VAS (Visual Analog Scale). Results : Chiljehyangbuhwan significantly decreased the severity of dysmenorrhea. Furthermore Chiljehyangbuhwan had an effect on dysmenorrhea for next menstrual cycle without taking. Chiljehyangbuhwan did not show hepatic and renal virulence. Conclusion : This study shows that Chiljehyangbuhwan has remarkable effects on dysmenorrhea patients and that effects continue to next menstrual cycle without taking medicine.