• Journal of Korean Medicine Rehabilitation
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• v.24 no.4
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• pp.61-70
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• 2014

Objectives The purpose of this study was to investigate the characteristics in obesity classification group of college students having health checkup by analyzing their BMI and blood test and determine the association between factors contributing to obesity and obesity according to BMI. Methods A group of 2992 test subjects took their medical examination and their body composition, height, weight, blood pressure were measured and blood test was done. With these results we diagnosed obesity, and analysed relationship between obesity and cholesterol, triglyceride, LDL (low density lipoprotein)-cholesterol, HDL (high density lipoprotein)-cholesterol, liver function, renal function and blood pressure. Results 1. Overweight individuals showed high total cholesterol, LDL-cholesterol, triglyceride, GOT (glutamic oxalacetic transaminase), GPT (glutamic pyruvate transaminase), Urea-nitrogen, Creatinine and low HDL-cholesterol. 2. BMI showed a significant association with other factors. BMI has a negative correlation with sex and HDL-cholesterol. BMI had positive correlations with other factors. 3. There was no relation between BMI and sex. Those six factors, liver function, cholesterol, blood pressure, kidney function, neutral fat, and blood sugar were related to BMI. Conclusions There was a significant relation between college students' BMI and their liver function, cholesterol, blood pressure, kidney function, neutral fat, and blood sugar. The diseases related to liver function, cholesterol, blood pressure, kidney function, neutral fat, and blood sugar were clearly associated with obesity.

• The Journal of Internal Korean Medicine
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• v.25 no.3
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• pp.609-614
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• 2004

Multiple Sclerosis(MS) is an acquired, demyelinating disease of the central nervous system. Clinically, it is characterized by episodes of focal disorder of the optic nerves, spinal cord, and brain, which remit to varying extent and recur over a period of many years. The average age at diagnosis is 30, typically starting between the ages of 15 and 50. Women are affected at least twice as often as men. It is more common in persons of northern European heritage and those living furthest from the equator. The diagnosis of MS is based on a history of multiple attacks of neurologic lesions over time that affect different parts of the central nervous system. A case of MS was confronted. The patient was treated with Cheongsimyonjaum-gami(淸心蓮字飮加味), YangMyung channel(陽明) and had significant improvement was seen.

• The Journal of Internal Korean Medicine
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• v.33 no.2
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• pp.160-171
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• 2012

Background and Objective : Warfarin is the standard anticoagulation treatment for atrial fibrillation, venous thromboembolism (VTE), and mechanical heart valves. Close monitoring of the International Normalized Ratio (INR) is required due to the drug's very narrow therapeutic window. Many factors can affect INR levels. Drug and food interactions are frequently cited as causes of adverse events with warfarin. We discussed interactions between herbs and warfarin studied in this research. Methods : In this review, PubMed was used to search medical journals. Keywords "warfarin AND interaction" were applied. Results : 55 articles were included. The possibility of correlation between warfarin and single herbal medicines such as Salviae Miltiorrhizae Radix, Angelicae Gigantis Radix, Ginseng Radix Alba, Lycii Fructus, Ginkgo Folium, Menthae Herba, Trigonellae semen was suggested. Furthermore, some herbal compounds interacting with warfarin were reported. The conclusion of studies reporting the effect of herbal medicine on warfarin were controversial due to small size or quality of research. Conculsions : We suggest that we should prescribe therapeutic herbal medicines to patients using warfarin more carefully and do INR follow-up regularly.

• Journal of Korean Medicine for Obesity Research
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• v.8 no.1
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• pp.63-70
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• 2008

Objectives Obesity is the major risk factor of the heart disease and the metabolic disease. The autonomic nervous system is a key contributor in the regulation of energy balance, so the blunted activity may contribute to the maintenance of the obese state. So we evaluated the function of the autonomic nervous system in young overweight and obese women with heart rate variability. Methods The subjects were 26 overweight and obese young women(BMI〉$23kg/m^2$) and 25 lean women who visited Kangnam Kyunghee hospital for obesity management from March 2006 to April 2008. Bioimpedance Analysis (BIA), short-term spectral analysis of heart rate variability (HRV) were performed. Results HRV of obese young group was lower than the lean young group, but there is no statistical significance. BMI had significantly a negative correlation with Low Frequency(LF) of HRV. LF power is mediated by sympathetic nervous system activity. These results indicate a decrease of sympathetic modulation in overweight and obese young women. Conclusions Overweight and obese young women have decreased sympathetic nervous system activity. In clinical practice, an assessement of HRV would be noninvasive and sensitive methods for sympathetic nervous system of young overweight and obese women.

• Journal of Korean Medicine for Obesity Research
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• v.8 no.1
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• pp.81-88
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• 2008

Objectives To investigate the relationship between Heart Rate Variability and menopause among obese middle-aged women in Korea. Subjects and Methods Forty middle-aged women (age 49.05 $\pm$ 2.64 years) with BMI > $23kg/m^2$ were recruited by local advertisement. Blood profiles of estrogen, FSH, LH, glucose, total cholesterol, HDL-cholesterol, and triglyceride were measured. Autonomic Nervous System (ANS) was estimated by short-term spectral analysis of heart rate variability (HRV). Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were accessed using Computerized Tomography (CT), Bioimpedance Analysis (BIA), and anthropometry. To scrutinize the influence of ANS on obesity-related factors, we divided the subjects into pre- and post-menopausal women. Results The total cholesterol, FSH and LH were significantly higher in post-menopausal obese women group. The estradiol and standard deviation of all normal R-R intervals (SDNN), high-frequency components (HF) of the HRV were significantly lower in postmenopausal obese women group (P<0.05). Adipose tissue distribution and blood profiles were not significantly different between two groups. Conclusion Menopause induced a decrease in SDNN and HF values and increase in total cholesterol level in obese women although the VAT itself was not related with ANS in obese women.

• The Journal of Korean Obstetrics and Gynecology
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• v.23 no.2
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• pp.116-123
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• 2010

Purpose: During Postpartum period many women complain multiple pain, cold hypersensitivity, hot flush, sweating and so on. We call the postpartum disease as San Hu Pung. We studied DITI Characters of women suffering from Postpartum disease. Methods: We studied 74 postpartum women visiting OOhospital from February 2006 to December 2009. The subjects were categorized in two groups, symptom group and no symptom group. We measured the temperatures of abdomen, upper and lower limb and back. We studied the difference of DITI between two groups by Student T-test using SPSS for windows(version 17.0). Results: The general characteristics were not different statistically. Temperatures of abdomen and back of two groups were not different statistically. Temperatures of both LR3 of symptom group were statistically higher than no symptom group. The difference of both PC8 and LU4, both LR3 and ST32 of symptom group were statistically higher than no symptom group. Conclusion: The results suggest that women suffering from Postpartum disease shows high temperatures on hand and foot. It seems that postpartum disease patients tend to have blood deficiency. DITI can be useful to diagnose San Hu Pung. More studies to diagnose San Hu Pung would be needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.2
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• pp.214-231
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• 2008

Purpose: The purpose of this research is a comparative study of the actual, the perceptive and the ideal body shape of the obese and non-obese female in their twenties and thirties Methods: The actual, the perceptive and the ideal body shape of the obese female and the non-obese female were collected and statistically analyzed in 25-34 years old. Results: In 25-29 years old the obese group and the non-obese group shows considerable difference in the weight, abdomen, calf circumstance in their actual body shape, but they recognize similar size as their ideal body shape in the hip, thigh and calf circumstances. They recognized that they are fatter than the actual body shape in the thigh, hip, and calf circumstances in common. In 30-34 years old the obese group and the non-obese group shows considerable difference in the weight, upper arm, abdomen, hip, thigh, calf circumstances in the actual body shape, but they recognize similar size as their ideal body shape in the thigh, hip, and calf circumstances. They recognized that they are fatter than the actual body shape in the weight, upper arm circumstances in common. Conclusion: These new data about body shape in 25-34 years women could be adopt as a useful clinical tool for body image related patients such as obesity, PCOD and postpartum patient in Korean women.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.2
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• pp.17-26
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• 2008

Purpose: This study was conducted to investigate the effects of Cervi Pontotrichum Cornu extract solution on the cell cycle regulation and apoptosis in human leiomyoma cell. Methods: The leiomyoma cell of patients was used in the study, and we administered the extract solution of Cervi Pontotrichum Cornu concentration at 1, $10mg/m{\ell}$ to the leiomyoma cell for 48 hours. We used flow cytometry and western blotting to confirm cell cycle and apoptosis. Results: In flow cytometry, G1 phase of the $1mg/m{\ell}$ group prolonged. But G1 phase of $10mg/m{\ell}$ group was shortened and S phase was increased. Cyclin D1 expression increased in higher concentration group. And Bax expression that regulates cell apoptosis increased in $1mg/m{\ell}$ and $10mg/m{\ell}$ group than control group. Bcl-2 expression decreased in 1, $10mg/m{\ell}$ groups than control group. VEGF expression rised in higher Cervi Pontotrichum Cornu concentration group. Conclusion: This study means that Cervi Pontotrichum Cornu could induce the apoptosis of leiomyoma cell by increasing Bax and decreasing Bcl-2 expression. But Cervi Pontotrichum Cornu could increase Cyclin D1 and VEGF expression, so more detailed studies would be needed.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.3 s.31
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• pp.55-59
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• 2006

Objective : This experimental study was performed to investigate the contents of glucan from mycellium and its activity against methicillin-resistant Staphylococcus(MRSA). Methods : A gel permeation chromatography method was develped for the determination and isolation of glucan in mycellium. Their structures were elucidated using ^1H-NMR$, ^{13}C-NMR$. Also, The antibacterial activity of the glucan against MRSA was estimathed by determining the minimum inhibitory concentration(MIC). Results : The contents of glucan in mycellium was $766{\pm}0.19$ mg/g. Glucan exhibited activity against MRSA, with an MIC values of 4 to 9 mg/mL. Conclusions : These findings suggested that glucan might be useful in controlling MRSA infections.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.3
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• pp.127-137
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• 2007

Objects : This study was designed to determine origin-plants of 3 kinds of Scrophulariaceae herbs reported worldwide 220 families 3000 species, domestic 21 families 55 species by researching efficacy of each herb. Furthermore the objects of study were confirmation of genuine species and substitution species standing on the results. Methods : In this studies, the origin-plants and efficacy were determined by bibliographic method. Results : The results indicate that 1. There were total 15 species of original plants of Scrophulariaceae herbs, 9 species for Radix Scrophulariae, 4 species for Radix Rehmanniae Recens, 2 species for Rhizoma Picrorrhizae. 2. In the view of authenticity of Radix Scrophulariae, there were 2 genuine species, 1 species for substitution, and study of 6 species later on. 3. In the view of authenticity of Radix Rehmanniae Recens, there were 2 genuine species, 1 species for substitution, and study of 1 species later on. 4. In the view of authenticity of Rhizoma Picrorrhizae, all the original species was genuine species. 5. The each efficacy of origin-plants were reported in the main subject. Conclusions : The 15 original plants were present among the 3 medicinal herbs in the common family scrophul ariaceae. There were 2 genuine species in Radix Scrophulariae and Rhizoma Picrorrhizae. All the original species was genuine species in Rhizoma Picrorrhizae.