• Journal of Korean Medicine for Obesity Research
• /
• v.7 no.2
• /
• pp.15-25
• /
• 2007

Objectives In clinical studies, the visceral fat obesity has been emphasized because of its correlation with the metabolic syndrome. But the subcutaneous adipose tissue also would correlate with the risk factor of metabolic syndrome. Especially deep tissue, which is a subdivision of the subcutaneous adipose tissue would be more related. This study is to investigate the relationship between subcutaneous adipose tissue and various diseases. Methods We searched for papers which had subcutaneous adipose tissue, deep subcutaneous adipose tissue and obesity for subjects in the Pubmed site. Results : 24 papers were found. Subcutaneous adipose tissue, deep subcutaneous adipose tissue especially, was related with the insulin resistance, metabolic syndrome, sex hormones and other diseases. Conclusions Subcutaneous adipose tissue is a risk factor of insulin resistance but not lipoprotein. But deep subcutaneous adipose tissue was related with lipoprotein. So deep tissue, which is a subdivision of the subcutaneous adipose tissue is a more important risk factor of the metabolic syndrome.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.22 no.2
• /
• pp.82-91
• /
• 2009

Objectives : The purpose of this study is to investigate whitening effects and anti-wrinkle effects of a few 80% ethanol extracted herbal medicines. Methods : In the first study, a few 80% ethanol extracted herbal medicines were screened for their inhibitory activities against the tyrosinase. In the second study, a few 80% ethanol extracted herbal medicines were screened for their inhibitory activities against elastase. Results : 1. We showed 28%, 27% and 19% inhibitions of mushroom tyrosinase at 500 $\mu$g/ml concentration of ASR, AIF and ABR extracts and they were showed higher anti-tyrosinase activity than arbutin's. We also could observe that the decreased mushroom tyrosinase activities in RR, CML, LR, AGR and TH extracts. 2. RR, AF and ABR (final concentrstion 1 mg/ml) were appeared 60%, 98%, 83% of inhibitions of elastase activity, and they were showed higher anti-elastase activity than that of ursolic acid. We also could observe that the decreased elastase activities in AIF, AR, LR and CML extracts. Conclusions : These results suggest that ASR, AIF and ABR extracts contribute to the anti-melanin activities and represent potential sources of whitening agent, and RR, AF and ABR extracts contribute to the anti-elastase activities and represent potential sources of anti-wrinkle agent. These results suggest that some herbal medicines could be strong potential sources of inhibition about anti-aging and whitening effects for the skin.

• The Journal of Internal Korean Medicine
• /
• v.34 no.4
• /
• pp.375-383
• /
• 2013

Objectives : This study was performed to investigate the metabolic site of some medicinal herbs in the liver associated with CYP (Cytochrome P450). Methods : Cytochrome P450 is the major enzymes involved in drug metabolism and bioactivation. CYP3A4 and CYP2D6, the major CYP isoforms in humans, catalyse the major proportion of drugs available on the market. Scintillation proximity assay (SPA) is often used in studies to identify compounds that inhibit CYP3A4 and CYP2D6. 28 herbal extracts and radioisotopes were attached competitively to SPA beads, and followed by measuring the remaining radioisotopes in the medium. Erythromycin and dexamethasone, inhibitors of CYP3A4 and CYP2D6, were used as controls respectively. Results : Most of the 28 herbal extracts showed dose-dependent affinity to the CYP3A4 while some of the herbs showed affinity to the CYP2D6. Conclusions : These results suggest that most of the 28 herbal extracts are metabolized safely in the liver, combined with CYP3A4 and CYP2D6.

• The Journal of Internal Korean Medicine
• /
• v.20 no.1
• /
• pp.167-180
• /
• 1999

Cervus elaphus, being known to reinforce Kidney, have tested to study the effects concerning damages of brain tissue induced by lipid peroxidation. In vitro, the level of lipid peroxide in brain tissue was decreased proportinally according to dose by Cervus elaphus extract solution for aqua-acupuncture (CESAA). It was much more decreased, when lipid peroxidation was induced with Fe(II). And, it was seen proportinally decrease according to the dose of CESAA on xanthine oxidase activities and type conversion ratio. However, I can not find special changes about aldehyde oxidase activities. And, I had observed the effects of CESAA on damages of rat's brain following ischemia and reflow. Before ischemia was caused, CESAA was applied 0.2 ml per 250 g through femoral vein in ischemia and reflow group and normal sailine was applied in normal group. Ischemia was caused by cervical artery's clamp for 30 min and reflowed by clamp remove after 15 min. It was increased on the content of lipid peroxidation, activies and type conversion ratio of xanthine oxidase following ischemia and reflow. However, they were decreased when CESAA was pre-appllied. However, it could not seen special changes on aldehyde oxidase activities, either. In conclusion. CESAA recovers the damage of brain due to ischemia and reflow by decreasing the lipid peroxidation through decreasing of xanthine oxidase activies and type conversion ratio.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.15 no.1
• /
• pp.285-290
• /
• 2002

Urticaria is classified as Eunjin in Oriental Medicine. The intrinsic causes include digestive system disorder, food poison, parasite, female reproductive health problem, nervous breakdown, and disorder of endocrine hormone. The extrinsic sources include all kinds of insect bites or stings, medications, pollen, dirt, and toxic smells. Some unknown sources also produce urticaria. The urticaria that lasts for more than six weeks, is categorized as chronic urticaria which is not very different from acute urticaria that occurs rapid but for a short period. The chronic urticaria may come every day, and its symptoms can even get worse at irregular or regular intervals. The cycle is hard to predict. It could be weeks or years. In clinical treatments, the syndromes of patient's chronic urticaria with cerebral hemorrhage have been analyzed and identified as follows: The diagnosis by asking the patient's case history showed that the root cause was retention of food resulting from dysfunction of the spleen and stomach. First, Pyeongwisan was dosed. From the syndrome differentiation with four diagnostic methods, we diagnosed the symptoms as Poong yoel (wind-heat). Then, Hyeongbangpaedocksangamibang was prescribed to get very effective results.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.16 no.3
• /
• pp.230-241
• /
• 2003

Nowadays Aromatherapy has been proved its own superiority and is getting popular for its specipic effects. Then, we can find some of aroma herbs are similar to those of Oriental medicine herbs. The purpose of this study was to identify the heating effect in Fennel essential oil on Aromatherapy, which is known for an effect of Hui-Hyang(Foeniculm vulgare) on Oriental medicine. We studied a patient who has visited Dongseo Oriental Hospital with Handam From November 29th 2001 to April 12th 2003 and has been observed for 5 months. We chose three spots in his body where the temperatures were lower than the other sides over $0.4^{\circ}C$. Then we treated him only with Fennel essential oil for 20 days. We used Digital Infrared Thermographic Imaging to analyze the symptoms and assess the results of treatment. The results we obtained were as follows; 1. Fennel essential oil showed the heating effect at all the three spots on the Handam patient. 2. Fennel essential oil has the characteristics of Warmness and Heat in Oriental Medicine. 3. More studies are needed to analyze what kind of characteristics Other essential oils have by Oriental medical thought for better clinical use in Oriental Medicine.

• Journal of Korean Medicine Rehabilitation
• /
• v.18 no.3
• /
• pp.201-210
• /
• 2008

Objectives : This report was performed to evaluate the treatment of acupuncture therapy, Bee venom acupuncture therapy and herbal medication in Baastrup's disease. Methods : We treated 1 case of Baastrup's disease with acupuncture therapy, Bee venom acupuncture therapy one times a week and took herbal medicine after a meal two times daily. The patients' symptoms were assessed 3 month, 6 month, 9 month by Visual analogue scale(VAS), Oswestry disability index(ODI). Results : Visual Analog Scale(VAS), Oswestry Disability Index(ODI) was significantly improved after treatment for 9 months. Conclusions : This study suggested that acupuncture therapy, Bee venom acupuncture therapy and herbal medicine can be effective for decreasing pain and improving functional recovery. We think that it need the further study and clinical trial for Baastrup's disease.

• Journal of Korean Medicine Rehabilitation
• /
• v.21 no.1
• /
• pp.47-56
• /
• 2011

Objectives : This study was conducted to identify the antimicrobial anti-oxidative and tyrosinase inhibitory effect of three kinds of herbal plants, Polygonum cuspidatum, Chelidonii herba, Pharbitis nil L. naturally grown across the nation. Methods : To investigate in vitro anti-oxidative activity assay, antimicrobial effect and tyrosinase inhibitory activity, MeOH 80% extract, n-hexane, chloroform, ethyl acetate, n-butanol and water fractions of herbal plants were tested by diphenylpicrylhydrazyl(DPPH) method. Results : Bsutanol fractions of each plants showed about 90% on anti-oxidative effect. In case of tyrosinase activity, ethlyacetate fraction of Polygonum cuspidatum showed a potent inhibition effect. In the antimicrobial effect, ethylacetate fraction of Polygonum cuspidatu, hexane fractions of Chelidonii herba and the methanol 80% extracts of Pharbitis nil L. exhibited inhibition effect significantly. Conclusions : In MeOH 80% extracts, we couldn't found any extracts or fractions which have antimicrobial, anti-oxidative and tyrosinase inhibitory activity, however ethylacetate fractions of Polygonum cuspidatum showed effects commonly in these three assay system.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.20 no.3
• /
• pp.178-184
• /
• 2007

Purpose: During postpartum period, many women complain multiple pain, sweating, cold hypersensitivity, abdominal pain, hot flush and so on. We called the postpartum disease as San Hu Pung. The San Hu Pung could related with dysautonomia. So we studied the character of the postpartum disease patients as heart rate variability(H.R.V) Methods: The subjects were 63 women who visited Kangnam Kyunghee hospital for postpartum management from February 2006 to June 2007. From history taking, 42 symptomatic women was divided at the postpartum disease group, 21 asymptomatic women was divided at the control group. All women was measured HRV, we studied the difference of HRV between two group. Results: Compared with the control group, SDNN of the disease group was significant low. TP, LF and HF of the disease group were significantly lower than the control group. Conclusion: The difference of HRV between the disease group and the control group was significant. The results of HRV on the disease group could mean that San hu pung is related dysautonomia. The more studies to diagnose San hu pung would be needed.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.21 no.3
• /
• pp.167-178
• /
• 2008

Purpose: Many breastfeeding women have used complementary and alternative medicine, but the guideline for lactation does not exist on complementary medicine. This study is to investigate efficacy and safety of complementary and alternative medicine in breastfeeding. Methods: We searched for papers which had breastfeeding, complementary medicine, acupuncture and herb in the pubmed, scopus site and Korean journals. Results: 38 papers were found. Acupuncture could have the efficacy on hypogalatia and mastitis. Compound herb therapy had effect on hypogalactia, but none of herbs were investigated for safety all except for St John's wort. So more clinical trials about herbs would be needed. Massage and the other complementary therapies would be helpful for breastfeeding mother. Conclusion: Acupuncture could be a good treatment for hypogalactia and inflammation of the breast. For making guidelines on complementary and alternative medicine during lactation, more research will be needed.