• Korean Journal of Clinical Laboratory Science
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• v.50 no.1
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• pp.1-10
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• 2018

During early pregnancy, before the development of a functioning thyroid gland, thyroid stimulating hormone (TSH) is a very sensitive marker of thyroid dysfunction during pregnancy. Normal values have been modified during gestation with a downward shift. The fetus is influenced by the TSH supplied by the mother. TSH and free thyroxine (FT4) concentrations vary during pregnancy and conventional units can vary between laboratories. A downward shift of the TSH reference range occurs during pregnancy, with a decrease in both the lower and upper limits of maternal TSH, relative to the typical non-pregnant TSH reference range. Each laboratory produces its own reference TSH and FT4 concentrations because there are many different assays that yield different results in pregnancy. Therefore, automated immunoassays used for serum FT4 analysis are still used widely, but the important considerations discussed above must be noted. The use of population-based, trimester-specific reference ranges remains the best way to handle this issue The slight downward shift in the upper reference range of TSH occurring in the latter first trimester (7~12 weeks) of pregnancy, typically not observed prior to 7 weeks. Their use indicates high or low levels in a quantitative manner independent of the reference ranges. These data highlight the importance of calculating population-based pregnancy-specific thyroid parameter reference intervals. A precision medicine initiative in this area will require the collection and analysis of a large number of genetic, biological, psychosocial, and environmental variables in large cohorts of individuals. Large prospective randomized controlled trials will be needed to resolve these controversies.

• Korean Journal of Materials Research
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• v.3 no.2
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• pp.121-130
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• 1993

The GaP crystals were grown by synthesis solute diffusion method and its properties were investigated. High quality single crystals were obtained by pull-down the crystal growing ampoule with velocity of 1.75mm/day. Etch pits density along vertical direction of ingot was increased from 3.8 ${\times}{10^4}$c$m^{-2}$ of the first freeze to 2.3 ${\times}{10^5}$c$m^2$ of the last freeze part. The carrier concentration and mobilities at room temperature were measured to 197.49cc$m^2$/V.sec and 6.75 ${\times}{10^{15}}$c$m^{-3]$, respectively. The temperature dependence of optical energy gap was empirically fitted to $E_g$(T)=[2.3383-(6.082${\times}{10^{-4}}$)$T^2$/(373. 096+TJeV. Photoluminescence spectra measured at low temperature were consist with sharp line-spectra near band-gap energy due to bound-exciton and phonon participation in band edge recombination process. Zn-diffusion depth in GaP was increased with square root of diffusion time and temperature dependence of diffusion coefficient was D(Tl = 3.2 ${\times}{10^3}$exp( - 3.486/$k_{\theta}$T)c$m^2$/sec. Electroluminescence spectra of p-n GaP homojunction diode are consisted with emission at 630nm due to recombination of donor in Zn-O complex center with shallow acceptors and near band edge emission at 550nm. Photon emission at current injection level of lower than 100m A was due to the band-filling mechanism.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.7-7
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• 2017

범람파동 개념에 따르면 하도와 홍수터의 횡적 연결성은 하천 생태계의 생물다양성과 생산성 증대에 중요한 역할을 한다. 제방에 의하여 제내지 홍수터가 하도와 차단된 우리나라 하천에서 생태적 서비스를 증대하기 위해서 횡적 연결성을 복원하는 기술 개발이 필요하다. 횡적 연결성의 복원 기술을 개발하기 위해서는 우선 하도와 홍수터 사이에 생태적 연결성의 현황을 파악하고 연결성을 저해하는 요인을 진단하는 평가 기술 개발이 시급히 요청되고 있다. 따라서 본 연구에서는 제방에 의하여 차단된 제내지 하천환경에서 수리적, 생태적 횡적 연결성을 평가하고 진단하는 기술을 개발하고 연결성 회복 방안을 제안하고자 한다. 차단된 제내지 하천환경 평가는 1) 지리정보시스템을 이용하여 차단된 하천공간을 탐색하고, 2) 탐색된 전체 재내지에서 원격평가에 의하여 간편하게 횡적 연결성 평가를 실시하고, 3) 선정된 특정 제내지 대상지에서 현장평가에 의하여 상세하게 연결성을 평가하는 순서로 수행된다. 차단된 하천공간의 획정은 홍수가 범람할 수 있는 제내지 공간을 잠재적 하천공간으로 정의하고 수치표고모델 (DEM)과 하천기본계획의 30년 빈도 홍수위 자료를 이용하여 제내지 홍수터를 탐색하였다. 제내지 홍수터의 원격 연결성평가는 지리정보시스템에서 수치지도와 토지피복도 등 공간자료를 이용하여 수리 및 서식처 환경성, 제방 차단성과 하도 및 육상 연결성을 평가하고 원격평가 결과를 토대로 현장평가 대상지를 선정하였다. 횡적 연결성의 현장평가를 위하여 크게 하도-홍수터 연결성과 제내지 서식처 보존성으로 평가 항목을 선정하였다. 또한 연결성 평가는 수리연결성과 생물연결성으로, 서식처 보존성 평가는 습지유지율, 습지보존성, 육역지보존성을 세부항목으로 구성하였다. 평가 항목별로 5 등급의 평가 기준에 따라서 평가 점수를 부여하고 평가 총점을 산출하여 최종 연결성 평가 등급을 5 단계로 구분하였다. 현장평가를 위한 MS Access 기반 소프트웨어를 개발하여, 데이터 입력과 관리 및 평가 결과 산출과 비교를 편리하게 하였다. 개발된 제내지 하천환경 평가법을 청미천과 만경강에 적용하여 검증하였다. 개발된 평가법을 바탕으로 차단된 제내지 하천환경에서 연결성 회복에 따른 어류와 식생의 분포를 예측하는 수리생태 결합모델을 개발하였다. 먼저 차단된 제내지에서 연결 수로를 복원하여 유속, 수심 분포를 준이차 수리수문 모델로 예측하였다. 예측된 수리 환경에 따라서 지표어종의 서식처 적합도 지수 (HSI)를 이용하여 서식 분포 확률을 모의하였다. 또한 일반화가법모델 (GAM)을 이용하여 환경구배에 의한 우점식생의 분포를 예측하였다. 차단된 제내지 하천환경의 생태적 연계성 평가 기술을 기반으로 제방제거, 제방후퇴, 제방고 하강, 수문 및 연결수로 개선, 생물이동 저해 장벽 제거 등의 다양한 복원기술이 개발되어야 할 것으로 생각된다.

• The Journal of Engineering Geology
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• v.7 no.2
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• pp.113-126
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• 1997

Electrical resistivity methods of dipole - dipole array profiling and Schiumberger array sounding were tested on a segment of the Woraksan granitic batholith for the research into the imaging of irregular attitudes of fracture zones in the crystaaline rock in terms of processing and interpretation schemes. By the dipole - dipole array method, inhomogeneities such as small scale of fracture zones were properly delineated down at some depth even within hard rock environment. Fracture zones were interpreted to be at the boundaries between the high amplitude zone and very low amplitude zone in the resistivity plot and they were also successfully outlined in two - dimensional layer and pseudo - three - dimensional volume constructed by the incorporation of vertical sounding data. The surface location of the fracture zones was correlated by the zero - crossing point in the VLF(very low frequency) electromagnetic data. Pseudo - three - dimensional attitudes of fracture zones were efficiently illuminated by optimum projection angle. The mean of bulk resistivity for the Woraksan granite and the near fracture zones is estimated to be approximately of 4,000 ohm - m which is much higher than the value of 700 ohm - m for the Rwachunri limesilicate environment. This difference is due to both the rock type, i.e., biotite granite vs limesilicate, and the occurrence of secondary openings of fold and fault associated with the intrusion of granite. In this study statistical analyses on the resistivity color plot were performed in terms of three representative statistical moments, i.e., standard deviation, skewness, and kurtosis. The fracture zones in the standard deviation plot were characterized by the higher value, compared to the value of homogeneous portion. The upper boundary of the high resistivity zone was also successfully delineated in the skewness and kurtosis plots.

• Journal of Life Science
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• v.28 no.6
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• pp.639-647
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• 2018

A new heat shock protein 70 was identified in red-spotted grouper (Epinephelus akaara) based on an expression analysis. The cDNA of red-spotted grouper Hsp70 (designated RgHsp70) was cloned by the rapid amplification of cDNA ends (RACE) techniques. The full-length of RgHsp70 cDNA was 2,152 bp, consisting of a 5'-terminal untranslated region (UTR) of 105 bp, a 3'-terminal UTR of 274 bp, and an open reading frame (ORF) of 1,773 bp that encode a polypeptide of 590 amino acids with a theoretical molecular weight of 64.9 kDa and an estimated isoelectric point of 5.2. Multiple alignment and phylogenetic analyses revealed that the RgHsp70 gene shares a high similarity with other Hsp70 fish genes. RgHsp70 contained all three classical Hsp70 family signatures. The results indicated the RgHsp70 is a member of the heat shock protein 70 family. RgHsp70 mRNA was predominately expressed in the liver, with reduced expression noted in the head-kidney tissues. The expression analysis of different water temperatures (21, 18, 15 and $12^{\circ}C$) for sampled livers revealed that expression gradually increased at $12^{\circ}C$ compared to $21^{\circ}C$. In this study, the effects of water temperature lowering on the physiological conditions were investigated, and the results revealed that novel RgHsp70 may be an important molecule involved in stress responses.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.10
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• pp.648-654
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• 2018

In order to maintain manholes installed on the road, the manhole should be easy to open and close. Manhole covers under harsh conditions require that they can be lifted when attempting to open the manhole because the frame and cover are stuck and difficult to open and close. In this study, the design of a lifting mechanism was carried out to improve and integrate the locking type manhole. The mechanism of the locking manhole is that when the bolt located at the center is turned, the hub connected with the bolt descends, and the hook connected to the hub is rotated. The end of the hook is hooked to the manhole frame. The auxiliary device was installed on the hook so that the manhole cover can be lifted. The structure was designed to endure about 300kg of lifting force based on 70% of the yield stress of the hook to perform lifting function. The shape design was performed through the structural analysis using the finite element method. First, the basic design was performed with the simplified 2-dimensional model and the attachment position and shape were designed through the 3-dimensional model. In order to find out the structural problems of the designed shape, the scale downed model was fabricated through 3D printing and confirmed that the lifting function worked. Finally, it was confirmed that both the locking and the average lifting of about 6.1 mm can be done by applying the lifting mechanism through the machining and applying it to the existing locking manhole.

• Journal of Yeungnam Medical Science
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• v.11 no.2
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• pp.277-283
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• 1994

We studied the change in intraocular pressure (IOP) in 15 consecutive cataract patients who underwent extracapsular cataract extraction and posterior chamber lens implantation between Feb. 1993 and Apr. 1993 to evaluate the effect of this surgery on postoperative IOP. To evaluate the clinical usefulness of non-contact tonometer, the intraocular pressures were measured with Kowa non-contact tonometer (TM-2000, Japan) as well as Goldmann applanation tonometer. There was a decrease in IOP of $3.4{\pm}2.9$mmHg (p<0.00l) 3 months after this surgery and the intraocular pressure differences between pseudophakic eyes and contralateral phakic eyes at 3 months postoperatively were $2.4{\pm}3.8$mmHg (p<0.05). The correlation coefficient between non-contact tonometer and Goldmann tonometer was 0.8876 (p=0.001) in the postoperative 76 eyes. Therefore, our results suggest that extracapsular cataract extracion and posterior chamber lens implantation alone can be a useful surgical method in cataract patient with ocular hypertension, and non-contact tonometer was relatively accurate in measuring the postoperative intraocular pressure.

• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.684-688
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• 2008

레이더 강우와 관련한 대부분의 연구나 실무적용이 제한을 받는 이유는 레이더 반사도 등의 원시자료를 획득하기가 어려울 뿐만 아니라 이를 처리하여 수문해석에 적용하는 과정이 간단하지 않기 때문이다. 이를 해결하기 위하여 다음과 같은 내용을 연구하였다. (1) 레이더 영상자료를 실용적으로 활용하기 위한 '레이더 영상 디지털 변환법(RAIDOM)'을 연구 개발하였다. 또한 오프라인상에서도 기상청 레이더 합성 CAPPI 이미지 자료를 디지털 강우자료로 직접 변환할 수 있는 방법을 제시하였다. 이러한 기술은 앞으로 레이더 강우 연구와 레이더 강우의 활용성을 넓히는데 크게 기여할 것으로 기대된다. (2) RAIDOM 레이더 강우와 연계한 분포형 강우유출모형을 구축하였다. 본 연구에서는 DEM, 토지피복도, 토양도로부터 분포형 강우-유출모형의 매개변수를 산정하는 방법을 상세히 연구하여 제시하였다. 이러한 연구결과는 앞으로 분포형 강우유출모형에 대한 연구와 활용성을 넓히는데 기여할 것으로 기대된다. (3) 주요 관측 레이더 호우사상을 이용하여 RAIDOM 강우와 구축된 분포형 모형의 적용성을 검증하였다. 이를 위하여 먼저 강우유출자료가 체계적으로 관리되고 있는 평창강 국제수문개발계획(IHP) 시범유역의 자료를 이용하여 모형의 매개변수 보정을 수행하였다. 강우 전 하천의 기저유량과 유역의 초기함수조건을 제외한 나머지 매개변수는 유역특성을 나타내는 인자들이므로 모든 강우사상에 대하여 일정한 것으로 가정하여 매개변수 보정을 수행하였다. 6개 주요 호우사상에 대하여 보정한 결과 4개의 호우사상에 대하여 강우-유출과정을 거의 완벽하게 재현하였으며, 2개의 호우사상에 대해서는 수문곡선의 상승과 하강은 비교적 일치하나 첨두부에서 다소차이가 발생하였다. (4) 보정된 분포형 모형을 2006년 7월에 발생한 국지성 집중호우와 한강유역 중상류지역에 걸쳐 큰 홍수량을 발생시킨 2개의 호우사상에 대하여 레이더 강우자료를 적용하여 검토하였다. 검토결과 임진강유역 3개 수위관측소와 우이천수위관측소 및 중랑교수위관측소에서 모의된 홍수수문곡선은 실측치와 잘 일치하는 것으로 나타나 본 연구에서 제시한 RAIDOM과 이를 적용한 분포형 모형이 강우유출 모의를 위하여 활용될 수 있음을 보여주었다. 앞으로 태풍에 수반된 강우와 장마전선 등을 포함한 다양한 유형의 여러 가지 강우에 대한 적용을 통하여 모형의 검증과 보완을 수행하여 RAIDOM 레이더 강우와 분포형 강우유출모형을 연계한 홍수 예보 시스템으로 발전시켜 나갈 예정이다.

• Journal of the Korean Magnetics Society
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• v.14 no.1
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• pp.33-37
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• 2004

Cu$_{0.1}$Fe$_{0.9}$Cr$_2$S$_4$ has been studied with Mossbauer spectroscopy, x-ray diffraction, vibrating sample magnetometer (VSM), and magnetoresistance (MR) measurement. The crystal structure was determined to be a cubic spinel with lattice parameter a$_{0}$=9.9880 $\AA$. The MR measurements show a semiconductor behavior below 110 K and metal behaved above 100 K. The temperature dependence of magnetization of Cu$_{0.1}$Fe$_{0.9}$Cr$_2$S$_4$ was reported. In addition to a large irreversibility between the zero-field-cooling (ZFC) and the field-cooling (FC) magnetization at applied field H=100 Oe, a cusp-like anomaly was observed in both the FC and ZFC curves. It shifted toward the lower temperature region with increasing magnetic field, and then showed convex type maximum at 110 K, under the applied field of 5 kOe. The Mossbauer spectra were measured from 15 K to room temperature. The asymmetric line broadening was observed for the sample Cu$_{0.1}$Fe$_{0.9}$Cr$_2$S$_4$, and it was considered to be dynamic Jahn-Teller relaxation. The charge state of Fe ions was ferrous in character. The unusual reduction of magnetic hyperfine field below 110 K was interpreted in terms of cancellation effect between the mutually opposite orbital current field (H$_{L}$) and Fermi contact field (H$_{C}$).

• The Korean Journal of Malacology
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• v.30 no.1
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• pp.1-8
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• 2014

Oxygen isotope analysis was carried out on a oyster (Crassostrea gigas) from the neolithic age Gagok-ri shell midden site, Dangjin, Korea to determine the seasonality of shellfish gathering and site occupation. Isotope samples were taken from the hinge section of the left valve of the oyster. The isotope values of the shell range from -2.02‰ to -6.05‰ vs PDB. The isotope profile shows a seasonal temperature cycle, providing information related to seasonality of shellfish gathering. The isotope values towards the edge of the hinge are gradually increasing, suggesting progressively cooling and a fall period of shell gathering and site occupation. The result shows that the oxygen isotope analysis using oyster shell hinges can be used for archaeological seasonality studies.