• Journal of Life Science
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• v.32 no.3
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• pp.210-221
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• 2022

This study investigated the mechanisms underlying the anti-cancer effects of non-steroidal anti-inflammatory drugs (NSAIDs) in human cancer cells in combination with either N-[N-(3, 5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), a γ-secretase inhibitor, or MHY2245, a new synthetic sirtuin 1 inhibitor. The results showed both DAPT and MHY2245 as novel chemosensitizers of human colon cancer KM12 and human hepatocellular carcinoma SNU475 cells to NSAIDs involving celecoxib and 2, 5-dimethyl celecoxib. The NSAID-induced cytotoxicity of these cells was significantly increased by DAPT and MHY2245 in a cyclooxygenase-2 independent manner. In addition, DAPT and MHY2245 reduced levels of p62, Notch1 intracellular domain, and multiple cancer stemness (CS)-related markers including Notch1, CD44, CD133, octamer-binding transcription factor 4, mutated p53 and c-Myc. However, the level of activating transcription factor 4 (ATF4) was enhanced, probably indicating the down-regulation of multiple CS-related markers by DAPT or MHY2245-mediated autophagy induction. Moreover, the NSAID-mediated reduction of p62/nuclear factor erythroid-derived 2-like 2 and CS-related marker proteins and the up-regulation of C/EBP homologous protein (CHOP)/ATF4 were accelerated by DAPT and MHY2245. As such, the combination of NSAID and either DAPT or MHY2245 resulted in higher cytotoxicity than NSAID alone by accelerating the down-regulation of multiple CS-related markers and PARP activation, indicating that both inhibitors promote NSAID-mediated autophagic cell death, possibly through the CHOP/ATF4 pathway. In conclusion, either combination strategy may be useful for the effective treatment of human cancer cells expressing CS-related markers.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2021.11a
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• pp.85-86
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• 2021

해상 교량의 증가에 따라 교량 통항 선박의 해상사고가 지속적으로 발생하고 있으며, 적절한 교량표지 설치·운영을 통해 사고저감에 기여할 필요가 있다. 교량등의 광학적인 성능 분석을 통해 향후 개선방안을 도출하고자 현재 국내에서 사용중인 교량등명기의 광학특성을 분석하였으며, 야간 교량표지 현장조사 및 선박운항자 의견수렴을 통해 개선 방안을 제시하였다.

• Journal of Navigation and Port Research
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• v.47 no.3
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• pp.128-133
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• 2023

In order for Aids to Navigation to provide sustainable services to users, it is possible when there is no Aids to Navigation accident. If an Aids to Navigation accident occurs, the manager should efficiently manage it to prevent the same accident. However, the current Aids to Navigation accident management only specifies the cause and type of the accident. There are no separate guidelines. Thus, the accident is recorded differently depending on the manager. Therefore, this study attempted to redefine Aids to Navigation accident. To this end, Aids to Navigation accidents that have occurred over the past 23 years (year 2000 to years 2022), IALA's Aids to Navigation information standard, S-201, and categories of accidents (traffic accidents and marine accidents) were analyzed. Causes of Aids to Navigation accidents were divided into internal and external causes. Accidents were divided into three types: Light tower accident, buoy accident, and equipment accident. By further subdividing primary items, the cause of accident was reestablished into 7 items such as mooring and bad weather and 11 items such as Light tower damage, buoy loss, and equipment breakdown. These research results can be used as basic data to provide future Aids to Navigation accident statistics.

• 대한위암학회:학술대회논문집
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• 2001.11a
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• pp.34-34
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• 2001

• Proceedings of the Korean Institute of Industrial Safety Conference
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• 2000.11a
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• pp.486-489
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• 2000

산업안전표지는 시스템안전의 우선 순위에서 보면, '설계단계에서의 안전확보', '기계설비 및 시스템에 안전장치 설치'에 뒤이은 방법론임에도 불구하고 위험에 대한 정보를 작업자에게 빠르고 정확하게 전달한다는 측면에서, 안전교육과 더불어 안전분야에서 소홀히 취급되어서는 안 되는 분야이다. 그러나, 지금까지 선행하는 두 분야는 안전분야에서 핵심으로 인식되어 왔지만 안전표지는 상대적으로 주의를 끌지 못한 것이 사실이다.(중략)

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2022.06a
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• pp.66-67
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• 2022

등부표는 항로표지 중 유일하게 해상에 설치되는 항로표지이다. 등부표의 중심은 침추이지만, 항해자에게 시각적으로 확인되는 등부표의 실제위치는 외력에 의해 지속적으로 표류한다. 이러한 등부표의 위치를 확인하기 위하여 지난 5년간(2017-2021년) 전국 255기의 등부표 위치를 분석하였다. 분석결과 Data 오류는 17.94%였으며, 위치는 집중형, 이격형 등으로 구분되었다.

• Journal of Navigation and Port Research
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• v.43 no.4
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• pp.243-249
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• 2019

Seonhwa Bongsa Goryeodogyeong written by Seogeung of Song nationality is the most vivid record of sailing in the West Sea of Goryeo. Seogeung who visited Goryeo on a ship sailed from Heuksando to Byeokrando using a fire signal of the islands area. Fire signal was installed in the Goryeo area, was located nearby the sea route at that time, and was marked by smoke during the day and torched at night so that the navigators could identify it 24 hours. In addition, it was installed at the top of the mountain so that the navigators could easily identify it from a distance. Goryeo fire signal is satisfied by qualification of modern aids to navigation and Visual range is checked about 29-39 miles, Luminous intensity of fire signal estimates to approximately 9,105-168,610cd. Therefore, the fire signal of Goryeo was very easy to use and was highly reliable as operated by the nation and its role in aiding navigations facility as an essential for safe navigation.

• Journal of Chest Surgery
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• v.38 no.12 s.257
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• pp.835-843
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• 2005

Background: Cancer of the esophagus is one of the most malignant tumors with poor prognosis. The p53 gene alteration, over expression of Cyclin D1, and Ki67 index were thought to be the prognostic factors. However, their clinical significances in esophageal squamous cell carcinoma are controversial and p53 accumulation may not correlate with genetic mutation. The current study investigates their prognostic significance in squamous cell carcinoma of the esophagus. Material and Method: The Subjects studied were 124 esophageal squamous cell carcinoma patients who underwent esophagectomy. The mutation of p53, over expression of Cyclin D1, Ki67 labelling index, mitotic index were examined by using an immunohistochemical staining. We compared the results and investigated the correlation with the mutation of p53, overexpression of Cyclin D1, Ki67 labelling index, mitotic index and tumor size, and duration of survival. Result: There was no correlation between the results in immunohistochemical staining according to age, sex, tumor size, Iymph node status, and clinical stage of the disease. Mutant p53 protein was found in 69 cases (55.6$\%$). Median survival time was 21 months in cases with negative for mutant p53 protein and 22 months in positive cases. There was no significant difference in survival (p=0.46). Median survival time was 22 months in cases with negative for Cyclin D1 and 16 months in positive cases (p=0.18). Median and mean survival time was 22 months and 36 months when Ki67 labeling index was 40 or less (102 cases). Median and mean survival was 16 months and 23 months, when Ki67 labeling index was more than 40 (22 cases). There was significant difference in survival rate (p=0.011). Conciusion: Positivity of p53 and cyclin D1 was not useful in predicting the prognosis in our study. There was no significant correlation among mutant p53 protein accumulation, Cyclin D1 over expression, and Ki67 labeling index. However, in several studies, PCR single strand conformational polymorphism analysis of p53 showed a correlation to the prognosis. We thought that there was a significant discordance between p53 gene mutation and mutant p53 protein accumulation. When Ki67 labeling index was more than 40, prognosis was poorer, Ki67 seems to be a prognostic factor in our study. Therefore, we confirmed the possibility of using molecular markers as prognostic factors.

• 대한두경부종양학회:학술대회논문집
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• 1997.11a
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• pp.281.2-282
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• 1997

• 대한예방의학회:학술대회논문집
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• 2004.10a
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• pp.52.1-52.1
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• 2004