• Clinical and Experimental Pediatrics
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• v.52 no.12
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• pp.1370-1376
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• 2009

Purpose:Treatment of precocity with gonadotropin releasing hormone analogue (GnRHa) might theoretically exert a detrimental effect on the bone mass during pubertal development. We investigated the short-term changes in bone mineral density (BMD) during GnRHa treatment and the enhancement in the changes with the co-administration of GnRHa and human growth hormone (hGH). Methods:Forty girls with precocious or early puberty who were using GnRHa for more than 1 year were enrolled. Of them, 14 concurrently received hGH. Lumbar bone mineral density was measured before and after the treatment, and bone mineral density-standard deviation scores (BMD-SDSs) were compared according to chronologic age (CA) and bone age (BA), as well as according to the administration of GnRHa alone (Group I) or the co-administration of hGH and GnRHa (Group II). Results:BMDs before and after treatment were in the normal range according to CA but were significantly lower according to BA (P<0.05). During treatment, BMD-SDSs did not change according to CA but significantly increased according to BA (P<0.05). BMD-SDSs in group I did not change during treatment according to CA or BA, while those in group II increased significantly according to BA (P<0.05), but not according to CA. Conclusion:Lumbar BMD was adequate according to CA at initial manifestation of precocity but was lower if compared to BA, that is, BMD did not increase with BA. Because co-treatment with hGH significantly increased BMD-SDSs according to BA, hGH co-treatment could be considered during GnRHa therapy.

• The Journal of the Korea Contents Association
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• v.17 no.9
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• pp.498-509
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• 2017

Caregiving supports have been provided to decrease caregiving burdens of families of children with disabilities, but there are needs for improving caregiving services. The purpose of this study was to conceptualize content items and domains of caregiving supports from the perspectives of parents and service providers in order to help families of children with disabilities to decrease their caregiving burdens. This study used concept mapping that was useful for service-needs identification and program development. First, focus group interviews with two parent groups and one service provider group were conducted to generate a total of 31 items. Also, they sorted the items in terms of conceptual similarity and rated the items in terms of their needs. Next, the sorting data were analyzed using multidimensional scaling and cluster analysis and the rating data were calculated for mean. The results provided 31 content items in four domains: regular caregiving, activity-based caregiving, parent empowerment for caregving, and strengthening family relationships. All the domains were rated as important to decrease caregiving burdens. This study has practical implications for improving caregiving services and the related policies.

• Journal of Applied Biological Chemistry
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• v.61 no.3
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• pp.219-226
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• 2018

The purpose of this study was to investigate the effect of thermal treatments, such as a sous-vide and a conventional hot water cooking, on the texture changes of soybean sprout. A novel method to measure texture properties of soybean sprout have been determined because of the irregular geometry of soybean sprout. The shape of cotyledon of bean spout was accurately analyzed using an image processing and a geometry model. To minimize the effect of the contact area on the texture measurement, a blade type of probe was selected for the measurement. True stress was evaluated to reflect the shape changes during deformation, and demonstrated that the measurement accurately distinguished the effect of thermal treatment on the texture. Different heating time (i.e., 0, 10, 20, and 30 min) was applied for both sous-vide and conventional cooking. Thermal processing caused hardening of textures for both cotyledon and hypocotyl of soybean sprout. The conventional cooking method showed higher stress values than those of sous-vide cooking. Sprouts cooked by sous-vide released the moisture after thermal processing while sprout cooked by a conventional water bath method could hold the moisture content during thermal processing. The soybean sprouts treated by conventional cooking method showed a higher score in sensory evaluation.

• Environmental Analysis Health and Toxicology
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• v.21 no.2 s.53
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• pp.185-195
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• 2006

환경오염물질로부터 수생태계 보호를 위한 표준적인 평가 및 관리 수단인 수질환경기준은 오염물질의 독성작용이 일어나는 표적기관에서의 오염물질의 농도에 대한 대체측정치로서 환경 내 오염물질의 농도를 이용해 왔다. 이러한 '외부환경농도에 기반한 접근방법'은 표적기관에서의 독성물질의 농도가 생물체내 농도에 비례하고, 결국 외부환경농도에도 비례할 것이라고 가정한다. 따라서 환경오염물질의 생물이용도나 생물축적 양상의 차이 때문에 고유 독성치를 비교 평가하는데 한계가 있다. 이와 달리 '생물체내 농도에 기반한 접근방법(이하 생체잔류량 접근법)'은 환경오염물질의 생물이용도나 종 특이적 생물축적 양상과 관련된 불확실성을 제거하고, 환경오염물질 고유의 독성을 비교 평가할 수 있게 해준다. 특히 생체잔류량 접근법을 독성동태학 및 독성역학 모델과 함께 사용하는 경우는 실제 현장에서 일어나는 복잡한 노출조건에서의 독성영향을 예측하는데 활용할 수 있다. '생체잔류량 접근법'은 독성기작별 임계잔류량(Critical Body Residue)을 결정함으로써 생물모니터링의 결과를 해석하는데 적용되고 있다. 또한 생태위해성평가를 위해서 필요한 '무영향예측농도(Predicted No-effect Concentration, PNEC)를 예측하기 위한 방법으로 생체 내 잔류량에 기반해서 농도-시간-반응관계를 기술하고, 예측할 수 있는 새로운 유형의 독성역학 및 독성동태학 모델을 제시하고, 생체내 '무영향농도(No Effect Concentration, NEC)'를 추정하게 해 준다. 특히 생체내 NEC는 '무영향관찰농도(No Observed Effect Concentration, NOEC)'와 '영향농도(Effect Concentration, EC)'처럼 분산분석이나 회귀분석모델과 같은 통계적 모델에 기반해서, 농도-반응관계만을 기술할 뿐인 기존 독성모델을 대체할 대안으로 최근에 OECD와 ISO에 의해서 추천되었다.분석을 시행한 결과 인지기능 장애정도 및 MMSEK 점수 증가에 따른 사망위험도는 어느 모형에서도 인지기능 장애정도가 사망에 미치는 위험도는 통계적으로 유의하지 않았다(표 6, 표 7). 이상 본 연구는 농촌지역 노인들에서 인지기능 장애정도가 사망에 미치는 영향을 알아보고자 하였지만, 인지기능 장애정도가 사망에 미치는 영향을 통계적으로 유의하게 고찰하지 못하였다.의한 차이를 보였다. (P<0.05, P<0.001) 5. Excelco로 부식처리된 도재가 5% HF 용액으로 부식처리된 도재보다 부식정도가 더 현저하였다.은 제언을 하고자 한다. 먼저, 학교급식에 대한 식단 작성 시 학생들이 학교에서 제공되기 원하는 식단에 대한 의견을 받고 그 의견에 대한 결과를 게시하여 학생들이 제공되기 원하는 식단을 급식 시 제공하여 학생들이 식단선택에 동참할 수 있는 기회를 주는 것이 바람직하겠다. 또한 영양사는 학급의 반대표와의 정기적인 모임을 가짐으로서 학생들의 불만사항 및 개선 요구사항에대해 서로 의견을 교환하여 설문지조사가 아닌 직접적인 대화를 하여 문제점을 파악하고자 하는 적극적인 자세가 필요하겠다. 특히 아침식사의 결식 빈도가 높았고 이는 급식성과에 부정적인 영향을 줄 뿐 아니라 학교에서 제공하는 음식의 섭취정도에도 영향을 주고 있으므로 학생들에게 학부모와 전담교사 및 학교영양사는 학생들에게 이상적인 아침식사에 대한 교육은 물론이고 아침식사를 실천할 수 있도록 다양한 방안에 대해 함께 연구해야 하겠다. 정부차원에서 학교급식에 아침식사 프로그램을 도입할 수 있는 방안을 연구하고, 아침을 결식하는 학생이 학교에서 수업시작 하기 전에 간단한 식사를 할 수 있는 정책 도입이 필요하다acid의 생성량(生成量)을 측정(測定)하였는데 periodate의 소비량(消費量)은 1.23 mole, formic acid의 생성량(生成量)은 0.78 mole이다.한 경우도 비교적 많이 먹고 있었다(24.3%). 남 여

• Journal of agricultural medicine and community health
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• v.34 no.3
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• pp.324-333
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• 2009

Objectives: The purpose of this study was to examine the health promoting lifestyle(HPL) practices and to provide the baseline data for development of church setting-centered health promotion program. Methods: For the study, 315 adults were selected from a church in G city by convenient sampling method. The data were analyzed using frequencies, ANOVA, t-test, Duncan test, and Pearson's correlation coefficient with the SPSS/PC program. Results: The mean score on HPL was 3.3. The item of the lowest score HPL was smoking. In the mean score of knowledge, behavior, and practice on HPL, the highest score of knowledge on HPL was drinking, but the highest score of practice was smoking. On the other hand, the highest score of behavior was: exercise, nutrition, stress respectably. Analysis of HPL according to the demographic characteristics showed there was a statistically significant difference by age. Subcategories of HPL showed positive correlations statistically significant: Exercise with nutrition, stress and drinking. Nutrition with stress and drinking. Drinking with stress and smoking. Conclusions: Based on the above findings, it is suggested to develop church setting-centered health promotion program with areas focused on management of stress, antismoking, sobriety, practice in nutrition and exercises.

• Korean Journal of Food Science and Technology
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• v.16 no.2
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• pp.242-250
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• 1984

Flavor components extracted from eighty species of Korean ordinary soy sauce were analyzed by gas chromatography. The relationship between the sensory scores of soy sauce flavor and the gas chromatographic data transformed with variables were analysed by method of multiple regression analysis. Simple correlation between values of each peak and sensory scores were totally low. The tenth and 12th peak had the highest correlation, 0.331. Determination coefficients of data obtained by transformation of each variables were not significantly different from each other. Flavor of soy sauce was explained about 56% at step 16 in case of stepwise multiple regression analysis of absolute values. The fact that the minimum standard errors of an estimate was found at the 16th step suggests the importance of selecting of independent variables from the whole gas chromatogram together with the results of F ratio. In the contributing proportion of each peak examined, peak 10 and 12 were contributing mainly to the good flavor of soy sauce.

• Korean Journal of Construction Engineering and Management
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• v.9 no.2
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• pp.136-145
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• 2008

Recently the Ministry of Finance and Economy of Korea launched two new project delivery systems called "Best Value Contract (Design-Bid-Build)" and "Bridging Contract (Design-Build)" in October of 2007 by revising enforcement ordinances of "Act on Contracts to Which the State is a Party". These project delivery systems require the bidders to submit technical proposal adjusted to the project characteristics and objectives for selecting the contractor by evaluating technical proposals. This research aimed to suggest guideline to effectively operate the project delivery systems described above. To reach the goal of the research, the framework of the operation model was developed, which includes the four categories: the standard bidding process, the technical proposal requirements, the technical proposal evaluation criteria, and the award methods. The contents of the four categories above were fulfilled throughout conferring with the advisory experts. In particular, the award methods, which are the important decision-making factor in the perspective of the owner, consist of four types: Low Bid-Fully Qualified, Weighted Criteria, Adjusted Bid, and Adjusted Score. The quantitative features and application criteria of these four types of award methods were suggested throughout the simulation using the virtual case.

• Proceedings of the KAIS Fall Conference
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• 2010.11b
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• pp.901-903
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• 2010

본 연구에서는 2007-2009년에 간호학과 및 스포츠과학부 해부학 강의에 있어 가상강의를 실시하였고 이에 따른 학생들의 가상강의 컨텐츠의 만족도와 가상강의실 활용빈도에 따른 학업성취도와의 상관관계를 분석하였다. 2007-2009학년도 1학기 해부학 강의를 가상강의 방식으로 수강한 2개 학과 231명을 대상으로 강의 종료 후 가상강의실 게시판 및 컨텐츠 활용 빈도, 개별 설문조사, 학기말 성적을 확보하여 상호간의 상관관계를 분석하였다. 각 학과별 일반 특성을 보기 위하여 연속 변수의 경우 평균과 표준오차를, 범주형 변수의 경우 그 분포 퍼센트를 이용하여 제시하였다. 학과별로 모든 학생들의 총점을 3분위수로 구분하여 낮음, 중간, 높음으로 분류하였으며, 조사된 모든 변수들의 일반 선형성을 GLM 모델을 이용하여 검증하였다. 사후 검증은 최소자승법을 이용하여 실시하였으며, 이를 이용하여 각각의 세부 집단별 점수 차이에 대한 유의성을 평가하였다. 관련 항목들 간 상관성 분석을 위하여 스피어만 상관계수를 이용하여 p 값 0.05를 기준으로 유의성 검증을 실시하였다. 모든 통계분석은 SAS 9.12 버전을 이용하여 분석하였다. 설문 대상자들은 학과와 해부학 성적에 상관없이 가상강의 전반에 대해 높은 만족도를 가졌다. 해부학 성적이 좋을수록 가상강의실 접속횟수가 유의하게 높았다. 아울러 해부학 성적이 좋을수록 난이도가 낮고 흥미도는 높게 나타났다. 또한 평가 요인들 간의 상관관계를 분석한 결과, 가상강의의 만족도는 흥미도와 전공과의 연계성과 밀접한 관련이 있었다. 가상강의 게시판을 통한 과제물 관리, 질의응답에 대한 적절성에 대해서는 성적에 따라 일부 유의한 차이가 나타났으나 높은 만족도를 나타내었다. 결론적으로 건강 및 의료 전공자들을 위한 해부학 강의에 있어 가상강의의 도입과 적용은 성공적이었으며, 이는 해부학 전공 교수진이 매우 부족한 현실에서 해부학 강의의 질적 저하를 막고 효율적인 교육을 위한 대안이 될 것으로 판단된다. 단, 해부학 가상강의 컨텐츠의 개선, 자료 보강 및 가상강의의 접근성 확보는 시급히 개선해야할 과제로 남아 있다.

• KIPS Transactions on Software and Data Engineering
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• v.11 no.3
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• pp.107-114
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• 2022

In this paper, we have enhanced the risk prediction of hypertension using the feature selection method in the Korean National Health and Nutrition Examination Survey (KNHANES) database of the Korea Centers for Disease Control and Prevention. The study identified various risk factors correlated with chronic hypertension. The paper is divided into three parts. Initially, the data preprocessing step of removes missing values, and performed z-transformation. The following is the feature selection (FS) step that used a factor analysis (FA) based on the feature selection method in the dataset, and feature importance (FI) and multicollinearity analysis (MC) were compared based on FS. Finally, in the predictive analysis stage, it was applied to detect and predict the risk of hypertension. In this study, we compare the accuracy, f-score, area under the ROC curve (AUC), and mean standard error (MSE) for each model of classification. As a result of the test, the proposed MC-FA-RF model achieved the highest accuracy of 80.12%, MSE of 0.106, f-score of 83.49%, and AUC of 85.96%, respectively. These results demonstrate that the proposed MC-FA-RF method for hypertension risk predictions is outperformed other methods.

• Childhood Kidney Diseases
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• v.13 no.2
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• pp.176-188
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• 2009

Purpose : Peritoneal dialysis (PD) is the major form of dialysis in use for infants and children with end-stage renal disease (ESRD). The aim of this study was to gain insight into the current status of children on PD in Korea. Methods : In May 2008, questionnaires were sent to the pediatric nephrologists via e-mail. Four centers replied and those data were reviewed. Results : A total of 103 patients were included in this study. Male to female ratio was 1.6:1. Mean age was $11.5{\pm}4.9$ years (0-19 years). Primary renal diseases diagnosed were as follows: primary glomerular disease (34%), chronic pyelonephritis-reflux nephropathy (14.6%), systemic disease (9.7%), renal hypoplasia/dysplasia (8.7%), heredofamilial disease (6.8%), vascular disease (3.9%), drug-induced nephropathy (1.0%), and unknown (12.6%). PD modalities were as follows: CAPD (42.7%), CCPD (27.2%), NIPD (11.7%), and Hybrid (18.4%). Weekly total Kt/V was $2.1{\pm}0.7$ (0.3-4.1). Results of peritoneal equilibrium test were as follows: low 36.8%, low average 31.6%, high average 19.7%, and high 11.8%. Z-score for weight was $-1.00{\pm}1.20$ (-4.54~+2.50). Z-score for height was $-1.55{\pm}1.65$ (-9.42~+1.87). Growth hormone was administered in 24.3% of patients. Anti-hypertensive drugs were administered in 64.0% of patients. Laboratory findings were as follows: hemoglobin $10.5{\pm}1.4$ g/dL, calcium $9.7{\pm}0.7$ mg/dL, phosphorus $5.4{\pm}1.4$ mg/dL, and parathyroid hormone $324.2{\pm}342.8$ pg/mL. Conclusion : Primary glomerular disease was the most common cause of ESRD. CAPD was the most prevalent PD modality. Low and low average peritoneal transport type were common. Growth disturbance were noted in many patients. Some patients had hypertension even with anti- hypertensive drugs. Calcium-phosphorus levels were maintained adequately, but many patients had secondary hyperparathyroidism.