• Korean Journal of Clinical Pharmacy
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• v.17 no.1
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• pp.13-18
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• 2007

The purpose of the present study was to investigate the effect of cimetidine on theophylline pharmacokinetics in Korean healthy normal subjects. Eight subjects were enrolled and open label, two period cross-over study was conducted without significant drug related adverse reactions. Cimetidine seemed that significantly inhibited the metabolism of theophylline, oral clearance decreased significantly when cimetidine was coadministered. Coadministered cimetidine increased $AUC_t$ and $C_{max}$ of theophylline. All subjects were genotyped using PCR-RFLP methods to evaluate the differences in metabolic capacity in accordance with CYP1A2 genotypes, but no mutant genotype was found. This suggests that metabolic capacities were not significantly affected by CYP1A2 genotypes among subjects. In conclusion, disposition of theophylline was significantly affected by coadministered cimetidine. Further evaluation with well-designed drug interaction study in accordance with various genotype of CYP1A2 is needed.

• Journal of Korea Game Society
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• v.15 no.5
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• pp.57-78
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• 2015

This Study is the effect of the inclusive institution on a nation's economic development. Therefore, we focused on the gaming industry as an index that can drive the economic growth in the future. The reason to compare the game institution in South Korea and Germany is that both countries began to develop the game by the State, but the game institution in South Korea and Germany at the present time are sharply opposed, because the institutions can focus on the main points that are experiencing this difference. The results of this study, first, open/closed network in institutionalized aspect affects the social status of the game. This second, game workers in the legal institution has been classified as artists in Germany, as addicts in South Korea. And, Germany also has incentives to creators protected profits reinvested in the gaming industry, Korea leads to punitive exploitation is being transferred to the group for addiction treatment that revenue. Third, this exclusive and inclusive institutional system could affect the stable growth of the game market. As a result, South Korea's state institutions will notice that you get a result away from opportunities for economic development due to the loss of inclusiveness.

• Journal of IKEEE
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• v.24 no.2
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• pp.638-648
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• 2020

Currently, the method of user-follwoing in intelligent cooperative robots usually based in vision system and using Lidar is common and have excellent performance. But in the closed space of Corona 19, which spread worldwide in 2020, robots for cooperation with medical staff were insignificant. This is because Medical staff are all wearing protective clothing to prevent virus infection, which is not easy to apply with existing research techniques. Therefore, in order to solve these problems in this paper, the ultrasonic sensor is separated from the transmitting and receiving parts, and based on this, this paper propose that estimating the user's position and can actively follow and cooperate with people. However, the ultrasonic sensors were partially applied by improving the Median filter in order to reduce the error caused by the short circuit in communication between hard reflection and the number of light reflections, and the operation technology was improved by applying the curvature trajectory for smooth operation in a small area. Median filter reduced the error of degree and distance by 70%, vehicle running stability was verified through the training course such as 'S' and '8' in the result.

• Development and Reproduction
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• v.2 no.1
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• pp.1-8
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• 1998

In mammalian ovary, major portion(>99%) of ovarian follicles undergo atresia. Recent studies have shown that this phenomenon is mediated via GC apoptosis. Ceramide, a product of sphingomyelin hydrolysis, has been proposed as a novel lipid second messenger with specific roles in mediating antiproliferative responses including apoptosis and cell cycle arrest. In the present study, we have examined the effect of ceramide on apoptotic cell death of GC in vitro. GCs were harvested by squeezing the antral follicles from the immature mice (3-4 weeks) and cultured in MEM medium with 10% fetal bovine serum. The cells were treated with various concentrations of ceramide (0 to 50 \mu M)and cultured up to 24 h.Cell death was determined by MTT cell viability assay and apoptosis was examined by acridine orange staining, in situ 3'-end labeling(TUNEL), and flow cytometry. Ceramid treatment induced apoptotic cell death of GC in a time- and a dose-dependent manner. Results of flow cytometric analysis showed that creamide-induced cell death was mostly confined to the $G_{0}$/$G_{1}$ cells. these results provide an evidence for ceramide as a lipid second messenger of apoptosis in mouse GC.

• Korean journal of communication and information
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• v.74
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• pp.177-196
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• 2015

This paper aims to plan a new research program on the parallel relationship between Korean press and political power, by providing concepts on the mode of existence of professional journalists in Korea. In the midst of the economic crisis of Korean journalism, relative deteriorisation in the political democracy and the liberty of press, and changes in news ecosystem due to the revolution of digital news, the status of professional journalists is at stake. In these circumstances, this paper argues that many existing researches on journalistic professionalism need to be reconstructed in the perspective of professional project. It enables, first of all, an evaluation on actual issues of professional journalists from the actor perspective, i.e. economic interests, social closure, regulative bargain with the authority. Secondly, concerning decoupling phenomenon of journalism and democracy which became salient in the contemporary society, this study raises a necessity to create new logical relations around concepts of journalist professionalism. And we will find, in this situation, a beginning of new evaluation on the mode of existence of professional journalists, that has been possibly developped within the old, assymetric relationship between State-press. And finally, this study proposes to consider a category of professional journalists as a vehicle that helps to conceptualize the old, parallel relationship between Korean press and political power.

• Korean journal of communication and information
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• v.60
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• pp.52-74
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• 2012

Legislation needs to be understood within a political, societal relationship among lawmaking bodies rather than by legal provision itself. In order to examine features and functions of communication in the process of legislation, this study conducted focus group interviews with experts as well as in-depth individual interviews. The result of this research as follows: First, the study found that although the domestic legislative process has been made by active interactions among lawmaking subjects, it was hard to conclude that this procedure is providing effective and productive legislative agenda because of chaotic communications made along the process. Second, the study found that national legislative process has been gradually moving, although restricted, to an open political space, the National Assembly, from a closed space, the executive branch. Third, the study found a remarkable feature including growing influence of experts groups and civic organizations in the legislative process. It is a significant change that legislative staff such as National Assembly aides, investigators, expert committeemen and deputy director generals played a role of "insiders," unnoticeably influencing the legislative process, and that civic organizations and NGOs, which have been excluded in the previous legislative processes, emerged as a new influencing circle in the process. Lastly, the study found that media organizations, in the process of developing agenda, had a strong impact on the National Assembly as a subject forming public issues and as a messenger of the legislative agenda while they played a limited role in affecting the government. This study discusses why communication in the domestic legislative process is important and what are some hindering and facilitating factors in the process.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.3
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• pp.197-209
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• 2018

In this study, numerical analyses on Quad Tilt Rotor(QTR) are carried out to investigate the interference effect of components and effect of operating condition during forward flight. Actuator Surface Method(ASM) which is implemented in an open source CFD code, OpenFOAM, is used to calculate the flow field around QTR with high computational efficiency. The lift of the front and rear wing is found to increase or decrease depending on the rotation direction of the rotor. At the rear wing, the interference effects of the front and rear rotor appear as a combined manner. Performance change due to the phase difference is found to be insignificant. For both rotors, the locally higher thrust is generated by the blockage effect of the wing. The interference effect of wake from the front nacelle contributes to higher local thrust for the rear rotor compared to the front rotor. And it is observed that the amplitude of thrust oscillation can decrease depending on the phase difference between the rotors. Aerodynamic performances of both rotors and the entire aircraft were compared and analyzed for various operating conditions.

• Biomedical Science Letters
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• v.3 no.1
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• pp.29-35
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• 1997

Cardiovascular disease has been the leading cause of death among patients with chronic renal failure. Many reports have been described that homocysteine is one of the independent risk factor to the occulsive vascular disease. In this study, HPLC/FLD (high performance liquid chromatography-fluorescence detector) technique was used to measure homocysteine level in patients with chronic renal failure and normal control group. The detection limit and recovery of total plasma homocysteine using HPLC/FLD were 98.6$\pm$5.8% and 0.2 nmol/ml, respectively. The linearity of this method was established in concentration range of 2~50 nmol/ml (correlation coefficient=0.9997). The concentrations of total plasma homocysteine were 6.81$\pm$1.54 nmol/ml and 27.28$\pm$14.94 nmol/ml in normal control (n=20) and patient group (n=90), respectively (p<0.05). In this study, the HPLC/FLD method showed high sensitivity and reproducibility for a routine clinical laboratory testing. Moreover determination of homocysteine level in plasma might be useful for a biochemical marker for predicting the cardiovascular diseases and for monitoring of therapeutic effect of lowering homocysteine in patients with chronic renal failure.

• Proceedings of the Korean Society for Rock Mechanics Conference
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• 2008.03a
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• pp.79-88
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• 2008

Since the hydraulic fracturing field testing method was introduced first to Korean geotechnical engineers in 1994, there have been lots of progresses in a hardware system as well as an interpretation tool. The hydrofracturing system of first generation was the pipe-line type, so it was not easy to handle. It had been modified to a wire-line system at their second generation. It was more compact one but it also needed an additional air-compressor. Our current system is much more compact and operated by all-in-one system, so it doesn't need an additional air-compressor. With a progress in a hardware system, the software for analyzing the in-situ stress regime has also been progressed. For example, the shut-in pressure, which is the most ambiguous parameter to be obtained from hydrofracturing pressure curves, can now be acquired automatically from the various methods. While the hardware and software for hydrofracturing tests are being developed during the last decade, the author could accumulate the field test results which can cover the almost whole area of South Korea. Currently these field data are used widely in a feasibility study or a preliminary design step for tunnel construction in Korea. Regarding the difficulties in a site selection and a test performance for the in-situ stress measurement at an off-shore area, the in-situ stress regime obtained from the field experiences in the land area can be used indirectly for the design of a sub-sea tunnel. From the hydrofracturing stress measurements, the trend of magnitude and direction of in-situ stress field was shown identically with the geological information in Korea.

• Information Systems Review
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• v.18 no.2
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• pp.1-22
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• 2016

In response to changes in the global market environment, companies in the Information and Communications Technology (ICT) industry have begun to pursue cooperation and competition on a business ecosystem level. In particular, to become a leader in the new growth engine industry of Internet of Things (IoT), companies around the globe aim to consolidate vertically up the value chain through a solid establishment of their platforms. This paper looks at Samsung and Xiaomi, whose strategies for creating an ecosystem based on their own platforms differ in accordance to the ecosystem in which they compete. An analysis of these two companies indicate that Samsung pursues a strategy to become the market standard by openly sharing its platform with complementary companies, whereas Xiaomi pursues a strategy that achieves value as a channel owner through the restriction on which companies may become partners. This paper concludes that as Samsung and Xiaomi strive to become IoT industry leaders, each company pursues a variant of a platform-based value chain integration strategy based on the specific nature of the ecosystems in which they compete, thereby creating value through a symbiotic relationship with their partner companies.