• Journal of Ginseng Research
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• v.20 no.3
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• pp.339-343
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• 1996

The effect of ginseng on the reactivity of penile corpus cavernosal smooth muscle strips of rabbits was investigated to support the clinical application of ginseng for the treatment of erectile dysfunction. New Zealand white rabbits were randomly divided into two groups, normal diet group (n=9) and ginseng saponin diet group (n=5). Then, each group was fed normal diet and Korean red ginseng saponin diet (50 mg/kg/day) for 10 weeks. We measured concentration dependent relaxation of corporal smooth muscle to acetylcholine (10-8 M to 10-4M) in organ chamber. The degree of relaxation was expressed as percentage of maximal relaxation obtained by papaverine (10-4M). Dose dependent relaxation of corpus cavernosal smooth muscle to acetylcholine, at the concentration of 10-8 M to 10-4M by half log increment, was 4.06$\pm$0.00, 4.30$\pm$1.30, 5.32$\pm$0.68, 11.64$\pm$1.74, 16.24$\pm$1.61, 23.33$\pm$ 2.29, 26.45$\pm$2.25, 30.43$\pm$2.40 and 33.41 $\pm$2.48 (%), respectively in normal diet group and 9. 83$\pm$4.15, 20.60$\pm$4.62, 24.1815.12, 35.75$\pm$5.71, 43.35$\pm$6.11, 51.30$\pm$6.22, 56.33$\pm$6.22, 54.30$\pm$4.17 and 51.98$\pm$3.92 (Vc), respectively in ginseng group. These data suggest that ginseng enhances ondothelium-dependent acetylcholine-induced relaxation of penile corpus cal.ernosal smooth muscle in rabbits.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.38 no.3
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• pp.21-28
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• 2015

As film products are increasingly used in a wide range of areas, from producing traditional flexible packaging to high-tech electronic products, a higher level of quality is demanded. Most film products are made in the form of rolled finished goods, therefore, various quality issues related to their shape characteristics must be addressed. The thickness of the film products is one of the most common and important critical-to-quality attributes (CTQs). Particularly, the degree of thickness uniformity is more important than other thickness parameters, because it will be potential causes of many secondary thickness-related quality problems, such as wrinkles or faulty windings. To control the degree of thickness uniformity, the fixed bending region is oneof the most important CTQs to manage. Fixed bending regions are special points in the transverse direction of a rolled product with consistent minute variations of the thickness gap. This paper describes the measurement and analysis of thickness uniformity data, which were performed in a real manufacturing field of biaxial oriented polypropylene (BOPP) film. In previous researches, quality function deployment (QFD) or fault tree analysis were used to find the most critical process attributes out to controlthe CTQ of thickness uniformity. Whereas, this paper uses traditional control charts to find the most critical process attributes out in this problem. In addition, the selection of one of the major critical process attributes (CTPs) that is expected to affect the CTQ of thickness uniformity is also described. The selected critical-to-process attributes are the controlled temperatures along the transverse direction. A dramatic improvement in thickness uniformity was observed when the selected CTPs were controlled.

• The Korea Journal of Herbology
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• v.23 no.3
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• pp.155-162
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• 2008

Objectives : This study was evaluated to elucidate the inhibitory potential of Bodusan (BDS) and its components, Strychnos ignatii semen (SIS) and Glycyrrhizae Radix (GR), on human aortic smooth muscle cells (HASMC) migration and production of matrix metalloproteinase (MMP)-2 and MMP-9 by $TNF-{\alpha}$ treatment. Methods : Cytotoxic activity of BDS and its components on HASMC was using 5-(3-caroboxymeth- oxyphenyl)-2H-tetra-zolium inner salt (MTS) assay. Effect of BDS, SIS and GR on $TNF-{\alpha}-induced$ HASMC migration underside of matrigel filter was stained with hematoxylin-eosin. And total number of cells that migrated to the underside of the filter was counted. MMP-2 and MMP-9 activity was evaluated by gelatin zymography assay. Results : The matrigel migration assay showed that BDS effectively inhibited the $TNF-{\alpha}-induced$ migration of HASMC. Moreover, BDS significantly inhibited MMP-9 activity. Our present study demonstrates that BDS and its components inhibits $TNF-{\alpha}-induced$ HASMC migration and MMP-9 activity. The inhibitory effect of BDS extract is more potent than that of its component herb extracts. Conclusions : These results provide evidence that BDS has multiple effects in the inhibition of HASMC migration and may offer a therapeutic approach to block HASMC migration.

• The Journal of the Acoustical Society of Korea
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• v.15 no.4
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• pp.36-42
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• 1996

In this paper, we have proposed the robust estimation of HMM parameters which is based on CDDN(codeword dependent distance normalization)and codeword weighting by distance. The proposed method has used a distance normalization based on the characteristics of a codeword dependent distribution and have computed fuzzy contributions of codeword to a input vector with a fuzzy objective function. From experimental results, we have shown the effectiveness of the proposed method in that the correction rate of the proposed method is improved 4.5% over the conventional FVQ based method. Especially, the application of distance weighting to smoothing of output probability is improved the performance of 2.5% compared to distance based codeword weighting.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.19 no.9
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• pp.615-621
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• 2007

Experimental study on the heat transfer characteristics of $CO_2$ in a horizontal smooth tube was carried out to investigate the heat transfer coefficient and pressure drop during evaporation of $CO_2$. The experiment apparatus consisted of a test section, a DC power supply, a heater, a chiller, a mass flow meter, a pump and a measurement system. Experiment was conducted for various mass fluxes ($200{\sim}1200kg/m^2s$), heat flukes ($10{\sim}100kW/m^2$) and saturation temperatures (-5, 0, $5^{\circ}C$). With increasing the heat flux, the evaporation heat transfer coefficient increased. But the variation of the heat transfer coefficient on the increase of the mass flux was not large. And the significantly drops of the heat transfer coefficient was observed at any heat flux and mass flux because of the change of the flow pattern in the tube. With increasing the saturation temperature, the heat transfer coefficient increased due to the promotion of a nucleate boiling. The measured pressure drop during evaporation increased with increasing the mass flux and decreasing the saturation temperature.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1981.05a
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• pp.13.2-13
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• 1981

Authors was experienced a case of mucocele in the left frontal sinus. A 24-years-old Korean male soldier was admitted to C.A.F.G.H. on 16th May 1980, with chief complaints of dull headache, exophthalmos, visual disturbance and intermittent epistaxis on the left side. On physical examination, left turbinates and septum were revealed hyperemic middle turbinate with blood tinged spots and deviated slightly to right side, and felt round, smooth, rubbery painless swelling within the orbit at the left inner canthus. The left orbital contents was displaced laterally producing proptosis with diplopia. On the radiological examination, Caldwell and Water's view showed hazy density in medial side of left orbital and left frontal sinus. Tomography of orbit showed hazy increased mass density with rather sharply defined outer margin of left bony orbit probably due to compressive erosion. The case was treated with surgical removal of the Lynch frontal approach, so present this case with a brief review of the literature.

• Journal of Life Science
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• v.16 no.7 s.80
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• pp.1229-1234
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• 2006

This study investigated whether matrix metalloproteinases (MMPs) can be modified in apoptotic smooth muscle cell (SMC) using the SMC that undergoes apoptotic death by expressing Fas-associated death domain containing protein (FADD) when they are grown without tetracycline in culture medium. In the absence of tetracycline, FADD-SMC lost adherence and showed the fragmentation of the nuclei. In proportion to duration of tetracycline removal, phosphorylated form of p38 MAPK and of ERK increased, whereas phosphorylation of protein kinase B (PKB) was not changed very much in response to tetracycline The levels of cyclin A and cyclin D were also decreased in a time dependent manner. Up-regulation of MMP-9 expression and activity was observed when the SMC were grown without tetracycline. Immunoreactivity of MMP-9 was detected from both attached and floating FADD-SMCs grown without tetracycline. An inhibitor of MAPK kinase, PD098059, and an inhibitor of p38 MAPK, SB203580, inhibited the up-regulation of MMP-9. Treatment of the SMC with a synthetic MMP inhibitor, BB94, attenuated death occurring in the absence of tetracycline. These results indicate that SMC undergoing death is able to up-regulate MMP-9 and that the enzyme can affect cell viability.

• The Korean Journal of Physiology
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• v.11 no.2
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• pp.33-39
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• 1977

It has been reported that administration of Ginseng powder to the Guinea pig reduces anaphylactic shook induced by horse serum (Lee, 1939). However, Lee et al. (1960) and Paik et al. (1976) have demonstrated that Ginseng increases capillary permeabilites and histamine release from the mast cell. These facts suggest that Ginseng acts directly on the bronchial muscle causing it to dilate. Recently, a number of investigators(Kidakawa & Iwasiro 1963; Takagi et al. 1973) have reported that Ginseng reverses acetylcholine- or histamine- induced contraction in the isolated Guinea pig ileum. We, therefore, undertook the present study to examine if Ginseng relaxes the spasm of bronchial muscle induced by acetylcholine or histamine. We have also attempted to identify the mechanism of the Ginseng effect. Male Guinea Pig was sacrificed by a blow on the head, The trachea was removed and sectioned with scissors into about 12 rings. After the 'C' shaped ring of cartilage was sectioned the one end of ring was tied to the bottom of the incubation bath and the other end was connected to a force transducer (FTO 3C) to record tension on a Polygraph. When the antispasmodic action of Ginseng effect was first examined in the normal trachea which was not treated by the drug. And then the Ginseng effect was tested in the muscle treated by histamine hydrochloride, acetylcholine hydrochloride or barium chloride. The results indicate that Ginseng alcohol extract relaxes the contraction of isolated tracheal muscle induced by histamine $(1{\mu}g/ml{\sim}10{\mu}g/ml)$, acetylcholine $(1{\mu}g/ml{\sim}5{\mu}g/ml)$ and barium chloride (1.5 mg/ml). The mechanism of this action is in Pa.1 due to nonspecific antimuscarinic and antihistaminic effect and in part by predominant action in the adrenergic ${\beta}-receptor$ although the ${\alpha}-receptor$ is also involved. We, therefore, conclude that Ginseng can be act as a bronchodilator.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.26 no.11A
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• pp.1872-1879
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• 2001

As multiview video applications become more popular, correspondence problem for stereo image matching plays an important role in expanding view points. Thus, we propose an efficient dense disparity estimation algorithm considering features of each image pair of multiview image sets. Main concepts of the proposed algorithm are based on the region-dividing-bidirectional-pixel-matching method. This algorithm makes matching process efficient and keeps the reliability of the estimated disparities. Other improvement have obtained by proposed cost function, matching window expanding technique, disparity regularization, and disparity assignment in ambiguous region. These techniques make disparities more stable by removing false disparities and ambiguous regions. The estimated disparities are used to synthesize intermediate views of multiview images. Computer simulation demonstrates the excellence of the proposed algorithm in both subjective and objective evaluations. In addition, processing time is reduced as well.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.4C
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• pp.424-432
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• 2003

In this paper, an effective method of stereo image reconstruction through the regularized adaptive disparity estimation is proposed. Althougth the conventional adaptive disparity estimation method can sharply improve the PSNR of a reconstructed stereo image, but some problems of overlapping between the matching windows and disallocation of the matching windows can be occurred, because the matching window size changes adaptively in accordance with the magnitude of feature values. Accordingly, in thia paper, a new regularized adaptive disparity estimation technique is proposed. That is, by regularizing the estimated disparity vector with the neughboring disparity vectors, problems of the conventional adaptive disparity estimated scheme might be solved, and also the predicted stereo image can be more effectively reconstructed. From some experiments using the CCETT'S stereo image pairs of 'Man' and 'Claude', it is analyzed that the proposed disparity estimation scheme can improve PSNRs of the reconstructed images to 10.89dB, 6.13dB for 'Man' and 1.41dB, 0.81dB for 'Claude' by comparing with those of the conventional pixel-based and adaptive estimation method, respectively.