• Spatial Information Research
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• v.22 no.6
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• pp.91-103
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• 2014

The high popularity of geo-referenced mash-up improves the quality and availability of geo-referenced contents. Such contents which accurately represent the real world in street level as well as in aerial level have appeared. Despite the advent of geo-referenced contents of street level, it is still hardly used for mash-up. In this study, we thus find out its obstacles to spatial mash-up and solutions to overcome them to activate the mash-up based on street level contents. By analyzing the current geo-referenced content with respect to its spatial scope and the way of representation, we draw the limitations of current street level contents. Furthermore, we propose the 'new media geo-referenced content' as a solution to overcome those limitations. With 'new media geo-referenced content', it is able to determine the 3D coordinates of given object in real world. Using those coordinates, database linkage can be more closer, flexible and organic. Such 'new media geo-referenced content' can contribute to activation of geo-referenced contents in street level and its mash-up.

• Geophysics and Geophysical Exploration
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• v.19 no.2
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• pp.67-75
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• 2016

To investigate spatial and temporal variations of low-frequency (${\leq}5Hz$) ambient seismic noise, we analyzed the noise data recorded for one whole year of 2014 at surface accelerometer stations in South Korea. After decomposed into low-frequency (LF; < 1 Hz) and high-frequency (HF; ${\geq}1Hz$) components, the root-mean-squared (RMS) amplitudes and power spectral densities (PSD) of the noise data were computed. The RMS amplitudes were larger on islands and near-shore stations, but also large RMS amplitudes were observed at inland stations in large cities only for HF components. The RMS amplitudes of HF components were larger in the daytime than at nighttime and during weekdays than on Sunday and holidays. This indicates the HF components are closely related to human activities. On the contrary, daily and weekly variations were not clear in the LF components while they showed seasonal variations with its maximum during the winter and a good correlation with significant wave height. Therefore, we interpret the mechanism of LF components is closely related to natural phenomena such as sea. The amplitude of LF components decreased as an exponential function of the distance to the center of typhoons. The exponential index of -0.76 suggested that ambient seismic noise included both surface and body waves. Peak frequencies of the PSD curves were near 0.34 Hz indicating the double frequency. No temporal variation in the peak frequency was clearly noticed.

• Journal of Korea Port Economic Association
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• v.26 no.4
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• pp.122-146
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• 2010

This purpose of this study is to analyze the causal relation among constituent concepts and verify the relation among internal marketing, service quality and customer satisfaction in shipping companies. To achieve the goal of this study, the author studied literatures on internal marketing, service quality and customer satisfaction, and carried out a survey targeting people working for shipping companies and international logistics freight forwarders to make an empirical analysis. The results are as follows. It was confirmed that education and training, reward system, empowerment among internal marketing elements of a shipping company have a positive effect on the service quality and customer satisfaction of the shipping company, and the service quality of a shipping company also has a positive effect on customer satisfaction. As it can be known from these results, it would be necessary to concentrate on internal marketing of a shipping company in order to increase service quality and customer satisfaction.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.2
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• pp.167-172
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• 2004

In the human skin, vitamin C (L -ascorbic acid) that is well known as the activated materials has effects that is skin anti-aging and wrinkle repair by giving impetus to collagen biosynthesis and anti-oxidation, and that is the sun screen, a wound recovering, inhibition melanogenesis and so on. In spite of its effects, vitamin C has the defects of the skin stimulation and easily oxidized instability by water, air, heat and light. For solving their matters, many investigation is advanced and its results are synthesized the various vitamin C derivatives. And yet they have not solved the unstable property of vitamin C and were still insufficient for the comparing with the effect of the pure vitamin C itself. In this study, in order to prepare vitamin C derivative of being improved the stability and to apply vitamin C effect in the skin, we prepared new vitamin C derivative, phytosphingosine ascorbate, by using phytosphingosine, one of sphingolipids, which have a distinguished skin affinity. Phytosphingosine ascorbate can be prepared as the ionic bond between amine group (-NH$_2$) of phytosphingosine and hydroxy group (-OH) of vitamin C by way of the relatively simple reaction. So the structure and properties of the synthesized phytosphingosine ascorbate was confirmed the use of elemental analysis (C 58.3 : H 9.3 : N 2.8 : O 29.5), MALDI TOF-MS (Mw=492.58), Ultraviolet spectra (268.5nm), lH NMR, FT-IR spectra, thermal analysis (m.p=l54$^{\circ}C$), HPLC and so on. And we could confirm the anti-bacterial and anti-oxidation effects. Based on these results, we could confirm to prepare a new material that was expected of both effects of vitamin C and phytosphingosine and that is improved properties of vitamin C.

• Journal of Periodontal and Implant Science
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• v.30 no.1
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• pp.111-120
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• 2000

Purpose We designed this study for the purpose of determining the relationship between periodontal disease activity and PLBW, using the evaluation of probing pocket depth, loss of attachment, gingival index, gingival crevicular fluid amount and subgingival microflora. Methods A total of 100 volunteer mothers(mean age 30.44) at the Department of Obstetrics and Gynecology Seoul National University Hospital were selected for this study.Pregnancy outcomes were categorized into cases and controls in two ways. our definition was based on the following; Group 1 : Any PLBW cases Vs. All NBW controls Group 2 : PLBW cases Vs. NBW controls A periodontal exam was performed on the Ramfjord( #16, 21, 24, 36, 41, 44) teeth and Clinical evaluation consisted of probing pocket depth, loss of attachment, gingival index and gingival crevicular fluid amount. Subgingival plaque samples were collected by three sterile #35 paper points. The total number of anaerobic colonies and aerobic bacteria were enumerated after incubation. Antisera to P. gingivalis, P. intermedia, A. actinomycetemcomitans were produced in white rabbits with live whole cells suspensions. The specific fluorescent bacteria obtained by immunofluorescence and total cell counts obtained by dark-field microscopy were counted on four fields. The percent of each specific microorganism in the total cell count was determined. Results Any PLBW and PLBW cases showed significantly greater probing depth and attachment loss than all NBW and NBW controls. Cases group had significantly increased anaerobic bacterial counts compared with control group and no differences in the other microbes. This study confirmed that periodontal disease is a statistically significant risk factor for PLBW by investigating clinical parameters and subgingival plaque analysis.

• Journal of Periodontal and Implant Science
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• v.35 no.2
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• pp.427-436
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• 2005

Objective: MMP-8 is a neutrophil enzyme and its level increases in some inflammatory diseases, including periodontal disease. We knew that the lipopolysaccharide of E.coli(E-LPS) induced MMP-8 release from human neutrophils. E-LPS is known to induce the production and release of inflammatory cytokines through CD14, Toll-like receptor(TLR). In the present study, we investigated whether MMP-8 release by E-LPS is induced via CD14-TLR pathway and the cellular mechanism of MMP-8 release in human neutrophils. Material and methods: Human neutrophils were isolated from the peripheral blood of healthy donors and pre-incubated in medium containing antibodies against CD14, anti-TLR2 and anti-TLR4 or several inhibitors of microtubules and microfilaments and then incubated with E-LPS. The cells were treated TPCK and E-LPS simultaneously. The MMP-8amount in the culture medium was determined using ELISA. Results: E-LPS increased MMP-8release from neutrophils and its induction was inhibited by anti-CD14 and anti-TLR4 but not by anti-TLR2 antibodies. The inhibitors of microtubule and microfilament polymerization significantly decreased E-LPS-induced MMP-8release. TPCK inhibited E-LPS-induced MMP-8 release. Conclusion: These results suggest that MMP-8 release is induced by E-LPS via the CD14-TLR4 signal pathway in human neutrophils and may be depedent on microtubule and microfilament systems and $NF-{\kappa}B$ pathway.

• Journal of Periodontal and Implant Science
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• v.35 no.2
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• pp.335-343
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• 2005

Inorganic bovine bone mineral has been widely researched as bone substitution materials in orthopedic and oral and maxillofacial application. OCS-B(NIBEC, Korea) is newly-developed inorganic bovine bone mineral. The aim of this study is to evaluate the safety and efficacy of bovine bone-derived bone graft material(OCS-B). Micro-structure of newly-developed inorganic bovine bone mineral(OCS-B) was analyzed by scanning electron microscope(SEM). Round cranial defects with eight mm diameter were made and filled with OCS-B in rabbits. OCS-B was inserted into femoral quadrant muscle in mouse. In scanning electron microscope, OCS-B was equal to natural hydroxyapatite. Rabbits were sacrificed at 2 weeks and 4 weeks after surgery and mice were sacrificed at 1 week and 2 weeks after surgery. Decalcified specimens were prepared and observed by microscope. In calvarial defects, osteoid and new bone were formed in the neighborhood of OCS-B at 2 weeks after surgery. And at 4 weeks after surgery osteoid and new bone bridge formed flourishingly. No inflammatory cells were seen on the surface of OCS-B at 1 week and 2 weeks in mouse experimental group. It is concluded that newly-developed inorganic bovine bone mineral(OCS-B) is a flourishing bone-forming material and biocompatible material.

• Journal of Periodontal and Implant Science
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• v.35 no.3
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• pp.537-548
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• 2005

1. 목적 이 연구의 목적은 기존의 평가기준에 따라 관찰자에 의해 주관적으로 판단된 치은형과 실제 치은두께와의 상관관계를 규명하고 임상검사 시에 측정할 수 있는 변수들과 치은두께의 연관성을 평가하는 것이다. 2 방법 211명의 치과대학생(22-43세, 평균 24.7세)을 연구대상으로 하여 상악중절치부위에서 국소마취하에 근관 치료용 파일을 치은에 삽입하여 두께를 측정하고 임상검사를 통해 치주낭깊이, 치태지수, 치은지수, 치은퇴축, 체형 및 비만도, 피부형, 치경부의 형태, 관측자가 임의로 판단한 치은형을 기록하였다. 임상사진으로 치관의 폭경과 길이의 비율, 치은외형의 만곡정도를 조사하고 평행촬영법을 이용한 방사선사진으로 치아의 장평비율 및 치아의 치관 폭경과 치경부 폭경의 비율을 조사하였다. 전체 대상을 치은의 두께를 기준으로 평균두께보다 얇은 군과 두꺼운 군의 두 개의 군으로 분류하여 임상검사 사에 측정한 변수들이 각 군 간에 유의할 만한 차이를 보이는지와 임의로 판단한 치은형이 실제 치은두께와 연관이 있는지를 알아보았다. 통계처리는 Student t-test를 이용하였다. 3. 결과 치주낭 깊이, 치은지수, 체형 및 비만도, 피부형, 치아의 형태, 치경부의 형태, 치아의 장평비율의 경우 실제 측정하여 얻은 치은의 두께와의 상관관계는 통계적으로 유의성이 없었다. 치은의 형태는 치은의 두께와 상관성은 보이고 있으나 통계적으로 유의하지 않았다. 관측자가 임의로 평가한 치은형과 실제 측정치도 유의할만한 일치를 보이지 않고 있다. 4. 결론 치은의 형태는 치은의 두께를 예상하는데 약간의 도움이 될 수 있으나 실제 치은의 두께는 임상적으로 간단히 측정할 수 있는 겸사지수들과 직접적인 상관관계를 보이지 않았다. 따라서 치료결과의 예측에 있어서 치은형을 분류하여 예상하는 것은 큰 도움이 되지 않는다고 할 수 있다.

• Journal of Periodontal and Implant Science
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• v.35 no.3
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• pp.525-536
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• 2005

여러 연구들을 통해 많은 학자들이 임프란트 안정성(stability)은 표면의 특징에 달려있다고 생각하게 되었다. 표면의 구조, 에너지, 산화물(oxide) 두께와 표면성상(topography)등 임프란트의 표면의 특징은 임프란트와 골조직의 반응에서 중요한 역할을 하는 것이 알려짐에 따라 티타뮨 임프란트의 표면의 처리 방법에 큰 관심을 가지게 되었다. 그 중에서 티타늄 임프란트 표면의 산화피막화(anodization)가 한 방법으로 대두되었다. 이 방법은 전기화학적 방식으로 임프란트 표면에 거칠고(rough)두꺼우며(thick), 기공(pore)을 가지는 산화물 막을 형성하는 것으로 산화물의 두께는 coronal 부분(l-2 ${\mu}m$)으로부터 apical부분(7-10 ${\mu}m$)까지 증가하게 된다. 산화피막의 표면에는 다양한 크기의 수많은 기공이 주로 1-2 ${\mu}m$ 두께로 임프란트의 apical 부분에서 존재하며, 임프란트 표면의 거칠기는 conical 위부분에서 apical 부분까지 계속 증가한다(평균 Ra value=1.2 ${\mu}m$). 또 다른 표면 처리 방법으로는 blasting 후에 etching을 한 SLA 표면이 있다. 이 연구의 목적은 일반적으로 많이 이용되고 있는 anodized 표면과 SLA 표면의 조직학적 반응을 비교 분석하는 것이다. 24개 임프란트를(anodized surfaced implant-12개 , SLA-12개, 8mm ${\times}\;{\Phi}$ 4.3) 6마리 토끼의 오른쪽과 왼쪽 femur에 식립하였다. 12주후에 동물들을 희생하여 EXACT cutting-grinding system을 이용하여 샘플을 절단하고 800, 1200 및 4000 번 연마제(abrasive) paper로 20-50 ${\mu}m$ 까지 grinding하였다. 샘플은 Multiple staining 용액으로 염색하여 SLA 임프란트 군과 비교하였다. 골과 임프란트 사이에 연결을 TDI 프로그램을 이용하여 %로 측정하였다. SLA 임프란트 군 경우에는 골과 임프란트 사이의 연결이 $74{\pm}19%$ 이고, 양극 산화한 임프란트 군 경우에는 $77{\pm}9%$이었다. 양극 산화한 티타늄 임프란트의 골 접촉률이 SLA 표면 임프란트 경우과 통계학적으로 유의한 차이는 보이지 않았다.

• Journal of Periodontal and Implant Science
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• v.35 no.2
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• pp.511-524
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• 2005

The regeneration of lost periodontal tissue is a major goal of therapy. Periodontal ligament cell(PDL) is a specialized connective tissue that connects cementum and alveolar bone to maintain and support teeth in situ and preserve tissue homoeostasis. Bone morphogenetic proteins(BMPs) have shown much potential in the reconstruction of the periodontum by stimulate new bone and new cementum formation. Limitiations of BMP administration to periodontal lesions is high dose delivery, BMP transient biological activity, and low bioavailability of factors at the wound site. Gene delivery method can be alternative treatment strategy to deliver BMPs to periodontal tissue. The purpose of this study is to investigate efficiency of BMP-2 gene delivery with cell-based therapy using PDL cells. PDL cell were transduced with adenoviruses encoding either BMP-2 or Lac-Z gene. To evaluate osteogenic activity of expressed BMP-2 on PDL cells, we investigated secreted BMP-2, cellular activity, ALPase, produced mineralized nodules. To evaluate collagen scaffold as carrier for transduced cell delivery, we examined morphology and secreted BMP-2 of transducd PDL cells on it. BMP-2 transducd PDL cells produced higher levels of BMP-2, ALPase, mineralized nodules than non transduced cells. Cellular activity of transduced cells was showed similar activity to non transduced cells. Transduce cells attached on collagen scaffold secreted BMP-2 at 7day and was showed similar morphology to non transduced cells. These results demonstrated that transduced PDL cells produced biologically active BMP-2 and collagen scaffold could be carrier of transducd cells.