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Effect of hydroxybutyric-acid on lipid bilayers with respect to layer phase

  • Lee, Gaeul;Park, Jin-Won
    • Journal of the Korean Applied Science and Technology
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    • v.39 no.5
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    • pp.720-726
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    • 2022
  • The behavior changes of the lipid bilayer, induced by the hydroxybutyric-acid incorporation, were investigated with respect to each phase of the layer using fluorescence intensity change. Spherical phospholipid bilayers, called vesicles, were prepared using an emulsion technique. Only in the aqueous inside of the vesicles was encapsulated 8-Aminonaphthalene-1,3,6-trisulfonic-acid-disodium-salt(ANTS). p-Xylene-bis-N-pyridinium-bromide(DPX) was included as a quencher only outside of the vesicles. The fluorescence scale was calibrated with the ANTS-encapsulated vesicles in DPX-dispersed-buffer taken as 100% and the mixture of ANTS and DPX in the buffer as 0%. Hydroxybutyric-acid addition into the vesicle solution led the change in the bilayer. The change was found to be related to the phase of each layer according to the ratio of hydroxybutyric-acid to lipid. These results seem to depend on the stability of the vesicles, due to the osmotic and volumetric effects on the arrangement in both head-group and tail-group.

A Study on Machine Learning Based Anti-Analysis Technique Detection Using N-gram Opcode (N-gram Opcode를 활용한 머신러닝 기반의 분석 방지 보호 기법 탐지 방안 연구)

  • Kim, Hee Yeon;Lee, Dong Hoon
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.32 no.2
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    • pp.181-192
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    • 2022
  • The emergence of new malware is incapacitating existing signature-based malware detection techniques., and applying various anti-analysis techniques makes it difficult to analyze. Recent studies related to signature-based malware detection have limitations in that malware creators can easily bypass them. Therefore, in this study, we try to build a machine learning model that can detect and classify the anti-analysis techniques of packers applied to malware, not using the characteristics of the malware itself. In this study, the n-gram opcodes are extracted from the malicious binary to which various anti-analysis techniques of the commercial packers are applied, and the features are extracted by using TF-IDF, and through this, each anti-analysis technique is detected and classified. In this study, real-world malware samples packed using The mida and VMProtect with multiple anti-analysis techniques were trained and tested with 6 machine learning models, and it constructed the optimal model showing 81.25% accuracy for The mida and 95.65% accuracy for VMProtect.

Timing Driven Analytic Placement for FPGAs (타이밍 구동 FPGA 분석적 배치)

  • Kim, Kyosun
    • Journal of the Institute of Electronics and Information Engineers
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    • v.54 no.7
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    • pp.21-28
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    • 2017
  • Practical models for FPGA architectures which include performance- and/or density-enhancing components such as carry chains, wide function multiplexers, and memory/multiplier blocks are being applied to academic FPGA placement tools which used to rely on simple imaginary models. Previously the techniques such as pre-packing and multi-layer density analysis are proposed to remedy issues related to such practical models, and the wire length is effectively minimized during initial analytic placement. Since timing should be optimized rather than wire length, most previous work takes into account the timing constraints. However, instead of the initial analytic placement, the timing-driven techniques are mostly applied to subsequent steps such as placement legalization and iterative improvement. This paper incorporates the timing driven techniques, which check if the placement meets the timing constraints given in the standard SDC format, and minimize the detected violations, with the existing analytic placer which implements pre-packing and multi-layer density analysis. First of all, a static timing analyzer has been used to check the timing of the wire-length minimized placement results. In order to minimize the detected violations, a function to minimize the largest arrival time at end points is added to the objective function of the analytic placer. Since each clock has a different period, the function is proposed to be evaluated for each clock, and added to the objective function. Since this function can unnecessarily reduce the unviolated paths, a new function which calculates and minimizes the largest negative slack at end points is also proposed, and compared. Since the existing legalization which is non-timing driven is used before the timing analysis, any improvement on timing is entirely due to the functions added to the objective function. The experiments on twelve industrial examples show that the minimum arrival time function improves the worst negative slack by 15% on average whereas the minimum worst negative slack function improves the negative slacks by additional 6% on average.

Effect of Acrylic Acid on the Physical Properties of UV-cured Coating Films for Metal Coating (금속코팅용 광경화 코팅필름의 물성에 대한 아크릴산(Acrylic acid)의 영향)

  • Seo, Jong-Chul;Choi, Jun-Suk;Jang, Eui-Sung;Seo, Kwang-Won;Han, Hak-Soo
    • Korean Chemical Engineering Research
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    • v.49 no.1
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    • pp.75-82
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    • 2011
  • Five different composition UV-cured poly(urethane acrylate-co-acrylic acid) (PU-co-AA) films have been prepared by reacting isophorone diisocyanate(IPDI), polycaprolactone triol(PCLT), 2-hydroxyethyl acrylate(HEA), and different weight ratio trimethylolpropane triacrylate(TMPTA) and acrylic acid(AA) as diluents, and characterized using a Fourier transform infrared spectroscopy(FT-IR). The adhesion properties onto the stainless steel, morphology, mechanical hardness, and electrical property of UV-cured PU-co-AA films were investigated as a function of acrylic acid(AA) content. All the PU-co-AA films are structure-less and the molecular ordering and packing density decreased with increasing content of AA due to the flexible structure and -COOH side chains in AA. The crosscut test showed that PU-co-AA films without AA and with low content of AA showed 0% adhesion(0B) and the adhesion of PU-co-AA films in the range of 40-50% AA increased dramatically as the content of AA increases. The pull-off measurements showed that the adhesion force of PU-co-AA films to stainless steel substrate varied from 6 to 31 kgf /$cm^2$ and increased linearly with increasing AA content. The mechanical hardness also decreased as the content of AA increases. This may come from relatively linear and flexible structure in AA and low crystallinity in PU-co-AA films with higher content of AA. The higher AA-containing PU-co-AA films showed higher dielectric constant due to the increase of polarization by introducing AA monomer. In conclusion, the physical properties of UV-cured PU-co-AA films are strongly dependent upon the content of AA and the incorporation of AA in polyurethane acrylate is very useful way to increase the adhesion strength of UV-curable polymers on the stainless steel substrate.

1H Solid-state NMR Methodology Study for the Quantification of Water Content of Amorphous Silica Nanoparticles Depending on Relative Humidity (상대습도에 따른 비정질 규산염 나노입자의 함수량 정량 분석을 위한 1H 고상 핵자기 공명 분광분석 방법론 연구)

  • Oh, Sol Bi;Kim, Hyun Na
    • Korean Journal of Mineralogy and Petrology
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    • v.34 no.1
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    • pp.31-40
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    • 2021
  • The hydrogen in nominally anhydrous mineral is known to be associated with lattice defects, but it also can exist in the form of water and hydroxyl groups on the large surface of the nanoscale particles. In this study, we investigate the effectiveness of 1H solid-state nuclear magnetic resonance (NMR) spectroscopy as a robust experimental method to quantify the hydrogen atomic environments of amorphous silica nanoparticles with varying relative humidity. Amorphous silica nanoparticles were packed into NMR rotors in a temperature-humidity controlled glove box, then stored in different atmospheric conditions with 25% and 70% relative humidity for 2~10 days until 1H NMR experiments, and a slight difference was observed in 1H NMR spectra. These results indicate that amount of hydrous species in the sample packed in the NMR rotor is rarely changed by the external atmosphere. The amount of hydrogen atom, especially the amount of physisorbed water may vary in the range of ~10% due to the temporal and spatial inhomogeneity of relative humidity in the glove box. The quantitative analysis of 1H NMR spectra shows that the amount of hydrogen atom in amorphous silica nanoparticles linearly increases as the relative humidity increases. These results imply that the sample sealing capability of the NMR rotor is sufficient to preserve the hydrous environments of samples, and is suitable for the quantitative measurement of water content of ultrafine nominally anhydrous minerals depending on the atmospheric relative humidity. We expect that 1H solid-state NMR method is suitable to investigate systematically the effect of surface area and crystallinity on the water content of diverse nano-sized nominally anhydrous minerals with varying relative humidity.

Intensified Low-Temperature Fischer-Tropsch Synthesis Using Microchannel Reactor Block : A Computational Fluid Dynamics Simulation Study (마이크로채널 반응기를 이용한 강화된 저온 피셔-트롭쉬 합성반응의 전산유체역학적 해석)

  • Kshetrimatum, Krishnadash S.;Na, Jonggeol;Park, Seongho;Jung, Ikhwan;Lee, Yongkyu;Han, Chonghun
    • Journal of the Korean Institute of Gas
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    • v.21 no.4
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    • pp.92-102
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    • 2017
  • Fischer-Tropsch synthesis reaction converts syngas (mixture of CO and H2) to valuable hydrocarbon products. Simulation of low temperature Fischer -Tropsch Synthesis reaction and heat transfer at intensified process condition using catalyst filled single and multichannel microchannel reactor is considered. Single channel model simulation indicated potential for process intensification (higher GHSV of $30000hr^{-1}$ in presence of theoretical Cobalt based super-active catalyst) while still achieving CO conversion greater than ~65% and $C_{5+}$ selectivity greater than ~74%. Conjugate heat transfer simulation with multichannel reactor block models considering three different combinations of reactor configuration and coolant type predicted ${\Delta}T_{max}$ equal to 23 K for cross-flow configuration with wall boiling coolant, 15 K for co-current flow configuration with subcooled coolant, and 13 K for co-current flow configuration with wall boiling coolant. In the range of temperature maintained (498 - 521 K), chain growth probability calculated is desirable for low-temperature Fisher-Tropsch Synthesis.

Design and Implementation of a Linux-based Message Processor to Minimize the Response-time Delay of Non-real-time Messages in Multi-core Environments (멀티코어 환경에서 비실시간 메시지의 응답시간 지연을 최소화하는 리눅스 기반 메시지 처리기의 설계 및 구현)

  • Wang, Sangho;Park, Younghun;Park, Sungyong;Kim, Seungchun;Kim, Cheolhoe;Kim, Sangjun;Jin, Cheol
    • Journal of KIISE
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    • v.44 no.2
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    • pp.115-123
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    • 2017
  • A message processor is server software that receives non-realtime messages as well as realtime messages from clients that need to be processed within a deadline. With the recent advances of micro-processor technologies and Linux, the message processor is often implemented in Linux-based multi-core servers and it is important to use cores efficiently to maximize the performance of system in multi-core environments. Numerous research efforts on a real-time scheduler for the efficient utilization of the multi-core environments have been conducted. Typically, though, they have been conducted theoretically or via simulation, making a subsequent real-system application difficult. Moreover, many Linux-based real-time schedulers can only be used in a specific Linux version, or the Linux source code needs to be modified. This paper presents the design of a Linux-based message processor for multi-core environments that maps the threads to the cores at user level. The message processor is implemented through a modification of the traditional RM algorithm that consolidates the real-time messages into certain cores using a first-fit-based bin-packing algorithm; this minimizes the response-time delay of the non-real-time messages, while guaranteeing the violation rate of the real-time messages. To compare the performances, the message processor was implemented using the two multi-core-scheduling algorithms GSN-EDF and P-FP, which are provided by the LITMUS framework. The benchmarking results show that the response-time delay of non-real-time messages in the proposed system was improved up to a maximum of 17% to 18%.

The Design of IoT-based Drive Through Service System for Customers in Distribution Stores (대형 유통매장의 고객을 위한 IoT기반 드라이브 스루 서비스 시스템 설계)

  • Min, So-Yeon;Lee, Jong-Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.11
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    • pp.151-157
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    • 2017
  • Recently, the retail industry has created efficient store operations, and has differentiated customer service through the future store. The intelligence of these stores is being applied by using technologies such as the Internet of Things (IoT), and the business process is being improved through this. The process also focuses on efficient store operations and service developments to provide customers with shopping convenience. The change in trends in the industry means that domestic distribution has already reached maturity. Even in countries where retail industries are mature, such as the U.S. and Europe, recent trends are moving toward maximizing operational efficiency and customer service. The reason is that many retailers have already reached saturation and survived the competition. This paper is a study of a drive-through service for automation and efficiency in receiving service after ordering by a customer of the distribution store. When ordering a product being purchased by a customer, the product picking process is done in a timely fashion through a picking scheduling agent. When the customer enters the store parking lot, a service supports the entry of information and finding a parking place so the customer can quickly pick up the goods. The proposed service can be applied to a retail store drive-through system, the distribution store's delivery system, the digital picking system, and indoor/outdoor large parking management systems, and it is possible to provide one-dimensional customer service through the application of IoT technology.

Preparation of crosslinkable imide oligomers and Applications in Polyether Imides for Dual-ovenable Packaging (가교형 이미드 올리고머 제조 및 듀얼 오브너블 용기(Dual-Ovenable Packaging) 용 폴리에테르이미드에 대한 적용 연구)

  • Seo, Jongchul;Park, Su-Il;Choi, Seunghyuk;Jang, Wongbong;Han, Haksoo
    • Korean Chemical Engineering Research
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    • v.48 no.1
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    • pp.45-52
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    • 2010
  • Two different imide oligomers(6FDA-ODA/APA and 6FDA-MDA/MA) having crosslinkable end groups were prepared by using a solution imidization method and their properties were investigated. Also, semi-interpenetrating polymer networks(semi-IPN) were prepared using the blends of imide oligomers with polyetherimide $Ultem^{(R)}$, which is used in dual-ovenable packaging materials. The characteristic properties of semi-IPN films were interpreted by using TGA, Thin Film Diffusion Analyzer, and WAXD. Molecular weights of imide oligomers were successfully controlled utilizing 2-aminophenylacetylene(APA) and maleic anhydride(MA) as an endcapping agent. Exotherm reactions by crosslinking appeared and the amount of exthotherm heat was linearly increased as the content of imide oligomers was increased. For semi-IPNs of $Ultem^{(R)}$ and imide oligomers, 5% and 10% weight loss temperatures increased as the contents of imide oligomers were increased. Diffusion coefficient and water uptake of semi-IPNs decreased as the content of imide oligomers was increased, which might be resulted from hydrophobic fluorine group and high packing density. It was concluded that relatively low thermal stability and hydrolytic stability of polyetherimide $Ultem^{(R)}$ were improved by incorporating new developed imide oligomers.

Implementation of Pixel Subword Parallel Processing Instructions for Embedded Parallel Processors (임베디드 병렬 프로세서를 위한 픽셀 서브워드 병렬처리 명령어 구현)

  • Jung, Yong-Bum;Kim, Jong-Myon
    • The KIPS Transactions:PartA
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    • v.18A no.3
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    • pp.99-108
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    • 2011
  • Processor technology is currently continued to parallel processing techniques, not by only increasing clock frequency of a single processor due to the high technology cost and power consumption. In this paper, a SIMD (Single Instruction Multiple Data) based parallel processor is introduced that efficiently processes massive data inherent in multimedia. In addition, this paper proposes pixel subword parallel processing instructions for the SIMD parallel processor architecture that efficiently operate on the image and video pixels. The proposed pixel subword parallel processing instructions store and process four 8-bit pixels on the partitioned four 12-bit registers in a 48-bit datapath architecture. This solves the overflow problem inherent in existing multimedia extensions and reduces the use of many packing/unpacking instructions. Experimental results using the same SIMD-based parallel processor architecture indicate that the proposed pixel subword parallel processing instructions achieve a speedup of $2.3{\times}$ over the baseline SIMD array performance. This is in contrast to MMX-type instructions (a representative Intel multimedia extension), which achieve a speedup of only $1.4{\times}$ over the same baseline SIMD array performance. In addition, the proposed instructions achieve $2.5{\times}$ better energy efficiency than the baseline program, while MMX-type instructions achieve only $1.8{\times}$ better energy efficiency than the baseline program.