• Journal of Food Hygiene and Safety
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• v.36 no.1
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• pp.17-23
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• 2021

This evaluation tested the skin irritation and sensitization of an acaricide (Wagoojabi II®, WGJB) for the control of poultry red mite, containing 20% Chamaecyparis obtusa oil and 56% Cinnamomum camphora oil. In a primary skin irritation test, rabbits were dermally treated with WGJB for 24 h. The acaricide did not induce any adverse reactions such as erythema and edema on intact skin sites, but on abraded skin sites, some rabbits showed very slight erythema and edema 24 h after topical application. So, the acaricide was classified as a practically mild-irritating material based on a 0.625 primary irritation index score. In the skin sensitization test, guinea pigs were sensitized with intradermal injection of 0.1mL WGJB for 24 h. After 1 week, The WGJB was treated on the site of injection, and challenged 2 weeks later. The WGJB did not induce any allergic reactions. Therefore, the WGJB was graded as a weak material at '0' in both sensitization score and rate. From the results of this study, it is suggested that WGJB does not cause contact irritation and sensitization.

• Journal of Environmental Impact Assessment
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• v.10 no.1
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• pp.1-8
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• 2001

Detection of red tides by satellite remote sensing can be done either by detecting enhanced level of chlorophyll pigment or by detecting changes in the spectral composition of pixels. Using chlorophyll concentration, however, is not effective currently due to the facts: 1) Chlorophyll-a is a universal pigment of phytoplankton, and 2) no accurate algorithm for chlorophyll in case 2 water is available yet. Here, red band algorithm, classification and PCA (Principal Component Analysis) techniques were applied for detecting patches of Cochlodinium polykrikoides red tides which occurred in Korean waters in 1995. This dinoflagellate species appears dark red due to the characteristic pigments absorbing lights in the blue and green wavelength most effectively. In the satellite image, the brightness of red tide pixels in all the three visible bands were low making the detection difficult. Red band algorithm is not good for detecting the red tide because of reflectance of suspended sediments. For supervised classification, selecting training area was difficult, while unsupervised classification was not effective in delineating the patches from surrounding pixels. On the other hand, PCA gave a good qualitative discrimination on the distribution compared with actual observation.

• Journal of Chest Surgery
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• v.30 no.2
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• pp.209-212
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• 1997

A fifteen-year-old boy was transported to our hospital emmergency room due to sudden onset of chest pain, hemoptysis and dyspnea. He was diagnosed as persistent ductus arteriosus that had developed acute bacterial endocarditis with pulmonic valve vegetation and pulmonary embolism with pulmonary infarction. After conservative antibiotic therapy (vancomycin + aminoglycoside), we operated this patient successfully - patch closer of the ductus and pulmonary valve valvuloplasty - under the cardiopulmonary bypass.

• Journal of Chest Surgery
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• v.41 no.5
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• pp.647-650
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• 2008

Aortic disease usually recurs after aortic surgery in the form a new aneurysm distal to the previous operation site, and finding a penetrating atherosclerotic ulcer proximal to the previous operation site has rarely been reported. We report here on a case of successful patch repair of a ruptured penetrating ulcer in the distal aortic arch, and this developed late after replacement of the descending thoracic aorta.

• Journal of Pharmaceutical Investigation
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• v.25 no.1
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• pp.47-54
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• 1995

Transdermal patch formulations of estradiol to treat post-menopausal symptoms and prevent osteoporosis in women were developed and evaluated for the permeation characteristics through the excised hairless mouse abdorminal skin and the uterotropic effect on the ovariectomized rabbits. The design of patch formulations was optimized by varying several formulation parameters, such as type of enhancers, amount of enhancers, amount of drug loading and coating thickness. Compared to a commercially available transdermal product, several patch formulations showed the similar skin permeation profiles (following zero-order kinetics), but their skin permeation rates were lasted for the longer period (a week). In one-week uterotropic efficacy test in the ovariectimized rabbits, the selected patch formulations showed the positive effect in atrophy of the urogenital epithelium. The mean values of uterus weight in rabbits after application of patches containing estradiol were much higher than those in control group (containing no drug).

• Journal of Pharmaceutical Investigation
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• v.36 no.6
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• pp.393-399
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• 2006

This study was aimed to design, formulate and characterize the moisture-activated patches containing acyclovir for antiviral action. Gel intermediates for film-type patches were prepared with mucoadhesive polymer, viscosity builders, enhancers and acyclovir. Patches containing acyclovir were characterized by in vitro measurement of drug release rates through a cellulose barrier membrane, and of drug flux through the hairless mouse skin. Film-type patches obtained were uniform in the thickness and showed a mucoadhesive property when contacted with moisture. The formulation was optimized, which consisted of $Cantrez^{\circledR}$ AN-169(2%), $Kollidon^{\circledR}$ VA 64(1%), $Natrosol^{\circledR}$(1%), hydroxypropyl-$\beta$-cyclodextrin(1%) and dimethylsulfoxide(0.5%). Release rates of acyclovir patches increased dose-dependently. The addition of terpenes such as d-limonene or cineole increased release rates of acyclovir, but decreased permeation rates. The permeation rates were enhanced by 2 and 2.5 times by the addition of glycyrrhizic acid ammonium salt and sodium glycocholate, respectively, compared with that of no enhancer. These results suggest that it may be feasible to deliver acyclovir through the skin or gingival mucosa from the moisture-activated patches.

• Journal of the Korean Society for Railway
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• v.12 no.1
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• pp.110-114
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• 2009

This study is for the evaluation of compressive strength restoration of sandwich composite laminates with adhesively bonded scarf patches. It was used in this study that the sandwich composite laminate with an aluminum honeycomb core and CF1263 woven fabric carbon/epoxy faces was applied to the car body structure for Korean tiling train. In this study, it was damaged by low velocity impact and repaired using scarf repair method. Then, the compressive strength restoration of assessed by compressive after impact (CAI) test. From the test, it could be known that the compressive strength was restored up to 72% by only scarf repair method and 91% applied by an extra ply over the undamaged one.

• Proceedings of the KIEE Conference
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• 1995.11a
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• pp.46-48
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• 1995

An efficient technique for the analysis of a general class of microstrip structures with a substrate is applied in this paper using newly-derived closed-form spatial domain Green's functions employed in conjunction with the Method of Moments(MoM). The computed current distributions on the microstrip structures are used to determine the scattering parameters of microstrip discontinuties and the input impedances of microstrip patch antennas. It is shown that the use of the closed-form Green's functions in the context of the MoM provides a computational advantage in terms of the CPU time by almost two orders of magnitude over the conventional spectral domain approach employing the transformed version of the Green's functions.

• Journal of Korea Multimedia Society
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• v.7 no.1
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• pp.80-90
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• 2004

Watermarking algorithm for 3D mesh model using EGI distribution of each patch is proposed. The proposed algorithm divides a 3D mesh model into 6 patches to have the robustness against the partial geometric deformation. Plus, it uses EGI distributions as the consistent factor that has the robustness against the topological deformation. To satisfy both geometric and topological deformation, the same watermark bits for each subdivided patch are embedded by changing the mesh normal vectors. Moreover, the proposed algorithm does not need not only the original mesh model but also the resampling process to extract the watermark. Experimental results verify that the proposed algorithm is imperceptible and robust against geometrical and topological attacks.

• YAKHAK HOEJI
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• v.43 no.4
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• pp.447-457
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• 1999

The purpose of this study is to prepare the adhesive type patch containing flurbiprofen, and to demonstrate the feasibility of flurbiprofen administration through the intact skin using adhesive type patch preparation. For this purpose, two pressure sensitive adhesives, Polyisobutylene(PIB) and $Gelva^{\circledR}737$, were selected from the chemical grade of polymers, and the adhesive type patches of flurbiprofen were prepared. The release rate of flurbiprofen from the PIB-based adhesive patch was higher than that from $Gelva^{\circledR}737$ based adhesive patch. The release rate of flurbiprofen from the PIB-based A-type patch with 1.0mm, 1.5mm or 2.0mm thicknesses followed the first order kinetics. In the skin permeation study, using male hairless mouse skin, a monophasic skin permeation profile was observed with 1% flurbiprofen loading dose. The inclusion of palmitic acid or SLS(0.25~0.5%) as an enhancer produced a remarkable enhancement in the skin permeation rate of flurbiprofen, and the percentile ratio of drug and enhancer appeared to be important for the effective enhancement. In the in vivo percutaneous absorption study, the plasma concentration of the optimal formulation was significantly (p<0.01) higher than that of the conventional cataplasma ($Bifen^{\circledR}$). These studies demonstrate a good feasibility of flurbiprofen administration through the intact skin using a transdermal patch, and show a possibility of the development of flurbiprofen patches.