• Proceedings of the Korean Society of Applied Pharmacology
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• 1992.05a
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• pp.59-59
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• 1992

간헐적 혈액투석 또는 지속적 복막투석 요법을 받고 있는 만성 신부전 환자에서 carumonam의 약동학적 변화를 분석하여 이 환자들에서 적절한 투여용법을 고안하고, 이들 특수 질환군에서의 임상시험모형을 도굴하고자 하였다. 혈액투석환자는 carumonam 1g을 20분간 지속 정주 후 약물의 분포기 종료가 예상되는 시간에 혈액투석을 4-5시간 시행하였으며, 혈액, 투석액, 뇨를 경시적으로 채취하였다. 지속적 복막투석 환자군에 있어서는 1일 3회(6, 6, 12시간) 복막 투석을 시행하는 환자를 대상으로 carumonam 1g을 정주하고 24시간동안 혈액 및 투석액, 뇨를 경시적으로 채취하였다. 혈액, 투석액 및 뇨중 carumonam의 농도는 HPLC방법으로 측정하였으며, 경시적인 혈장 carumonam 농도변화 및 투석에 따른 약물의 제거를 혈액 투석환자는 2 compartmental model, 복막투석환자에서는 bidirectional 2 compartmental model에 의해 그 약동학적 성상을 분석하였다.

• The Journal of the Convergence on Culture Technology
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• v.4 no.4
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• pp.11-20
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• 2018

The purpose of this study was to examine the effect of the application of cool dialysis on dialytic stability, feeling of fatigue, pruritus and dialysis adequacy in hemodialysis. Methods: The study design was nonequivalent control group pretest-posttest design. The subjects were 50 patients who were hospitalized to hemodialysis. The experimental group cool dialysis(n=25) and the control group received only the usual treatment (n=25). The collected data were analyzed using independent t-test to examine study hypothesis. Results: The level of dialytic stability (F=5.53, p=.023) and feeling of fatigue (F=4.01, p<.001) in the experimental group were significantly different from that of the control group. However, the level of pruritus(F=.74, p=.394) and dialysis adequacy(F=1.02, p=.327) in the experimental group were not different from that of the control group. Conclusion: The study findings confirm that cool dialysis as an effective intervention alleviating dialytic stability and feeling of fatigue.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.4
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• pp.265-275
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• 2018

This study is a qualitative investigation that used Colaizzi's (1978) phenomenological method to evaluate the meaning and nature of the experience of dialysis of eight long-term (>30 years) hemodialysis patients with chronic renal failure. Data were collected from February 27, 2017 to May 30, 2017 by in-depth interviews. Respondents were then divided into three categories, 'entirely different life', 'getting back up again' and 'focusing on survival' with nine theme clusters and 22 themes. In general, patients initially experienced an entirely different life and overcame a difficult situation when beginning dialysis, then came to know methods for self-care, shared the experience of dialysis, and focused on survival while receiving dialysis over the long-term. Development of variety of education methods depending on long-term experience of dialysis and nursing care intervention to enable chronic patients to adapt to dialysis and continue their own self-management is necessary.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.333-333
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• 1994

목적 : 만성신부전환자에서 carumonam의 약동학적 특성을 검토하고, 동시에 투석에 의한 carumonam의 제거 양상을 분석하여 이들 환자에서 carumonam의 적절한 투여용량 및 용법을 고안하고자 하였다. 방법 : 혈액투석(HD) 또는 지속성 복막투석(CAPD)을 받고 있는 14명의 말기 신부전중 환자를 대상으로 하였다. HD환자에서는 carumonam 1 g을 20분간 지속정주하고 4시간 이후 혈액투석을 4 또는 5 시간 시행하였으며 투약 후 36시간까지 경시적으로 혈액 및 투석액을 채취하여 체액내 약물 농도를 측정하였다. CAPD환자는 1일 3회 (6.6, 12 시간) 투석액을 교환하는 환자를 대상으로 하였고 투석직후 carumonam 1g을 지속정주하고, 투약후 36시간 후까지 경시적으로 혈액 및 투석액을 채취하여 CAPD 환자에서 carumonam의 약동학적 특성을 검토하였다. 체내 동태는 HD의 경우 dialyser를 포함하는 2-compartmental model에 의한 분석을 시행하였고, CAPD를 시행받는 환자의 경우에는 체액과 투석액사이에 bidirectional clearance 개념을 도입한 모델을 이용하여 분석하였다.

• The Microorganisms and Industry
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• v.20 no.2
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• pp.15-19
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• 1994

전기투석은 전하를 갖는 막과 전위차가 존재하는 장치에서 전해질을 분리하는 공정이다(fig. 1). 전기투석은 1980년대 이전까지는 주로 담수제조, 소금제조와 같은 무기이온제거에 사용되었으나 1980년대 들어 식품제조, 의약제조, 생물공정, 폐수처리 공정 등 다양한 방면으로 응용범위를 넓혀가고 있다. 전통적인 전기투석은 염, 산, 염기들을 수용액상에서 분리하거나 농축하는데 사용되었지만 근래에는 아미노산, 단백질을 분리하는데 전기투석의 활용연구가 시도되고 있다. 본 논문에서는 전기투석의 새로운 응용분야인 전기투석생물반응기에 대해 간단한 설명과 1980년대 후반부터의 연구논문의 소개, 그리고 전기투석에서의 간단한 물질전달이론 설명을 시도하고자 한다.

• Journal of Digital Convergence
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• v.13 no.7
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• pp.269-282
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• 2015

This study is to define the hemodiafiltration treatment compliance indicators and discriminate standards for hemodiafiltration patients and development of hemodiafiltration treatment compliance measurement-convergent form. Date was collected from 300 on-line hemodiafiltration patients. To verify the hemodiafiltration treatment compliance indicators and discriminate standards, used construct validity and content validity by clinical professional group. Discriminant ability of 3 indicators-interdialysis weight gain rate(IWGR), serum phosphate level, rate of self change of total hemodiafiltration treatment time(SCR-HEFTT)- is 95.6%(wilks ramda=.256, p=.002). And hemodiafiltration treatment compliance measurement-convergent form has 91.7% discriminant accuracy. Hemodiafiltration treatment compliance is important that nurses can aware pre-stage of complication and give appropriate nursing intervention. Also this measurement can be used for foundation data of the nursing intervention development that prevent dialysis patient's complication.

• Proceedings of the KSCN Conference
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• 2004.05a
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• pp.423.1-423
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• 2004

최근 보고에 의하면 국내에서 투석치료를 받고 있는 만성신부전 환자가 매년 증가 추세에 있다고 보고하였는데 그 원인으로는 신장 대체요법의 발전으로 인한 수명연장, 신장질환을 유발할 수 있는 타 질환으로부터의 생존율 증가에 따라 만성 신장질환의 발병률 증가를 주요 원인으로 지적하고 있다. 이처럼 투석 환자들의 수적인 증가뿐만 아니라 투석치료법의 발달에 따른 투석환자들의 수명도 연장되고 있어 투석환자의 재활에 대한 관심이 점차 증가하고 있다.(중략)

• Journal of Veterinary Clinics
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• v.32 no.5
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• pp.399-403
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• 2015

Peritoneal dialysis (PD) is a treatment for renal failure and acute poisoning, and uses the patient's peritoneum in the abdomen as a membrane across which fluids and dissolved substances are exchanged from the blood. In this study, we evaluated the therapeutic efficacy and complications of automated peritoneal dialyzer (APD) in dogs with renal failure. PD was performed in 10 dogs using a swan neck catheter (Neonatal, Coviden) and automatic APD. The efficacy for each dog was assessed by calculating urea reduction ratio (URR) and creatinine reduction ratio (CRR). Mean concentrations of pre-dialysis creatinine and blood urea (BUN) were $7.09{\pm}3.84$ and $145.8{\pm}48.5$, respectively. The mean number of peritoneal dialysis cycles applied was $6{\pm}1$ cycles. Peritoneal dialysis resulted in a significant decrease in BUN concentration in 7/10 dogs, while a significant decrease in creatinine concentration in 9/10 dogs. The mean of URR was higher than that of CRR ($0.39{\pm}0.16$ vs $0.38{\pm}0.13$). The mean CRR and URR per dialysis cycles were $0.064{\pm}0.023$ and $0.065{\pm}0.023$, respectively. Complications found in this study were catheter occlusion, subcutaneous dialysate leakage, septic peritonitis, hypoalbuminemia and overhydration. This study found PD using a swan neck catheter and APD machine showed acceptable efficacy for successful peritoneal dialysis in dogs. However, close monitoring is required to minimize the risk of complication.

• Childhood Kidney Diseases
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• v.11 no.1
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• pp.41-50
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• 2007

Purpose : Dialysis in children with chronic renal failure presents with many difficulies. The purpose of this study is to find an improved method in chronic dialysis in infants and children less than 2 years of age by analyzing the experience with 10 cases. Methods : A retrospective review of the medical records of 10 patients(6 boys and 4 girls) was conducted. The patients had chronic renal failure and underwent chronic dialysis at Samsung medical center from March 1999 to February 2007. Results : At Initiation of dialysis, the median age was 3 months old(22 days-20 months), the median body weight was 3.75 kg(2.2-10.3 kg), and the median serum creatinine level was 4.3 mg/dL(2.0-11.4 mg/dL). The median duration of dialysis was 29.5 months(3-62 months). Dysplastic kidney disease was the most common underlying renal disease. Two patients were treated with hemodialysis, 4 patients with peritoneal dialysis, and 4 patients eventually switched dialysis modality. Nine of the 10 patients took erythropoietin and anti-hypertensive drugs. At the end of the follow up period, 1 patient received kidney transplantation, 2 patients died due to sepsis, and 5 patients were treated with peritoneal dialysis. Two patients were lost to follow up. The most common complication of dialysis was infection. Achieving vascular access and maintaining proper catheter function were the most important factors in treating patients with hemodialysis. The growth status of patients was aggravated after 6 month of dialysis but improved after 1 year of dialysis. Patients showed better growth on peritoneal dialysis than hemodialysis. Conclusion : Chronic dialysis can be performed successfully in infants and children under 2 years of age. Vascular access was the main limitation of hemodialysis, and infection was the common problem in both hemodialysis and peritoneal dialysis. To improve the patients survival rate and quality of life, major efforts should be directed toward the prevention of infection and preservation of catheter function. (J Korean Soc Pediatr Nephrol 2007;11:41-50)

• Proceedings of the Membrane Society of Korea Conference
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• 1996.10a
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• pp.8-11
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• 1996

전기투석은 역삼투압, 한외여과와 함께 가장 많이 이용되고 막공정 중의 하나이다. 전기투석은 다른 막공정과 같이 막의 선택성에 의한 분리조작이며 병렬식 배열에 의한 막의 이용이 가능하고 막오염 현상이 있으며 따라서 막-유체간의 접촉에 대한 제어가 필요하다. 전기투석은 운전목적에 따라 desalting electrodialysis(ED)와 water-splitting electrodiaiysis(WSED)로 구분할 수 있다. Desalting electrodialysis는 고전적 의미의 탈염을 위한 전기투석공정이며 WSED는 bipolar membrane을 이용하여 염을 산과 염기로 분리시키는 기능을 갖는 전기투석 공정을 말한다. WSED는 전기적으로 물을 분리한다는 의미로서 Electrohydrolysis로 불리기도 한다. WSED의 기본원리는 bipolar membrane의 양쪽면에서 수소이옹과 수산이온을 발생시켜 산 또는 염기용액으로 전달하고 bipolar membrane에 접하고 있는 양이온 또는 음이온 교환막에서는 각 용액의 전기적 중성을 유지하기 위해 대응하는 이온을 투과시키는 것이다. WSED는 염으로부터 산 염기제조 뿐만아니라 염의 형태로 생성되는 유기산, 아미노산 등 발효생성물의 회수 또는 acidification에 이용되고 있다.