• Journal of the KSME
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• v.50 no.2
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• pp.47-50
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• 2010

퇴행성관절염은 많은 인구가 앓고 있는 노인성 질병 중의 하나로 기계적인 원인과 생물학적인 원인에 의해 발생하고 진행한다고 보고되고 있다. 특히 슬관절은 보행 중에 많은 하중을 받고, 퇴행성관절염이 가장 흔한 관절이다. 이 글에서는 이전 보고들과 현재 인구 결과들을 바탕으로 보행역학과 퇴행성관절염에 대해 알아본다.

• Journal of Korean Foot and Ankle Society
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• v.15 no.3
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• pp.119-123
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• 2011

This article has reviewed the alignment of the ankle and hindfoot in varus ankle osteoarthritis. The indication and surgical technique of the supramalleolar osteotomy has been reviewed. Alignment of tibial plafond and hindfoot is variable in early stages of ankle osteoarthritis. Supramalleolar osteotomy is indicated for the treatment of ankle osteoarthritis in patients with minimal talar tilt and neutral or varus heel alignment.

• 대한관절경학회:학술대회논문집
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• 2007.10a
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• pp.11-12
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• 2007

• Journal of the Korean Society of Food Science and Nutrition
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• v.45 no.5
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• pp.634-641
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• 2016

The objective of this research was to investigate the in vivo effects of treatment with mulberry extract complex (MEC) on cartilage degeneration and pain severity in an experimental model of rat degenerative arthritis. Monosodium iodoacetate ($2mg/50{\mu}L$) was injected into right knee joints of rats, followed by administration of MEC for 8 weeks at 400 mg/kg or 800 mg/kg of body weight. The experimental data show that treatment with MEC inhibited degradation of glycosaminoglycan and collagen in cartilage. On the other hand, concentrations of cartilage oligomeric matrix protein, C-terminal telopeptide-2, matrix metalloproteinase (MMP)-2, MMP-9, and MMP-13 in serum decreased in comparison with the control. The MEC at all dose levels could inhibit formation of xylene-induced ear edema. In this study, MEC demonstrated significant anti-arthritis activity, which is required for improvement of degenerative arthritis. Based on these results, MEC may be employed for the development of new health foods to ease symptoms of degenerative arthritis.

• Applied Microscopy
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• v.35 no.2
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• pp.73-80
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• 2005

To observe the morphological changes and the expression of tenascin in synovium of human knee joint, between normal condition and degenerative arthritis, were processed by immunoelectron microscopic method. The results were summarized as follows. 1. In degenerative arthritis, the hyperplasia of synovial membrane was characterized by the increase of cell number in secretory synovial cells. 2. In normal condition, there was no marking of the immuno-gold for tenascin in synovial membrane. 3. In degenerative arthritis, the immuno-gold for tenascin were observed in endoplasmic reticulum of secretory synovial cells and extracellular matrix of synovial layer. On the basis of above findings, the hyperplasia of synovial membrane and the pathologic processes may be concerned with the increase of number of secretory synovial cells and of expression of tenascin, in degenerative arthritis.

• Journal of Veterinary Clinics
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• v.26 no.2
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• pp.144-149
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• 2009

Chondrocytes and synovial fluid derived markers are used to monitor for osteoarthritis(OA). Specific inhibitors, known as tissue inhibitors of metalloproteinases(TIMP), regulate the proteolytic activity of matrix metalloproteinases(MMP). This study investigated whether MMP and TIMP levels were altered in synovial fluid and cartilage following the experimental induction of OA in canines. Twenty mature beagle dogs underwent a unilateral surgical transection of the cranial cruciate ligament and the medial collateral ligament as well as a medial meniscectomy. Matrix metalloproteinase-2 and MMP-9 levels were assayed using Western blot and TIMP-2 levels were measured with enzyme-linked immunosorbent assays four weeks after OA induction. Increased MMP-2 expression was observed in chondrocytes isolated from cartilage following OA induction, but MMP-9 expression decreased. Matrix metalloproteinase-2 and MMP-9 levels in synovial fluid from the OA induced joint significantly increased compared to those of the sham group. Tissue inhibitors of metalloproteinase-2 concentrations were higher in chondrocytes from the OA cartilage, yet TIMP-2 remained lower in the synovial fluid of OA. This suggests the elevated release of MMP-9 over MMP-2 into the synovial fluid following the cartilage degradation-related death of chondrocytes after OA. Osteoarthritis can be further deteriorated by increased MMP activity in the synovial fluid because TIMP-2 exist low concentration into the extracellular matrix. As a result, MMP activity, particularly MMP-9 activity, can be useful as a biomarker in diagnosing and monitoring the early stages of canine OA.

• 건강소식
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• v.35 no.7
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• pp.24-25
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• 2011

퇴행성 관절염은 관절을 보호하고 있는 연골이 마모되면서 뼈끼리 맞닿아 마찰을 이루면서 통증, 부종, 염증뿐 아니라 관절 변형 및 운동 장애까지 불러오는 질환이다. 50세 이상의 노년층에서 가장 흔히 찾아볼 수 있으며, 손가락, 발가락부터 허리, 고관절 등 전신의 어느 부위에서나 나타날 수 있다.

• 건강소식
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• v.30 no.1 s.326
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• pp.6-9
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• 2006

관절염은 관절에 염증을 일으키는 현상을 말하며, 염증이란 병든 부위에 부종, 홍조, 발열, 동통과 같은 병리학적인 반응을 특징으로 한다. 관절염은 그 자체가 병명이 아니고 어떤 질환의 한결과로서 나타난다. 그러므로 관절염이 발생하면 그 원인 질환이 무엇인지 찾아보아야 한다. 관절염의 종류는 무려 100여 가지가 넘으며 퇴행성 관절염, 류머티스 관절염, 통풍성 관절염, 루푸스, 통풍 등이 일반적으로 흔한 종류이다.

• Journal of the Korean Applied Science and Technology
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• v.38 no.2
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• pp.368-377
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• 2021

The present study aimed to evaluate the effects of radiation mutant Perilla frutescens var. crispa and Atractylodes macrocephala Koidzumi complex extract(Perilla frutescens var. crispa complex extract) on the mediators related to degenerative arthritis in a monosodium iodoacetate-induced rat model of degenerative arthritis. Perilla frutescens var. crispa complex extract was administered orally at doses of 25, 50 or 100 mg/kg/day for 2 weeks before direct injection of monosodium iodoacetate (3 mg/50 µl of 0.9% saline) into the intra-articular space of the rats' right knees. The rats subsequently received the same doses of oral Perilla frutescens var. crispa complex extract for another 4 weeks. It was evaluated that the treatment effects based on serum bio-markers, and morphological and histopathological analysis of the knee joints. Compared with those in negative control rats, the Perilla frutescens var. crispa complex extract treatments significantly reduced the serum levels of inflammation, bone metabolism markers (i.e., TNF-α, MMP-3, COX-2, PGE₂, COMP, and Aggrecan). Otherwise, it was significantly increased the production of CTX-2 in cartilage absorption mediators. In addition, the Perilla frutescens var. crispa complex extract treatments effectively preserved the knee cartilage and synovial membrane. As a result, it indicates that the Perilla frutescens var. crispa complex extract improved degenerative arthritis symptoms. Thus, the Perilla frutescens var. crispa complex can be used in food material for the management of degenerative arthritis.

• Journal of Digital Convergence
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• v.11 no.9
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• pp.247-254
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• 2013

This study was to investigate the effects of pain control and improvement function to far infrared ray of carbon surface heating element applied on elderly women with knee osteoarthritis. The subjects for this study were forty-five subjects with osteoarthritis, who were divided convenice sampling into 3 groups, control(15 female, no intervention), ceramic far infrared ray(15 female, applied ceramic far infrared rays) and carbon surface-heating(15 female, applied carbon surface-heating) after treatment measuring VAS, PPT and K-WOMAC. These results represent decreased pain and improved function by applied carbon surface heating element and ceramic far infrared ray on osteoarthritis knee. Therefore, carbon surface heating element will be a good treatment for osteoarthritis.